A proposed method for assembly and interpretation of short-term test data.

abstract：BACKGROUND:Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density-lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein an...

journal_title：Environmental health perspectives

authors： Ayotte P,Carrier A,Ouellet N,Boiteau V,Abdous B,Sidi EA,Château-Degat ML,Dewailly É

更新日期：2011-08-01 00:00:00

abstract：:There is a significant public health concern about the potential effects of occupational exposure to toxic substances on reproductive outcomes. Several toxicants with reported reproductive and developmental effects are still in regular commercial or therapeutic use and thus present potential exposure to workers. Examp...

journal_title：Environmental health perspectives

authors： Lawson CC,Schnorr TM,Daston GP,Grajewski B,Marcus M,McDiarmid M,Murono E,Perreault SD,Schrader SM,Shelby M

更新日期：2003-04-01 00:00:00

abstract：:Studies of structure-activity relationships and molecular mechanisms of action are fundamental to our understanding of the harmful effects of chemicals on the environment and their more direct effects on human health. It is important to identify factors that determine toxicological effects of foreign chemicals in biol...

journal_title：Environmental health perspectives

authors： McKinney JD

更新日期：1985-09-01 00:00:00

abstract：:Attention has been focussed, both in man and experimental animals, on the effects of inhalation of the gas monomer, vinyl chloride. Recently, note is being taken of the possible effects of the inhalation of the polymer in man. The particles in question are those produced commercially as paste polymer or dispersion pol...

journal_title：Environmental health perspectives

authors： Wagner JC,Johnson NF

更新日期：1981-10-01 00:00:00

abstract：:A set of 53 individuals from a population highly exposed to airborne hexachlorobenzene (HCB) were selected to study the elimination kinetics of this chemical in humans. The volunteers provided blood, 24-hr urine, and feces samples for analysis of HCB and metabolites. The serum HCB concentrations ranged from 2.4 to 1,4...

journal_title：Environmental health perspectives

authors： To-Figueras J,Barrot C,Sala M,Otero R,Silva M,Ozalla MD,Herrero C,Corbella J,Grimalt J,Sunyer J

更新日期：2000-07-01 00:00:00

abstract：:Occupational cancer research methods was identified in 1996 as 1 of 21 priority research areas in the National Occupational Research Agenda (NORA). To implement NORA, teams of experts from various sectors were formed and given the charge to further define research needs and develop strategies to enhance or augment res...

journal_title：Environmental health perspectives

authors： Ward EM,Schulte PA,Bayard S,Blair A,Brandt-Rauf P,Butler MA,Dankovic D,Hubbs AF,Jones C,Karstadt M,Kedderis GL,Melnick R,Redlich CA,Rothman N,Savage RE,Sprinker M,Toraason M,Weston A,Olshan AF,Stewart P,Zahm SH,

更新日期：2003-01-01 00:00:00

abstract：:In previous attempts to model disposition of 1,3-butadiene in mice and rats, parameter values for 1,2-epoxybut-3-ene metabolism were optimized to reproduce elimination of this gas from closed chambers. However, each of these models predicted much higher concentrations of circulating epoxybutene than were subsequently ...

journal_title：Environmental health perspectives

authors： Kohn MC,Melnick RL

更新日期：2000-10-01 00:00:00

abstract：:Scaling of the quantified dispositional parameters of xenobiotics from animals to man is of interest from the standpoint of toxicology (e.g., poisoning and risk assessment). Scaling is also important from the standpoint of therapeutics because it represents a strategy for predicting first-use-in-human doses in clinica...

journal_title：Environmental health perspectives

authors： Bachmann K,Pardoe D,White D

更新日期：1996-04-01 00:00:00

abstract：:In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation. These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrin...

journal_title：Environmental health perspectives

authors： Mossman BT,Faux S,Janssen Y,Jimenez LA,Timblin C,Zanella C,Goldberg J,Walsh E,Barchowsky A,Driscoll K

更新日期：1997-09-01 00:00:00

abstract：:Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when ...

journal_title：Environmental health perspectives

authors： Bombi GG,Corain B,Favarato M,Giordano R,Nicolini M,Perazzolo M,Tapparo A,Zatta P

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Perfluoroalkyl acids are persistent compounds used in various industrial -applications. Of these compounds, perfluorooctanoate (PFOA) is currently detected in humans worldwide. A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in ...

