Polybrominated biphenyls in model and environmentally contaminated human blood: protein binding and immunotoxicological studies.

abstract：:Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...

journal_title：Environmental health perspectives

authors： Hood E,Tillett T,Phelps J

更新日期：2006-05-01 00:00:00

abstract：:Biological markers of intermediate health outcomes sometimes provide a superior alternative to traditional measures of pollutant-related disease. Some opportunities and methodologic issues associated with using markers are discussed in the context of exposures to four complex mixtures: environmental tobacco smoke and ...

journal_title：Environmental health perspectives

authors： Wilcosky TC

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:THE APHENA (AIR POLLUTION AND HEALTH: A Combined European and North American Approach) study is a collaborative analysis of multicity time-series data on the effect of air pollution on population health, bringing together data from the European APHEA (Air Pollution and Health: A European Approach) and U.S. N...

journal_title：Environmental health perspectives

authors： Samoli E,Peng R,Ramsay T,Pipikou M,Touloumi G,Dominici F,Burnett R,Cohen A,Krewski D,Samet J,Katsouyanni K

更新日期：2008-11-01 00:00:00

abstract：:This paper examines behavioral changes in natural populations of wildlife associated with pollution. Although some changes such as lack of nest attentiveness and decreased nest defense have been noted, the results have not been consistent and have been difficult to relate to specific pollutants. Experimental studies i...

journal_title：Environmental health perspectives

authors： Peakall DB

更新日期：1996-04-01 00:00:00

abstract：:To elucidate problems with microfungal infestation in indoor environments, a multidisciplinary collaborative pilot study, supported by a grant from the Danish Ministry of Housing and Urban Affairs, was performed on 72 mold-infected building materials from 23 buildings. Water leakage through roofs, rising damp, and def...

journal_title：Environmental health perspectives

authors： Gravesen S,Nielsen PA,Iversen R,Nielsen KF

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health. OBJECTIVES:We studied the association of air pollution exposure during pregnancy and the first year of life with respiratory illnesses, ear infections, and eczema during the first 12-18 months of a...

journal_title：Environmental health perspectives

authors： Aguilera I,Pedersen M,Garcia-Esteban R,Ballester F,Basterrechea M,Esplugues A,Fernández-Somoano A,Lertxundi A,Tardón A,Sunyer J

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:We previously conducted a study to assess whether household exposures to tap water increased an individual's internal dose of trihalomethanes (THMs). Increases in blood THM levels among subjects who showered or bathed were variable, with increased levels tending to cluster in two groups. OBJECTIVES:Our goal...

journal_title：Environmental health perspectives

authors： Backer LC,Lan Q,Blount BC,Nuckols JR,Branch R,Lyu CW,Kieszak SM,Brinkman MC,Gordon SM,Flanders WD,Romkes M,Cantor KP

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The emerging consensus that exposure to near-roadway traffic-related pollution causes asthma has implications for compact urban development policies designed to reduce driving and greenhouse gases. OBJECTIVES:We estimated the current burden of childhood asthma-related disease attributable to near-roadway an...

journal_title：Environmental health perspectives

authors： Perez L,Lurmann F,Wilson J,Pastor M,Brandt SJ,Künzli N,McConnell R

更新日期：2012-11-01 00:00:00

abstract：:The spatial and temporal regulation of intracellular free Ca2+ serves as a modulator of signal transduction pathways involved in cell growth and differentiation. Thus, interference of metals with intracellular Ca2+ homeostasis has been considered as a target of toxic action. We used the fluorescence indicator fura-2 t...

journal_title：Environmental health perspectives

authors： Hechtenberg S,Beyersmann D

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties. OBJECTIVES:We aimed to study associations between prenatal exposure to phthalates and seve...

journal_title：Environmental health perspectives

authors： Philippat C,Nakiwala D,Calafat AM,Botton J,De Agostini M,Heude B,Slama R,EDEN Mother–Child Study Group.

