The sources, fate, and toxicity of chemical warfare agent degradation products.

Abstract:

:We include in this review an assessment of the formation, environmental fate, and mammalian and ecotoxicity of CW agent degradation products relevant to environmental and occupational health. These parent CW agents include several vesicants: sulfur mustards [undistilled sulfur mustard (H), sulfur mustard (HD), and an HD/agent T mixture (HT)]; nitrogen mustards [ethylbis(2-chloroethyl)amine (HN1), methylbis(2-chloroethyl)amine (HN2), tris(2-chloroethyl)amine (HN3)], and Lewisite; four nerve agents (O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate (VX), tabun (GA), sarin (GB), and soman (GD)); and the blood agent cyanogen chloride. The degradation processes considered here include hydrolysis, microbial degradation, oxidation, and photolysis. We also briefly address decontamination but not combustion processes. Because CW agents are generally not considered very persistent, certain degradation products of significant persistence, even those that are not particularly toxic, may indicate previous CW agent presence or that degradation has occurred. Of those products for which there are data on both environmental fate and toxicity, only a few are both environmentally persistent and highly toxic. Major degradation products estimated to be of significant persistence (weeks to years) include thiodiglycol for HD; Lewisite oxide for Lewisite; and ethyl methyl phosphonic acid, methyl phosphonic acid, and possibly S-(2-diisopropylaminoethyl) methylphosphonothioic acid (EA 2192) for VX. Methyl phosphonic acid is also the ultimate hydrolysis product of both GB and GD. The GB product, isopropyl methylphosphonic acid, and a closely related contaminant of GB, diisopropyl methylphosphonate, are also persistent. Of all of these compounds, only Lewisite oxide and EA 2192 possess high mammalian toxicity. Unlike other CW agents, sulfur mustard agents (e.g., HD) are somewhat persistent; therefore, sites or conditions involving potential HD contamination should include an evaluation of both the agent and thiodiglycol.

authors

Munro NB,Talmage SS,Griffin GD,Waters LC,Watson AP,King JF,Hauschild V

doi

10.1289/ehp.99107933

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

933-74

issue

12

eissn

0091-6765

issn

1552-9924

pii

sc271_5_1835

journal_volume

107

pub_type

杂志文章,评审
  • Deposit and mobility of cadmium in a marsh-cove ecosystem and the relation to cadmium concentration in biota.

    abstract::The study reported here presents the results of an investigation of a marsh-cove ecosystem heavily contaminated by cadmium. The most contaminated aquatic sediments were dredged in 1972-73, but the resuspension of the sediments and recycle of water from the dredge spoil resulted in reestablishment of a large contaminat...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.792867

    authors: Kneip TJ,Hazen RE

    更新日期:1979-02-01 00:00:00

  • Long-Term Exposure to Transportation Noise in Relation to Development of Obesity—a Cohort Study.

    abstract:BACKGROUND:Exposure to transportation noise is widespread and has been associated with obesity in some studies. However, the evidence from longitudinal studies is limited and little is known about effects of combined exposure to different noise sources. OBJECTIVES:The aim of this longitudinal study was to estimate the...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP1910

    authors: Pyko A,Eriksson C,Lind T,Mitkovskaya N,Wallas A,Ögren M,Östenson CG,Pershagen G

    更新日期:2017-11-20 00:00:00

  • Erratum: "Prenatal Organophosphate Pesticide Exposure and Traits Related to Autism Spectrum Disorders in a Population Living in Proximity to Agriculture".

    abstract::[This corrects the article DOI: 10.1289/EHP2580.]. ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,已发布勘误

    doi:10.1289/EHP4002

    authors: Sagiv SK,Harris MH,Gunier RB,Kogut KR,Harley KG,Deardorff J,Bradman A,Holland N,Eskenazi B

    更新日期:2018-07-05 00:00:00

  • Shorter anogenital distance predicts poorer semen quality in young men in Rochester, New York.

    abstract:BACKGROUND:In male rodents, anogenital distance (AGD) provides a sensitive and continuous correlate of androgen exposure in the intrauterine environment and predicts later reproductive success. Some endocrine-disrupting chemicals can alter male reproductive tract development, including shortening AGD, in both rodents a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1103421

    authors: Mendiola J,Stahlhut RW,Jørgensen N,Liu F,Swan SH

    更新日期:2011-07-01 00:00:00

  • Prediction and assessment of the effects of mixtures of four xenoestrogens.

