Neurogenic inflammation and sensitivity to environmental chemicals.


:Neurogenic inflammation as a pathway distinct from antigen-driven, immune-mediated inflammation may play a pivotal role in understanding a broad class of environmental health problems resulting from chemical exposures. Recent progress in understanding the mediators, triggers, and regulation of neurogenic inflammation is reviewed. Evidence for and speculations about a role for neurogenic inflammation in established disorders such as asthma, rhinitis, contact dermatitis, migraine headache, and rheumatoid arthritis are presented. The sick building syndrome and multiple chemical sensitivity syndrome have been defined as clinical entities in which exposure to chemical inhalants gives rise to disease. Current data on the existence of chemical irritant receptors in the airway and skin are discussed; neurogenic inflammation arising from stimulation of chemical irritant receptors is a possible model to explain many of the aspects of chemical sensitivities.


Meggs WJ




Has Abstract


1993-08-01 00:00:00












  • Environmental noise pollution in the United States: developing an effective public health response.

    abstract:BACKGROUND:Tens of millions of Americans suffer from a range of adverse health outcomes due to noise exposure, including heart disease and hearing loss. Reducing environmental noise pollution is achievable and consistent with national prevention goals, yet there is no national plan to reduce environmental noise polluti...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Hammer MS,Swinburn TK,Neitzel RL

    更新日期:2014-02-01 00:00:00

  • Dioxins and endometriosis: a plausible hypothesis.

    abstract::A potential connection exists between exposure to organochlorine chemicals and the increasing prevalence of endometriosis. Evidence shows that dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin) can increase the incidence and severity of the disease in monkeys and can promote the growth or survival of endometrial tissue impl...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Birnbaum LS,Cummings AM

    更新日期:2002-01-01 00:00:00

  • Blood pressure in relation to concentrations of PCB congeners and chlorinated pesticides.

    abstract:BACKGROUND:Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed. OBJECTIVES:The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Goncharov A,Pavuk M,Foushee HR,Carpenter DO,Anniston Environmental Health Reseach Consortium.

    更新日期:2011-03-01 00:00:00

  • Possibilities of detecting health effects by studies of populations exposed to chemicals from waste disposal sites.

    abstract::Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such epidemiologic studies will most likely be prompted either by a known release of chemicals into the environment around the site, or by an unusual disease cluster in a population...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Buffler PA,Crane M,Key MM

    更新日期:1985-10-01 00:00:00

  • Reduced cadmium levels in human kidney cortex in sweden.

    abstract::Environmental pollution with the nephrotoxic metal cadmium is considered a potential health risk for the general population. In 1976 it was reported that the cadmium concentration in human kidney cortex in Sweden had increased in parallel with increasing levels in soil and grain during the twentieth century. Since the...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Friis L,Petersson L,Edling C

    更新日期:1998-04-01 00:00:00

  • Examples of uses of databases for quantitative and qualitative correlation studies between genotoxicity and carcinogenicity.

    abstract::In this paper we give some examples of using databases of genotoxicity and carcinogenicity for quantitative and qualitative correlation studies between short-term tests and carcinogenicity. The quality of the databases is obviously important, but one of the major deficiencies of present databases is that they are too ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Parodi S,Malacarne D,Taningher M

    更新日期:1991-12-01 00:00:00

  • Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley.

    abstract:BACKGROUND:Ambient levels of pesticides ("pesticide drift") are detectable at residences near agricultural field sites. OBJECTIVE:Our goal was to evaluate the hypothesis that maternal residence near agricultural pesticide applications during key periods of gestation could be associated with the development of autism s...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Roberts EM,English PB,Grether JK,Windham GC,Somberg L,Wolff C

    更新日期:2007-10-01 00:00:00

  • Rat pleural mesothelial cells show damage after exposure to external but not internal cigarette smoke.

    abstract::The combination of cigarette smoke and high-level occupational asbestos exposure produces a synergistic increase in the incidence of lung cancer; however, smoking does not affect the incidence of mesothelioma. Here we present the results of tests of two theories that have been proposed to explain this phenomenon; name...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Sekhon HS,Keeling B,Churg A

    更新日期:1993-09-01 00:00:00

  • The risk of childhood cancer from intrauterine and preconceptional exposure to ionizing radiation.

    abstract::The findings of studies investigating whether exposures to ionizing radiation before birth, either pre- or post-conception, increase the risk of childhood cancer have provoked much scientific controversy. An epidemiological association between the abdominal exposure of pregnant women to diagnostic X-rays and childhood...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Wakeford R

    更新日期:1995-11-01 00:00:00

  • Environmental practices for biomedical research facilities.

    abstract::As a result of the Leadership Conference on Biomedical Research and the Environment, the Facilities Committee focused its work on the development of best environmental practices at biomedical research facilities at the university and independent research facility level as well as consideration of potential involvement...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Medlin EL,Grupenhoff JT

    更新日期:2000-12-01 00:00:00

  • Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh.

