Abstract:
:Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to trichloroethylene. Evidence of excess cancer incidence among occupational cohorts with the most rigorous exposure assessment is found for kidney cancer (relative risk [RR] = 1.7, 95% confidence interval [CI] 1.1-2.7), liver cancer (RR = 1.9, 95% CI(1.0-3.4), and non-Hodgkin's lymphoma (RR = 1.5, 95% CI 0.9-2.3) as well as for cervical cancer, Hodgkin's disease, and multiple myeloma. However, since few studies isolate trichloroethylene exposure, results are likely confounded by exposure to other solvents and other risk factors. Although we believe that solvent exposure causes cancer in humans and that trichloroethylene likely is one of the active agents, we recommend further study to better specify the specific agents that confer this risk and to estimate the magnitude of that risk.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Wartenberg D,Reyner D,Scott CSdoi
10.1289/ehp.00108s2161subject
Has Abstractpub_date
2000-05-01 00:00:00pages
161-76eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
108 Suppl 2pub_type
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更新日期:2011-12-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2020-06-01 00:00:00
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更新日期:2006-04-01 00:00:00