Abstract:
:Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. Recent progress in understanding the mediators, triggers, and regulation of neurogenic inflammation is reviewed. Evidence for and speculations about a role for neurogenic inflammation in established disorders such as asthma, rhinitis, contact dermatitis, migraine headache, and rheumatoid arthritis are presented. The sick building syndrome and multiple chemical sensitivity syndrome have been defined as clinical entities in which exposure to chemical inhalants gives rise to disease. Current data on the existence of chemical irritant receptors in the airway and skin are discussed; neurogenic inflammation arising from stimulation of chemical irritant receptors is a possible model to explain many of the aspects of chemical sensitivities.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Meggs WJdoi
10.1289/ehp.93101234subject
Has Abstractpub_date
1993-08-01 00:00:00pages
234-8issue
3eissn
0091-6765issn
1552-9924journal_volume
101pub_type
杂志文章,评审abstract:BACKGROUND:Drinking water in multiple water districts in the Mid-Ohio Valley has been contaminated with perfluorooctanoic acid (PFOA), which was released by a nearby DuPont chemical plant. Two highly contaminated water districts began granular activated carbon filtration in 2007. OBJECTIVES:To determine the rate of de...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901252
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (AR...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002304
更新日期:2011-01-01 00:00:00
abstract::The purpose of the study was to determine whether the risk of childhood acute lymphoblastic leukemia (ALL) associated with drinking water disinfection by-products was modified in the presence of variants in genes involved in the metabolism of trihalomethanes (THMs). We included a subset of cases from a population-base...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110591
更新日期:2002-06-01 00:00:00
abstract::Untreated wastewater from the Mexico City basin has been used for decades to irrigate cropland in the Mezquital Valley, State of Hidalgo, Mexico. Excess irrigation water recharges the near-surface aquifer that is used as a domestic water supply source. We assessed the groundwater quality of three key groundwater sourc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107553
更新日期:1999-07-01 00:00:00
abstract::A combined cytogeneticurine metabolite analysis approach was used to assess potential interactive effects between Fenarimol (FN), a fungicide, and trichloroethylene (TRI), a halogenated solvent. FN was demonstrated to selectively induce P450-2B1 isoforms in different organs of treated mice. Since the rate of metabolis...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s931
更新日期:1994-11-01 00:00:00
abstract::Occupational cancer research methods was identified in 1996 as 1 of 21 priority research areas in the National Occupational Research Agenda (NORA). To implement NORA, teams of experts from various sectors were formed and given the charge to further define research needs and develop strategies to enhance or augment res...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.111-1241299
更新日期:2003-01-01 00:00:00
abstract::Under a mandate from the U.S. Congress, the National Toxicology Program (NTP) of the U.S. Department of Health and Human Services conducts animal bioassays for carcinogenicity of potentially toxic chemicals to which the U.S. population might be exposed. Methyleugenol, a natural as well as synthesized substance, was no...
journal_title:Environmental health perspectives
pub_type: 临床试验,杂志文章
doi:10.1289/ehp.6766
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:Due to the large number of chemicals not yet tested for carcinogenicity but to which people are exposed, the limited number of human and animal cancer studies conducted each year, and the frequent need for a timely response, mechanistic data are playing an increasingly important role in carcinogen hazard ide...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5672
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Adapting to extreme heat is becoming more critical as our climate changes. Previous research reveals that very few communities in the United States have programs to sufficiently prevent health problems during hot weather. OBJECTIVE:Our goal was to examine county-level local heat preparedness and response in...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1306693
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Although a long latency period of toxicity after exposure to methylmercury (MeHg) is known to exist in humans, few animal studies have addressed this issue. Substantiation of delayed MeHg toxicity in animals would affect the risk evaluation of MeHg. OBJECTIVES:Our goal in this study was to demonstrate the e...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10906
更新日期:2008-06-01 00:00:00
abstract::Ecological risk assessment can be enhanced with predictive models for metal toxicity. Modelings of published data were done under the simplifying assumption that intermetal trends in toxicity reflect relative metal-ligand complex stabilities. This idea has been invoked successfully since 1904 but has yet to be applied...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s61419
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Traffic noise affects a large number of people, particularly in urbanized areas. Noise causes stress and annoyance, but less is known about the relationship between noise and depression. OBJECTIVE:We investigated the association of residential road traffic noise with depressive symptoms using 5-year follow-...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409400
更新日期:2016-05-01 00:00:00
abstract::Epidemiological studies report a small but positive association between short-term increases in airborne particulate matter and small increases in morbidity and mortality from respiratory and cardiovascular disease in urban areas. However, the lack of a mechanistic explanation to link particle exposure and human healt...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106127
更新日期:1998-03-01 00:00:00
