Abstract:
:Multiple chemical sensitivity (MCS) is a condition in which persons experience negative health effects in multiple organ systems from exposure to low levels of common chemicals. Although symptoms experienced from particular chemicals vary across persons, they are generally stable within persons. The sensitivities often spread over time, first to related chemicals and then to other classes of chemicals. This study examined self-reported perceived treatment efficacy of 101 treatments used by 917 persons with self-reported MCS. Treatments examined included environmental medicine techniques, holistic therapies, individual nutritional supplements, detoxification techniques, body therapies, Eastern-origin techniques, newer therapies, prescription items, and others. The three most highly rated treatments were creating a chemical-free living space, chemical avoidance, and prayer. Both creating a chemical-free living space and chemical avoidance were rated by 95% of respondents as helpful. Results for most therapies were mixed. Participants had consulted a mean of 12 health care providers and spent over one-third of their annual income on health care costs. We discuss this drain on personal resources and describe respondents' attitudes toward the possibility of healing from MCS.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Gibson PR,Elms AN,Ruding LAdoi
10.1289/ehp.5936subject
Has Abstractpub_date
2003-09-01 00:00:00pages
1498-504issue
12eissn
0091-6765issn
1552-9924journal_volume
111pub_type
杂志文章abstract:BACKGROUND:Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent. OBJECTIVES:We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general popula...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307309
更新日期:2014-05-01 00:00:00
abstract::Systemic lupus erythematosus and systemic scleroderma are autoimmune diseases thought to have an exogenous trigger. This review summarizes relevant case-control and cohort studies that investigated exogenous sex hormones, silica, silicone, solvents, pesticides, mercuric chloride, and hair dyes as putative risk factors...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.99107s5743
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Epidemiologic studies of postnatal PCB exposure and behavior have not reported consistent evidence of adverse associations, possibly because of challenges in exposure estimation. We previously developed a pharmacokinetic model to improve estimation of children's PCB exposure. OBJECTIVES:We aimed to assess w...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408084
更新日期:2015-09-01 00:00:00
abstract::Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. Recent progress in understanding the mediators, triggers, and regulation of neurogenic inflammation ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.93101234
更新日期:1993-08-01 00:00:00
abstract::Rates of developmental and respiratory diseases are disproportionately high in underserved, minority populations such as those in New York City's Washington Heights, Harlem, and the South Bronx. Blacks and Latinos in these neighborhoods represent high risk groups for asthma, adverse birth outcomes, impaired developmen...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110197
更新日期:2002-02-01 00:00:00
abstract::Dose influences mechanism; and over a wide range of doses, one can envision that mechanism will change with changing dose. This basic concept in toxicology is juxtaposed with the biologic importance of maintaining normal DNA methylation status to provide the focus of this paper. The idea that altered DNA methylation p...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106s1285
更新日期:1998-02-01 00:00:00
abstract::Biological markers of intermediate health outcomes sometimes provide a superior alternative to traditional measures of pollutant-related disease. Some opportunities and methodologic issues associated with using markers are discussed in the context of exposures to four complex mixtures: environmental tobacco smoke and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s4193
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND:Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES:We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. ME...
journal_title:Environmental health perspectives
pub_type: 杂志文章,多中心研究
doi:10.1289/EHP155
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Organophosphorus pesticides (OPs) are developmental neurotoxicants but also produce lasting effects on metabolism. OBJECTIVES/METHODS:We administered diazinon (DZN) or parathion (PRT) to rats on postnatal days 14 at doses straddling the threshold for systemic signs of exposure and assessed the effects on he...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901237
更新日期:2010-02-01 00:00:00
abstract::A review and summary is given of analytical, biochemical, and immunological studies made following an immunodiagnostic investigation which revealed significant decreases in the numbers, and changes in the functional integrity, of both T-and B-lymphocytes in a group of Michigan dairy farmers exposed to polybrominated b...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8560107
更新日期:1985-05-01 00:00:00
abstract:BACKGROUND:The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer is controversial, but animal studies directly linking DDT to risk are lacking. Concerns with DDT reside in its environmental persistence, bioaccumulation in breast adipose tissue, and endocrine-disrupting actions. Whereas most attent...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104327
更新日期:2012-08-01 00:00:00
abstract::Pregnant Sprague Dawley rats were given 0, 0.25, 0.5, 1, 5, and 10 mg of a commercial polybrominated biphenyl, FireMaster BP-6 (PBB), in olive oil by gavage each day from days 7 through 15 of pregnancy. Laboratory chow and water were given ad libitum. Treatment with PBB had no significant effect on body weight gain, f...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7823295
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Because of complex interactions of climate variables at the levels of the pathogen, vector, and host, the potential influence of climate change on vector-borne and zoonotic diseases (VBZDs) is poorly understood and difficult to predict. Climate effects on the nonvector-borne zoonotic diseases are especially ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.0901389
