Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.

abstract：:This paper examines recent risk assessments for benzene and observes a number of inconsistencies within the study and consistencies between studies that should effect the quantitative determination of the risk from benzene exposure. Comparisons across studies show that only acute myeloid leukemia (AML) is found to be ...

journal_title：Environmental health perspectives

authors： Lamm SH,Walters AS,Wilson R,Byrd DM,Grunwald H

更新日期：1989-07-01 00:00:00

abstract：:In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation. These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrin...

journal_title：Environmental health perspectives

authors： Mossman BT,Faux S,Janssen Y,Jimenez LA,Timblin C,Zanella C,Goldberg J,Walsh E,Barchowsky A,Driscoll K

更新日期：1997-09-01 00:00:00

abstract：:Chlorination has been the major strategy for disinfection of drinking water in the United States. Concern about the potential health effects of the reaction by-products of chlorine has prompted use of alternative strategies. One such method is chloramination, a treatment process that does not appear to have carcinogen...

journal_title：Environmental health perspectives

authors： Zierler S,Danley RA,Feingold L

更新日期：1986-11-01 00:00:00

abstract：:Spatial epidemiology is the description and analysis of geographic variations in disease with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk factors. We focus on small-area analyses, encompassing disease mapping, geographic correlation studies, disease clusters, and clus...

journal_title：Environmental health perspectives

authors： Elliott P,Wartenberg D

更新日期：2004-06-01 00:00:00

abstract：:A brief review of the literature indicates that nutritional deficiencies have been shown to increase the absorption and toxicity of orally ingested lead and cadmium. Results from recent studies indicates that low level oral ingestion of cadmium and lead perturbs the metabolism of zinc, copper, and iron and that these ...

journal_title：Environmental health perspectives

authors： Petering HG

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Exposure to flame retardants has been associated with negative health outcomes including metabolic effects. As polybrominated diphenyl ether flame retardants were pulled from commerce, human exposure to new flame retardants such as Firemaster® 550 (FM550) has increased. Although previous studies in murine sy...

journal_title：Environmental health perspectives

authors： Tung EWY,Peshdary V,Gagné R,Rowan-Carroll A,Yauk CL,Boudreau A,Atlas E

更新日期：2017-09-14 00:00:00

abstract：:The role of the knowledge of high risk groups in the standard-setting process is examined. The overall conclusion is that many potential high risk segments of the population have not been studied adequately and that this deficiency in our knowledge markedly reduces the ability of decision makers to derive appropriate ...

journal_title：Environmental health perspectives

authors： Calabrese EJ

更新日期：1983-10-01 00:00:00

abstract：:The capacity of in vitro bioassays to detect the potential carcinogenicity of metal compounds is reviewed. The in vitro bioassays discussed include: bacterial reversion analysis to determine the capacity of metal salts to revert Salmonella typhimurium histidine auxotrophs or to revert Escherichia coli WP 2 tryp- to tr...

journal_title：Environmental health perspectives

authors： Sirover MA

更新日期：1981-08-01 00:00:00

abstract：OBJECTIVES:There are some common occupational agents and exposure circumstances for which evidence of carcinogenicity is substantial but not yet conclusive for humans. Our objectives were to identify research gaps and needs for 20 agents prioritized for review based on evidence of widespread human exposures and potenti...

journal_title：Environmental health perspectives

authors： Ward EM,Schulte PA,Straif K,Hopf NB,Caldwell JC,Carreón T,DeMarini DM,Fowler BA,Goldstein BD,Hemminki K,Hines CJ,Pursiainen KH,Kuempel E,Lewtas J,Lunn RM,Lynge E,McElvenny DM,Muhle H,Nakajima T,Robertson LW,Rothma

更新日期：2010-10-01 00:00:00

abstract：:Pavlovian conditioning processes may contribute to some symptoms of multiple chemical sensitivity (MCS). This review summarizes the potential relevance of the literature on conditional taste and olfactory aversions, conditional sensitization, and conditional immunomodulation to understanding MCS. A conditioning-based ...

