Using metal-ligand binding characteristics to predict metal toxicity: quantitative ion character-activity relationships (QICARs).

abstract：:The Sertoli cell is the primary target for FSH action in the mammalian testis. These cells contain the majority of testicular plasma membrane receptors for this hormone. Receptor occupancy is directly correlated with a stimulation of adenylyl cyclase and a decrease in the activity of a cytoplasmic Ca++-sensitive cAMP ...

journal_title：Environmental health perspectives

authors： Tindall DJ,Tash JS,Means AR

更新日期：1981-04-01 00:00:00

abstract：:Asbestos and silica are well-known fibrogenic dusts. However, there is no comprehensive understanding of the molecular and cellular events that lead to fibrosis as a consequence of asbestos or silica inhalation. Previous studies have shown that asbestos stimulates superoxide anion production in alveolar macrophages th...

journal_title：Environmental health perspectives

authors： Holian A,Kelley K,Hamilton RF Jr

更新日期：1994-12-01 00:00:00

abstract：:Cytotoxic chemicals have in common the ability to act specifically on cells in cycle. Bacteria are more sensitive in the exponential growth phase than when growing slowly in media. Similar observations have been made on a variety of systems ranging from bacteria, yeast, higher plants and invertebrates to vertebrates i...

journal_title：Environmental health perspectives

authors： Harbison RD

更新日期：1978-06-01 00:00:00

abstract：:The relationship between blood lead concentration and blood pressure is examined in a survey of 7371 men aged 40 to 59 from 24 British towns. After allowance for relevant confounding variables, including town of residence and alcohol consumption, there exists a very weak but statistically significant positive associat...

journal_title：Environmental health perspectives

authors： Pocock SJ,Shaper AG,Ashby D,Delves HT,Clayton BE

更新日期：1988-06-01 00:00:00

abstract：:A literature review of experimental and human exposure studies of skin permeation and cutaneous hypersensitivity reactions evoked by chromium was carried out to provide a basis for making a risk assessment of chromium as a soil contaminant. In vitro and in vivo studies demonstrated that 1 to 4% of the applied dose of ...

journal_title：Environmental health perspectives

authors： Bagdon RE,Hazen RE

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Preterm birth (PTB), a leading cause of infant mortality and morbidity, has a complex etiology with a multitude of interacting causes and risk factors. The role of environmental contaminants, particularly bisphenol A (BPA), is understudied with regard to PTB. OBJECTIVES:In the present study we examined the ...

journal_title：Environmental health perspectives

authors： Cantonwine DE,Ferguson KK,Mukherjee B,McElrath TF,Meeker JD

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Exposure to organophosphate (OP) pesticides is an occupational hazard for farmworkers and affects their children through the take-home pathway. OBJECTIVES:We examined the effectiveness of a randomized community intervention to reduce pesticide exposure among farmworkers and their children. METHODS:We condu...

journal_title：Environmental health perspectives

authors： Thompson B,Coronado GD,Vigoren EM,Griffith WC,Fenske RA,Kissel JC,Shirai JH,Faustman EM

更新日期：2008-05-01 00:00:00

abstract：:The importance of urban dust as a source of lead for young children is still disputed. Although blood-lead data from various population surveys usually show a peak concentration in early childhood, there is evidence that such a peak is small or absent altogether in children without much access to the general environme...

journal_title：Environmental health perspectives

authors： Duggan MJ

更新日期：1983-04-01 00:00:00

abstract：:The mutagenic activities of several phthalate esters have been evaluated in an 8-azaguanine resistance assay in Salmonella typhimurium. Three phthalate esters were found to be mutagenic: dimethyl phthalate, diethyl phthalate and di-n-butyl phthalate. A number of other phthalate esters were not found to be mutagenic, i...

journal_title：Environmental health perspectives

authors： Seed JL

更新日期：1982-11-01 00:00:00

abstract：:The problem of byssinosis has plagued cotton textile mills for hundreds of years, and it is still a problem today. With the regulations on airborne raw cotton dust set by OSHA and the ACGIH, research regarding the measurement of cotton dust in lint fiber is a necessity. A procedure known as the mass concentration part...

