Interference of cadmium with ATP-stimulated nuclear calcium uptake.

abstract：BACKGROUND:Findings from national surveys suggest that everyone in the United States is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and nitrate inhibit iodide uptake into the thyroid and decrease thyroid hormone production. Small changes in thyroid hormones during pregnancy, including changes withi...

journal_title：Environmental health perspectives

authors： Steinmaus C,Pearl M,Kharrazi M,Blount BC,Miller MD,Pearce EN,Valentin-Blasini L,DeLorenze G,Hoofnagle AN,Liaw J

更新日期：2016-06-01 00:00:00

abstract：:This study constitutes one part of a program for assessing the impact of coal-fired power plants on the surrounding communities. A questionnaire was mailed to a total of 12,000 subjects living in six areas with coal-fired plants and in matched reference areas. The participation rate was 77.3%. In one coal-fired plant/...

journal_title：Environmental health perspectives

authors： Pershagen G,Hammar N,Vartiainen E

更新日期：1986-12-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH-DNA adducts, or BaP-DNA adducts as their proxy, provide a measure of chemical-specific genetic dama...

journal_title：Environmental health perspectives

authors： Perera FP,Tang D,Rauh V,Lester K,Tsai WY,Tu YH,Weiss L,Hoepner L,King J,Del Priore G,Lederman SA

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Associations between airborne particles and health outcomes have been documented worldwide; however, there is limited information regarding health effects associated with different particle sizes. OBJECTIVES:We explored the association between size-fractionated particle number concentrations (PNCs) and dail...

journal_title：Environmental health perspectives

authors： Meng X,Ma Y,Chen R,Zhou Z,Chen B,Kan H

更新日期：2013-10-01 00:00:00

abstract：:A combined cytogeneticurine metabolite analysis approach was used to assess potential interactive effects between Fenarimol (FN), a fungicide, and trichloroethylene (TRI), a halogenated solvent. FN was demonstrated to selectively induce P450-2B1 isoforms in different organs of treated mice. Since the rate of metabolis...

journal_title：Environmental health perspectives

authors： Hrelia P,Maffei F,Vigagni F,Fimognari C,Flori P,Stanzani R,Cantelli Forti G

更新日期：1994-11-01 00:00:00

abstract：:Striking similarities have been observed in a number of extrapulmonary responses of rodents to seemingly disparate ambient pollutants. These responses are often characterized by primary decreases in important indices of cardiac and thermoregulatory function, along with secondary decreases in associated parameters. For...

journal_title：Environmental health perspectives

authors： Watkinson WP,Campen MJ,Nolan JP,Costa DL

更新日期：2001-08-01 00:00:00

abstract：:Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure...

journal_title：Environmental health perspectives

authors： Luster MI,Faith RE,Moore JA

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density-lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein an...

journal_title：Environmental health perspectives

authors： Ayotte P,Carrier A,Ouellet N,Boiteau V,Abdous B,Sidi EA,Château-Degat ML,Dewailly É

更新日期：2011-08-01 00:00:00

abstract：:The phthalate acid esters (PAEs), and, in particular, di(2-ethylhexyl) phthalate (DEHP) and its monoester, monoethylhexyl phthalate (MEHP), can adversely affect rodent testes but only at high doses. Rat gonadal zinc levels can be decreased by the injection of DEHP, but not MEHP. The rat prostate gland seems to be part...

journal_title：Environmental health perspectives

authors： Thomas JA,Curto KA,Thomas MJ

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Lead exposure is associated with elevated blood pressure during pregnancy; however, the magnitude of this relationship at low exposure levels is unclear. OBJECTIVES:Our goal was to determine the association between low-level lead exposure and blood pressure during late pregnancy. METHODS:We collected admis...

journal_title：Environmental health perspectives

authors： Wells EM,Navas-Acien A,Herbstman JB,Apelberg BJ,Silbergeld EK,Caldwell KL,Jones RL,Halden RU,Witter FR,Goldman LR