    abstract::The assessment of mixture effects of estrogenic agents is regarded as an issue of high priority by many governmental agencies and expert decision-making bodies all over the world. However, the few mixture studies published so far have suffered from conceptual and experimental problems and are considered to be inconclu...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108983

    authors: Payne J,Rajapakse N,Wilkins M,Kortenkamp A

    更新日期:2000-10-01 00:00:00

  • Chrysotile in water.

    abstract::The problems of quantitating chrysotile in water by fiber count techniques are reviewed briefly and the use of mass quantitation is suggested as a preferable measure. Chrysotile fiber has been found in almost every sample of natural water examined, but generally transmission electron miscroscopy (TEM) is required beca...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.749161

    authors: Speil S

    更新日期:1974-12-01 00:00:00

  • Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts.

    abstract:BACKGROUND:Cadmium (Cd) is a ubiquitous environmental toxicant that can accumulate in the placenta during pregnancy, where it may impair placental function and affect fetal development. OBJECTIVES:We aimed to investigate Cd-associated variations in placental DNA methylation (DNAM) and associations with gene expression...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP2192

    authors: Everson TM,Punshon T,Jackson BP,Hao K,Lambertini L,Chen J,Karagas MR,Marsit CJ

    更新日期:2018-01-22 00:00:00

  • Sensitivity of health endpoints: effect on conclusions of studies.

    abstract::The types of biological response to an environmental agent can depend on dose, thus in this case a family of widely different dose-response relationships would be expected. For those situations where the magnitude of the effect may be determined on probabilistic grounds as a function of dose ("stochastic" model), no p...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.814245

    authors: Radford EP

    更新日期:1981-12-01 00:00:00

  • Urban form and extreme heat events: are sprawling cities more vulnerable to climate change than compact cities?

    abstract:BACKGROUND:Extreme heat events (EHEs) are increasing in frequency in large U.S. cities and are responsible for a greater annual number of climate-related fatalities, on average, than any other form of extreme weather. In addition, low-density, sprawling patterns of urban development have been associated with enhanced s...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0901879

    authors: Stone B,Hess JJ,Frumkin H

    更新日期:2010-10-01 00:00:00

  • Risk screening for exposure to groundwater pollution in a wastewater irrigation district of the Mexico City region.

    abstract::Untreated wastewater from the Mexico City basin has been used for decades to irrigate cropland in the Mezquital Valley, State of Hidalgo, Mexico. Excess irrigation water recharges the near-surface aquifer that is used as a domestic water supply source. We assessed the groundwater quality of three key groundwater sourc...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.99107553

    authors: Downs TJ,Cifuentes-García E,Suffet IM

    更新日期:1999-07-01 00:00:00

  • Mortality among pesticide applicators exposed to chlorpyrifos in the Agricultural Health Study.

    abstract:BACKGROUND:Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited. OBJECTIVE:To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9662

    authors: Lee WJ,Alavanja MC,Hoppin JA,Rusiecki JA,Kamel F,Blair A,Sandler DP

    更新日期:2007-04-01 00:00:00

  • Spatial Modeling to Identify Sociodemographic Predictors of Hydraulic Fracturing Wastewater Injection Wells in Ohio Census Block Groups.

    abstract:BACKGROUND:Hydraulically fractured wells produce 2-14 million liters of wastewater, which may contain toxic and radioactive compounds. The wastewater is predominantly disposed of using Class II injection wells. OBJECTIVE:Our objective was to evaluate the relationship between sociodemographic characteristics and inject...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP2663

    authors: Silva GS,Warren JL,Deziel NC

    更新日期:2018-06-27 00:00:00

  • Tissue damage and nutritional factors in experimental respiratory tract (Co-)carcinogenesis.

    abstract::Cofactors involved in respiratory tract carcinogenesis were studied in Syrian golden hamsters or in rats using benzo(a)pyrene as the carcinogenic agent. These factors included severe tissue damage induced by electro-coagulation, glass fibers administered by intratracheal instillation, acetaldehyde as irritant vapor, f...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8350275

    authors: Reuzel PG,Feron VJ,Spit BJ,Beems RB,Kroes R

    更新日期:1983-04-01 00:00:00

  • A brief survey of butadiene health effects: a role for metabolic differences.

