Abstract:
BACKGROUND:Benzene is a common industrial chemical known to induce leukemia and other blood disorders, as well as aneuploidy, in both human blood cells and sperm at exposures > 10 ppm. Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S. Occupational Safety and Health Administration.
OBJECTIVE:We investigated whether occupational exposures to benzene near 1 ppm induce aneuploidy in sperm.
METHODS:We used multicolor fluorescence in situ hybridization to measure the incidence of sperm with numerical abnormalities of chromosomes X, Y, and 21 among 33 benzene-exposed men and 33 unexposed men from Chinese factories. Individual exposures were assessed using personal air monitoring and urinary concentrations of benzene and trans,trans-muconic acid (E,E-MA). Air benzene concentrations were not detectable in unexposed men; in exposed men, concentrations ranged from below the detection limit to 24 ppm (median, 2.9 ppm), with 27% of exposed men (n = 9) having concentrations of journal_name journal_title authors doi subject pub_date pages issue eissn issn journal_volume pub_type
abstract:BACKGROUND:Prospective cohort studies constitute the major source of evidence about the mortality effects of chronic exposure to particulate air pollution. Additional studies are needed to provide evidence on the health effects of chronic exposure to particulate matter < or = 2.5 microm in aerodynamic diameter (PM(2.5)...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11449
更新日期:2008-12-01 00:00:00
abstract::Studies performed earlier have shown a positive relation between blood lead (a parameter for lead body burden) and blood pressure, whereas such a relation between urine cadmium (a parameter for cadmium body burden) and blood pressure could not be shown. Median (i.e., 50th percentile, P50) blood levels in the general p...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.887867
更新日期:1988-06-01 00:00:00
abstract::Droplets of toluene and three chlorinated organics, ortho-dichlorobenzene, 1,2-dichloroethane, and trichloroethylene, were pyrolyzed in pure nitrogen. The composition and bacterial mutagenicity of the product tars were measured. The presence of organic chlorine was found to affect both pyrolysis product tar compositio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s1283
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Chronic exposure to well water arsenic (As) remains a major rural health challenge in Bangladesh and some other developing countries. Many mitigation programs have been implemented to reduce As exposure, although evaluation studies for these efforts are rare in the literature. OBJECTIVES:In this study we es...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409462
更新日期:2015-12-01 00:00:00
abstract::Considerable attention has been given to the relationship between levels of fine particulate matter (particulate matter < or = 2.5 microm in aerodynamic diameter; PM(2.5) in the atmosphere and health effects in human populations. Since the U.S. Environmental Protection Agency began widespread monitoring of PM(2.5) lev...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6980
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Associations between airborne particles and health outcomes have been documented worldwide; however, there is limited information regarding health effects associated with different particle sizes. OBJECTIVES:We explored the association between size-fractionated particle number concentrations (PNCs) and dail...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1206398
更新日期:2013-10-01 00:00:00
abstract::Consideration of needs for public health interventions and new research requires comparative assessments of the health benefits that are likely to result from alternative uses of limited regulatory and technical resources. This paper briefly examines regulatory and research priorities in the light of recent informatio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8141227
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:The potential impact of microwave radiofrequency electromagnetic fields (RF-EMF) emitted by wireless communication devices on neurocognitive functions of adolescents is controversial. In a previous analysis, we found changes in figural memory scores associated with a higher cumulative RF-EMF brain dose in ad...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP2427
更新日期:2018-07-23 00:00:00
abstract::Soil samples were collected from 28 fields which had received manure from Michigan's most highly contaminated dairy herds. The number of fields in each concentration range of PBB in soil were: 2, not detectable; 15, 0.0 to 8.0 ppb; 6, 14-102 ppb, and 5, 153 to 371 ppb. Plant tissue sampled from the 10 most highly cont...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.78231
更新日期:1978-04-01 00:00:00
abstract::The integrated exposure uptake biokinetic model for lead in children was developed to provide plausible blood lead distributions corresponding to particular combinations of multimedia lead exposure. The model is based on a set of equations that convert lead exposure (expressed as micrograms per day) to blood lead conc...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106s61513
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Exposure to organophosphate (OP) pesticides is an occupational hazard for farmworkers and affects their children through the take-home pathway. OBJECTIVES:We examined the effectiveness of a randomized community intervention to reduce pesticide exposure among farmworkers and their children. METHODS:We condu...
