Abstract:
:Calcium has been implicated as a regulatory factor in many physiological and pathophysiological processes in the renal cell. Under physiological conditions, the cytosolic free calcium concentration is maintained at approximately 100 nM. Most of the releasable cell Ca2+ resides in the nonmitochondrial compartments. In addition to the plasma membrane Ca2+ transport processes, there is a high-affinity, low-capacity buffering capability of nonmitochondrial organelles and a lower-affinity high-capacity mitochondrial Ca2+ buffering capability. A critical enzymatic effector of Ca2+ action in the cell is phospholipase A2. By using digitonin-permeabilized renal mesangial cells, the [Ca2+] dependency of phospholipase A2 was characterized. The [Ca2+] sensitivity was insufficient to explain the phospholipase A2 activation observed with vasopressin. In both intact cells, as well as permeabilized cells, it was found that protein kinase C activation markedly enhanced the Ca2+ calmodulin-dependent activation of phospholipase A2. In response to platelet-derived growth factor, it was found that arachidonic acid release preceded phospholipase C activation. This suggests that other effectors besides Ca2+ and protein kinase C may also be important for phospholipase A2 activation. In an experimental model designed to mimic postischemic reperfusion damage to renal mitochondria, it was demonstrated that reactive oxygen species act synergistically with Ca2+ to activate mitochondrial phospholipase A2, which mediates damage to site I of the electron transport chain, the F1F0 ATPase, and the adenine nucleotide translocase.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Bonventre JVdoi
10.1289/ehp.9084155subject
Has Abstractpub_date
1990-03-01 00:00:00pages
155-62eissn
0091-6765issn
1552-9924journal_volume
84pub_type
杂志文章,评审abstract:BACKGROUND:Ambient air ozone (O3) is a pulmonary irritant that has been associated with respiratory health effects including increased lung inflammation and permeability, airway hyperreactivity, respiratory symptoms, and decreased lung function. Estimation of O3 exposure is a complex task because the pollutant exhibits...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1306566
更新日期:2014-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5672
更新日期:2019-12-01 00:00:00
abstract::Isolated rat and human hepatocytes in primary culture were shown to metabolize AAF to reactive intermediates which damaged hepatocyte DNA. A significant increase in unscheduled DNA synthesis was detectable by autoradiography in rat and human hepatocytes exposed to concentrations of AAF as low as 1 microM. When rat hep...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8349165
更新日期:1983-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/EHP483
更新日期:2017-06-13 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1996-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002720
更新日期:2010-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.94102s5277
更新日期:1994-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5799
更新日期:2003-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9088149
更新日期:1990-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108239
更新日期:2000-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901768
更新日期:2010-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8140163
更新日期:1981-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7933101
更新日期:1979-12-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.813899
更新日期:1981-04-01 00:00:00
abstract::Numerous publications and reports have expressed health and safety concerns about the production and use of nanoparticles, especially in areas of exposure monitoring, personal use, and environmental fate and transport. We suggest that stable isotopic tracers, which have been used widely in the earth sciences and in me...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9277
更新日期:2006-10-01 00:00:00
abstract::The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1788
更新日期:2017-06-20 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1289
更新日期:2018-01-11 00:00:00
abstract::Although exposure to many industrially important monomers is controlled by law, few of these reactive chemicals have been determined in human tissues. Analogy with other fat-soluble organic substances strongly implies that these monomers may be retained in tissue, subject to the usual physiological constraints of meta...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.7617183
更新日期:1976-10-01 00:00:00
abstract::Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); northwest region three (wheat, sugar beets, potatoes); and northeast region four (forested and urban in character). Cancer mortality (1980-...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107205
更新日期:1999-03-01 00:00:00
abstract::Studies performed earlier have shown a positive relation between blood lead (a parameter for lead body burden) and blood pressure, whereas such a relation between urine cadmium (a parameter for cadmium body burden) and blood pressure could not be shown. Median (i.e., 50th percentile, P50) blood levels in the general p...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.887867
更新日期:1988-06-01 00:00:00
abstract::Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice were more sensitive to the carcinogenic effects of benzene than were F344 rats. A physiological model was developed to describe the uptake and metabolism of benzene in rats and mice. Our objective was to ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.898243
更新日期:1989-07-01 00:00:00
abstract::The potential impact of an agent altering male reproductive function is greater for humans than for animals. Consequently, it is essential that sensitive criteria be used to look for effects on a multiplicity of target sites when an agent is evaluated using an animal model. No animal model has reproductive characteris...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8670149
更新日期:1986-12-01 00:00:00
abstract::The phenylphosphonothioate insecticides EPN and leptophos, and several analogs, were evaluated with respect to their delayed neurotoxic effects in hens and their environmental behavior in a terrestrial-aquatic model ecosystem. Acute toxicity to insects was highly correlated with sigma sigma of the substituted phenyl g...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8036187
更新日期:1980-06-01 00:00:00
abstract::A previously healthy woman developed hypersensitivity pneumonitis of such severity that she required chronic systemic corticosteroid therapy for symptom control. Detailed investigation of her workplace and home environments revealed fungi in her typical suburban home, to which she had specific serum precipitating anti...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109979
更新日期:2001-09-01 00:00:00
abstract::Cytotoxic chemicals have in common the ability to act specifically on cells in cycle. Bacteria are more sensitive in the exponential growth phase than when growing slowly in media. Similar observations have been made on a variety of systems ranging from bacteria, yeast, higher plants and invertebrates to vertebrates i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782487
更新日期:1978-06-01 00:00:00
abstract::A major goal of studying farmworkers is to better understand how their work environment, including exposure to pesticides, affects their health. Although a number of health conditions have been associated with pesticide exposure, clear linkages have yet to be made between exposure and health effects except in cases of...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8526
更新日期:2006-06-01 00:00:00
abstract::Biological markers of intermediate health outcomes sometimes provide a superior alternative to traditional measures of pollutant-related disease. Some opportunities and methodologic issues associated with using markers are discussed in the context of exposures to four complex mixtures: environmental tobacco smoke and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s4193
更新日期:1993-12-01 00:00:00
abstract::Fluorescence in situ hybridization with chromosome-specific composite DNA probes (chromosome painting) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed peop...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104s3489
更新日期:1996-05-01 00:00:00
abstract::Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.5847
更新日期:2003-04-01 00:00:00
abstract::Previously we have demonstrated that several xenobiotics can induce multidrug (mdr) gene expression in cultures of primary isolated hepatocytes. One of the best of these xenobiotic inducers in rat hepatocytes is 2-acetylaminofluorene (2-AAF), which induces mdr expression by an enhancement of mdr gene transcription. In...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s6209
更新日期:1994-10-01 00:00:00