    abstract::1,3-Butadiene is a major monomer in the rubber and plastics industry and is one of the highest-production industrial chemicals in the United States. Although not highly acutely toxic to rodents, inhalation of concentrations as low as 6.25 ppm causes tumors in mice. Butadiene is oncogenic in rats, but much higher expos...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.93101s6161

    authors: Birnbaum LS

    更新日期:1993-12-01 00:00:00

  • Effects of sex hormones on oncogene expression in the vagina and on development of sexual dimorphism of the pelvis and anococcygeus muscle in the mouse.

    abstract::Neonatal treatment of female mice with diethystilbestrol (DES) is known to induce ovary-independent persistent proliferation and cornification of vaginal epithelium. This irreversibly changed vaginal epithelium persistently expressed higher levels of c-jun and c-fos mRNAs, which was not altered by postpubertal estroge...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s779

    authors: Iguchi T,Fukazawa Y,Bern HA

    更新日期:1995-10-01 00:00:00

  • Calcium in renal cells. Modulation of calcium-dependent activation of phospholipase A2.

    abstract::Calcium has been implicated as a regulatory factor in many physiological and pathophysiological processes in the renal cell. Under physiological conditions, the cytosolic free calcium concentration is maintained at approximately 100 nM. Most of the releasable cell Ca2+ resides in the nonmitochondrial compartments. In ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.9084155

    authors: Bonventre JV

    更新日期:1990-03-01 00:00:00

  • Cancer mortality in agricultural regions of Minnesota.

    abstract::Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); northwest region three (wheat, sugar beets, potatoes); and northeast region four (forested and urban in character). Cancer mortality (1980-...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.99107205

    authors: Schreinemachers DM,Creason JP,Garry VF

    更新日期:1999-03-01 00:00:00

  • Severity of health effects associated with building-related illness.

    abstract::Building-related illness ranges from mild rhinitis to potentially life-threatening hypersensitivity pneumonitis and legionellosis. Sick-building syndrome, consisting of headache, mucous membrane irritation, and fatigue, may be present in 30% of all office workers. Hypersensitivity pneumonitis, asthma, and legionellosi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.919567

    authors: Welch LS

    更新日期:1991-11-01 00:00:00

  • Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines.

    abstract:OBJECTIVE:We synthesized the main findings from an international epidemiologic study on the impact of biopersistent organic pollutants (POPs) on human reproductive function. DATA SOURCES AND EXTRACTION:We used a database with interview and biological data from 2,269 women and their spouses, and 18 published core paper...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.10700

    authors: Bonde JP,Toft G,Rylander L,Rignell-Hydbom A,Giwercman A,Spano M,Manicardi GC,Bizzaro D,Ludwicki JK,Zvyezday V,Bonefeld-Jørgensen EC,Pedersen HS,Jönsson BA,Thulstrup AM,INUENDO.

    更新日期:2008-03-01 00:00:00

  • Health status of Japanese and Taiwanese after exposure to contaminated rice oil.

    abstract::Mass poisonings, called yusho and yu-cheng, occurred in western Japan in 1968 and central Taiwan in 1979, respectively. These occurrences were separately caused by ingestion of rice oils contaminated with polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls. The tot...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8560321

    authors: Masuda Y

    更新日期:1985-05-01 00:00:00

  • Oral toxicity of 1,1-dichloroethylene in the rat: effects of sex, age, and fasting.

    abstract::Mortality curves for groups of fasted male rats treated with single, oral doses of 1,1-dichloroethylene (1,1-DCE, vinylidene chloride) were not monotonically increasing sigmoids, but were complex with maxima or extended plateaus in the region of dose between 100 and 700 mg of 1,1-DCE/kg. The exact shape was a function...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7721157

    authors: Andersen ME,Jenkins LJ Jr

    更新日期:1977-12-01 00:00:00

  • Mercury in Alaskan Eskimo mothers and infants.

    abstract::The potential danger of natural mercury accumulation in the diet of the Eskimo is evaluated through mercury levels determined in cord blood, placenta, maternal blood, hair, and milk of 38 maternal-infant pairs from Anchorage and the Yukon-Kuskokwim Delta. Although mercury levels are not discernably dangerous, trends t...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7615135

    authors: Galster WA

    更新日期:1976-06-01 00:00:00

  • Manganese: brain transport and emerging research needs.

