Nitrate contamination of drinking water: evaluation of genotoxic risk in human populations.

abstract：:This paper addresses the subject of the use of selected toxicology information resources in assessing relationships between chemical structure and specific biological end points. To assist the researcher in how to access the primary literature of genetic toxicology, teratogenesis, and carcinogenesis, three specific sp...

journal_title：Environmental health perspectives

authors： Wassom JS

更新日期：1985-09-01 00:00:00

abstract：:Many epidemiologic reports associate ambient levels of particulate matter (PM) with human mortality and morbidity, particularly in people with preexisting cardiopulmonary disease (e.g., chronic obstructive pulmonary disease, infection, asthma). Because much ambient PM is derived from combustion sources, we tested the ...

journal_title：Environmental health perspectives

authors： Costa DL,Dreher KL

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Chronic exposure to arsenic (As), a human toxicant and carcinogen, remains a global public health problem. Health risks persist after As exposure has ended, suggesting epigenetic dysregulation as a mechanistic link between exposure and health outcomes. OBJECTIVES:We investigated the association between tota...

journal_title：Environmental health perspectives

authors： Bozack AK,Domingo-Relloso A,Haack K,Gamble MV,Tellez-Plaza M,Umans JG,Best LG,Yracheta J,Gribble MO,Cardenas A,Francesconi KA,Goessler W,Tang WY,Fallin MD,Cole SA,Navas-Acien A

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Hormonally active environmental agents have been measured among U.S. children using exposure biomarkers in urine. However, little is known about their variation by race, age, sex, and geography, and no data exist for newly developed biomarkers. OBJECTIVE:Our goal was to characterize relevant, prevalent expo...

journal_title：Environmental health perspectives

authors： Wolff MS,Teitelbaum SL,Windham G,Pinney SM,Britton JA,Chelimo C,Godbold J,Biro F,Kushi LH,Pfeiffer CM,Calafat AM

更新日期：2007-01-01 00:00:00

abstract：:Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when ...

journal_title：Environmental health perspectives

authors： Bombi GG,Corain B,Favarato M,Giordano R,Nicolini M,Perazzolo M,Tapparo A,Zatta P

更新日期：1990-11-01 00:00:00

abstract：:Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how...

journal_title：Environmental health perspectives

authors： Carpenter DO,Arcaro KF,Bush B,Niemi WD,Pang S,Vakharia DD

更新日期：1998-12-01 00:00:00

abstract：INTRODUCTION:Prenatal exposure to some pesticides can adversely affect male reproductive health in animals. We investigated a possible human association between maternal exposure to 27 organochlorine compounds used as pesticides and cryptorchidism among male children. DESIGN:Within a prospective birth cohort, we perfo...

journal_title：Environmental health perspectives

authors： Damgaard IN,Skakkebaek NE,Toppari J,Virtanen HE,Shen H,Schramm KW,Petersen JH,Jensen TK,Main KM,Nordic Cryptorchidism Study Group.

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Although accumulating evidence suggests that exposure to organochlorine pesticides and polychlorinated biphenyls (PCBs) may contribute to the development of prostate cancer, few investigations have used biological samples to classify exposure to specific organochlorines. To our knowledge, this is the first p...

journal_title：Environmental health perspectives

authors： Sawada N,Iwasaki M,Inoue M,Itoh H,Sasazuki S,Yamaji T,Shimazu T,Tsugane S,Japan Public Health Center Based Prospective (JPHC) Study Group.

更新日期：2010-05-01 00:00:00

abstract：:Implications of the multistage theory of carcinogenesis for evaluating the effect of exposure to carcinogens in the workplace are described. This theory predicts different patterns of excess risk related to duration of exposure, age at initial exposure, and follow-up time since exposure stopped, depending upon which s...

journal_title：Environmental health perspectives

authors： Brown CC,Chu KC

更新日期：1983-04-01 00:00:00

abstract：:We include in this review an assessment of the formation, environmental fate, and mammalian and ecotoxicity of CW agent degradation products relevant to environmental and occupational health. These parent CW agents include several vesicants: sulfur mustards [undistilled sulfur mustard (H), sulfur mustard (HD), and an ...

