Cell signaling pathways elicited by asbestos.

abstract：BACKGROUND:The mechanisms governing the correlation between exposure to ultrafine particles and the increased incidence of cardiovascular disease remain unknown. Ultrafine particles appear to cross the pulmonary epithelial barrier into the bloodstream, raising the possibility of direct contact with the vascular endothe...

journal_title：Environmental health perspectives

authors： Gojova A,Guo B,Kota RS,Rutledge JC,Kennedy IM,Barakat AI

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Discoveries that emerging and re-emerging pathogens have their origin in environmental change has created an urgent need to understand how these environmental changes impact disease burden. In this article we present a framework that provides a context from which to examine the relationship between environme...

journal_title：Environmental health perspectives

authors： Eisenberg JN,Desai MA,Levy K,Bates SJ,Liang S,Naumoff K,Scott JC

更新日期：2007-08-01 00:00:00

abstract：:Many epidemiologic reports associate ambient levels of particulate matter (PM) with human mortality and morbidity, particularly in people with preexisting cardiopulmonary disease (e.g., chronic obstructive pulmonary disease, infection, asthma). Because much ambient PM is derived from combustion sources, we tested the ...

journal_title：Environmental health perspectives

authors： Costa DL,Dreher KL

更新日期：1997-09-01 00:00:00

abstract：:We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detect...

journal_title：Environmental health perspectives

authors： Barr DB,Barr JR,Bailey SL,Lapeza CR Jr,Beeson MD,Caudill SP,Maggio VL,Schecter A,Masten SA,Lucier GW,Needham LL,Sampson EJ

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Cadmium (Cd) is a human toxicant and carcinogen. Genetic variation might affect long-term accumulation. Cd is absorbed via iron transporters. OBJECTIVES:We evaluated the impact of iron homeostasis genes [divalent metal transporter 1 (SLC11A2), transferrin (TF), transferrin receptors (TFR2 and TFRC), and fer...

journal_title：Environmental health perspectives

authors： Rentschler G,Kippler M,Axmon A,Raqib R,Ekström EC,Skerfving S,Vahter M,Broberg K

更新日期：2013-04-01 00:00:00

abstract：:The current Good Manufacturing Practice (cGMP) and effluent emission (use and disposal) regulations of the U.S. Food and Drug Administration (FDA) and manufacturing effluent discharge and emission regulations of the U.S. Environmental Protection Agency (U.S. EPA) require contained manufacture, use, and disposal of pha...

journal_title：Environmental health perspectives

authors： Velagaleti R,Burns PK,Gill M,Prothro J

更新日期：2002-03-01 00:00:00

abstract：:A major goal of studying farmworkers is to better understand how their work environment, including exposure to pesticides, affects their health. Although a number of health conditions have been associated with pesticide exposure, clear linkages have yet to be made between exposure and health effects except in cases of...

journal_title：Environmental health perspectives

authors： McCauley LA,Anger WK,Keifer M,Langley R,Robson MG,Rohlman D

更新日期：2006-06-01 00:00:00

abstract：:Metals have been mined and used since ancient times. The industrial era has seen a sharp increase in both the amounts and variety of metals that find applications in industry. The inadvertent release of metals, such as from fossil fuel consumption, also adds to the global burden. A number of catastrophic outbreaks hav...

journal_title：Environmental health perspectives

authors： Clarkson T

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Because of complex interactions of climate variables at the levels of the pathogen, vector, and host, the potential influence of climate change on vector-borne and zoonotic diseases (VBZDs) is poorly understood and difficult to predict. Climate effects on the nonvector-borne zoonotic diseases are especially ...

journal_title：Environmental health perspectives

authors： Mills JN,Gage KL,Khan AS

更新日期：2010-11-01 00:00:00

abstract：:Implementation of the Toxic Substances Control Act of 1977 creates the need to reliably establish testing priorities because laboratory resources are limited and the number of industrial chemicals requiring evaluation is overwhelming. The use of quantitative structure activity relationship (QSAR) models as rapid and p...

