Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research.

abstract：:The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c ...

journal_title：Environmental health perspectives

authors： Dippold W,Steinborn A,Meyer zum Büschenfelde KH

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Few studies have examined the relationship between long-term exposure to ambient fine particulate matter (PM2.5) and nonaccidental mortality in rural populations. OBJECTIVE:We examined the relationship between PM2.5 and nonaccidental and cardiovascular mortality in the U.S. Agricultural Health Study cohort....

journal_title：Environmental health perspectives

authors： Weichenthal S,Villeneuve PJ,Burnett RT,van Donkelaar A,Martin RV,Jones RR,DellaValle CT,Sandler DP,Ward MH,Hoppin JA

更新日期：2014-06-01 00:00:00

abstract：:The genetic toxicology databases for chemicals that have been tested extensively are generally composed of inconsistent responses from a diverse set of assays. Consequently, difficulties arise when the data are evaluated for classifying the agent or for assessing the chemical's hazard potential. Several years ago, the...

journal_title：Environmental health perspectives

authors： Brusick D

更新日期：1991-12-01 00:00:00

abstract：:U.S. chemical plants currently have potentially catastrophic vulnerabilities as terrorist targets. The possible consequences of these vulnerabilities echo from the tragedies of the Bhopal incident in 1984 to the terrorist attacks on 11 September 2001 and, most recently, Hurricanes Katrina and Rita. Findings from a 200...

journal_title：Environmental health perspectives

authors： Lippin TM,McQuiston TH,Bradley-Bull K,Burns-Johnson T,Cook L,Gill ML,Howard D,Seymour TA,Stephens D,Williams BK

更新日期：2006-09-01 00:00:00

abstract：:The binary, ternary, quaternary, and quintary interactions of a five-component mixture of carcinogenic environmental polycyclic aromatic hydrocarbons (PAHs) using response surface analyses are described. Initially, lung tumor dose-response curves in strain A/J mice for each of the individual PAHs benzo[a]pyrene (B[a]P...

journal_title：Environmental health perspectives

authors： Nesnow S,Mass MJ,Ross JA,Galati AJ,Lambert GR,Gennings C,Carter WH Jr,Stoner GD

更新日期：1998-12-01 00:00:00

abstract：:A cohort of 12,110 male workers employed 1 or more years in eight styrene-butadiene polymer (SBR) manufacturing plants in the United States and Canada has been followed for mortality over a 40-year period, 1943 to 1982. The all-cause mortality of these workers was low [standardized mortality ratio (SMR) = 0.81] compar...

journal_title：Environmental health perspectives

authors： Matanoski GM,Santos-Burgoa C,Schwartz L

更新日期：1990-06-01 00:00:00

abstract：:We review pharmacokinetic and pharmacodynamic factors that should be considered in the design and interpretation of developmental neurotoxicity studies. Toxicologic effects on the developing nervous system depend on the delivered dose, exposure duration, and developmental stage at which exposure occurred. Several phar...

journal_title：Environmental health perspectives

authors： Dorman DC,Allen SL,Byczkowski JZ,Claudio L,Fisher JE Jr,Fisher JW,Harry GJ,Li AA,Makris SL,Padilla S,Sultatos LG,Mileson BE

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:The upward trend in industrial nations in the incidence of male genitourinary (GU) conditions may be attributed to increased exposure to endocrine disruptors. Polybrominated biphenyl (PBB), a brominated flame retardant, is one such suspected endocrine disruptor. OBJECTIVE:We investigated the relationship be...

journal_title：Environmental health perspectives

authors： Small CM,DeCaro JJ,Terrell ML,Dominguez C,Cameron LL,Wirth J,Marcus M

更新日期：2009-07-01 00:00:00

abstract：:Ambient monitoring of acid aerosols in four U.S. cities and in a rural region of southern Ontario clearly show distinct periods of strong acidity. Measurements made in Kingston, TN, and Steubenville, OH, resulted in 24-hr H+ ion concentrations exceeding 100 nmole/m3 more than 10 times during summer months. Periods of ...

journal_title：Environmental health perspectives

authors： Spengler JD,Keeler GJ,Koutrakis P,Ryan PB,Raizenne M,Franklin CA

更新日期：1989-02-01 00:00:00

abstract：:We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, life...