journal_title：Environmental health perspectives

authors： Parnell CB Jr,Niles GA,Rutherford RD

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Tremor is one of the most common neurological signs, yet its etiology is poorly understood. Case-control studies suggest an association between blood lead and essential tremor, and that this association is modified by polymorphisms in the δ-aminolevulinic acid dehydrogenase (ALAD) gene. OBJECTIVE:We aimed t...

journal_title：Environmental health perspectives

authors： Ji JS,Power MC,Sparrow D,Spiro A 3rd,Hu H,Louis ED,Weisskopf MG

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Because of complex interactions of climate variables at the levels of the pathogen, vector, and host, the potential influence of climate change on vector-borne and zoonotic diseases (VBZDs) is poorly understood and difficult to predict. Climate effects on the nonvector-borne zoonotic diseases are especially ...

journal_title：Environmental health perspectives

authors： Mills JN,Gage KL,Khan AS

更新日期：2010-11-01 00:00:00

abstract：:The industrial accident that occurred in the town of Seveso, Italy, in 1976 exposed a large population to substantial amounts of relatively pure 2,3,7,8-tetrachlorodibenzo-p-dioxin. Extensive monitoring of soil levels and measurements of a limited number of human blood samples allowed classification of the exposed pop...

journal_title：Environmental health perspectives

authors： Bertazzi PA,Bernucci I,Brambilla G,Consonni D,Pesatori AC

更新日期：1998-04-01 00:00:00

abstract：:We analyzed data from 798 lead workers to determine whether polymorphisms in the genes encoding delta-aminolevulinic acid dehydratase (ALAD), endothelial nitric oxide synthase (eNOS), and the vitamin D receptor (VDR) were associated with or modified relations of lead exposure and dose measures with renal outcomes. Lea...

journal_title：Environmental health perspectives

authors： Weaver VM,Schwartz BS,Ahn KD,Stewart WF,Kelsey KT,Todd AC,Wen J,Simon DJ,Lustberg ME,Parsons PJ,Silbergeld EK,Lee BK

更新日期：2003-10-01 00:00:00

abstract：:The integrated exposure uptake biokinetic model for lead in children was developed to provide plausible blood lead distributions corresponding to particular combinations of multimedia lead exposure. The model is based on a set of equations that convert lead exposure (expressed as micrograms per day) to blood lead conc...

journal_title：Environmental health perspectives

authors： White PD,Van Leeuwen P,Davis BD,Maddaloni M,Hogan KA,Marcus AH,Elias RW

更新日期：1998-12-01 00:00:00

abstract：:Adults eating a Western diet digest and absorb ingested food containing approximately 100 g fat, 350 g carbohydrate, and 75 g protein daily. Normal fat absorption requires adequate gastric, pancreatic, liver-biliary, mucosal, and lymphatic function. Carbohydrate and protein absorption is much less dependent on liver-b...

journal_title：Environmental health perspectives

authors： Heizer WD

更新日期：1979-12-01 00:00:00

abstract：:The lung epithelium resorbs alveolar fluid through combined action of sodium channels and the sodium pump, Na,K-ATPase. The lung often is exposed to hyperoxia in disease states and hyperoxia generates a mixture of reactive oxygen species. In vivo and in vitro exposure of rat lung and alveolar type II cells, respective...

journal_title：Environmental health perspectives

authors： Wendt CH,Sharma R,Bair R,Towle H,Ingbar DH

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. OBJECTIVE:Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age chil...

journal_title：Environmental health perspectives

authors： Rosado JL,Ronquillo D,Kordas K,Rojas O,Alatorre J,Lopez P,Garcia-Vargas G,Del Carmen Caamaño M,Cebrián ME,Stoltzfus RJ

更新日期：2007-09-01 00:00:00

abstract：:The neurochemical basis of memory has been approached experimentally in four different ways: the bioassay; the interventive approach; the interventive-correlative approach; and the correlative approach. These approaches are fundamentally similar to those used for the study of the chemistry of any behavior. Each of the...

journal_title：Environmental health perspectives

authors： Dunn AJ

更新日期：1978-10-01 00:00:00

abstract：:Children are uniquely vulnerable to toxic chemicals in the environment. Among the environmental toxicants to which children are at risk of exposure are endocrine disruptors (EDs)--chemicals that have the capacity to interfere with hormonal signaling systems. EDs may alter feedback loops in the brain, pituitary, gonads...