journal_title：Environmental health perspectives

authors： Halldorsson TI,Rytter D,Haug LS,Bech BH,Danielsen I,Becher G,Henriksen TB,Olsen SF

更新日期：2012-05-01 00:00:00

abstract：:Studies have shown that female mosquitofish living downstream of a paper mill located on the Fenholloway River, Florida, have masculinized secondary sex characteristics, including altered anal fin development and reproductive behavior. Masculinization can be caused by exposure to androgens in the water or from an alte...

journal_title：Environmental health perspectives

authors： Orlando EF,Davis WP,Guillette LJ Jr

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Although 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been associated with alterations in ovarian function and hormones in animals, it has not been studied in humans. On 10 July 1976, an explosion exposed residents of Seveso, Italy, to the highest levels of TCDD in a population. Twenty years later, we init...

journal_title：Environmental health perspectives

authors： Warner M,Eskenazi B,Olive DL,Samuels S,Quick-Miles S,Vercellini P,Gerthoux PM,Needham L,Patterson DG,Mocarelli P

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is thought to be a major cause of morbidity and mortality in sub-Saharan Africa, but few controlled studies on the etiology of cirrhosis have been conducted in this region. OBJECTIVES:We aimed to elucidate the association between environmental and infectious exposures and cirrhosis in...

journal_title：Environmental health perspectives

authors： Kuniholm MH,Lesi OA,Mendy M,Akano AO,Sam O,Hall AJ,Whittle H,Bah E,Goedert JJ,Hainaut P,Kirk GD

更新日期：2008-11-01 00:00:00

abstract：:The articles in this monograph focus on the mechanisms whereby ambient particulate matter (PM) and co-pollutants deposited in the respiratory tract cause cardiovascular and systemic effects, especially in persons with preexisting conditions such as allergic hyperresponsiveness and pulmonary, cardiac, and vascular dise...

journal_title：Environmental health perspectives

authors： Yeates DB,Mauderly JL

更新日期：2001-08-01 00:00:00

abstract：:Children are uniquely vulnerable to toxic chemicals in the environment. Among the environmental toxicants to which children are at risk of exposure are endocrine disruptors (EDs)--chemicals that have the capacity to interfere with hormonal signaling systems. EDs may alter feedback loops in the brain, pituitary, gonads...

journal_title：Environmental health perspectives

authors： Landrigan P,Garg A,Droller DB

更新日期：2003-10-01 00:00:00

abstract：:Bisphenol A (BPA) is the monomer used to manufacture polycarbonate plastic, the resin lining of cans, and other products, with global capacity in excess of 6.4 billion lb/year. Because the ester bonds in these BPA-based polymers are subject to hydrolysis, leaching of BPA has led to widespread human exposure. A recent ...

journal_title：Environmental health perspectives

authors： vom Saal FS,Hughes C

更新日期：2005-08-01 00:00:00

abstract：:Over 250 adults and children were exposed to chlordane when the wooden building surfaces and soil around an apartment complex were sprayed in 1987. Two hundred-sixteen adults had neurobehavioral functions measured and completed questionnaires for symptom frequency, mood status, confounding factors, and medical, rheuma...

journal_title：Environmental health perspectives

authors： Kilburn KH,Thornton JC

更新日期：1995-07-01 00:00:00

abstract：:Pyrethroids are important insecticides used in agriculture, forestry, horticulture, and in the home. In humans, they are rapidly metabolized and renally eliminated. In numerous studies, pyrethroid metabolites have been detected in urine after occupational exposure to insecticides. In this study, we used a new, reliabl...

journal_title：Environmental health perspectives

authors： Heudorf U,Angerer J

更新日期：2001-03-01 00:00:00

abstract：:Epidemiologic studies have shown that airborne particulate matter (PM) with a mass median aerodynamic diameter < 10 microm (PM10) is associated with an increase in respiratory-related disease. However, there is a growing consensus that particles < 2.5 microm (PM2.5), including many in the ultrafine (< 0.1 microm) size...

journal_title：Environmental health perspectives

authors： Smith KR,Kim S,Recendez JJ,Teague SV,Ménache MG,Grubbs DE,Sioutas C,Pinkerton KE