journal_title：Environmental health perspectives

authors： Siegel S,Kreutzer R

更新日期：1997-03-01 00:00:00

abstract：:A comparative analysis was performed of the phenotype and function of peripheral blood leukocytes of two age-matched cohorts of industrial workers in chemical plants, one of which was exposed occupationally to high concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Median actual TCDD burdens were 116 ng/kg ...

journal_title：Environmental health perspectives

authors： Ernst M,Flesch-Janys D,Morgenstern I,Manz A

更新日期：1998-04-01 00:00:00

abstract：:The National Urban Air Toxics Research Center (NUATRC) hosted its first scientific workshop in 1994 that focused on possible relationships between air toxics and asthma. From that meeting came recommendations for future research including a need for more complete individual personal exposure assessments so that determ...

journal_title：Environmental health perspectives

authors： Larsen GL,Beskid C,Shirnamé-Moré L

更新日期：2002-08-01 00:00:00

abstract：:Ecological risk assessment can be enhanced with predictive models for metal toxicity. Modelings of published data were done under the simplifying assumption that intermetal trends in toxicity reflect relative metal-ligand complex stabilities. This idea has been invoked successfully since 1904 but has yet to be applied...

journal_title：Environmental health perspectives

authors： Newman MC,McCloskey JT,Tatara CP

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:In the United States, most of the treated sewage sludge (biosolids) is applied to farmland as a soil amendment. Critics suggest that rules regulating sewage sludge treatment and land application may be insufficient to protect public health and the environment. Neighbors of land application sites report illne...

journal_title：Environmental health perspectives

authors： Lowman A,McDonald MA,Wing S,Muhammad N

更新日期：2013-05-01 00:00:00

abstract：:Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an early stage of the disease may be related to the fact that a number of disc...

journal_title：Environmental health perspectives

authors： Nakanishi Y,Shigematsu N,Kurita Y,Matsuba K,Kanegae H,Ishimaru S,Kawazoe Y

更新日期：1985-02-01 00:00:00

abstract：:Studies on the fate of 14C-labeled vinyl chloride (VC) following oral administration and inhalation exposure in rats demonstrated that the disposition of VC in the body is a function of the dose. More importantly, from the data available, it appears that a correlation exists between doses of VC which cause tumors and ...

journal_title：Environmental health perspectives

authors： Watanabe PG,Gehring PJ

更新日期：1976-10-01 00:00:00

abstract：:Environmental pollution with the nephrotoxic metal cadmium is considered a potential health risk for the general population. In 1976 it was reported that the cadmium concentration in human kidney cortex in Sweden had increased in parallel with increasing levels in soil and grain during the twentieth century. Since the...

journal_title：Environmental health perspectives

authors： Friis L,Petersson L,Edling C

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is thought to be a major cause of morbidity and mortality in sub-Saharan Africa, but few controlled studies on the etiology of cirrhosis have been conducted in this region. OBJECTIVES:We aimed to elucidate the association between environmental and infectious exposures and cirrhosis in...

journal_title：Environmental health perspectives

authors： Kuniholm MH,Lesi OA,Mendy M,Akano AO,Sam O,Hall AJ,Whittle H,Bah E,Goedert JJ,Hainaut P,Kirk GD

更新日期：2008-11-01 00:00:00

abstract：:For workers in the nuclear industry, the primary route for the entry of radioactive materials into the body is by inhalation, and the rate of clearance of particles from the pulmonary region of the lung is an important factor in determining radiation dose. It is the function of alveolar macrophages (AM) to maintain th...

journal_title：Environmental health perspectives

authors： Kellington JP,Gibson K,Buckle TM,Talbot RJ,Hornby SB

更新日期：1992-07-01 00:00:00

abstract：:Pheromones are substances emitted by one individual of a species and eliciting a specific response in a second individual of the same species. In moths (Lepidoptera) generally females lure males for mating by emission of a sex attractant pheromone comprised of either one or more components. Since 1966 the identificati...

journal_title：Environmental health perspectives

authors： Cardé RT

更新日期：1976-04-01 00:00:00

abstract：:Enhanced transport of trace metal in porous media can occur in the presence of a ligand or "carrier" that has a high affinity for binding the pollutant, is dispersed and mobile in the soil environment, is recalcitrant with respect to microbial degradation, and is acceptable to the public. These aspects of the facilita...