更新日期：2011-05-01 00:00:00

abstract：:The binary, ternary, quaternary, and quintary interactions of a five-component mixture of carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) using response surface analyses are described. Initially, lung tumor dose-response curves in strain A/J mice for each of the individual PAHs benzo[a]pyrene (B[a]P...

journal_title：Environmental health perspectives

authors： Nesnow S,Mass MJ,Ross JA,Galati AJ,Lambert GR,Gennings C,Carter WH Jr,Stoner GD

更新日期：1998-12-01 00:00:00

abstract：:The types of reactive intermediates generated upon reduction of chromium(VI) by glutathione or hydrogen peroxide and the resulting DNA damage have been determined. In vitro, reaction of chromium(VI) with glutathione led to formation of two chromium(V) complexes and the glutathione thiyl radical. When chromium(VI) was ...

journal_title：Environmental health perspectives

authors： Aiyar J,Berkovits HJ,Floyd RA,Wetterhahn KE

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Most research on walking for transport has focused on the walkability of residential neighborhoods, overlooking the contribution of places of work/study and the ease with which destinations outside the immediate neighborhood can be accessed, referred to as regional accessibility. OBJECTIVES:We aimed to exam...

journal_title：Environmental health perspectives

authors： Barr A,Simons K,Mavoa S,Badland H,Giles-Corti B,Scheurer J,Korevaar E,Stewart J,Bentley R

更新日期：2019-09-01 00:00:00

abstract：:Studies have shown that female mosquitofish living downstream of a paper mill located on the Fenholloway River, Florida, have masculinized secondary sex characteristics, including altered anal fin development and reproductive behavior. Masculinization can be caused by exposure to androgens in the water or from an alte...

journal_title：Environmental health perspectives

authors： Orlando EF,Davis WP,Guillette LJ Jr

更新日期：2002-06-01 00:00:00

abstract：:The development of inhalation toxicology as a distinct discipline can be traced back well over one hundred years. The technology has advanced in terms of materials and designs used to construct inhalation chambers and the equipment used to generate controlled test atmospheres of a wide variety of gases, vapors, dusts,...

journal_title：Environmental health perspectives

authors： Dorato MA

更新日期：1990-04-01 00:00:00

abstract：:We investigated the metabolic fate of a low dose (25 micro g/kg) of bisphenol A [2,2-bis(4-hydroxy-phenyl)propane] (BPA) injected subcutaneously in CD1 pregnant mice using a tritium-labeled molecule. Analytic methods were developed to allow a radio-chromatographic profiling of BPA residues in excreta and tissues, as w...

journal_title：Environmental health perspectives

authors： Zalko D,Soto AM,Dolo L,Dorio C,Rathahao E,Debrauwer L,Faure R,Cravedi JP

更新日期：2003-03-01 00:00:00

abstract：:Congress has demonstrated interest in toxic compensation legislation, but not enough agreement to make significant progress. Advocates of reform claim that the legal system is heavily weighed against victims who seek compensation through the courts. Proposed reforms include a compensation fund and a cause of action in...

journal_title：Environmental health perspectives

authors： Anderson RC

更新日期：1985-10-01 00:00:00

abstract：:Epidemiological studies report a small but positive association between short-term increases in airborne particulate matter and small increases in morbidity and mortality from respiratory and cardiovascular disease in urban areas. However, the lack of a mechanistic explanation to link particle exposure and human healt...

journal_title：Environmental health perspectives

authors： Holian A,Hamilton RF Jr,Morandi MT,Brown SD,Li L

更新日期：1998-03-01 00:00:00

abstract：:This cross-sectional study examined the association between environmental lead measurements surrounding a Los Angeles County battery recycling facility and the blood lead levels of the children living nearby. Environmental lead measurements and blood lead levels of young children living in a community adjacent to a st...