journal_title：Environmental health perspectives

authors： McKim JM,Bradbury SP,Niemi GJ

更新日期：1987-04-01 00:00:00

abstract：:Adults eating a Western diet digest and absorb ingested food containing approximately 100 g fat, 350 g carbohydrate, and 75 g protein daily. Normal fat absorption requires adequate gastric, pancreatic, liver-biliary, mucosal, and lymphatic function. Carbohydrate and protein absorption is much less dependent on liver-b...

journal_title：Environmental health perspectives

authors： Heizer WD

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Drinking water contamination related to the use of aqueous film-forming foam (AFFF) has been documented at hundreds of military bases, airports, and firefighter training facilities. AFFF has historically contained high levels of long-chain per- and polyfluoroalkyl substances (PFAS), which pose serious health...

journal_title：Environmental health perspectives

authors： Annunziato KM,Doherty J,Lee J,Clark JM,Liang W,Clark CW,Nguyen M,Roy MA,Timme-Laragy AR

更新日期：2020-09-01 00:00:00

abstract：:A human lymphoblastoid cell line has been used to test for mutations caused by combustion-generated soot particles and their constituent components, which are substrate carbon-black and adsorbed condensate, principally in the form of polycyclic aromatic hydrocarbons (PAH). It was found that the mutagenicity of the PAH...

journal_title：Environmental health perspectives

authors： Bolsaitis PP,Feitelberg AS,Dekermendjian V,Elliott JF,Sarofim AF,Thilly WG

更新日期：1991-12-01 00:00:00

abstract：:Although press reports indicate that the leakage of methyl isocyanate (MIC) on December 3, 1984, in Bhopal has led to an increase in spontaneous abortions, stillbirths, infant mortality, and fetal abnormalities, no clinical or experimental studies on the reproductive toxicity of MIC were reported in scientific journal...

journal_title：Environmental health perspectives

authors： Varma DR

更新日期：1987-06-01 00:00:00

abstract：:Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1...

journal_title：Environmental health perspectives

authors： Meeker JD,Ryan L,Barr DB,Herrick RF,Bennett DH,Bravo R,Hauser R

更新日期：2004-12-01 00:00:00

abstract：:The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c ...

journal_title：Environmental health perspectives

authors： Dippold W,Steinborn A,Meyer zum Büschenfelde KH

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:The metabolome is a collection of exogenous chemicals and metabolites from cellular processes that may reflect the body's response to environmental exposures. Studies of air pollution and metabolomics are limited. OBJECTIVES:To explore changes in the human metabolome before, during, and after the 2008 Beiji...

journal_title：Environmental health perspectives

authors： Mu L,Niu Z,Blair RH,Yu H,Browne RW,Bonner MR,Fanter T,Deng F,Swanson M

更新日期：2019-05-01 00:00:00

abstract：:An intercomparison exercise was conducted for the quantification of arsenic species in spiked human urine. The primary objective of the exercise was to determine the variance among laboratories in the analysis of arsenic species such as inorganic As (As+3 and As+5), monomethylarsonic acid (MMA), and dimethylarsinic ac...

journal_title：Environmental health perspectives

authors： Crecelius E,Yager J

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Due to the large number of chemicals not yet tested for carcinogenicity but to which people are exposed, the limited number of human and animal cancer studies conducted each year, and the frequent need for a timely response, mechanistic data are playing an increasingly important role in carcinogen hazard ide...

journal_title：Environmental health perspectives

authors： Atwood ST,Lunn RM,Garner SC,Jahnke GD

更新日期：2019-12-01 00:00:00

abstract：:To study the effect of processing on polybrominated biphenyl (PBB) levels, milk from four dairy herds containing less than 0.3 ppm (fat basis) of physiologically incorporated PBBs was presented individually into cream, skim milk, butter, and stirred curd cheese. Pasteurized and freeze-dried whole milk, skim milk, and ...