journal_title：Environmental health perspectives

authors： Landrigan P,Garg A,Droller DB

更新日期：2003-10-01 00:00:00

abstract：:Impairment of any of the major components of the immune system (T-cells, B-cells phagocytes, complement) may result in clinical immunodeficiency. Immune defects can arise from intrinsic or heritable defects of lymphoid elements, failure of normal cellular differentiation, viral infection or other acquired causes. Clin...

journal_title：Environmental health perspectives

authors： Heise ER

更新日期：1982-02-01 00:00:00

abstract：:Toxicologic diseases of man and animals, associated with molds growing on foods, have been recognized for centuries. Only in recent years, however, have these mycotoxicoses received the attention of many laboratories and skilled scientists around the world in a broad inter-disciplinary effort. This review covers the l...

journal_title：Environmental health perspectives

authors： Newberne PM

更新日期：1974-12-01 00:00:00

abstract：:Recent studies show that young children can be exposed to pesticides during normal oral exploration of their environment and their level of dermal contact with floors and other surfaces. Children living in agricultural areas may be exposed to higher pesticide levels than other children because of pesticides tracked in...

journal_title：Environmental health perspectives

authors： Eskenazi B,Bradman A,Castorina R

更新日期：1999-06-01 00:00:00

abstract：:The phenylphosphonothioate insecticides EPN and leptophos, and several analogs, were evaluated with respect to their delayed neurotoxic effects in hens and their environmental behavior in a terrestrial-aquatic model ecosystem. Acute toxicity to insects was highly correlated with sigma sigma of the substituted phenyl g...

journal_title：Environmental health perspectives

authors： Francis BM,Hansen LG,Fukuto TR,Lu PY,Metcalf RL

更新日期：1980-06-01 00:00:00

abstract：:For workers in the nuclear industry, the primary route for the entry of radioactive materials into the body is by inhalation, and the rate of clearance of particles from the pulmonary region of the lung is an important factor in determining radiation dose. It is the function of alveolar macrophages (AM) to maintain th...

journal_title：Environmental health perspectives

authors： Kellington JP,Gibson K,Buckle TM,Talbot RJ,Hornby SB

更新日期：1992-07-01 00:00:00

abstract：:The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as ...

journal_title：Environmental health perspectives

authors： Halden RU,Lindeman AE,Aiello AE,Andrews D,Arnold WA,Fair P,Fuoco RE,Geer LA,Johnson PI,Lohmann R,McNeill K,Sacks VP,Schettler T,Weber R,Zoeller RT,Blum A

更新日期：2017-06-20 00:00:00

abstract：:Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how...

journal_title：Environmental health perspectives

authors： Carpenter DO,Arcaro KF,Bush B,Niemi WD,Pang S,Vakharia DD

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:Adverse cardiorespiratory health is associated with exposure to ambient particulate matter (PM). The highest PM concentrations in London occur in proximity to waste transfer stations (WTS), sites that experience high numbers of dust-laden, heavy-duty diesel vehicles transporting industrial and household wast...

journal_title：Environmental health perspectives

authors： Godri KJ,Duggan ST,Fuller GW,Baker T,Green D,Kelly FJ,Mudway IS

更新日期：2010-04-01 00:00:00

abstract：:Acetylcholinesterase (AChE) is the enzyme that hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses and neuromuscular junctions. However, results from our laboratory and others indicate that AChE has an extrasynaptic, noncholinergic role during neural development. This article is a review of our findi...

journal_title：Environmental health perspectives

authors： Bigbee JW,Sharma KV,Gupta JJ,Dupree JL

更新日期：1999-02-01 00:00:00

abstract：:All cells contain elaborate systems for the spatial and temporal regulation of the calcium ion, [Ca2+]i, and diverse Ca2+ receptor and biochemical response systems that are regulated by these changes in [Ca2+]i. Toxicants that perturb the mobilization or homeostasis of [Ca2+]i will place the regulation of these proces...

journal_title：Environmental health perspectives

authors： Pounds JG

更新日期：1990-03-01 00:00:00