Abstract:
BACKGROUND:Arsenic, cadmium, mercury, and lead are associated with cardiovascular disease in epidemiologic research. These associations may be mediated by direct effects of the metals on blood pressure (BP) elevation. Manganese is associated with cardiovascular dysfunction and hypotension in occupational cohorts. OBJECTIVES:We hypothesized that chronic arsenic, cadmium, mercury, and lead exposures elevate BP and that manganese lowers BP. METHODS:We conducted a cross-sectional analysis of associations between toenail metals and BP among older men from the Normative Aging Study (n = 639), using linear regression and adjusting for potential confounders. RESULTS:An interquartile range increase in toenail arsenic was associated with higher systolic BP [0.93 mmHg; 95% confidence interval (CI): 0.25, 1.62] and pulse pressure (0.76 mmHg; 95% CI: 0.22, 1.30). Positive associations between arsenic and BP and negative associations between manganese and BP were strengthened in models adjusted for other toenail metals. CONCLUSIONS:Our findings suggest associations between BP and arsenic and manganese. This may be of public health importance because of prevalence of both metal exposure and cardiovascular disease. Results should be interpreted cautiously given potential limitations of toenails as biomarkers of metal exposure.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Mordukhovich I,Wright RO,Hu H,Amarasiriwardena C,Baccarelli A,Litonjua A,Sparrow D,Vokonas P,Schwartz Jdoi
10.1289/ehp.1002805subject
Has Abstractpub_date
2012-01-01 00:00:00pages
98-104issue
1eissn
0091-6765issn
1552-9924journal_volume
120pub_type
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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更新日期:1985-10-01 00:00:00
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更新日期:2002-10-01 00:00:00
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更新日期:2008-11-01 00:00:00