更新日期:2010-11-01 00:00:00
abstract::With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Orga...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7467
更新日期:2005-02-01 00:00:00
abstract::The metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant compound of the aminoimidazoazaarens (AIA) group of mutagens/carcinogens isolated from the crust of fried and broiled meat, was examined in freshly isolated hepatocytes from untreated rat, mouse, hamster, and guinea pig. Activa...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s6109
更新日期:1994-10-01 00:00:00
abstract::To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studied the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102298
更新日期:1994-03-01 00:00:00
abstract::In 1976, near Seveso, Italy, an industrial accident caused the release of large quantities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) into the atmosphere, resulting in the highest levels of the toxicant ever recorded in humans. The contaminated area was divided into three zones (A, B, R) corresponding to decreasing...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106273
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Health risks differ by fine particle (aerodynamic diameter ≤ 2.5 μm) component, although with substantial variability. Traditional methods to assess component-specific risks are limited, suggesting the need for alternative methods. OBJECTIVES:We examined whether the odds of daily hospital admissions differ ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002646
更新日期:2011-10-01 00:00:00
abstract::We used the case-crossover design to identify any increase in mortality in Seoul, Korea, when there were higher levels of ambient air pollution on case-days than would be expected solely as a result of chance. This empirical study showed that either unidirectional retrospective (selecting only control days prior to de...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107633
更新日期:1999-08-01 00:00:00
abstract::The in vivo effects of xenoestrogens are of interest in relation to their potential health risks and/or beneficial effects on humans and animals. However, the apparent in vivo potency of the examined response can be confounded by a short half-life, and the metabolism of estrogens is very dependent on the nature of con...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9810623
更新日期:1998-01-01 00:00:00
abstract::We conducted a study to examine seasonal changes in residential dust lead content and its relationship to blood lead in preschool children. We collected blood and dust samples (floors, windowsills, and carpets) to assess lead exposure. The geometric mean blood lead concentrations are 10.77 and 7.66 microg/dL for the d...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108177
更新日期:2000-02-01 00:00:00
abstract::Isoflavonoids and related compounds such as coumestrol have classically been categorized as phytoestrogens because these environmentally derived substances bind to the estrogen receptor (ER) and increase uterine wet weight in immature rats and mice. Assessment of the binding affinities of isoflavonoids for ER and subs...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103574
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Phthalates are metabolized and eliminated in urine within hours after exposure. Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months. OBJECTIVES:We examined inter- and intraperson and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002231
更新日期:2010-12-01 00:00:00
abstract::Descriptions of endocrine disruption have largely been associated with wildlife and driven by observations documenting estrogenic, androgenic, antiandrogenic, and antithyroid actions. These actions, in response to exposure to ecologically relevant concentrations of various environmental contaminants, have now been est...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8045
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:World Trade Center (WTC) rescue and recovery workers were exposed to a complex mix of pollutants and carcinogens. OBJECTIVE:The purpose of this investigation was to evaluate cancer incidence in responders during the first 7 years after 11 September 2001. METHODS:Cancers among 20,984 consented participants ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205894
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Exposure to inorganic arsenic is associated with numerous adverse health outcomes, with susceptibility differing by sex. Although evidence from in vitro studies suggests that arsenic alters post-translational histone modifications (PTHMs), evidence in humans is limited. OBJECTIVES:The objectives were to det...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1510412
更新日期:2016-08-01 00:00:00
abstract::Often a compound's biological activity is determined by complex relationships between its structural components. Such a relationship often can only be adequately described and exploited by multivariate structure-activity relationship (SAR) studies that can deal with many variables simultaneously. Pattern recognition (...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8561329
更新日期:1985-09-01 00:00:00
abstract::Epidemiologic studies long have played a role in the understanding of the effects of the general environment and various occupational exposures on the occurrence of acute and chronic diseases of the lung. This article is an overview of epidemiologic study designs that have particular relevance to studies of environmen...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.00108s4615
更新日期:2000-08-01 00:00:00
abstract::Ecological risk assessment can be enhanced with predictive models for metal toxicity. Modelings of published data were done under the simplifying assumption that intermetal trends in toxicity reflect relative metal-ligand complex stabilities. This idea has been invoked successfully since 1904 but has yet to be applied...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s61419
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expression, and we hypothe...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1937
更新日期:2017-10-16 00:00:00