Role of protein kinase C in regulation of gene expression and relevance to tumor promotion.

abstract：:In estimating the cancer mortality risk for radiation workers it is conventional to use data obtained from the populations exposed to radiation as a result of the atomic bomb blast in Hiroshima and Nagasaki. This A-bomb experience resulted in relatively high doses of radiation and short periods of exposure. The availa...

journal_title：Environmental health perspectives

authors： Stewart A

更新日期：1997-12-01 00:00:00

abstract：:Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); northwest region three (wheat, sugar beets, potatoes); and northeast region four (forested and urban in character). Cancer mortality (1980-...

journal_title：Environmental health perspectives

authors： Schreinemachers DM,Creason JP,Garry VF

更新日期：1999-03-01 00:00:00

abstract：:Using data from published studies, lung concentrations of nickel were compare for persons with and without occupational exposure to nickel. As expected, the concentrations were much higher for persons with occupational exposure. To estimate the effects of nickel-containing tobacco smoke and nickel in the ambient air o...

journal_title：Environmental health perspectives

authors： Edelman DA,Roggli VL

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES:We investigated the relation between urinary concentrations of GE metabolites i...

journal_title：Environmental health perspectives

authors： Béranger R,Garlantézec R,Le Maner-Idrissi G,Lacroix A,Rouget F,Trowbridge J,Warembourg C,Monfort C,Le Gléau F,Jourdin M,Multigner L,Cordier S,Chevrier C

更新日期：2017-04-01 00:00:00

abstract：:A major challenge in the emerging field of toxicogenomics is to define the relationships between chemically induced changes in gene expression and alterations in conventional toxicologic parameters such as clinical chemistry and histopathology. We have explored these relationships in detail using the rodent uterotroph...

journal_title：Environmental health perspectives

authors： Moggs JG,Tinwell H,Spurway T,Chang HS,Pate I,Lim FL,Moore DJ,Soames A,Stuckey R,Currie R,Zhu T,Kimber I,Ashby J,Orphanides G

更新日期：2004-11-01 00:00:00

abstract：:An intercomparison exercise was conducted for the quantification of arsenic species in spiked human urine. The primary objective of the exercise was to determine the variance among laboratories in the analysis of arsenic species such as inorganic As (As+3 and As+5), monomethylarsonic acid (MMA), and dimethylarsinic ac...

journal_title：Environmental health perspectives

authors： Crecelius E,Yager J

更新日期：1997-06-01 00:00:00

abstract：:We measured tumor-associated proteins (TAPs) and pollutants in blood, serum, and urine of 200 nonsmoking women 50-65 years of age, residing in the rural municipality of Peer or in Hoboken or Wilrijk, industrial suburbs of Antwerp, Belgium. Persons with occupational exposures or commuting to other towns were excluded. ...

journal_title：Environmental health perspectives

authors： van Larebeke NA,Bracke ME,Nelen V,Koppen G,Schoeters G,Van Loon H,Vlietinck R

更新日期：2006-06-01 00:00:00

abstract：:Some of the statistical properties of a simple two-stage model of carcinogenesis are explored. The implications of additive treatment effects versus independent treatment effects on the shape of the dose-response curve are considered. Response that is low-dose linear results in the cases where the mutation rates are a...

journal_title：Environmental health perspectives

authors： Portier CJ

更新日期：1987-12-01 00:00:00

abstract：:This work group report addresses the central question: What are the critical windows during development (preconception through puberty) when exposure to xenobiotics may have the greatest adverse impact on subsequent reproductive health? The reproductive system develops in stages, with sex-specific organogenesis occurr...

journal_title：Environmental health perspectives

authors： Lemasters GK,Perreault SD,Hales BF,Hatch M,Hirshfield AN,Hughes CL,Kimmel GL,Lamb JC,Pryor JL,Rubin C,Seed JG

更新日期：2000-06-01 00:00:00

abstract：:Effects of respirable aerosols of sulfuric acid, ammonium sulfate, sodium sulfite, and ammonium persulfate on lungs of rats are reviewed. The literature regarding interactions between ozone or nitrogen dioxide and acidic aerosols (ammonium sulfate, sulfuric acid) is discussed. An unexpected interaction between nitroge...