journal_title：Environmental health perspectives

authors： Cox-Ganser JM,White SK,Jones R,Hilsbos K,Storey E,Enright PL,Rao CY,Kreiss K

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Humans living near industrial point emissions can experience high levels of exposures to air pollutants. Map Ta Phut Industrial Estate in Thailand is the location of the largest steel, oil refinery, and petrochemical factory complexes in Southeast Asia. Air pollution is an important source of oxidative stres...

journal_title：Environmental health perspectives

authors： Peluso M,Srivatanakul P,Munnia A,Jedpiyawongse A,Ceppi M,Sangrajrang S,Piro S,Boffetta P

更新日期：2010-01-01 00:00:00

abstract：:This article briefly summarizes the epidemiology of the health effects of fine particulate air pollution, provides an early, somewhat speculative, discussion of the contribution of epidemiology to evaluating biologic mechanisms, and evaluates who's at risk or is susceptible to adverse health effects. Based on prelimin...

journal_title：Environmental health perspectives

authors： Pope CA 3rd

更新日期：2000-08-01 00:00:00

abstract：:Droplets of toluene and three chlorinated organics, ortho-dichlorobenzene, 1,2-dichloroethane, and trichloroethylene, were pyrolyzed in pure nitrogen. The composition and bacterial mutagenicity of the product tars were measured. The presence of organic chlorine was found to affect both pyrolysis product tar compositio...

journal_title：Environmental health perspectives

authors： Mulholland JA,Sarofim AF,Longwell JP,Lafleur AL,Thilly WG

更新日期：1994-01-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH-DNA adducts, or BaP-DNA adducts as their proxy, provide a measure of chemical-specific genetic dama...

journal_title：Environmental health perspectives

authors： Perera FP,Tang D,Rauh V,Lester K,Tsai WY,Tu YH,Weiss L,Hoepner L,King J,Del Priore G,Lederman SA

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Early-life exposure to lead is associated with deficits in neurodevelopment and with hematopoietic system toxicity. DNA methylation may be one of the underlying mechanisms for the adverse effects of prenatal lead on the offspring, but epigenome-wide methylation data for low levels of prenatal lead exposure a...

journal_title：Environmental health perspectives

authors： Wu S,Hivert MF,Cardenas A,Zhong J,Rifas-Shiman SL,Agha G,Colicino E,Just AC,Amarasiriwardena C,Lin X,Litonjua AA,DeMeo DL,Gillman MW,Wright RO,Oken E,Baccarelli AA

更新日期：2017-08-25 00:00:00

abstract：:Congress has demonstrated interest in toxic compensation legislation, but not enough agreement to make significant progress. Advocates of reform claim that the legal system is heavily weighed against victims who seek compensation through the courts. Proposed reforms include a compensation fund and a cause of action in...

journal_title：Environmental health perspectives

authors： Anderson RC

更新日期：1985-10-01 00:00:00

abstract：:Previous studies in our laboratory demonstrated that high-performance liquid chromatography (HPLC) analysis of ground corncob bedding extracts characterized two components (peak I and peak II) that disrupted endocrine function in male and female rats and stimulated breast and prostate cancer cell proliferation in vitr...

journal_title：Environmental health perspectives

authors： Markaverich BM,Crowley JR,Alejandro MA,Shoulars K,Casajuna N,Mani S,Reyna A,Sharp J

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:Nearly all China's rural residents and a shrinking fraction of urban residents use solid fuels (biomass and coal) for household cooking and/or heating. Consequently, global meta-analyses of epidemiologic studies indicate that indoor air pollution from solid fuel use in China is responsible for approximately 4...

journal_title：Environmental health perspectives

authors： Zhang JJ,Smith KR

更新日期：2007-06-01 00:00:00

abstract：:Pheromones are substances emitted by one individual of a species and eliciting a specific response in a second individual of the same species. In moths (Lepidoptera) generally females lure males for mating by emission of a sex attractant pheromone comprised of either one or more components. Since 1966 the identificati...

journal_title：Environmental health perspectives

authors： Cardé RT

更新日期：1976-04-01 00:00:00

abstract：:A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant articles were retrieved from preliminary computer database searches by using various key word descriptors and extensive cross-referencing. A priori evaluation criteria were established including...