    abstract::Idiopathic Parkinson's disease (IPD) represents a common neurodegenerative disorder. An estimated 2% of the U.S. population, age 65 and older, develops IPD. The number of IPD patients will certainly increase over the next several decades as the baby-boomers gradually step into this high-risk age group, concomitant wit...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.00108s3429

    authors: Aschner M

    更新日期:2000-06-01 00:00:00

  • Differences in tumor-associated protein levels among middle-age Flemish women in association with area of residence and exposure to pollutants.

    abstract::We measured tumor-associated proteins (TAPs) and pollutants in blood, serum, and urine of 200 nonsmoking women 50-65 years of age, residing in the rural municipality of Peer or in Hoboken or Wilrijk, industrial suburbs of Antwerp, Belgium. Persons with occupational exposures or commuting to other towns were excluded. ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8811

    authors: van Larebeke NA,Bracke ME,Nelen V,Koppen G,Schoeters G,Van Loon H,Vlietinck R

    更新日期:2006-06-01 00:00:00

  • The U.S. EPA Conference on Preventable Causes of Cancer in Children: a research agenda.

    abstract::On 15-16 September 1997, the U.S. Environmental Protection Agency sponsored the Conference on Preventable Causes of Cancer in Children. The conference was convened to examine rising trends in reported incidence of childhood cancer and the association of these trends with environmental exposures. This paper summarizes ...

    journal_title:Environmental health perspectives

    pub_type:

    doi:10.1289/ehp.98106867

    authors: Carroquino MJ,Galson SK,Licht J,Amler RW,Perera FP,Claxton LD,Landrigan PJ

    更新日期:1998-06-01 00:00:00

  • Barrier capacity of human placenta for nanosized materials.

    abstract:BACKGROUND:Humans have been exposed to fine and ultrafine particles throughout their history. Since the Industrial Revolution, sources, doses, and types of nanoparticles have changed dramatically. In the last decade, the rapidly developing field of nanotechnology has led to an increase of engineered nanoparticles with ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0901200

    authors: Wick P,Malek A,Manser P,Meili D,Maeder-Althaus X,Diener L,Diener PA,Zisch A,Krug HF,von Mandach U

    更新日期:2010-03-01 00:00:00

  • Biological effects of short-term, high-concentration exposure to methyl isocyanate. IV. Influence on the oxygen-binding properties of guinea pig blood.

    abstract::Whole blood oxygen equilibrium curves (O2 ECs), blood buffer lines, and several hematologic properties were determined for adult guinea pigs exposed to 700 ppm methyl isocyanate (MIC) for 15 min. MIC inhalation effected a significant reduction of blood O2 affinity; the half-saturation pressure (P50) at 38 degrees C in...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.877235

    authors: Maginniss LA,Szewczak JM,Troup CM

    更新日期:1987-06-01 00:00:00

  • Perceived treatment efficacy for conventional and alternative therapies reported by persons with multiple chemical sensitivity.

    abstract::Multiple chemical sensitivity (MCS) is a condition in which persons experience negative health effects in multiple organ systems from exposure to low levels of common chemicals. Although symptoms experienced from particular chemicals vary across persons, they are generally stable within persons. The sensitivities ofte...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.5936

    authors: Gibson PR,Elms AN,Ruding LA

    更新日期:2003-09-01 00:00:00

  • United Kingdom Beryllium Registry: mortality and autopsy study.

    abstract::This report is based on 30 deaths from chronic beryllium disease (CBD) in the United Kingdom with details of 19 autopsies. The majority were fluorescent lamp workers and machinists who died from respiratory failure. There were no cases of lung cancer. The survival times ranged from less than 1 to 29 years and was long...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.96104s5949

    authors: Williams WJ

    更新日期:1996-10-01 00:00:00

  • Developmental Neurotoxicity of the Harmful Algal Bloom Toxin Domoic Acid: Cellular and Molecular Mechanisms Underlying Altered Behavior in the Zebrafish Model.

    abstract:BACKGROUND:Harmful algal blooms (HABs) produce potent neurotoxins that threaten human health, but current regulations may not be protective of sensitive populations. Early life exposure to low levels of the HAB toxin domoic acid (DomA) produces long-lasting behavioral deficits in rodent and primate models; however, the...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP6652

    authors: Panlilio JM,Aluru N,Hahn ME

    更新日期:2020-11-01 00:00:00