Abstract:
:A previously healthy woman developed hypersensitivity pneumonitis of such severity that she required chronic systemic corticosteroid therapy for symptom control. Detailed investigation of her workplace and home environments revealed fungi in her typical suburban home, to which she had specific serum precipitating antibodies. Efforts to remove mold from the home were unsuccessful in relieving symptoms, and moving to another residence was the only intervention that allowed her to be withdrawn from corticosteroid therapy. Hypersensitivity pneumonitis is commonly associated with occupational or avocational exposures, such as moldy hay in farmers or bird antigen in bird breeders. We propose that hypersensitivity pneumonitis may occur in North America, as it does in Japan, from domestic exposures alone.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Apostolakos MJ,Rossmoore H,Beckett WSdoi
10.1289/ehp.01109979subject
Has Abstractpub_date
2001-09-01 00:00:00pages
979-81issue
9eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
109pub_type
杂志文章abstract::The central feature of hemopoiesis is life-long, stable cell renewal. This process is supported by hemopoietic stem cells which, in the steady state, appear to be dormant in cell cycling. The entry into cell cycle of the dormant stem cells may be promoted by such factors as interleukin-1, interleukin-6 (IL-6), and gra...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8980199
更新日期:1989-03-01 00:00:00
abstract::Dose influences mechanism; and over a wide range of doses, one can envision that mechanism will change with changing dose. This basic concept in toxicology is juxtaposed with the biologic importance of maintaining normal DNA methylation status to provide the focus of this paper. The idea that altered DNA methylation p...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106s1285
更新日期:1998-02-01 00:00:00
abstract::Polychlorinated dibenzo-p-dioxins (PCDDs, dioxins), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs) are environmental endocrine disruptors that have half-lives of 7-10 years in the human body and have toxicities that probably include carcinogenesis. A high ratio of 4-hydroxyl estradiol (4-O...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8809
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:High-level occupational exposures to some industrial chemicals have been associated with liver diseases, including nonalcoholic fatty liver disease (NAFLD). However, the potential role of low-level environmental pollution on liver disease in the general population has not been evaluated. OBJECTIVE:We determ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002720
更新日期:2010-12-01 00:00:00
abstract::The review of over 800 references on aluminum (Al) published since the mid-fifties covers the occurrence of Al in soil, air, water, plants and food products, as well as air and water pollution problems. In addition, the existing quality criteria, the biology and toxicology of Al, and the therapeutic and medical uses a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7483
更新日期:1974-08-01 00:00:00
abstract::We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, life...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7559
更新日期:2005-04-01 00:00:00
abstract::Large quantities of food processing, crop, forestry, and animal solid wastes are generated in the United States each year. The major components of these wastes are biodegradable. However, they also contain components such as nitrogen, human and animal pathogens, medicinals, feed additives, salts, and certain metals, t...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.7827261
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:According to a wide variety of analyses and projections, the potential effects of global climate change on human health are large and diverse. The U.S. National Institutes of Health (NIH), through its basic, clinical, and population research portfolio of grants, has been increasing efforts to understand how ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1104518
更新日期:2013-04-01 00:00:00
abstract::Environmental estrogens are of particular concern when exposure occurs during embryonic development. Although there are good models to study estrogenic activity of chemicals in adult animals, developmental exposure is much more difficult to test. The weak estrogenic activity of the environmental estrogen bisphenol A (...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7155
更新日期:2004-11-01 00:00:00
abstract::We extended our previous analyses of term low birth weight (LBW) and preterm birth to 1994-2000, a period of declining air pollution levels in the South Coast Air Basin. We speculated that the effects we observed previously for carbon monoxide, particulate matter < 10 microm in aerodynamic diameter (PM10), and traffic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7751
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:The U.S. Environmental Protection Agency is working toward gaining a better understanding of the human health impacts of exposure to complex air pollutant mixtures and the key features that drive the toxicity of these mixtures, which can then be used for future scientific and risk assessments. DATA SOURCES:...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1204939
更新日期:2012-09-01 00:00:00
abstract::The additives and contaminants which occur in textile fibers vary widely, depending on the type of fiber and the pretreatment which it has received. Synthetic fibers such as nylon and polyester contain trace amounts of contaminants such as catalysts and catalyst deactivators which remain after the synthesis of the bas...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.751141
更新日期:1975-06-01 00:00:00
abstract:BACKGROUND:Animal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast cancer risk. OBJECTIVES:We examined the association between residential outdoor LAN ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP935
更新日期:2017-08-17 00:00:00
abstract::Congress has demonstrated interest in toxic compensation legislation, but not enough agreement to make significant progress. Advocates of reform claim that the legal system is heavily weighed against victims who seek compensation through the courts. Proposed reforms include a compensation fund and a cause of action in...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8562365