journal_title：Environmental health perspectives

authors： Wohl AR,Dominguez A,Flessel P

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Maternal factors are implicated in the onset of childhood asthma. Differentiation of naïve CD4+ T lymphocytes into pro-allergic T-helper 2 cells induces interleukin (IL)4 expression and inhibits interferon (IFN)γ expression accompanied by concordant methylation changes in the promoters of these genes. Howeve...

journal_title：Environmental health perspectives

authors： Tang WY,Levin L,Talaska G,Cheung YY,Herbstman J,Tang D,Miller RL,Perera F,Ho SM

更新日期：2012-08-01 00:00:00

abstract：:Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At n...

journal_title：Environmental health perspectives

authors： Smuckler EA

更新日期：1976-06-01 00:00:00

abstract：:The central feature of hemopoiesis is life-long, stable cell renewal. This process is supported by hemopoietic stem cells which, in the steady state, appear to be dormant in cell cycling. The entry into cell cycle of the dormant stem cells may be promoted by such factors as interleukin-1, interleukin-6 (IL-6), and gra...

journal_title：Environmental health perspectives

authors： Ogawa M

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Studies estimating health effects of long-term air pollution exposure often use a two-stage approach: building exposure models to assign individual-level exposures, which are then used in regression analyses. This requires accurate exposure modeling and careful treatment of exposure measurement error. OBJEC...

journal_title：Environmental health perspectives

authors： Bergen S,Sheppard L,Sampson PD,Kim SY,Richards M,Vedal S,Kaufman JD,Szpiro AA

更新日期：2013-09-01 00:00:00

abstract：:Heightened concern over endocrine-disrupting chemicals is driven by the hypothesis that they could reduce reproductive success and affect wildlife populations, but there is little evidence for this expectation. The pharmaceutical ethynylestradiol (EE2) is a potent endocrine modulator and is present in the aquatic envi...

journal_title：Environmental health perspectives

authors： Nash JP,Kime DE,Van der Ven LT,Wester PW,Brion F,Maack G,Stahlschmidt-Allner P,Tyler CR

更新日期：2004-12-01 00:00:00

abstract：:A series of experiments is described in which operant methodology is used to study the effects of drugs on "learning." Emphasis is placed on the technique of repeated acquisition as a behavioral baseline for studying this type of transition state. In this technique, each subject is required to learn a new discriminati...

journal_title：Environmental health perspectives

authors： Thompson DM,Moerschbaecher JM

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Toxicology studies have shown adverse effects of developmental exposure to industrial phenols. Evaluation in humans is challenged by potentially marked within-subject variability of phenol biomarkers in pregnant women, which is poorly characterized. OBJECTIVES:We aimed to characterize within-day, between-da...

journal_title：Environmental health perspectives

authors： Vernet C,Philippat C,Calafat AM,Ye X,Lyon-Caen S,Siroux V,Schisterman EF,Slama R

更新日期：2018-03-16 00:00:00

abstract：BACKGROUND:Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (AR...

journal_title：Environmental health perspectives

authors： Zhao R,Hou Y,Xue P,Woods CG,Fu J,Feng B,Guan D,Sun G,Chan JY,Waalkes MP,Andersen ME,Pi J

更新日期：2011-01-01 00:00:00

abstract：:Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...

journal_title：Environmental health perspectives

authors： Hood E,Tillett T,Phelps J

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Endocrine-disrupting chemicals (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects have been reported in animal studies and extrapolated to human studies. Unlike humans, rodents express a novel isoform of ERβ (mERβ2) with a modified...

journal_title：Environmental health perspectives

authors： Donoghue LJ,Neufeld TI,Li Y,Arao Y,Coons LA,Korach KS

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed. OBJECTIVES:The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB ...

journal_title：Environmental health perspectives

authors： Goncharov A,Pavuk M,Foushee HR,Carpenter DO,Anniston Environmental Health Reseach Consortium.

更新日期：2011-03-01 00:00:00