更新日期：2017-09-15 00:00:00

abstract：:The mutagenic activities of several phthalate esters have been evaluated in an 8-azaguanine resistance assay in Salmonella typhimurium. Three phthalate esters were found to be mutagenic: dimethyl phthalate, diethyl phthalate and di-n-butyl phthalate. A number of other phthalate esters were not found to be mutagenic, i...

journal_title：Environmental health perspectives

authors： Seed JL

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:Hexavalent chromium [Cr(VI)] is recognized as a human carcinogen via inhalation. However, the molecular mechanisms by which Cr(VI) causes cancers are not well understood. OBJECTIVES:We evaluated cyclooxygenase-2 (COX-2) expression and the signaling pathway leading to this induction due to Cr(VI) exposure in...

journal_title：Environmental health perspectives

authors： Zuo Z,Cai T,Li J,Zhang D,Yu Y,Huang C

更新日期：2012-04-01 00:00:00

abstract：:Previous occupational cohort studies of benzene-exposed workers have for the most part used only death certificates to validate diagnoses of workers developing leukemia and other hematopoietic and lymphoproliferative malignancies and related disorders (HLD). In a follow-up study of 74,828 benzene-exposed workers and a...

journal_title：Environmental health perspectives

authors： Linet MS,Yin SN,Travis LB,Li CY,Zhang ZN,Li DG,Rothman N,Li GL,Chow WH,Donaldson J,Dosemeci M,Wacholder S,Blot WJ,Hayes RB

更新日期：1996-12-01 00:00:00

abstract：:The in vivo effects of xenoestrogens are of interest in relation to their potential health risks and/or beneficial effects on humans and animals. However, the apparent in vivo potency of the examined response can be confounded by a short half-life, and the metabolism of estrogens is very dependent on the nature of con...

journal_title：Environmental health perspectives

authors： Milligan SR,Balasubramanian AV,Kalita JC

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:In the 1990s, the mercury-based preservative thimerosal was used in most pediatric vaccines. Although there are currently only two thimerosal-containing vaccines (TCVs) recommended for pediatric use, parental perceptions that vaccines pose safety concerns are affecting vaccination rates, particularly in ligh...

journal_title：Environmental health perspectives

authors： Curtis B,Liberato N,Rulien M,Morrisroe K,Kenney C,Yutuc V,Ferrier C,Marti CN,Mandell D,Burbacher TM,Sackett GP,Hewitson L

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Environmental air pollutants are inhaled as complex mixtures, but the long dominant focus of monitoring and research on individual pollutants has provided modest insight into pollutant interactions that may be important to health. Trends toward managing multiple pollutants to maximize aggregate health gains ...

journal_title：Environmental health perspectives

authors： Mauderly JL,Samet JM

更新日期：2009-01-01 00:00:00

abstract：:The nasal cavity is susceptible to chemically induced injury as a result of exposure to inhaled irritants. Some responses of the nasal mucosa to inhaled toxicants are species specific. These species-related differences in response may be due to variations in structural, physiologic, and biochemical factors, such as gr...

journal_title：Environmental health perspectives

authors： Harkema JR

更新日期：1990-04-01 00:00:00

abstract：:Cytochrome P450 (CYP) enzymes catalyze the generation of reactive species capable of binding with cellular macromolecules, leading to acute and delayed toxicity. Since individual CYP forms differ markedly in their substrate preferences and regulation, the expression profiles of CYP in various cell types are important ...

journal_title：Environmental health perspectives

authors： Pelkonen O,Raunio H

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:A critical question regarding the association between short-term exposure to ozone and mortality is the extent to which this relationship is confounded by ambient exposure to particles. OBJECTIVES:We investigated whether particulate matter < 10 and < 2.5 microm in aerodynamic diameter (PM(10) and PM(2.5)) i...

journal_title：Environmental health perspectives

authors： Bell ML,Kim JY,Dominici F

更新日期：2007-11-01 00:00:00

abstract：:The gas phase reactions of carbanions with molecular oxygen in both its ground state (X3 sigma g-) and first electronically excited state (a1 delta g) have been studied by the flowing afterglow technique. Reactions include cleavage processes, charge transfer, hydride transfer, formation of hydroxide ion and processes ...

journal_title：Environmental health perspectives

authors： Bierbaum VM,Schmitt RJ,DePuy CH

更新日期：1980-06-01 00:00:00

abstract：:Although exposure to many industrially important monomers is controlled by law, few of these reactive chemicals have been determined in human tissues. Analogy with other fat-soluble organic substances strongly implies that these monomers may be retained in tissue, subject to the usual physiological constraints of meta...