更新日期：2003-06-01 00:00:00

abstract：:The available data on binary interactions are yet to be considered within the context of mixture risk assessment because of our inability to predict the effect of a third or a fourth chemical in the mixture on the interacting binary pairs. Physiologically based pharmacokinetic (PBPK) models represent a potentially use...

journal_title：Environmental health perspectives

authors： Krishnan K,Haddad S,Béliveau M,Tardif R

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Diethylstilbestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes. OBJECT...

journal_title：Environmental health perspectives

authors： Li Y,Hamilton KJ,Lai AY,Burns KA,Li L,Wade PA,Korach KS

更新日期：2014-03-01 00:00:00

abstract：:Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids and proteins, and the carcinogenicity of 10 of these HAs in rodents and of 1 in monkeys has been reported. Quantification of these carcinogenic HAs in various kinds of cooked foods indicated that the level of 2...

journal_title：Environmental health perspectives

authors： Wakabayashi K,Ushiyama H,Takahashi M,Nukaya H,Kim SB,Hirose M,Ochiai M,Sugimura T,Nagao M

更新日期：1993-03-01 00:00:00

abstract：:The subchronic inhalation toxicology of ethylene glycol monoethyl ether (EGEE) was evaluated in rats and rabbits using a 13-week exposure regimen. Groups of 20 rabbits (10 M, 10 F) and 30 rats (15 M, 15 F) were exposed to a vapor of 25 ppm, 100 ppm, or 400 ppm, 6 hr/day, 5 days/week. The control groups received air on...

journal_title：Environmental health perspectives

authors： Barbee SJ,Terrill JB,DeSousa DJ,Conaway CC

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:Eliminating silicosis is a priority of the International Labour Organization and the World Health Organization. Prevalence is particularly high in developing countries. OBJECTIVES:We describe trends in silicosis among South African gold miners who had had an autopsy between 1975 and 2007 and quantify the co...

journal_title：Environmental health perspectives

authors： Nelson G,Girdler-Brown B,Ndlovu N,Murray J

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Miners inhaling respirable coal dust (CD) frequently develop coal workers' pneumoconiosis, a dust-associated pneumoconiosis characterized by lung inflammation and variable fibrosis. Many coal miners are also exposed to polycyclic aromatic hydrocarbon (PAH) components of diesel engine exhaust and cigarette sm...

journal_title：Environmental health perspectives

authors： Ghanem MM,Battelli LA,Mercer RR,Scabilloni JF,Kashon ML,Ma JY,Nath J,Hubbs AF

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Controversy remains regarding the relationship between ambient ozone and mortality worldwide. In mainland China, the largest developing country, there has been no prior study investigating the acute effect of O3 on death risk. Given the changes in types of air pollution from conventional coal combustion to t...

journal_title：Environmental health perspectives

authors： Zhang Y,Huang W,London SJ,Song G,Chen G,Jiang L,Zhao N,Chen B,Kan H

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Chronic exposure to well water arsenic (As) remains a major rural health challenge in Bangladesh and some other developing countries. Many mitigation programs have been implemented to reduce As exposure, although evaluation studies for these efforts are rare in the literature. OBJECTIVES:In this study we es...

journal_title：Environmental health perspectives

authors： Khan K,Ahmed E,Factor-Litvak P,Liu X,Siddique AB,Wasserman GA,Slavkovich V,Levy D,Mey JL,van Geen A,Graziano JH

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Prenatal exposure to some pesticides can adversely affect male reproductive health in animals. We investigated a possible human association between maternal exposure to 27 organochlorine compounds used as pesticides and cryptorchidism among male children. DESIGN:Within a prospective birth cohort, we perfo...

journal_title：Environmental health perspectives

authors： Damgaard IN,Skakkebaek NE,Toppari J,Virtanen HE,Shen H,Schramm KW,Petersen JH,Jensen TK,Main KM,Nordic Cryptorchidism Study Group.

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVES:We evaluated the association between drinking-water disinfection by-products and preterm births using improved exposure assessment and more appropriate analysis methods than used in prior studies. METHODS:During 1999-2001, vital record data were obtained for a large, racially diverse population residing in ...

journal_title：Environmental health perspectives

authors： Lewis C,Suffet IH,Hoggatt K,Ritz B

更新日期：2007-02-01 00:00:00