DNA damage-inducible genes as biomarkers for exposures to environmental agents.

abstract：BACKGROUND:Preimplantation embryo loss during oviduct transit has been observed in adult mice after a 5-day neonatal exposure to the phytoestrogen genistein (Gen; 50 mg/kg/day). OBJECTIVE:We investigated the mechanisms underlying the contribution of the oviduct to infertility. METHODS:Female mice were treated on post...

journal_title：Environmental health perspectives

authors： Jefferson WN,Padilla-Banks E,Phelps JY,Gerrish KE,Williams CJ

更新日期：2011-11-01 00:00:00

abstract：:Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); northwest region three (wheat, sugar beets, potatoes); and northeast region four (forested and urban in character). Cancer mortality (1980-...

journal_title：Environmental health perspectives

authors： Schreinemachers DM,Creason JP,Garry VF

更新日期：1999-03-01 00:00:00

abstract：:Methyl eugenol is a naturally occurring material found in a variety of food sources, including spices, oils, and nutritionally important foods such as bananas and oranges. Given its natural occurrence, a broad cross-section of the population is likely exposed. The availability of biomonitoring and toxicology data offe...

journal_title：Environmental health perspectives

authors： Robison SH,Barr DB

更新日期：2006-11-01 00:00:00

abstract：:This paper examines behavioral changes in natural populations of wildlife associated with pollution. Although some changes such as lack of nest attentiveness and decreased nest defense have been noted, the results have not been consistent and have been difficult to relate to specific pollutants. Experimental studies i...

journal_title：Environmental health perspectives

authors： Peakall DB

更新日期：1996-04-01 00:00:00

abstract：:Short-term increases in ambient air pollution have been associated with an increased incidence of acute cardiac events. We assessed the effect of inhalation exposure to concentrated ambient particles (CAPs) on myocardial ischemia in a canine model of coronary artery occlusion. Six mongrel dogs underwent thoracotomy fo...

journal_title：Environmental health perspectives

authors： Wellenius GA,Coull BA,Godleski JJ,Koutrakis P,Okabe K,Savage ST,Lawrence JE,Murthy GG,Verrier RL

更新日期：2003-04-01 00:00:00

abstract：:The types of reactive intermediates generated upon reduction of chromium(VI) by glutathione or hydrogen peroxide and the resulting DNA damage have been determined. In vitro, reaction of chromium(VI) with glutathione led to formation of two chromium(V) complexes and the glutathione thiyl radical. When chromium(VI) was ...

journal_title：Environmental health perspectives

authors： Aiyar J,Berkovits HJ,Floyd RA,Wetterhahn KE

更新日期：1991-05-01 00:00:00

abstract：:Many substances are active in in vitro tests for estrogenic activity, but data from multigenerational and other toxicity studies are not available for many of those substances. Controversy has arisen, therefore, concerning the likelihood of adverse health effects. Based on a toxic equivalence factor risk assessment ap...

journal_title：Environmental health perspectives

authors： Rudel R

更新日期：1997-04-01 00:00:00

abstract：:The chlorinated hydrocarbons chloroform (CHCl3), 1,1-dichlorethane (1,1-DCE) and 1,2-dichloroethane (1,2-DCE) have been detected in finished drinking water. When administered to B6C3F1 mice by gavage in corn oil, these compounds have been shown to induce hepatic tumors. The present study examines the effect on liver t...

journal_title：Environmental health perspectives

authors： Klaunig JE,Ruch RJ,Pereira MA

更新日期：1986-11-01 00:00:00

abstract：:This paper concerns the testing for Hardy-Weinberg equilibrium and the estimation of gene frequency in the human leukocyte antigens (HLA) system. An extensive simulation study for both testing and estimation is given for investigating the performance of the projection method by Eguchi and Matsuura, which has a closed ...

journal_title：Environmental health perspectives

authors： Matsuura M,Eguchi S

更新日期：1990-07-01 00:00:00

abstract：:The epidemiological data linking air pollution and lung cancer are derived from statistical associations concerning rates of cancer among urban and rural residents, migrant studies and studies of occupational groups exposed to effluents from fossil fuel combinations. Few, if any of these studies, are adequately adjust...