    abstract:BACKGROUND:There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh. OBJECTIVE:We evaluated the effectiveness of a multifaceted mitigation program to reduce As exposure among 11,746 individuals in a prospective cohort study initiated in 2000 in Ara...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Chen Y,van Geen A,Graziano JH,Pfaff A,Madajewicz M,Parvez F,Hussain AZ,Slavkovich V,Islam T,Ahsan H

    更新日期:2007-06-01 00:00:00

  • Mortality in the Medicare population and chronic exposure to fine particulate air pollution in urban centers (2000-2005).

    abstract:BACKGROUND:Prospective cohort studies constitute the major source of evidence about the mortality effects of chronic exposure to particulate air pollution. Additional studies are needed to provide evidence on the health effects of chronic exposure to particulate matter < or = 2.5 microm in aerodynamic diameter (PM(2.5)...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Zeger SL,Dominici F,McDermott A,Samet JM

    更新日期:2008-12-01 00:00:00

  • The effect of fine and coarse particulate air pollution on mortality: a national analysis.

    abstract:BACKGROUND:Although many studies have examined the effects of air pollution on mortality, data limitations have resulted in fewer studies of both particulate matter with an aerodynamic diameter of 2.5 and < 10 mi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Zanobetti A,Schwartz J

    更新日期:2009-06-01 00:00:00

  • Monitoring metal concentrations in tissues and single cells using ultramicrosensors.

    abstract::Intercellular and extracellular metal concentrations were measured using carbon fiber ultramicrosensors plated with mercury or with polymeric porphyrinic p-type semiconductors. Concentrations of unbound nickel and lead ions were studied within individual BC3H-1 myocytes, and H4-11-C3 rat hepatoma cells. Unbound ions a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Malinski T,Grunfeld S,Taha Z,Tomboulian P

    更新日期:1994-09-01 00:00:00

  • Plasma organochlorines and subsequent risk of prostate cancer in Japanese men: a nested case-control study.

    abstract:BACKGROUND:Although accumulating evidence suggests that exposure to organochlorine pesticides and polychlorinated biphenyls (PCBs) may contribute to the development of prostate cancer, few investigations have used biological samples to classify exposure to specific organochlorines. To our knowledge, this is the first p...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Sawada N,Iwasaki M,Inoue M,Itoh H,Sasazuki S,Yamaji T,Shimazu T,Tsugane S,Japan Public Health Center Based Prospective (JPHC) Study Group.

    更新日期:2010-05-01 00:00:00

  • Historical and modern epidemiological studies on populations exposed to N-substituted aryl compounds.

    abstract::The historical exposures to aromatic amines of various occupational groups are briefly reviewed. Modern studies indicate that other occupational groups might have risks worth investigating; these include machinists and workers in the chemical industry. Details of a recent investigation into the exposure of dye workers...

    journal_title:Environmental health perspectives

    pub_type: 历史文章,杂志文章


    authors: Cartwright RA

    更新日期:1983-03-01 00:00:00

  • Particulate matter oxidative potential from waste transfer station activity.

    abstract:BACKGROUND:Adverse cardiorespiratory health is associated with exposure to ambient particulate matter (PM). The highest PM concentrations in London occur in proximity to waste transfer stations (WTS), sites that experience high numbers of dust-laden, heavy-duty diesel vehicles transporting industrial and household wast...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Godri KJ,Duggan ST,Fuller GW,Baker T,Green D,Kelly FJ,Mudway IS

    更新日期:2010-04-01 00:00:00

  • Litigation-generated science: why should we care?

    abstract:BACKGROUND:In a 1994 Ninth Circuit decision on the remand of Daubert v. Merrell Dow Pharmaceuticals, Inc., Judge Alex Kosinski wrote that science done for the purpose of litigation should be subject to more stringent standards of admissibility than other science. OBJECTIVES:We analyze this proposition by considering l...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Boden LI,Ozonoff D

    更新日期:2008-01-01 00:00:00

  • Organic Food Consumption during Pregnancy and Hypospadias and Cryptorchidism at Birth: The Norwegian Mother and Child Cohort Study (MoBa).

    abstract:BACKGROUND:The etiologies of the male urogenital anomalies hypospadias and cryptorchidism remain unclear. It has been suggested that maternal diet and environmental contaminants may affect the risk of these anomalies via placental or hormonal disturbances. OBJECTIVES:We examined associations between organic food consu...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Brantsæter AL,Torjusen H,Meltzer HM,Papadopoulou E,Hoppin JA,Alexander J,Lieblein G,Roos G,Holten JM,Swartz J,Haugen M

    更新日期:2016-03-01 00:00:00

  • Sources of mercury exposure for U.S. seafood consumers: implications for policy.

    abstract:BACKGROUND:Recent policies attempting to reduce adverse effects of methylmercury exposure from fish consumption in the United States have targeted reductions in anthropogenic emissions from U.S. sources. OBJECTIVES:To analyze the prospects for future North American and international emissions controls, we assessed the...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Selin NE,Sunderland EM,Knightes CD,Mason RP

