Abstract:
:Mortality curves for groups of fasted male rats treated with single, oral doses of 1,1-dichloroethylene (1,1-DCE, vinylidene chloride) were not monotonically increasing sigmoids, but were complex with maxima or extended plateaus in the region of dose between 100 and 700 mg of 1,1-DCE/kg. The exact shape was a function of the size (age) of the rat used. When groups of rats of various sizes were dosed with 50 mg/kg, mortality and hepatotoxicity were greatest for those groups whose average weight was between 100 and 150 g. Smaller and larger male rats were less susceptible to 1,1-DCE intoxication. The toxicity of 1,1-DCE was less severe in female rats and there was no significant effect of rat size on 1,1-DCE toxicity in females. In rats of both sexes the dose dependence of the hepatotoxic response was complex, possessing a threshold level, a region of precipitous increase, and a plateau, where larger doses were ineffective in increasing hepatotoxicity. The threshold in male rats of 100-150 g occurred near 50 mg/kg, and for females it was closer to 100 mg/kg. Considered in their entirety these data suggest that 1,1-DCE is metabolized to a toxic intermediate via some saturable pathway. Based on the effects of pretreatment with microsomal enzyme inhibitors and activators on 1,1-DCE toxicity in rats of various sizes, it appears that there are at least two microsomal reactions involved in 1,1-DCE metabolism.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Andersen ME,Jenkins LJ Jrdoi
10.1289/ehp.7721157subject
Has Abstractpub_date
1977-12-01 00:00:00pages
157-63eissn
0091-6765issn
1552-9924journal_volume
21pub_type
杂志文章abstract::Methylation is considered the detoxification pathway for inorganic arsenic (InAs), an established human carcinogen. Urinary speciation analysis is used to assess the distribution of metabolites [monomethylarsonate (MMA), dimethylarsinate (DMA), and unmethylated arsenic (InAs)], as indicators of methylation capacity. W...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104620
更新日期:1996-06-01 00:00:00
abstract::Two remote maritime populations were evaluated for their biological exposure to organochlorines in 1989-1990. Because of their high intake of seafood, these two populations have high biological levels. One hundred nine breast milk samples from Inuit women from Arctic Québec were analyzed to determine levels of polychl...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s1205
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Fine particulate matter (FPM) in ambient air causes premature mortality due to cardiac disease in susceptible populations. OBJECTIVE:Our objective in this study was to determine the most influential FPM components. METHODS:A mouse model of atherosclerosis (ApoE-/-) was exposed to either filtered air or con...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9150
更新日期:2006-11-01 00:00:00
abstract::Many epidemiologic reports associate ambient levels of particulate matter (PM) with human mortality and morbidity, particularly in people with preexisting cardiopulmonary disease (e.g., chronic obstructive pulmonary disease, infection, asthma). Because much ambient PM is derived from combustion sources, we tested the ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105s51053
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:Anogenital distance (AGD) in animals is a sensitive biomarker of fetal endocrine disruption and the associated testicular dysgenesis syndrome (TDS). However, AGD in human infants with cryptorchidism and hypospadias, which are potential manifestations of TDS during childhood, is not clearly described. OBJECT...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307178
更新日期:2014-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 历史文章,杂志文章
doi:10.1289/ehp.1104693
更新日期:2012-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5221
更新日期:2020-01-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205894
更新日期:2013-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:2006-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9273
更新日期:2007-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1002336
更新日期:2010-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.834887
更新日期:1983-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800149
更新日期:2009-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7475
更新日期:2005-01-01 00:00:00
abstract::The distribution of inhaled mineral fibers in the lung determines the site and severity of disease caused by the fibers. Some of our recent work has described the fate of inhaled asbestos fibers in rodents. After a brief inhalation exposure, asbestos fibers are deposited primarily at the first alveolar duct bifurcatio...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.94102s5197
更新日期:1994-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0800058
更新日期:2009-07-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s3265
更新日期:1994-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002805
更新日期:2012-01-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8561123
更新日期:1985-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109489
更新日期:2001-05-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.856453
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Exposure of the U.S. population to polybrominated diphenyl ethers (PBDEs) is thought to be via exposure to dust and diet. However, little work has been done to empirically link body burdens of these compounds to either route of exposure. OBJECTIVES:The primary goal of this research was to evaluate the dieta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0900817
更新日期:2009-10-01 00:00:00
abstract::Because of their history of widespread use in the United States and unknown long-term health effects, organophosphate pesticides (OPs) are being considered as a chemical class of interest in planning for the National Children's Study, a longitudinal study of children's environmental health. The availability and approp...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.6179
更新日期:2003-12-01 00:00:00
abstract::This study was undertaken to explore the effects of chronic low-level cadmium ingestion in Dahl hypertension-resistant (R) and hypertension-sensitive (S) lines of rats. Groups of weanling female R and S rats were given 0 or 1 mg cadmium/1. in drinking water and fed either a low salt (0.4% NaCl) or a high salt (4% NaCl...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7928261
更新日期:1979-02-01 00:00:00
abstract::We investigated the metabolic fate of a low dose (25 micro g/kg) of bisphenol A [2,2-bis(4-hydroxy-phenyl)propane] (BPA) injected subcutaneously in CD1 pregnant mice using a tritium-labeled molecule. Analytic methods were developed to allow a radio-chromatographic profiling of BPA residues in excreta and tissues, as w...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5603
更新日期:2003-03-01 00:00:00
abstract::The Lower North Shore region of the St. Lawrence River is home to a fish-eating population that displays an unusually high body burden of several organochlorines, including polychlorinated biphenyls (PCBs) and dioxin-like compounds (DLCs). We measured biomarkers indicative of liver enzyme induction and investigated th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7970
更新日期:2005-10-01 00:00:00
abstract::Current research indicates a role for several oncogenes in radiation-induced carcinogenesis in vivo and cell transformation in vitro. Certain oncogenes are probably also involved in some cases of human cancer caused by exposure to nonionizing radiation and may play a mechanistic role in the phenomenon of radioresistan...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.919345
更新日期:1991-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s2457
更新日期:1997-03-01 00:00:00
abstract::In this study, we evaluated the impact of long-term occupational exposure to elemental mercury vapor (Hg0) on the personality traits of ex-mercury miners. Study groups included 53 ex-miners previously exposed to Hg0 and 53 age-matched controls. Miners and controls completed the self-reporting Eysenck Personality Quest...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7863
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Mortality displacement (or "harvesting") has been identified as a key issue in the assessment of the temperature-mortality relationship. However, only a few studies have addressed the "harvesting" issue and findings have not been consistent. OBJECTIVES:We examined the potential impact of both short- and lon...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307606
更新日期:2015-08-01 00:00:00