journal_title：Environmental health perspectives

authors： Speizer FE

更新日期：1983-01-01 00:00:00

abstract：:To analyze the implications for human health, the toxicologist requires four sets of data: the results of toxicity and other studies in animals; quantitative data on actual or potential human exposure; whatever information is available on effects of exposure in man; and the statistical extrapolations from the dose-res...

journal_title：Environmental health perspectives

authors： Golberg L

更新日期：1979-10-01 00:00:00

abstract：:A physiologically based pharmacokinetic model for trichloroethylene (TCE) in rodents and humans was calibrated with published toxicokinetic data sets. A Bayesian statistical framework was used to combine previous information about the model parameters with the data likelihood, to yield posterior parameter distribution...

journal_title：Environmental health perspectives

authors： Bois FY

更新日期：2000-05-01 00:00:00

abstract：:Multiple chemical sensitivity (MCS) is a condition in which persons experience negative health effects in multiple organ systems from exposure to low levels of common chemicals. Although symptoms experienced from particular chemicals vary across persons, they are generally stable within persons. The sensitivities ofte...

journal_title：Environmental health perspectives

authors： Gibson PR,Elms AN,Ruding LA

更新日期：2003-09-01 00:00:00

abstract：:The relationship between blood lead concentration and blood pressure is examined in a survey of 7371 men aged 40 to 59 from 24 British towns. After allowance for relevant confounding variables, including town of residence and alcohol consumption, there exists a very weak but statistically significant positive associat...

journal_title：Environmental health perspectives

authors： Pocock SJ,Shaper AG,Ashby D,Delves HT,Clayton BE

更新日期：1988-06-01 00:00:00

abstract：:Previous NIOSH studies demonstrated the embryo- and fetotoxicity and teratogenicity of ethylene glycol monoethyl ether (EGEE) applied to the shaved skin of pregnant rats. In the present study ethylene glycol monoethyl ether acetate (EGEEA), ethylene glycol monobutyl ether (EGBE), and diethylene glycol monoethyl ether ...

journal_title：Environmental health perspectives

authors： Hardin BD,Goad PT,Burg JR

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Evidence suggests that cardiovascular effects of air pollution are mediated by inflammation and that air pollution can induce genetic expression of the interleukin-6 gene (IL6). OBJECTIVES:We investigated whether IL6 and fibrinogen gene variants can affect plasma IL-6 responses to air pollution in patients ...

journal_title：Environmental health perspectives

authors： Ljungman P,Bellander T,Schneider A,Breitner S,Forastiere F,Hampel R,Illig T,Jacquemin B,Katsouyanni K,von Klot S,Koenig W,Lanki T,Nyberg F,Pekkanen J,Pistelli R,Pitsavos C,Rosenqvist M,Sunyer J,Peters A

更新日期：2009-09-01 00:00:00

abstract：:Dietary components express a wide range of activities that can affect carcinogenesis. Naturally occurring substances in foods have been shown in laboratory experiments to serve as dietary antimutagens, either as bioantimutagens or as desmutagens. Dietary desmutagens may function as chemical inactivaters, enzymatic ind...

journal_title：Environmental health perspectives

authors： Kohlmeier L,Simonsen N,Mottus K

更新日期：1995-11-01 00:00:00

abstract：:Impairment of any of the major components of the immune system (T-cells, B-cells phagocytes, complement) may result in clinical immunodeficiency. Immune defects can arise from intrinsic or heritable defects of lymphoid elements, failure of normal cellular differentiation, viral infection or other acquired causes. Clin...

journal_title：Environmental health perspectives

authors： Heise ER

更新日期：1982-02-01 00:00:00

abstract：:A meeting on Marine Biomedical Research, sponsored by the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health and the Smithsonian Institution Museum of Natural History, was attended by approximately 125 scientists, directors and representatives from many of the country's marine b...

journal_title：Environmental health perspectives

authors： Bessey O

更新日期：1976-02-01 00:00:00

abstract：:The discovery of the potent mutagenicity of AF-2, which was once used in Japan as a food preservative, has exerted a great influence not only on screening procedures for carcinogenic compounds but also on legislative approaches to mutagenic substances. It promoted the synthesis of exceedingly sensitive and reliable te...