    更新日期:2010-01-01 00:00:00

  • The potential of exposure biomarkers in epidemiologic studies of reproductive health.

    abstract::To further the development and application of exposure markers in field investigations in reproductive epidemiology, we have synthesized recent examinations of the issues surrounding exposure measurements in reproductive epidemiology. The specific goals of this paper are to define exposure biomarkers and explore their...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审


    authors: Hogue CJ,Brewster MA

    更新日期:1991-01-01 00:00:00

  • Structural and functional changes in acute liver injury.

    abstract::Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At n...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Smuckler EA

    更新日期:1976-06-01 00:00:00

  • A statistical model for assessing genetic susceptibility as a risk factor in multifactorial diseases: lessons from occupational asthma.

    abstract:BACKGROUND:Incorporating the influence of genetic variation in the risk assessment process is often considered, but no generalized approach exists. Many common human diseases such as asthma, cancer, and cardiovascular disease are complex in nature, as they are influenced variably by environmental, physiologic, and gene...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Demchuk E,Yucesoy B,Johnson VJ,Andrew M,Weston A,Germolec DR,De Rosa CT,Luster MI

    更新日期:2007-02-01 00:00:00

  • Mechanism of the testicular toxicity of boric acid in rats: in vivo and in vitro studies.

    abstract::High-dose boric acid (BA) exposure produces testicular lesions in adult rats characterized by inhibited spermiation (IS) that may progress to atrophy. In vivo and in vitro studies addressed possible mechanisms. In vivo, boron tissue disposition was examined, since no detailed data existed, and relevant boron concentra...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Ku WW,Chapin RE

    更新日期:1994-11-01 00:00:00

  • World Trade Center fine particulate matter--chemistry and toxic respiratory effects: an overview.

    abstract::The 11 September 2001 terrorist attack on New York City's World Trade Center (WTC) caused an unprecedented environmental emergency. The collapse of the towers sent a tremendous cloud of crushed building materials and other pollutants into the air of lower Manhattan. In response to the calamity, federal, state, and cit...

    journal_title:Environmental health perspectives

    pub_type: 评论,杂志文章


    authors: Gavett SH

    更新日期:2003-06-01 00:00:00

  • Inhalation exposure of rats and mice to 1,3-butadiene induces N6-adenine adducts of epoxybutene detected by 32P-postlabeling and HPLC.

    abstract::In this paper we report DNA binding of butadiene monoepoxide, a first metabolite of 1,3-butadiene catalyzed by monooxygenases. We prepared alkylated purines as marker compounds for 32-P-postlabeling and electrochemical analysis and developed methods to measure the corresponding products. The traditional postlabeling a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Koivisto P,Adler ID,Sorsa M,Peltonen K

    更新日期:1996-05-01 00:00:00

  • The effects of particulate matter sources on daily mortality: a case-crossover study of Barcelona, Spain.

    abstract:BACKGROUND:Dozens of studies link acute exposure to particulate matter (PM) air pollution with premature mortality and morbidity, but questions remain about which species and sources in the vast PM mixture are responsible for the observed health effects. Although a few studies exist on the effects of species and source...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Ostro B,Tobias A,Querol X,Alastuey A,Amato F,Pey J,Pérez N,Sunyer J

    更新日期:2011-12-01 00:00:00

  • Respiratory symptoms and annoyance in the vicinity of coal-fired plants.

    abstract::This study constitutes one part of a program for assessing the impact of coal-fired power plants on the surrounding communities. A questionnaire was mailed to a total of 12,000 subjects living in six areas with coal-fired plants and in matched reference areas. The participation rate was 77.3%. In one coal-fired plant/...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Pershagen G,Hammar N,Vartiainen E

    更新日期:1986-12-01 00:00:00

  • Compensatory regeneration as a mechanism for renal tubule carcinogenesis of fumonisin B1 in the F344/N/Nctr BR rat.

    abstract::Fumonisin B1(FB1) is a fungal metabolite of Fusarium verticillioides (= F. moniliforme), a fungus that grows on many crops worldwide. Previous studies demonstrated that male BD IX rats consuming diets containing 50 ppm fumonisin B1 developed hepatocellular carcinomas. In our recent studies, diets containing FB1 at 50 ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Howard PC,Warbritton A,Voss KA,Lorentzen RJ,Thurman JD,Kovach RM,Bucci TJ

    更新日期:2001-05-01 00:00:00

  • Cardiovascular actions of palladium compounds in the unanesthetized rat.

    abstract::The natural occurrence of palladium (Pd) is rare. It is obtained as a by-product during the extraction of platinum and, until the present time, its uses were small in number--principally in the manufacture of jewelry, dental alloys, chemical catalysts, and electrical contacts. Interest in Pd toxicology has been limite...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章


    authors: Wiester MJ

    更新日期:1975-12-01 00:00:00