journal_title：Environmental health perspectives

authors： Munro NB,Talmage SS,Griffin GD,Waters LC,Watson AP,King JF,Hauschild V

更新日期：1999-12-01 00:00:00

abstract：:Research conducted in recent years has increased public health concern about the toxicity of lead at low dose and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. In this article, which appears as part of a mini-monograph on adult lead exposure, we summarize a b...

journal_title：Environmental health perspectives

authors： Kosnett MJ,Wedeen RP,Rothenberg SJ,Hipkins KL,Materna BL,Schwartz BS,Hu H,Woolf A

更新日期：2007-03-01 00:00:00

abstract：:Poly(vinyl chloride) resins are produced by four basic processes: suspension, emulsion, bulk and solution polymerization. PVC suspensions resins are usually relatively dust-free and granular with varying degrees of particle porosity. PVC emulsion resins are small particle powders containing very little free monomer. B...

journal_title：Environmental health perspectives

authors： Wheeler RN Jr

更新日期：1981-10-01 00:00:00

abstract：:We examined 100 symptomatic Gulf War veterans (patients) and 100 controls for immunologic assays. The veterans and controls were compared for the percentage of T cells (CD3); B cells (CD19); helper:suppressor (CD4:CD8) ratio; natural killer (NK) cell activity; mitogenic response to phytohemagglutin (PHA) and pokeweed ...

journal_title：Environmental health perspectives

authors： Vojdani A,Thrasher JD

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The metabolome is a collection of exogenous chemicals and metabolites from cellular processes that may reflect the body's response to environmental exposures. Studies of air pollution and metabolomics are limited. OBJECTIVES:To explore changes in the human metabolome before, during, and after the 2008 Beiji...

journal_title：Environmental health perspectives

authors： Mu L,Niu Z,Blair RH,Yu H,Browne RW,Bonner MR,Fanter T,Deng F,Swanson M

更新日期：2019-05-01 00:00:00

abstract：:To evaluate the effectiveness of mass screening for uterine cancer in Japan, we compared the changes in the age-adjusted rates of potential years of life lost (PYLL) due to uterine cancer between 1969 and 1972 to 1973 through 1977 between the high coverage-rate (intensively screened) areas and the comparable control a...

journal_title：Environmental health perspectives

authors： Kuroishi T,Hirose K,Tominaga S

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight. OBJECTIVES:We aimed to investigate the relationship between residential traffic and railway noise and a...

journal_title：Environmental health perspectives

authors： Christensen JS,Raaschou-Nielsen O,Tjønneland A,Overvad K,Nordsborg RB,Ketzel M,Sørensen TIa,Sørensen M

更新日期：2016-03-01 00:00:00

abstract：:The biopersistence of fibers and minerals in the respiratory tract is an important parameter in the toxicity of those materials. The biopersistence of respirable synthetic fibers and minerals in man can be most closely evaluated in an animal model. While acellular and in vitro systems are important for initial evaluat...

journal_title：Environmental health perspectives

authors： Bernstein DM,Mast R,Anderson R,Hesterberg TW,Musselman R,Kamstrup O,Hadley J

更新日期：1994-10-01 00:00:00

abstract：:The effects of inhaled zinc oxide/hexachloroethane smoke (11,580 mg x min/m3) and intratracheally instilled zinc chloride (2.5 mg/kg body weight) have been studied in rat lung. The effects of subsequent treatment with 70% oxygen have been studied after both procedures. Both the inhalation of the smoke and instillation...

journal_title：Environmental health perspectives

authors： Brown RF,Marrs TC,Rice P,Masek LC

更新日期：1990-04-01 00:00:00

abstract：:Cytochrome P450 (CYP) enzymes catalyze the generation of reactive species capable of binding with cellular macromolecules, leading to acute and delayed toxicity. Since individual CYP forms differ markedly in their substrate preferences and regulation, the expression profiles of CYP in various cell types are important ...

journal_title：Environmental health perspectives

authors： Pelkonen O,Raunio H

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Arsenicals (roxarsone and nitarsone) used in poultry production likely increase inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and roxarsone or nitarsone concentrations in poultry meat. However, the association between poultry intake and exposure to these arsenic species, ...