journal_title：Environmental health perspectives

authors： Calabrese EJ,Baldwin LA

更新日期：1998-02-01 00:00:00

abstract：:Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing. The aim of the present study was to determine if biological samples from rats treated with various compounds can be classi...

journal_title：Environmental health perspectives

authors： Steiner G,Suter L,Boess F,Gasser R,de Vera MC,Albertini S,Ruepp S

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Ubiquitous polycyclic aromatic hydrocarbons (PAHs) have been shown to alter gene expression patterns and elevate micronuclei (MN) frequency, but the underlying mechanisms are largely unknown. MicroRNAs (miRNAs) are key gene regulators that may be influenced by PAH exposures and mediate their effects on MN fr...

journal_title：Environmental health perspectives

authors： Deng Q,Huang S,Zhang X,Zhang W,Feng J,Wang T,Hu D,Guan L,Li J,Dai X,Deng H,Zhang X,Wu T

更新日期：2014-07-01 00:00:00

abstract：:Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice were more sensitive to the carcinogenic effects of benzene than were F344 rats. A physiological model was developed to describe the uptake and metabolism of benzene in rats and mice. Our objective was to ...

journal_title：Environmental health perspectives

authors： Medinsky MA,Sabourin PJ,Henderson RF,Lucier G,Birnbaum LS

更新日期：1989-07-01 00:00:00

abstract：:In different weather conditions, constituents and concentrations of pollutants, personal exposure, and biologic responses to air pollution may vary. In this study we assessed the effects of four air pollutants on mortality in both cool and warm seasons in Hong Kong, a subtropical city. Daily counts of mortality, due t...

journal_title：Environmental health perspectives

authors： Wong CM,Ma S,Hedley AJ,Lam TH

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:The mechanisms governing the correlation between exposure to ultrafine particles and the increased incidence of cardiovascular disease remain unknown. Ultrafine particles appear to cross the pulmonary epithelial barrier into the bloodstream, raising the possibility of direct contact with the vascular endothe...

journal_title：Environmental health perspectives

authors： Gojova A,Guo B,Kota RS,Rutledge JC,Kennedy IM,Barakat AI

更新日期：2007-03-01 00:00:00

abstract：:The problems of quantitating chrysotile in water by fiber count techniques are reviewed briefly and the use of mass quantitation is suggested as a preferable measure. Chrysotile fiber has been found in almost every sample of natural water examined, but generally transmission electron miscroscopy (TEM) is required beca...

journal_title：Environmental health perspectives

authors： Speil S

更新日期：1974-12-01 00:00:00

abstract：:Epidemiologic studies of the link between particulate matter (PM) concentrations and mortality rates have yielded a range of estimates, leading to disagreement about the magnitude of the relationship and the strength of the causal connection. Previous meta-analyses of this literature have provided pooled effect estima...

journal_title：Environmental health perspectives

authors： Levy JI,Hammitt JK,Spengler JD

更新日期：2000-02-01 00:00:00

abstract：:Tobacco smoke contains a number of genotoxic compounds that are metabolized to their biologically active forms that subsequently react with cellular DNA to form covalently bound carcinogen-DNA adducts. Several analytical procedures have been developed to detect these adducts in human tissues. Using the nuclease P1-enh...

journal_title：Environmental health perspectives

authors： Hansen C,Asmussen I,Autrup H

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:In the 1990s, the mercury-based preservative thimerosal was used in most pediatric vaccines. Although there are currently only two thimerosal-containing vaccines (TCVs) recommended for pediatric use, parental perceptions that vaccines pose safety concerns are affecting vaccination rates, particularly in ligh...

journal_title：Environmental health perspectives

authors： Curtis B,Liberato N,Rulien M,Morrisroe K,Kenney C,Yutuc V,Ferrier C,Marti CN,Mandell D,Burbacher TM,Sackett GP,Hewitson L

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Chronic exposure to traffic-related air pollution (TRAP) may contribute to premature mortality, but few studies to date have addressed this topic. OBJECTIVES:In this study we assessed the association between TRAP and mortality in Toronto, Ontario, Canada. METHODS:We collected nitrogen dioxide samples over ...

journal_title：Environmental health perspectives

authors： Jerrett M,Finkelstein MM,Brook JR,Arain MA,Kanaroglou P,Stieb DM,Gilbert NL,Verma D,Finkelstein N,Chapman KR,Sears MR

更新日期：2009-05-01 00:00:00