journal_title：Environmental health perspectives

authors： Chen JH,Czajka DR,Lion LW,Shuler ML,Ghiorse WC

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Whether there is a causal relation between long-term exposure to traffic and asthma development is so far not clear. This may be explained by inaccurate exposure assessment. OBJECTIVE:We investigated the associations of long-term traffic-related exposures with asthma onset assessed retrospectively and respi...

journal_title：Environmental health perspectives

authors： Oftedal B,Nystad W,Brunekreef B,Nafstad P

更新日期：2009-05-01 00:00:00

abstract：:Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expres...

journal_title：Environmental health perspectives

authors： Andrew AS,Warren AJ,Barchowsky A,Temple KA,Klei L,Soucy NV,O'Hara KA,Hamilton JW

更新日期：2003-05-01 00:00:00

abstract：:There is a need to identify specific biological indicator(s) of cadmium exposure so that the renal damage can be prevented. Towards this end, we have examined the usefulness of urinary metallothionein as an indicator of cadmium body burden. It is found that, in both animals and humans, urinary metallothionein level is...

journal_title：Environmental health perspectives

authors： Shaikh ZA,Tohyama C

更新日期：1984-03-01 00:00:00

abstract：:The pneumoconioses are associated with chronic inflammatory processes during which increased amounts of reactive oxygen species are formed in the lower respiratory tract. To characterize the effect(s) of these processes on the defense system against free radicals, we studied 91 individuals with long-term occupational ...

journal_title：Environmental health perspectives

authors： Engelen JJ,Borm PJ,van Sprundel M,Leenaerts L

更新日期：1990-03-01 00:00:00

abstract：:Environmental chemicals that function as estrogens have been suggested to be associated with an increase in disease and dysfunctions in animals and humans. To characterize chemicals that may act as estrogens in humans, we have compared three in vitro assays which measure aspects of human estrogen receptor (hER)-mediat...

journal_title：Environmental health perspectives

authors： Klotz DM,Beckman BS,Hill SM,McLachlan JA,Walters MR,Arnold SF

更新日期：1996-10-01 00:00:00

abstract：:Metabolic enzymes involved in benzene activation or detoxification, including NAD(P)H, quinone oxidoreductase 1 (NQO1), cytochrome P450 2E1 (CYP2E1), myeloperoxidase (MPO), glutathione-S-transferase mu-1 (GSTM1), and glutathione-S-transferase theta-1 (GSTT1), were studied for their roles in human susceptibility to ben...

journal_title：Environmental health perspectives

authors： Wan J,Shi J,Hui L,Wu D,Jin X,Zhao N,Huang W,Xia Z,Hu G

更新日期：2002-12-01 00:00:00

abstract：:Molecular epidemiology has significant potential in preventing cancer and other diseases caused by environmental exposures (related to lifestyle, occupation, or ambient pollution). This approach attempts to prevent cancer by incorporating laboratory methods to document the molecular dose and preclinical effects of car...

journal_title：Environmental health perspectives

authors： Perera FP,Mooney LA,Dickey CP,Santella RM,Bell D,Blaner W,Tang D,Whyatt RM

更新日期：1996-05-01 00:00:00

abstract：:There are still many uncertainties regarding the risk of adverse pregnancy outcomes associated with exposure to drinking water disinfection by-products. In Montréal, Québec, Canada, we carried out a hospital-based case-control study including 493 cases of intrauterine growth restriction defined as birth weight below t...

journal_title：Environmental health perspectives

authors： Infante-Rivard C

更新日期：2004-08-01 00:00:00

abstract：:This study assessed whether exposure of male rats to two estrogenic, environmental chemicals, 4-octylphenol (OP) and butyl benzyl phthalate (BBP) during gestation or during the first 21 days of postnatal life, affected testicular size or spermatogenesis in adulthood (90-95 days of age). Chemicals were administered via...

journal_title：Environmental health perspectives

authors： Sharpe RM,Fisher JS,Millar MM,Jobling S,Sumpter JP

更新日期：1995-12-01 00:00:00