journal_title：Environmental health perspectives

authors： Tazima Y

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Exposure to arsenic via drinking water is a global environmental health problem. In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in early adulthood. OBJECTIVES:We aimed to investigate how arsenic exposu...

journal_title：Environmental health perspectives

authors： Ramsey KA,Bosco A,McKenna KL,Carter KW,Elliot JG,Berry LJ,Sly PD,Larcombe AN,Zosky GR

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Anogenital distance (AGD) in animals is a sensitive biomarker of fetal endocrine disruption and the associated testicular dysgenesis syndrome (TDS). However, AGD in human infants with cryptorchidism and hypospadias, which are potential manifestations of TDS during childhood, is not clearly described. OBJECT...

journal_title：Environmental health perspectives

authors： Thankamony A,Lek N,Carroll D,Williams M,Dunger DB,Acerini CL,Ong KK,Hughes IA

更新日期：2014-02-01 00:00:00

abstract：:Scaling of the quantified dispositional parameters of xenobiotics from animals to man is of interest from the standpoint of toxicology (e.g., poisoning and risk assessment). Scaling is also important from the standpoint of therapeutics because it represents a strategy for predicting first-use-in-human doses in clinica...

journal_title：Environmental health perspectives

authors： Bachmann K,Pardoe D,White D

更新日期：1996-04-01 00:00:00

abstract：:Exposure to air polluted with particles less than 2.5 micron in size is associated epidemiologically with adverse cardiopulmonary health consequences in humans. The goal of this study was to characterize human pulmonary responses to controlled experimental high-dose exposure to fine and ultrafine magnesium oxide parti...

journal_title：Environmental health perspectives

authors： Kuschner WG,Wong H,D'Alessandro A,Quinlan P,Blanc PD

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and gene...

journal_title：Environmental health perspectives

authors： Demchuk E,Yucesoy B,Johnson VJ,Andrew M,Weston A,Germolec DR,De Rosa CT,Luster MI

更新日期：2007-02-01 00:00:00

abstract：:Of 240 pesticides screened for carcinogenicity by the U.S. Environmental Protection Agency Office of Pesticide Programs, at least 24 (10%) produce thyroid follicular cell tumors in rodents. Thirteen of the thyroid carcinogens also induce liver tumors, mainly in mice, and 9 chemicals produce tumors at other sites. Some...

journal_title：Environmental health perspectives

authors： Hurley PM

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Evidence indicates that air pollution contributes to cardiopulmonary mortality. There is ongoing debate regarding the size and shape of the pollution–mortality exposure–response relationship. There are also growing appeals for estimates of pollution–mortality relationships that use public data and are based ...

journal_title：Environmental health perspectives

authors： Pope CA 3rd,Lefler JS,Ezzati M,Higbee JD,Marshall JD,Kim SY,Bechle M,Gilliat KS,Vernon SE,Robinson AL,Burnett RT

更新日期：2019-07-01 00:00:00

abstract：:In this paper we report yields, identities, and mutagenicities of products from heating a polycyclic aromatic hydrocarbon (PAH)-contaminated, Superfund-related synthetic soil matrix without exogenous oxygen. We heated batch samples of soil pretreated with 5.08 wt% (by weight) pyrene in a tubular furnace under a consta...

journal_title：Environmental health perspectives

authors： Richter H,Risoul V,Lafleur AL,Plummer EF,Howard JB,Peters WA

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES:In this case-control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. ME...

journal_title：Environmental health perspectives

authors： Scélo G,Metayer C,Zhang L,Wiemels JL,Aldrich MC,Selvin S,Month S,Smith MT,Buffler PA

更新日期：2009-01-01 00:00:00

abstract：:A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning. Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls. Lesions were characterized by the appearance of edema and epithelial...

journal_title：Environmental health perspectives

authors： Roncero V,Vincente JA,Redondo E,Gãzquez A,Duran E

更新日期：1990-11-01 00:00:00