journal_title：Environmental health perspectives

authors： Zabik ME,Johnson TM,Smith S

更新日期：1978-04-01 00:00:00

abstract：:Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such epidemiologic studies will most likely be prompted either by a known release of chemicals into the environment around the site, or by an unusual disease cluster in a population...

journal_title：Environmental health perspectives

authors： Buffler PA,Crane M,Key MM

更新日期：1985-10-01 00:00:00

abstract：:Scaling of the quantified dispositional parameters of xenobiotics from animals to man is of interest from the standpoint of toxicology (e.g., poisoning and risk assessment). Scaling is also important from the standpoint of therapeutics because it represents a strategy for predicting first-use-in-human doses in clinica...

journal_title：Environmental health perspectives

authors： Bachmann K,Pardoe D,White D

更新日期：1996-04-01 00:00:00

abstract：:The X-ray crystallographic structural determinations of synthetic estrogens and antiestrogens provide reliable information on the global minimum energy conformation of these molecules or a local minimum energy conformation that is within 1 or 2 kcal/mole of the global minimum. In favorable cases, state-of-the-art mole...

journal_title：Environmental health perspectives

authors： Duax WL,Griffin JF,Weeks CM,Korach KS

更新日期：1985-09-01 00:00:00

abstract：:High-dose boric acid (BA) exposure produces testicular lesions in adult rats characterized by inhibited spermiation (IS) that may progress to atrophy. In vivo and in vitro studies addressed possible mechanisms. In vivo, boron tissue disposition was examined, since no detailed data existed, and relevant boron concentra...

journal_title：Environmental health perspectives

authors： Ku WW,Chapin RE

更新日期：1994-11-01 00:00:00

abstract：:The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in our laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of ma...

journal_title：Environmental health perspectives

authors： Sorenson WG,Gerberick GF,Lewis DM,Castranova V

更新日期：1986-04-01 00:00:00

abstract：:The disruption of the reproductive system of male and female animals in the wild has been attributed to environmental chemicals (xenobiotics). The effects seen mirror alterations one might anticipate if the steroid hormone-dependent processes that regulate these systems were impaired. To determine whether xenobiotics ...

journal_title：Environmental health perspectives

authors： Danzo BJ

更新日期：1997-03-01 00:00:00

abstract：:To assess quantitatively the association between benzene and leukemia, we evaluated the rate of mortality experienced by a cohort occupationally exposed to benzene. Using data from historical air sampling surveys, we estimated the daily benzene exposure for each member of the cohort. The expected number of leukemia de...

journal_title：Environmental health perspectives

authors： Rinsky RA

更新日期：1989-07-01 00:00:00

abstract：:In this study, we evaluated the impact of long-term occupational exposure to elemental mercury vapor (Hg0) on the personality traits of ex-mercury miners. Study groups included 53 ex-miners previously exposed to Hg0 and 53 age-matched controls. Miners and controls completed the self-reporting Eysenck Personality Quest...

journal_title：Environmental health perspectives

authors： Kobal Grum D,Kobal AB,Arneric N,Horvat M,Zenko B,Dzeroski S,Osredkar J

更新日期：2006-02-01 00:00:00

abstract：:We present a model to plan a rational strategy for cancer prevention that has two main functions--assessment and intervention. The assessment function includes three main components: to identify populations at high cancer risk, which may be due to their ethnic group, occupational and environmental exposures, family hi...

journal_title：Environmental health perspectives

authors： Anton-Culver H

更新日期：1995-11-01 00:00:00

abstract：:In this study, we aimed to estimate the contribution of environmental pollutants to the incidence, prevalence, mortality, and costs of pediatric disease in American children. We examined four categories of illness: lead poisoning, asthma, cancer, and neurobehavioral disorders. To estimate the proportion of each attrib...

journal_title：Environmental health perspectives

authors： Landrigan PJ,Schechter CB,Lipton JM,Fahs MC,Schwartz J

更新日期：2002-07-01 00:00:00