Abstract:
BACKGROUND:Exposure to flame retardants has been associated with negative health outcomes including metabolic effects. As polybrominated diphenyl ether flame retardants were pulled from commerce, human exposure to new flame retardants such as Firemaster® 550 (FM550) has increased. Although previous studies in murine systems have shown that FM550 and its main components increase adipogenesis, the effects of FM550 in human models have not been elucidated. OBJECTIVES:The objectives of this study were to determine if FM550 and its components are active in human preadipocytes, and to further investigate their mode of action. METHODS:Human primary preadipocytes were differentiated in the presence of FM550 and its components. Differentiation was assessed by lipid accumulation and expression of peroxisome proliferator-activated receptor γ (PPARG), fatty acid binding protein (FABP) 4 and lipoprotein lipase (LPL). mRNA was collected for Poly (A) RNA sequencing and was used to identify differentially expressed genes (DEGs). Functional analysis of DEGs was undertaken in Ingenuity Pathway Analysis. RESULTS:FM550 triphenyl phosphate (TPP) and isopropylated triphenyl phosphates (IPTP), increased adipogenesis in human primary preadipocytes as assessed by lipid accumulation and mRNA expression of regulators of adipogenesis such as PPARγ, CCAAT enhancer binding protein (C/EBP) α and sterol regulatory element binding protein (SREBP) 1 as well as the adipogenic markers FABP4 LPL and perilipin. Poly (A) RNA sequencing analysis revealed potential modes of action including liver X receptor/retinoid X receptor (LXR/RXR) activation, thyroid receptor (TR)/RXR, protein kinase A, and nuclear receptor subfamily 1 group H members activation. CONCLUSIONS:We found that FM550, and two of its components, induced adipogenesis in human primary preadipocytes. Further, using global gene expression analysis we showed that both TPP and IPTP likely exert their effects through PPARG to induce adipogenesis. In addition, IPTP perturbed signaling pathways that were not affected by TPP. https://doi.org/10.1289/EHP1318.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Tung EWY,Peshdary V,Gagné R,Rowan-Carroll A,Yauk CL,Boudreau A,Atlas Edoi
10.1289/EHP1318subject
Has Abstractpub_date
2017-09-14 00:00:00pages
097013issue
9eissn
0091-6765issn
1552-9924pii
EHP1318journal_volume
125pub_type
杂志文章abstract:BACKGROUND:The 2008 Beijing Olympic Games provided a unique case study to investigate the effect of source control measures on the reduction in air pollution, and associated inhalation cancer risk, in a Chinese megacity. OBJECTIVES:We measured 17 carcinogenic polycyclic aromatic hydrocarbons (PAHs) and estimated the l...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1003100
更新日期:2011-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.96104s155
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091145
更新日期:2001-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8464
更新日期:2006-02-01 00:00:00
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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更新日期:1982-04-01 00:00:00
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更新日期:2002-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type:
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更新日期:1998-06-01 00:00:00
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更新日期:2006-11-01 00:00:00
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.6542
更新日期:2004-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1289/ehp.93101s3213
更新日期:1993-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1985-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1999-10-01 00:00:00
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更新日期:2000-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1289/ehp.93101s471
更新日期:1993-12-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.00108553
更新日期:2000-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8352131
更新日期:1983-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 历史文章,杂志文章
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更新日期:1983-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1983-03-01 00:00:00
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更新日期:2016-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1989-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1289/ehp.793167
更新日期:1979-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.866755
更新日期:1986-08-01 00:00:00
abstract::Surface IR (infrared) modes of crystalline and fumed (amorphous) silica particles, calcined at temperatures up to 1095 degrees C, have been studied by Fourier transform infrared spectroscopy. The ability of these same particles to lyse cells has been measured by a hemolysis protocol. The untreated crystalline and amor...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9086327
更新日期:1990-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110s2211
更新日期:2002-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7615135
更新日期:1976-06-01 00:00:00
abstract::Minority populations face a wide variety of economic, institutional, and cultural barriers to health care. These barriers and low levels of education and income pose significant challenges for health professionals in developing cancer research and prevention-control strategies. It is suggested that specific segments o...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s8287
更新日期:1995-11-01 00:00:00