Workshop to identify critical windows of exposure for children's health: reproductive health in children and adolescents work group summary.

abstract：:Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyo...

journal_title：Environmental health perspectives

authors： Lenzi P,Frenzilli G,Gesi M,Ferrucci M,Lazzeri G,Fornai F,Nigro M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Persistent organic pollutants (POPs) are developmental toxicants, but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored. OBJECTIVE:We examined associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutant...

journal_title：Environmental health perspectives

authors： Robledo CA,Yeung E,Mendola P,Sundaram R,Maisog J,Sweeney AM,Barr DB,Louis GM

更新日期：2015-01-01 00:00:00

abstract：:Differences in genetic susceptibility to hazardous chemicals affect individuals of both human and nonhuman populations. In both cases, differences in response to chemicals or general ill health result as a function of these differences in genetic susceptibility. However, ecological systems are a compilation of hundred...

journal_title：Environmental health perspectives

authors： Burger J

更新日期：1997-06-01 00:00:00

abstract：:This working paper summarizes the known ultrastructural and biochemical effects of lead, mercury, cadmium, and arsenic on subcellular organelle systems following in vivo administration. Documented metal-induced alterations in nuclear, mitochondrial, microsomal, and lysosomal functions are discussed in relation to thei...

journal_title：Environmental health perspectives

authors： Fowler BA

更新日期：1978-02-01 00:00:00

abstract：:To assess quantitatively the association between benzene and leukemia, we evaluated the rate of mortality experienced by a cohort occupationally exposed to benzene. Using data from historical air sampling surveys, we estimated the daily benzene exposure for each member of the cohort. The expected number of leukemia de...

journal_title：Environmental health perspectives

authors： Rinsky RA

更新日期：1989-07-01 00:00:00

abstract：:We describe the successes and challenges faced by federal and local government agencies in the United States as they have attempted in recent years to connect public and environmental health, housing, community development, and building design with environmental, housing, and building laws, codes, and policies. These ...

journal_title：Environmental health perspectives

authors： Jacobs DE,Kelly T,Sobolewski J

更新日期：2007-06-01 00:00:00

abstract：:We present a model to plan a rational strategy for cancer prevention that has two main functions--assessment and intervention. The assessment function includes three main components: to identify populations at high cancer risk, which may be due to their ethnic group, occupational and environmental exposures, family hi...

journal_title：Environmental health perspectives

authors： Anton-Culver H

更新日期：1995-11-01 00:00:00

abstract：:Many thousand organic compounds are in common use and new ones introduced daily. With many of these materials, little is known about their toxic hazard. For years scientists have been investigating the relation of structure and properties to biological activity. Among the factors relating to toxicity are bioaccumulati...

journal_title：Environmental health perspectives

authors： Freed VH,Chiou CT,Schmedding D,Kohnert R

更新日期：1979-06-01 00:00:00

abstract：:This paper describes quantitation of human hemoglobin and DNA adducts of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN). NNK and NNN are believed to be involved in cancers of the lung, esophagus, oral cavity, and pancreas in people wh...

journal_title：Environmental health perspectives

authors： Hecht SS,Carmella SG,Foiles PG,Murphy SE,Peterson LA

更新日期：1993-03-01 00:00:00

abstract：:An increased gastrointestinal cancer risk is associated with occupational exposure to asbestos fiber. Examination of tissues obtained from extrapulmonary organs of exposed workmen demonstrates the presence of asbestos fibers and bodies. The amount of fiber present in these tissues is many magnitudes less than encounte...

journal_title：Environmental health perspectives

authors： Langer AM

更新日期：1974-12-01 00:00:00

abstract：:Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1...

journal_title：Environmental health perspectives

authors： Fairchild WL,Swansburg EO,Arsenault JT,Brown SB

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Few studies have examined the association between home use of solvents and paint and the risk of childhood leukemia. OBJECTIVES:In this case-control study, we examined whether the use of paint and petroleum solvents at home before birth and in early childhood influenced the risk of leukemia in children. ME...