journal_title：Environmental health perspectives

authors： Last JA

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Cadmium (Cd) is a ubiquitous environmental toxicant that can accumulate in the placenta during pregnancy, where it may impair placental function and affect fetal development. OBJECTIVES:We aimed to investigate Cd-associated variations in placental DNA methylation (DNAM) and associations with gene expression...

journal_title：Environmental health perspectives

authors： Everson TM,Punshon T,Jackson BP,Hao K,Lambertini L,Chen J,Karagas MR,Marsit CJ

更新日期：2018-01-22 00:00:00

abstract：:The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentratio...

journal_title：Environmental health perspectives

authors： Regoli F,Orlando E

更新日期：1994-09-01 00:00:00

abstract：:The phthalate acid esters (PAEs), and, in particular, di(2-ethylhexyl) phthalate (DEHP) and its monoester, monoethylhexyl phthalate (MEHP), can adversely affect rodent testes but only at high doses. Rat gonadal zinc levels can be decreased by the injection of DEHP, but not MEHP. The rat prostate gland seems to be part...

journal_title：Environmental health perspectives

authors： Thomas JA,Curto KA,Thomas MJ

更新日期：1982-11-01 00:00:00

abstract：:There is a significant public health concern about the potential effects of occupational exposure to toxic substances on reproductive outcomes. Several toxicants with reported reproductive and developmental effects are still in regular commercial or therapeutic use and thus present potential exposure to workers. Examp...

journal_title：Environmental health perspectives

authors： Lawson CC,Schnorr TM,Daston GP,Grajewski B,Marcus M,McDiarmid M,Murono E,Perreault SD,Schrader SM,Shelby M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Thallium (Tl) is a highly toxic heavy metal widely present in the environment. Case reports have suggested that maternal exposure to high levels of Tl during pregnancy is associated with low birth weight (LBW), but epidemiological data are limited. OBJECTIVES:This study was designed to evaluate whether pren...

journal_title：Environmental health perspectives

authors： Xia W,Du X,Zheng T,Zhang B,Li Y,Bassig BA,Zhou A,Wang Y,Xiong C,Li Z,Yao Y,Hu J,Zhou Y,Liu J,Xue W,Ma Y,Pan X,Peng Y,Xu S

更新日期：2016-01-01 00:00:00

abstract：:We studied peripheral lymphocyte HPRT variant frequency and endogenous nitrosation in human populations exposed to various nitrate levels in their drinking water. Four test populations of women volunteers were compared. Low and medium tap water nitrate exposure groups (14 and 21 subjects) were using public water suppl...

journal_title：Environmental health perspectives

authors： van Maanen JM,Welle IJ,Hageman G,Dallinga JW,Mertens PL,Kleinjans JC

更新日期：1996-05-01 00:00:00

abstract：:Metallothionein (MT) promoter was methylated in rat hepatoma and in mouse lymphosarcoma cells by methylation of cytosine within the CpG dinucleotide region. After demethylation of MT-I promoter in mouse lymphosarcoma cells or in the transplanted rat hepatoma with 5-azacytidine, a potent inhibitor of DNA methyltransfer...

journal_title：Environmental health perspectives

authors： Jacob ST,Majumder S,Ghoshal K

更新日期：2002-10-01 00:00:00

abstract：:Laboratory and room-scale experiments were conducted with natural and synthetic polymers: cotton, paper, wood, wool, acetate, acrylic, nylon, and urethane. Smoke and off-gases from single materials were generated in a dual-compartment 110-liter exposure chamber. Multicomponent, composite fuel loads were burned within ...

journal_title：Environmental health perspectives

authors： Wright PL,Adams CH

更新日期：1976-10-01 00:00:00

abstract：:Epidemiologic studies of the link between particulate matter (PM) concentrations and mortality rates have yielded a range of estimates, leading to disagreement about the magnitude of the relationship and the strength of the causal connection. Previous meta-analyses of this literature have provided pooled effect estima...

journal_title：Environmental health perspectives

authors： Levy JI,Hammitt JK,Spengler JD

更新日期：2000-02-01 00:00:00

abstract：:We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, life...

journal_title：Environmental health perspectives

authors： Cox-Ganser JM,White SK,Jones R,Hilsbos K,Storey E,Enright PL,Rao CY,Kreiss K

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES:We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. ME...