journal_title:Environmental health perspectives
pub_type: 杂志文章,随机对照试验
doi:10.1289/ehp.10882
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Trying to publish a paper in a top-rated peer-reviewed journal can be a difficult and frustrating experience for authors. It is important that authors understand the general review process before submitting manuscripts for publication. OBJECTIVES:Editors-in-chief and associate editors from top-tier journals...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1003280
更新日期:2011-07-01 00:00:00
abstract::The association of blood lead (B-Pb) concentration to blood pressure was investigated in men aged 55 to 75 years living in the Rome area, who had no history of exposure to lead in the workplace and who participated between 1989 and 1990 in an epidemiologic survey for coronary heart disease (New Risk Factor Project). O...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s9107
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Exposure to metals has been implicated in the pathogenesis of Parkinson disease (PD). OBJECTIVES:We sought to examine in a large prospective study of female nurses whether exposure to airborne metals was associated with risk of PD. METHODS:We linked the U.S. Environmental Protection Agency (EPA)'s Air Toxi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307218
更新日期:2014-09-01 00:00:00
abstract::Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids and proteins, and the carcinogenicity of 10 of these HAs in rodents and of 1 in monkeys has been reported. Quantification of these carcinogenic HAs in various kinds of cooked foods indicated that the level of 2...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9399129
更新日期:1993-03-01 00:00:00
abstract::I examined non-Hispanic Black and non-Hispanic White differences in exposure to noncriteria air pollutants in 44 U.S. Census Bureau-defined metropolitan areas with populations greater than one million, using data on air toxics concentrations prepared for the U.S. Environmental Protection Agency as part of its Cumulati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110s2289
更新日期:2002-04-01 00:00:00
abstract::The available data on the influence of selenium on the toxicity of methylmercury and of methylmercury on selenium as a nutrient and toxic agent are reviewed. Selenium as selenite has a relative protective effect on acute and subacute toxicity of methylmercury in the rat and the quail. The protective mechanism is far f...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.782557
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Organophosphate flame retardants (PFRs) are becoming popular replacements for the phased-out polybrominated diphenyl ether (PBDE) mixtures, and they are now commonly detected in indoor environments. However, little is known about human exposure to PFRs because they cannot be easily measured in blood or serum...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408669
更新日期:2015-02-01 00:00:00
abstract::Metallothionein from livers of mice was isolated by gel chromatography and isoelectric focusing. One of two forms thus obtained contained 32 percent cysteine. This form, labeled in vitro with 109Cd, was injected intravenously in mice, and the distribution of 109Cd was studied. Animals killed after 4 hrs had over 80 pe...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7512103
更新日期:1975-12-01 00:00:00
abstract::The clinical use of polymeric materials in the body to repair and restore damaged or diseased tissues and organs is substantially increasing on an annual basis. Concomitant with this use is an increase in materials related research on medically used polymers. Information on the historical and current clinical use of p...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.751171
更新日期:1975-06-01 00:00:00
abstract::This work group report addresses the central question: What are the critical windows during development (preconception through puberty) when exposure to xenobiotics may have the greatest adverse impact on subsequent reproductive health? The reproductive system develops in stages, with sex-specific organogenesis occurr...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108s3505
更新日期:2000-06-01 00:00:00
abstract::Principles and practices of pediatric neurotoxicology are reviewed here with the purpose of guiding the design and execution of the planned National Children's Study. The developing human central nervous system is the target organ most vulnerable to environmental chemicals. An investigation of the effects of environme...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7672
更新日期:2005-10-01 00:00:00
abstract::Biological monitoring of exposure to chemicals in the workplace is an important component of exposure assessment and prevention of adverse health effects. It should be employed in conjunction with ambient air monitoring to provide information on the absorbed dose of a chemical agent and the effect of all routes of exp...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s1105
更新日期:1997-02-01 00:00:00
abstract::Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breas...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6220
更新日期:2003-07-01 00:00:00
abstract::The extracellular lining of the lungs is reviewed. The pulmonary extracellular lining is a complex mixture of phospholipids, proteins and carbohydrates which is absolutely essential for the maintenance of normal pulmonary functions such as gas exchange. Without the lining the lungs would collapse. Alterations in the p...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8455227
更新日期:1984-04-01 00:00:00
abstract::We examined the estrogenicity of binary mixtures of the hydroxylated polychlorinated biphenyls (OHPCBs) 2,4,6-trichloro-4'-biphenylol (2,4,6-TCB-4'-OH) and 2,3,4,5-tetrachloro-4'-biphenylol and the pesticides endosulfan and dieldrin. The OHPCBs and pesticides were tested in both the MCF-7 focus assay and a competitive...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s41041
更新日期:1998-08-01 00:00:00
abstract::We evaluated predictors of plasma concentrations of dichlorodiphenyldichloroethylene (DDE), a metabolite of dichlorodiphenyltrichloroethane (DDT), and polychlorinated biphenyls (PCBs) in a group of 240 women, controls from a breast cancer case-control study nested in the Nurses' Health Study. We considered personal at...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9910775
更新日期:1999-01-01 00:00:00
abstract::We evaluated the effect of chronic exposure to dioxin and dioxin-like compounds on the pancreas in female Harlan Sprague-Dawley rats. This investigation represents part of an ongoing National Toxicology Program initiative to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated diox...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6869
更新日期:2004-06-01 00:00:00
abstract::New technologies are providing innovative ways to reduce sound levels in many areas. Aircraft engineers are finding ways to reduce the noise produced by jet engines, while road builders are using rubber-enhanced pavement to quiet highway noise. Indoor acoustics are benefiting from materials that transform sound waves ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.113-a46
更新日期:2005-01-01 00:00:00
abstract::In the National Toxicology Program 2-year inhalation study of dichloromethane (DCM), there was a significant increase in pulmonary neoplasms in female B6C3F1 mice exposed to 2000 ppm (overall rates of 30/48 versus 5/50 in control). Replicative DNA synthesis was examined to evaluate the potential role of treatment-indu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s5271
更新日期:1993-12-01 00:00:00