journal_title：Environmental health perspectives

authors： Scélo G,Metayer C,Zhang L,Wiemels JL,Aldrich MC,Selvin S,Month S,Smith MT,Buffler PA

更新日期：2009-01-01 00:00:00

abstract：:Human fibroblasts (HFW) were 10-fold more susceptible than Chinese hamster ovary (CHO-K1) cells to sodium arsenite. Comparison of cellular antioxidant enzyme activities showed that CHO-K1 cells contained 3- and 8-fold more glutathione-peroxidase and catalase activities, respectively, than HFW cells. Since vitamin E, m...

journal_title：Environmental health perspectives

authors： Lee TC,Ho IC

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Epidemiological research on effects of transportation noise on incident hypertension is inconsistent. OBJECTIVES:We aimed to investigate whether residential road traffic noise increases the risk for hypertension. METHODS:In a population-based cohort of 57,053 individuals 50-64 years of age at enrollment, w...

journal_title：Environmental health perspectives

authors： Thacher JD,Poulsen AH,Roswall N,Hvidtfeldt U,Raaschou-Nielsen O,Jensen SS,Ketzel M,Brandt J,Overvad K,Tjønneland A,Münzel T,Sørensen M

更新日期：2020-05-01 00:00:00

abstract：:The neurochemical basis of memory has been approached experimentally in four different ways: the bioassay; the interventive approach; the interventive-correlative approach; and the correlative approach. These approaches are fundamentally similar to those used for the study of the chemistry of any behavior. Each of the...

journal_title：Environmental health perspectives

authors： Dunn AJ

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Findings from national surveys suggest that everyone in the United States is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and nitrate inhibit iodide uptake into the thyroid and decrease thyroid hormone production. Small changes in thyroid hormones during pregnancy, including changes withi...

journal_title：Environmental health perspectives

authors： Steinmaus C,Pearl M,Kharrazi M,Blount BC,Miller MD,Pearce EN,Valentin-Blasini L,DeLorenze G,Hoofnagle AN,Liaw J

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES:We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. ME...

journal_title：Environmental health perspectives

authors： Villanueva CM,Gracia-Lavedan E,Bosetti C,Righi E,Molina AJ,Martín V,Boldo E,Aragonés N,Perez-Gomez B,Pollan M,Acebo IG,Altzibar JM,Zabala AJ,Ardanaz E,Peiró R,Tardón A,Chirlaque MD,Tavani A,Polesel J,Serraino D,Pi

更新日期：2017-01-01 00:00:00

abstract：:We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detect...

journal_title：Environmental health perspectives

authors： Barr DB,Barr JR,Bailey SL,Lapeza CR Jr,Beeson MD,Caudill SP,Maggio VL,Schecter A,Masten SA,Lucier GW,Needham LL,Sampson EJ

更新日期：2000-04-01 00:00:00

abstract：:Whole blood oxygen equilibrium curves (O2 ECs), blood buffer lines, and several hematologic properties were determined for adult guinea pigs exposed to 700 ppm methyl isocyanate (MIC) for 15 min. MIC inhalation effected a significant reduction of blood O2 affinity; the half-saturation pressure (P50) at 38 degrees C in...

journal_title：Environmental health perspectives

authors： Maginniss LA,Szewczak JM,Troup CM

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Epidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear. OBJECTIVE:We developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters na...

journal_title：Environmental health perspectives

authors： Noah TL,Zhou H,Monaco J,Horvath K,Herbst M,Jaspers I

更新日期：2011-01-01 00:00:00

abstract：:We have previously reported that rats are resilient to the hepatotoxic and lethal combination of chlordecone (CD) and carbon tetrachloride (CCl4) during early postnatal development. The overall findings pointed to stimulated cell division and tissue repair mechanisms as the underlying cause of resistance. The objectiv...