journal_title：Environmental health perspectives

authors： Wolff MS

更新日期：1976-10-01 00:00:00

abstract：:Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such epidemiologic studies will most likely be prompted either by a known release of chemicals into the environment around the site, or by an unusual disease cluster in a population...

journal_title：Environmental health perspectives

authors： Buffler PA,Crane M,Key MM

更新日期：1985-10-01 00:00:00

abstract：:This paper summarizes the themes and recommendations that emerge from the papers presented by the Working Group on Tropospheric Ozone. In terms of current knowledge, the following are considered of particular importance: a) lack of clear evidence for a human analogue of the terminal bronchiolar and proximal acinar cha...

journal_title：Environmental health perspectives

authors： Tager IB

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Exposure of the U.S. population to polybrominated diphenyl ethers (PBDEs) is thought to be via exposure to dust and diet. However, little work has been done to empirically link body burdens of these compounds to either route of exposure. OBJECTIVES:The primary goal of this research was to evaluate the dieta...

journal_title：Environmental health perspectives

authors： Fraser AJ,Webster TF,McClean MD

更新日期：2009-10-01 00:00:00

abstract：:Organophosphates in increasing amounts and wider varieties of molecular structure are being used to replace the organochlorine pesticides. It has been assumed that the organophosphates as a class would have a minimal chronic toxicity due to rapid hydrolysis and an unfavorable partitioning as regards to lipids. The phy...

journal_title：Environmental health perspectives

authors： Freed VH,Haque R,Schmedding D,Kohnert R

更新日期：1976-02-01 00:00:00

abstract：:Exposure of rats to quartz (or various other particles) can lead to the development of lung tumors. At the moment, the mechanisms involved in particle-induced tumor formation are not clarified. However, it is suggested that inflammation, in conjunction with the production of reactive oxygen species (ROS) and an enhanc...

journal_title：Environmental health perspectives

authors： Nehls P,Seiler F,Rehn B,Greferath R,Bruch J

更新日期：1997-09-01 00:00:00

abstract：:In this paper we report yields, identities, and mutagenicities of products from heating a polycyclic aromatic hydrocarbon (PAH)-contaminated, Superfund-related synthetic soil matrix without exogenous oxygen. We heated batch samples of soil pretreated with 5.08 wt% (by weight) pyrene in a tubular furnace under a consta...

journal_title：Environmental health perspectives

authors： Richter H,Risoul V,Lafleur AL,Plummer EF,Howard JB,Peters WA

更新日期：2000-08-01 00:00:00

abstract：:Polychlorinated biphenyls (PCBs) are persistent pollutants that are ubiquitous in the food chain, and detectable amounts are in the blood of almost every person in most populations that have been examined. Extensive evidence from animal studies shows that PCBs are neurotoxins, even at low doses. Interpretation of huma...

journal_title：Environmental health perspectives

authors： Longnecker MP,Wolff MS,Gladen BC,Brock JW,Grandjean P,Jacobson JL,Korrick SA,Rogan WJ,Weisglas-Kuperus N,Hertz-Picciotto I,Ayotte P,Stewart P,Winneke G,Charles MJ,Jacobson SW,Dewailly E,Boersma ER,Altshul LM,Heinzow B

更新日期：2003-01-01 00:00:00

abstract：:Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to ...

journal_title：Environmental health perspectives

authors： Wartenberg D,Reyner D,Scott CS

更新日期：2000-05-01 00:00:00

abstract：:We analyzed data from 798 lead workers to determine whether polymorphisms in the genes encoding delta-aminolevulinic acid dehydratase (ALAD), endothelial nitric oxide synthase (eNOS), and the vitamin D receptor (VDR) were associated with or modified relations of lead exposure and dose measures with renal outcomes. Lea...

journal_title：Environmental health perspectives

authors： Weaver VM,Schwartz BS,Ahn KD,Stewart WF,Kelsey KT,Todd AC,Wen J,Simon DJ,Lustberg ME,Parsons PJ,Silbergeld EK,Lee BK

更新日期：2003-10-01 00:00:00