journal_title：Environmental health perspectives

authors： Villanueva CM,Gracia-Lavedan E,Bosetti C,Righi E,Molina AJ,Martín V,Boldo E,Aragonés N,Perez-Gomez B,Pollan M,Acebo IG,Altzibar JM,Zabala AJ,Ardanaz E,Peiró R,Tardón A,Chirlaque MD,Tavani A,Polesel J,Serraino D,Pi

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. OBJECTIVE:We examined 42 Faroese whaling men (30-70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whal...

journal_title：Environmental health perspectives

authors： Choi AL,Weihe P,Budtz-Jørgensen E,Jørgensen PJ,Salonen JT,Tuomainen TP,Murata K,Nielsen HP,Petersen MS,Askham J,Grandjean P

更新日期：2009-03-01 00:00:00

abstract：:Serious problems emerge when evaluating evidence on lead neurotoxicity in children. The extent of these problems and ways to control them were explored in a study of 1291 children from the first class in the schools of Aarhus municipality, Denmark. The lead retention in circumpulpal dentin in shed deciduous teeth was ...

journal_title：Environmental health perspectives

authors： Grandjean P,Lyngbye T,Hansen ON

更新日期：1991-08-01 00:00:00

abstract：:Ethene is, on a molar basis, a major urban air pollutant. It has been shown beyond doubt that a fraction of inhaled ethene is metabolized in mammals (including humans) via ethylene oxide, an electrophilic reagent that has been shown to be mutagenic and carcinogenic. To the extent that the linearity hypothesis for dose...

journal_title：Environmental health perspectives

authors： Törnqvist M

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Policy decisions regarding climate change mitigation are increasingly incorporating the beneficial and adverse health impacts of greenhouse gas emission reduction strategies. Studies of such co-benefits and co-harms involve modeling approaches requiring a range of analytic decisions that affect the model out...

journal_title：Environmental health perspectives

authors： Remais JV,Hess JJ,Ebi KL,Markandya A,Balbus JM,Wilkinson P,Haines A,Chalabi Z

更新日期：2014-05-01 00:00:00

abstract：:Collaborative studies were performed to develop a functional assay for fish-killing activity produced by Pfiesteria piscicida. Eight cell lines were used to screen organic fractions and residual water fraction by using a 3-[4, 5-dimethylthiazol-(2-4)]-diphenyltetrazolium bromide cytotoxicity assay. Diethyl ether and a...

journal_title：Environmental health perspectives

authors： Fairey ER,Edmunds JS,Deamer-Melia NJ,Glasgow H Jr,Johnson FM,Moeller PR,Burkholder JM,Ramsdell JS

更新日期：1999-09-01 00:00:00

abstract：:During a 2-year chronic inhalation study on methylene chloride (2000 or 0 ppm; 6 hr/day, 5 days/week), gas-uptake pharmacokinetic studies and tissue partition coefficient determinations were conducted on female B6C3F1, mice after 1 day, 1 month, 1 year, and 2 years of exposure. Using physiologically based pharmacokine...

journal_title：Environmental health perspectives

authors： Thomas RS,Yang RS,Morgan DG,Moorman MP,Kermani HR,Sloane RA,O'Connor RW,Adkins B Jr,Gargas ML,Andersen ME

更新日期：1996-08-01 00:00:00

abstract：:Human fibroblasts (HFW) were 10-fold more susceptible than Chinese hamster ovary (CHO-K1) cells to sodium arsenite. Comparison of cellular antioxidant enzyme activities showed that CHO-K1 cells contained 3- and 8-fold more glutathione-peroxidase and catalase activities, respectively, than HFW cells. Since vitamin E, m...

journal_title：Environmental health perspectives

authors： Lee TC,Ho IC

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Controversy remains regarding the relationship between ambient ozone and mortality worldwide. In mainland China, the largest developing country, there has been no prior study investigating the acute effect of O3 on death risk. Given the changes in types of air pollution from conventional coal combustion to t...

journal_title：Environmental health perspectives

authors： Zhang Y,Huang W,London SJ,Song G,Chen G,Jiang L,Zhao N,Chen B,Kan H

更新日期：2006-08-01 00:00:00

abstract：:The three modern "faces" of mercury are our perceptions of risk from the exposure of billions of people to methyl mercury in fish, mercury vapor from amalgam tooth fillings, and ethyl mercury in the form of thimerosal added as an antiseptic to widely used vaccines. In this article I review human exposure to and the to...

journal_title：Environmental health perspectives

authors： Clarkson TW

更新日期：2002-02-01 00:00:00