journal_title：Environmental health perspectives

authors： Dalu A,Rao PS,Mehendale HM

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Epidemiologic studies have demonstrated that occupational noise exposure is associated with hypertension, but the related mechanism in vascular structural changes is unclear. OBJECTIVE:This panel study aimed to investigate effects of occupational noise exposure on ambulatory vascular structural properties i...

journal_title：Environmental health perspectives

authors： Chang TY,Su TC,Lin SY,Jain RM,Chan CC

更新日期：2007-11-01 00:00:00

abstract：:The mammalian respiratory tract is densely innervated by autonomic and sensory nerves around airways and blood vessels. Subsets of these nerves contain a number of putative neurotransmitter peptides, such as substance P and calcitonin gene-related peptide (CGRP) in sensory nerves and vasoactive intestinal polypeptide ...

journal_title：Environmental health perspectives

authors： Springall DR,Edginton JA,Price PN,Swanston DW,Noel C,Bloom SR,Polak JM

更新日期：1990-04-01 00:00:00

abstract：:Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how...

journal_title：Environmental health perspectives

authors： Carpenter DO,Arcaro KF,Bush B,Niemi WD,Pang S,Vakharia DD

更新日期：1998-12-01 00:00:00

abstract：:Nitrate contamination of drinking water implies a genotoxic risk to man due to the endogenous formation of carcinogenic N-nitroso compounds from nitrate-derived nitrite. Thus far, epidemiological studies have presented conflicting results on the relation of drinking water nitrate levels with gastric cancer incidence. ...

journal_title：Environmental health perspectives

authors： Kleinjans JC,Albering HJ,Marx A,van Maanen JM,van Agen B,ten Hoor F,Swaen GM,Mertens PL

更新日期：1991-08-01 00:00:00

abstract：:Present available information regarding ovarian tumors in hens is incomplete in most aspects, and this lack of knowledge hampers use of hens as models for study of ovarian cancer. A study of 466 hens ranging from 2 to 7 years of age and covering a period of more than 3 years has provided much needed information relati...

journal_title：Environmental health perspectives

authors： Fredrickson TN

更新日期：1987-08-01 00:00:00

abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that have been widely used as flame retardants in furniture, carpet padding, car seats, and other consumer products during the past three decades. OBJECTIVE:We examined whether in utero exposure to PBDEs is associated with child cognitive funct...

journal_title：Environmental health perspectives

authors： Chen A,Yolton K,Rauch SA,Webster GM,Hornung R,Sjödin A,Dietrich KN,Lanphear BP

更新日期：2014-08-01 00:00:00

abstract：:This article reviews the epidemiologic studies of the association of ischemic heart disease risk and environmental tobacco smoke (ETS) exposure from a spouse who smokes. Seventeen studies (nine cohort, eight case-control) comprising more than 485,000 lifelong nonsmokers and 7,345 coronary heart disease (CHD) events we...

journal_title：Environmental health perspectives

authors： Thun M,Henley J,Apicella L

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Microcystin-LR, a cyclic heptapeptide, possesses the ability to inhibit the serine/threonine protein phosphatases PP1 and PP2A and, consequently, exhibits acute hepatocytotoxicity. Moreover, microcystin-LR induces cellular proliferation, resulting in tumor-promoting activity in hepatocytes. However, mechanis...

journal_title：Environmental health perspectives

authors： Takumi S,Komatsu M,Furukawa T,Ikeda R,Sumizawa T,Akenaga H,Maeda Y,Aoyama K,Arizono K,Ando S,Takeuchi T

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Organophosphate developmental neurotoxicity involves multiple mechanisms converging on neural cell replication and differentiation. OBJECTIVES:We evaluated mechanisms contributing to the adverse effects of chlorpyrifos (CPF) on DNA synthesis, cell number and size, and cell signaling mediated by adenylyl cyc...

journal_title：Environmental health perspectives

authors： Slotkin TA,MacKillop EA,Ryde IT,Seidler FJ

更新日期：2007-09-01 00:00:00