当前位置： SCI文献检索 > ENVIRONMENTAL HEALTH PERSPECTIVES期刊下所有文献 > Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus.

Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus.

Abstract：

BACKGROUND:Epidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear. OBJECTIVE:We developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters nasal inflammatory and antiviral responses to live attenuated influenza virus (LAIV). METHODS:This was an observational cohort study comparing nasal mucosal responses to LAIV among young adult active smokers (n = 17), nonsmokers exposed to secondhand smoke (SHS; n = 20), and unexposed controls (n = 23). Virus RNA and inflammatory factors were measured in nasal lavage fluids (NLF) serially after LAIV inoculation. For key end points, peak and total (area under curve) responses were compared among groups. RESULTS:Compared with controls, NLF interleukin-6 (IL-6) responses to LAIV (peak and total) were suppressed in smokers. Virus RNA in NLF cells was significantly increased in smokers, as were interferon-inducible protein 10:virus ratios. Responses in SHS-exposed subjects were generally intermediate between controls and smokers. We observed significant associations between urine cotinine and NLF IL-6 responses (negative correlation) or virus RNA in NLF cells (positive correlation) for all subjects combined. CONCLUSIONS:Nasal inoculation with LAIV results in measurable inflammatory and antiviral responses in human volunteers, thus providing a model for investigating environmental effects on influenza infections in humans. Exposure to cigarette smoke was associated with suppression of specific nasal inflammatory and antiviral responses, as well as increased virus quantity, after nasal inoculation with LAIV. These data suggest mechanisms for increased susceptibility to influenza infection among persons exposed to tobacco smoke.

journal_name

Environ Health Perspect

journal_title

Environmental health perspectives

authors

Noah TL,Zhou H,Monaco J,Horvath K,Herbst M,Jaspers I

doi

10.1289/ehp.1002258

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

78-83

issue

eissn

0091-6765

issn

1552-9924

journal_volume

119

pub_type

杂志文章

在线工具

Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus.