Abstract:
:An increased gastrointestinal cancer risk is associated with occupational exposure to asbestos fiber. Examination of tissues obtained from extrapulmonary organs of exposed workmen demonstrates the presence of asbestos fibers and bodies. The amount of fiber present in these tissues is many magnitudes less than encountered in the lung tissues from the same individuals. Ingestion of asbestos fiber in some environmental instances may approach in magnitude the amount resulting from occupational exposure. Disease factors are discussed.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Langer AMdoi
10.1289/ehp.749229subject
Has Abstractpub_date
1974-12-01 00:00:00pages
229-33eissn
0091-6765issn
1552-9924journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Population-based studies have estimated health risks of short-term exposure to fine particles using mass of PM(2.5) (particulate matter journal_title:Environmental health perspectives pub_type: 杂志文章 doi:10.1289/ehp.0800185 更新日期:2009-06-01 00:00:00
abstract::Our desire to understand the potential adverse human health effects of environmental chemical exposure has coincided with an increased understanding of the immune system and an appreciation of its complex regulatory network. This has spawned a broad interest in the area of immunotoxicology within the scientific commun...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.93100219
更新日期:1993-04-01 00:00:00
abstract::A stratified version of nested case-control sampling which we call "countermatching" is presented. This design uses data available for all cohort members to obtain a sample for collecting additional information in a case-control substudy. Hitherto the only stratified sampling design for such studies has involved match...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s847
更新日期:1994-11-01 00:00:00
abstract::Epidemiologic studies of the link between particulate matter (PM) concentrations and mortality rates have yielded a range of estimates, leading to disagreement about the magnitude of the relationship and the strength of the causal connection. Previous meta-analyses of this literature have provided pooled effect estima...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108109
更新日期:2000-02-01 00:00:00
abstract::The susceptibility to arsenic-induced diseases differs greatly between individuals, possibly due to interindividual variations in As metabolism that affect retention and distribution of toxic metabolites. To elucidate the role of genetic factors in As metabolism, we studied how polymorphisms in six genes affected the ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9734
更新日期:2007-04-01 00:00:00
abstract::The carcinogenic properties of selected metals and their compounds are reviewed to provide a useful reference for existing knowledge on relationships between physical and chemical forms, kinetics and carcinogenic potential and between epidemiology, bioassays, and short-term tests. Extensive consideration is given to a...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9195157
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:Environmental heat exposure is a public health concern. The impacts of environmental heat on mortality and morbidity at the population scale are well documented, but little is known about specific exposures that individuals experience. OBJECTIVES:The first objective of this work was to catalyze discussion o...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP556
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:In an effort to decrease the rates of smoking conventional tobacco cigarettes, electronic cigarettes (e-cigarettes) have been proposed as an effective smoking cessation tool. However, little is known about their toxicological impacts. This is concerning given that e-cigarette use is perceived as less harmful...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6067
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:In a 1994 Ninth Circuit decision on the remand of Daubert v. Merrell Dow Pharmaceuticals, Inc., Judge Alex Kosinski wrote that science done for the purpose of litigation should be subject to more stringent standards of admissibility than other science. OBJECTIVES:We analyze this proposition by considering l...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9987
更新日期:2008-01-01 00:00:00
abstract::Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice were more sensitive to the carcinogenic effects of benzene than were F344 rats. A physiological model was developed to describe the uptake and metabolism of benzene in rats and mice. Our objective was to ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.898243
更新日期:1989-07-01 00:00:00
abstract::Recent increases have been reported in industrial countries for several sites of cancer. The causes of these increases remain unknown. Efforts should proceed to identify those occupational groups with increases in the same sites, as these may indicate relevant exposures. Two analyses were undertaken: trends in cancer ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,meta分析
doi:10.1289/ehp.9310039
更新日期:1993-04-01 00:00:00
abstract:INTRODUCTION:Asians, Pacific Islanders, and Native Americans are a potentially high-risk group for dietary exposure to methylmercury through fish consumption. However, blood mercury levels in this group have not been identified in recent reports of the National Health and Nutrition Examination Survey (NHANES) for the y...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8464
更新日期:2006-02-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are important environmental contaminants, and their toxicity to wildlife and humans are of major concern. PCBs form persistent and abundant metabolites, PCB methyl sulfones, that accumulate in biota. We now report that certain hydroxylated PCB metabolites show a strong and selective ac...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102464
更新日期:1994-05-01 00:00:00
abstract::The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has highly pleiotropic effects on cells in culture and on tissues in vivo, including effects on protein kinase C (PKC) activation and gene expression. In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.877689
更新日期:1987-12-01 00:00:00
abstract::Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An understanding of these interesting human carcinogens, therefore, is an important problem in cancer research. Asbestos and other fibers induce predominantly two types o...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.898181
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Microcystin-LR, a cyclic heptapeptide, possesses the ability to inhibit the serine/threonine protein phosphatases PP1 and PP2A and, consequently, exhibits acute hepatocytotoxicity. Moreover, microcystin-LR induces cellular proliferation, resulting in tumor-promoting activity in hepatocytes. However, mechanis...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1001899
更新日期:2010-09-01 00:00:00
abstract::A physiologically based pharmacokinetic model for trichloroethylene (TCE) in rodents and humans was calibrated with published toxicokinetic data sets. A Bayesian statistical framework was used to combine previous information about the model parameters with the data likelihood, to yield posterior parameter distribution...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108s2307
更新日期:2000-05-01 00:00:00
abstract::Although para-nonylphenol (NP) is known as an endocrine disruptor, the immunologic effect of NP has been poorly analyzed. We found that NP from 5 to 50 microM caused a dose-dependent stimulatory effect on the generation of reactive oxygen species (ROS) in human blood neutrophils, which was measured by using a chemilum...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6584
更新日期:2004-04-01 00:00:00
abstract::Chlordane is a polychlorinated hydrocarbon that causes liver enlargement and induces mixed-function oxidases similar to those induced by phenobarbitone in the mouse. We have assessed the hepatocarcinogenicity (after 2 years) and the time course (over 6 months) of liver and thyroid cell proliferation in C57Bl/10J mice ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s5219
更新日期:1993-12-01 00:00:00
abstract::The effects of global change on biodiversity and ecosystem functioning encompass multiple complex dynamic processes. Climate change and exposure to endocrine-disrupting chemicals (EDCs) are currently regarded as two of the most serious anthropogenic threats to biodiversity and ecosystems. We should, therefore, be espe...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8057
更新日期:2006-04-01 00:00:00
abstract::A review of the literature is provided for the topic of health-related research and power frequency electromagnetic fields. Minimal evidence for concern is present on the basis of animal and plant research. General observation would accord with the implication that there is no single and manifest health effect as the ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8775159
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Experimental tools for studying the complex steroidogenic interactions that occur between placenta and fetus during human pregnancy are extremely limited. OBJECTIVES:We aimed to develop a co-culture model to study steroidogenesis by the human fetoplacental unit and its disruption by exposure to environmenta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307518
更新日期:2014-04-01 00:00:00
abstract::Southwest metropolitan Mexico City (SWMMC) inhabitants have been exposed several hours per day for the last 6 years to photochemical smog, ozone being the most important oxidant pollutant. Subjects exposed to the SWMMC atmosphere develop several histopathological changes in their nasal mucosa: dysplasia is the most si...
journal_title:Environmental health perspectives
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1289/ehp.101-1519752
更新日期:1993-06-01 00:00:00
abstract::The assessment of mixture effects of estrogenic agents is regarded as an issue of high priority by many governmental agencies and expert decision-making bodies all over the world. However, the few mixture studies published so far have suffered from conceptual and experimental problems and are considered to be inconclu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108983
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:Manganese is a common natural contaminant of groundwater in Bangladesh. In this cross-sectional study we assessed the association between water manganese and all-cause infant mortality in the offspring of female participants in the Health Effects of Arsenic Longitudinal Study Cohort. METHODS:In 2001, drinki...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10051
更新日期:2007-07-01 00:00:00
abstract::Lung counting is highly geometry dependent, especially at low photon energies. Monte Carlo simulations have been used to determine the magnitude of the errors obtained if it is assumed that the deposition is homogeneous, when in fact it is not. Simulation for a germanium lung counting system consisting of four, 70 mm ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s61393
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expression, and we hypothe...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1937
更新日期:2017-10-16 00:00:00
abstract::Although acute adverse effects on asthma have been frequently found for the U.S. Environmental Protection Agency's principal criteria air pollutants, there is little epidemiologic information on specific hydrocarbons from toxic emission sources. We conducted a panel study of 22 Hispanic children with asthma who were 1...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5992
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Preimplantation embryo loss during oviduct transit has been observed in adult mice after a 5-day neonatal exposure to the phytoestrogen genistein (Gen; 50 mg/kg/day). OBJECTIVE:We investigated the mechanisms underlying the contribution of the oviduct to infertility. METHODS:Female mice were treated on post...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104018
更新日期:2011-11-01 00:00:00
abstract::Alzheimer's disease is a progressive degenerative brain disease of unknown etiology, characterized by the development of large numbers of neurofibrillary tangles and senile plaques in the brain. Aluminum salts may be used experimentally to produce lesions which are similar, but not identical, to the neurofibrillary ta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8563149
更新日期:1985-11-01 00:00:00