更新日期:1985-10-01 00:00:00
abstract::A major challenge in the emerging field of toxicogenomics is to define the relationships between chemically induced changes in gene expression and alterations in conventional toxicologic parameters such as clinical chemistry and histopathology. We have explored these relationships in detail using the rodent uterotroph...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/txg.7345
更新日期:2004-11-01 00:00:00
abstract::Inspection of the available literature reveals that a detailed investigation of the aqueous organic chemistry of chlorine dioxide and systematic identification of products formed during water disinfection has not been considered. This must be done before an informed assessment can be made of the relative safety of usi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8246101
更新日期:1982-12-01 00:00:00
abstract::The toxic effects of cadmium and other heavy metals have been well established, and many of these and other environmental pollutants are known to be embryotoxic or teratogenic. However, it has proven difficult to identify individual cells that respond to toxicants among the wide range of cell populations in an intact ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.021101041
更新日期:2002-10-01 00:00:00
abstract::A subset of workers was followed after exposure to polychlorinated biphenyls (PCBs), dioxins, and furans in an occupational medicine clinic setting. Patterns of PCBs found in adipose tissue resembled the pattern seen when soot from the incident or Aroclor 1254 was examined by GC-MS. Adipose tissue also revealed levels...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8560241
更新日期:1985-05-01 00:00:00
abstract::The importance of urban dust as a source of lead for young children is still disputed. Although blood-lead data from various population surveys usually show a peak concentration in early childhood, there is evidence that such a peak is small or absent altogether in children without much access to the general environme...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350371
更新日期:1983-04-01 00:00:00
abstract::We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detect...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108323
更新日期:2000-04-01 00:00:00
abstract::The progression of the cell cycle is controlled by the action of both positive and negative growth regulators. The key players in this activity include a family of cyclins and cyclin-dependent kinases, which are themselves regulated by other kinases and phosphatases. Maintenance of balanced cell cycle controls may be ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.93101s59
更新日期:1993-12-01 00:00:00
abstract::This article summarizes the basic facts about the measurement of ionizing radiation, usually referred to as radiation dosimetry. The article defines the common radiation quantities and units; gives typical levels of natural radiation and medical exposures; and describes the most important biological effects of radiati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.919145
更新日期:1991-02-01 00:00:00
abstract::Striking similarities have been observed in a number of extrapulmonary responses of rodents to seemingly disparate ambient pollutants. These responses are often characterized by primary decreases in important indices of cardiac and thermoregulatory function, along with secondary decreases in associated parameters. For...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.01109s4539
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Many pesticides in current use have recently been revealed as in vitro androgen receptor (AR) antagonists, but information about their combined effects is lacking. OBJECTIVE:We investigated the combined effects and the competitive AR antagonism of pesticide mixtures. METHODS:We used the MDA-kb2 assay to te...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205391
更新日期:2012-11-01 00:00:00
abstract::To elucidate the effect of intake of mutagenic and/or carcinogenic pyrolysis products of proteins and amino acids on carcinogenesis in man, we have undertaken two epidemiologic cohort studies: one concerning the possible association of broiled fish consumption with cancer and the other concerning the cancer mortality ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8667143
更新日期:1986-08-01 00:00:00
abstract:OBJECTIVES:We evaluated the association between drinking-water disinfection by-products and preterm births using improved exposure assessment and more appropriate analysis methods than used in prior studies. METHODS:During 1999-2001, vital record data were obtained for a large, racially diverse population residing in ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9394
更新日期:2007-02-01 00:00:00
abstract:BACKGROUND:Evidence indicates that air pollution contributes to cardiopulmonary mortality. There is ongoing debate regarding the size and shape of the pollution–mortality exposure–response relationship. There are also growing appeals for estimates of pollution–mortality relationships that use public data and are based ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP4438
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Reported associations between gestational tobacco exposure and autism spectrum disorders (ASDs) have been inconsistent. OBJECTIVE:We estimated the association between maternal smoking during pregnancy and ASDs among children 8 years of age. METHODS:This population-based case-cohort study included 633,989 c...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104556
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:This study was designed to determine whether prenatal mercury exposure, including potential releases from the World Trade Center (WTC) disaster, adversely affects fetal growth and child development. METHODS:We determined maternal and umbilical cord blood total mercury of nonsmoking women who delivered at ter...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10831
更新日期:2008-08-01 00:00:00
abstract::The activities of plants and plant/microbial associations may offer a viable means of accomplishing the in situ remediation of contaminated soils. Two uses of plants for phytoremediation are reported here. In one set of studies, the ability of plants to foster degradative microorganisms was investigated. Results indic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s413
更新日期:1995-06-01 00:00:00