journal_title：Environmental health perspectives

authors： Nigra AE,Nachman KE,Love DC,Grau-Perez M,Navas-Acien A

更新日期：2017-03-01 00:00:00

abstract：:This paper describes quantitation of human hemoglobin and DNA adducts of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN). NNK and NNN are believed to be involved in cancers of the lung, esophagus, oral cavity, and pancreas in people wh...

journal_title：Environmental health perspectives

authors： Hecht SS,Carmella SG,Foiles PG,Murphy SE,Peterson LA

更新日期：1993-03-01 00:00:00

abstract：:The distribution of inhaled mineral fibers in the lung determines the site and severity of disease caused by the fibers. Some of our recent work has described the fate of inhaled asbestos fibers in rodents. After a brief inhalation exposure, asbestos fibers are deposited primarily at the first alveolar duct bifurcatio...

journal_title：Environmental health perspectives

authors： Coin PG,Roggli VL,Brody AR

更新日期：1994-10-01 00:00:00

abstract：:Spontaneous fetal death has been observed among various mammalian species after exposure to polychlorinated biphenyls (PCBs). Our exposure-based cohort study assessed the relationship between consumption of PCB-contaminated Lake Ontario sport fish and spontaneous fetal death using 1820 multigravid fertile women from t...

journal_title：Environmental health perspectives

authors： Mendola P,Buck GM,Vena JE,Zielezny M,Sever LE

更新日期：1995-05-01 00:00:00

abstract：:Embryonal carcinoma (EC) cells offer an interesting model system for evaluating differentiation because the cells are pluripotent, thus resembling germ cells and embryonic stem cells, and because a number of agents have been defined that are capable of promoting the differentiation of these cells. This chapter examine...

journal_title：Environmental health perspectives

authors： Astigiano S,Sherman MI,Abarzúa P

更新日期：1989-03-01 00:00:00

abstract：:A brief history of the development of the field of aquatic toxicology is provided. In order to provide a perspective on the state-of-the-art in aquatic toxicology relative to classical toxicology, the two fields are compared from the standpoint of the type of scientist practicing each field, the respective objectives ...

journal_title：Environmental health perspectives

authors： Macek KJ

更新日期：1980-02-01 00:00:00

abstract：:The lysosomes of several varieties of cells such as the tubular proximal cell of the kidney and the alveolar macrophage have the ability to concentrate and precipitate several elements inhaled in water-soluble form, usually as phosphate. The mechanism involved is attributed to the high acid phosphatase activity of lys...

journal_title：Environmental health perspectives

authors： Galle P,Berry JP,Galle C

更新日期：1992-07-01 00:00:00

abstract：:A stratified version of nested case-control sampling which we call "countermatching" is presented. This design uses data available for all cohort members to obtain a sample for collecting additional information in a case-control substudy. Hitherto the only stratified sampling design for such studies has involved match...

journal_title：Environmental health perspectives

authors： Langholz B,Clayton D

更新日期：1994-11-01 00:00:00

abstract：:We analyzed questionnaire and physician examination data for 1560 new immigrants from the former USSR divided into three groups by potential exposure to Chernobyl radiation. Two groups were chosen according to soil contamination by cesium-137 at former residences, as confirmed by our findings in a 137Cs body burden st...

journal_title：Environmental health perspectives

authors： Kordysh EA,Goldsmith JR,Quastel MR,Poljak S,Merkin L,Cohen R,Gorodischer R

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:The goal of this study was to identify mental, behavioral, and cognitive disorders that may be triggered or exacerbated during heat waves, predisposing individuals to heat-related morbidity and mortality. DESIGN:Using health outcome data from Adelaide, South Australia, for 1993-2006, we estimated the effect ...

journal_title：Environmental health perspectives

authors： Hansen A,Bi P,Nitschke M,Ryan P,Pisaniello D,Tucker G

更新日期：2008-10-01 00:00:00

abstract：:Lung burden analysis was performed on 126 autopsy cases of persons who died in New York City from 1966 through 1968. Of the 126 cases, 107 were probably non-occupationally exposed, judging by occupational history and asbestos body content of lung. Fifty-three of the 107 cases contained short chrysotile fibers/fibrils,...

journal_title：Environmental health perspectives

authors： Langer AM,Nolan RP

更新日期：1994-10-01 00:00:00