abstract::This paper addresses the subject of the use of selected toxicology information resources in assessing relationships between chemical structure and specific biological end points. To assist the researcher in how to access the primary literature of genetic toxicology, teratogenesis, and carcinogenesis, three specific sp...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8561287
更新日期:1985-09-01 00:00:00
abstract::To examine the effects of dibutyl phthalate (DBP) on gonadal sex differentiation, genetically male tadpoles of Rana rugosa were exposed to dilute solutions of DBP at concentrations of 0.1, 1, or 10 microM during days 19-23 after fertilization, which is the critical period of gonadal sex differentiation in R. rugosa. T...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.001081189
更新日期:2000-12-01 00:00:00
abstract::Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An understanding of these interesting human carcinogens, therefore, is an important problem in cancer research. Asbestos and other fibers induce predominantly two types o...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.898181
更新日期:1989-05-01 00:00:00
abstract::Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106s61263
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Biomass smoke is an important source of particulate matter (PM), and much remains to be discovered with respect to the human health effects associated with this specific PM source. Exposure to biomass smoke can occur in one of two main categories: short-term exposures consist of periodic, seasonal exposures ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11378
更新日期:2009-01-01 00:00:00
abstract::Biomedical developments in the 21st century provide an unprecedented opportunity to gain a dynamic systems-level and human-specific understanding of the causes and pathophysiologies of disease. This understanding is a vital need, in view of continuing failures in health research, drug discovery, and clinical translati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1510345
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:THE APHENA (AIR POLLUTION AND HEALTH: A Combined European and North American Approach) study is a collaborative analysis of multicity time-series data on the effect of air pollution on population health, bringing together data from the European APHEA (Air Pollution and Health: A European Approach) and U.S. N...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11345
更新日期:2008-11-01 00:00:00
abstract::Soil ingestion estimates play an important role in risk assessment of contaminated sites, and estimates of soil ingestion in children are of special interest. Current estimates of soil ingestion are trace-element specific and vary widely among elements. Although expressed as daily estimates, the actual estimates have ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103276
更新日期:1995-03-01 00:00:00
abstract::We measured volatile organic compound (VOC) exposures in multiple locations for a diverse population of children who attended two inner-city schools in Minneapolis, Minnesota. Fifteen common VOCs were measured at four locations: outdoors (O), indoors at school (S), indoors at home (H), and in personal samples (P). Con...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7107
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Arsenicals (roxarsone and nitarsone) used in poultry production likely increase inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and roxarsone or nitarsone concentrations in poultry meat. However, the association between poultry intake and exposure to these arsenic species, ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP351
更新日期:2017-03-01 00:00:00
abstract::A cohort of 12,110 male workers employed 1 or more years in eight styrene-butadiene polymer (SBR) manufacturing plants in the United States and Canada has been followed for mortality over a 40-year period, 1943 to 1982. The all-cause mortality of these workers was low [standardized mortality ratio (SMR) = 0.81] compar...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9086107
更新日期:1990-06-01 00:00:00
abstract::Possible effects of Chernobyl fallout on outcome of pregnancy in Finland were evaluated in a nationwide follow-up study. The outcomes were the rate of live births and stillbirths, pregnancy loss, and induced abortions by municipality. Exposure was assessed based on nationwide surveys of radiation dose rate from the Ch...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109179
更新日期:2001-02-01 00:00:00
abstract::The X-ray crystallographic structural determinations of synthetic estrogens and antiestrogens provide reliable information on the global minimum energy conformation of these molecules or a local minimum energy conformation that is within 1 or 2 kcal/mole of the global minimum. In favorable cases, state-of-the-art mole...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8561111
更新日期:1985-09-01 00:00:00
abstract::Previously we have demonstrated that several xenobiotics can induce multidrug (mdr) gene expression in cultures of primary isolated hepatocytes. One of the best of these xenobiotic inducers in rat hepatocytes is 2-acetylaminofluorene (2-AAF), which induces mdr expression by an enhancement of mdr gene transcription. In...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s6209
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Decision analysis-a systematic approach to solving complex problems-offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/EHP483
更新日期:2017-06-13 00:00:00
abstract:BACKGROUND:Endocrine-disrupting chemicals have been shown to have broad effects on development, but their mutagenic actions that can lead to cancer have been less clearly demonstrated. Physiological levels of estrogen have been shown to stimulate DNA damage in breast epithelial cells through mechanisms mediated by estr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5221
更新日期:2020-01-01 00:00:00
abstract::Direct studies of the function of a given cell type often require that the cell type be obtained in pure culture. A number of different specific metabolic activities have been attributed to pulmonary endothelial cells, yet with few exceptions the conclusions were based on indirect evidence. Thus, to improve our abilit...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8035171
更新日期:1980-04-01 00:00:00