Exposure to heterocyclic amines.

abstract：:Syrian hamster embryo cells were treated with galactose oxidase, followed by reduction with tritiated sodium borohydride at pH 7.4. The labeling patterns of galactosyl and N-acetyl galactosaminyl residues on the cell surface were altered in comparing scraped vs. unscraped and buffer vs. media-soaked cells treated with...

journal_title：Environmental health perspectives

authors： Newman HA,Saat YA,Hart RW

更新日期：1980-02-01 00:00:00

abstract：:Ingestion is an important exposure route for polycyclic aromatic hydrocarbons (PAHs) to enter the human body. Although the formation of hazardous PAH metabolites by human biotransformation enzymes is well documented, nothing is known about the PAH transformation potency of human intestinal microbiota. Using a gastroin...

journal_title：Environmental health perspectives

authors： Van de Wiele T,Vanhaecke L,Boeckaert C,Peru K,Headley J,Verstraete W,Siciliano S

更新日期：2005-01-01 00:00:00

abstract：:The last decade has marked a radical change in the business of sustainability, say environmental activists and industrialists alike. On the wane are "greenwashing" campaigns in which corporations promote dubious environmental accomplishments to draw attention away from environmentally damaging practices. On the rise a...

journal_title：Environmental health perspectives

authors： Fields S

更新日期：2002-03-01 00:00:00

abstract：:Consideration of needs for public health interventions and new research requires comparative assessments of the health benefits that are likely to result from alternative uses of limited regulatory and technical resources. This paper briefly examines regulatory and research priorities in the light of recent informatio...

journal_title：Environmental health perspectives

authors： Hattis D

更新日期：1981-10-01 00:00:00

abstract：:We conducted a 1-year epidemiologic study in Boston, Massachusetts, beginning May 1997, to examine the associations between environmental factors and office workers' health. We recruited 98 subjects (81 females and 17 males) in 21 offices in four office buildings. We conducted environmental sampling every 6 weeks and ...

journal_title：Environmental health perspectives

authors： Chao HJ,Schwartz J,Milton DK,Burge HA

更新日期：2003-07-01 00:00:00

abstract：:An important public health challenge has been the need to protect children's health. To accomplish this goal, the scientific community needs scientifically based child-specific risk assessment methods. Critical to their development is the need to understand mechanisms underlying children's sensitivity to environmental...

journal_title：Environmental health perspectives

authors： Faustman EM,Silbernagel SM,Fenske RA,Burbacher TM,Ponce RA

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Although patients with heart failure (HF) have been identified as particularly susceptible to the acute effects of air pollution, the effects of long-term exposure to air pollution on patients with this increasingly prevalent disease are largely unknown. OBJECTIVE:This study was designed to examine the mort...

journal_title：Environmental health perspectives

authors： Medina-Ramón M,Goldberg R,Melly S,Mittleman MA,Schwartz J

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Endocrine-disrupting chemicals (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects have been reported in animal studies and extrapolated to human studies. Unlike humans, rodents express a novel isoform of ERβ (mERβ2) with a modified...

journal_title：Environmental health perspectives

authors： Donoghue LJ,Neufeld TI,Li Y,Arao Y,Coons LA,Korach KS

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed. OBJECTIVES:The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB ...

journal_title：Environmental health perspectives

authors： Goncharov A,Pavuk M,Foushee HR,Carpenter DO,Anniston Environmental Health Reseach Consortium.

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs), commonly used in building materials, electronics, plastics, polyurethane foams, and textiles, are health hazards found in the environment. OBJECTIVE:In this study we investigated the effects of PBDE-209, a deca-PBDE, on the regulation of growth and apoptosis of breast...

journal_title：Environmental health perspectives

authors： Li ZH,Liu XY,Wang N,Chen JS,Chen YH,Huang JT,Su CH,Xie F,Yu B,Chen DJ

更新日期：2012-04-01 00:00:00

abstract：:The central feature of hemopoiesis is life-long, stable cell renewal. This process is supported by hemopoietic stem cells which, in the steady state, appear to be dormant in cell cycling. The entry into cell cycle of the dormant stem cells may be promoted by such factors as interleukin-1, interleukin-6 (IL-6), and gra...

journal_title：Environmental health perspectives

authors： Ogawa M

更新日期：1989-03-01 00:00:00

abstract：:Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1...

journal_title：Environmental health perspectives

authors： Fairchild WL,Swansburg EO,Arsenault JT,Brown SB

更新日期：1999-05-01 00:00:00

abstract：:Collaborative studies were performed to develop a functional assay for fish-killing activity produced by Pfiesteria piscicida. Eight cell lines were used to screen organic fractions and residual water fraction by using a 3-[4, 5-dimethylthiazol-(2-4)]-diphenyltetrazolium bromide cytotoxicity assay. Diethyl ether and a...

journal_title：Environmental health perspectives

authors： Fairey ER,Edmunds JS,Deamer-Melia NJ,Glasgow H Jr,Johnson FM,Moeller PR,Burkholder JM,Ramsdell JS

更新日期：1999-09-01 00:00:00

abstract：:The main source of cadmium in the diet is cereal or meat, especially in liver and kidney. Since the cadmium in both liver and kidney is bound to metallothionein, a heat-stable protein, the gastrointestinal absorption and metabolism of cadmium metallothionein (CdMt) was studied in detail. The selective renal cadmium de...

journal_title：Environmental health perspectives

authors： Cherian MG

更新日期：1979-02-01 00:00:00

abstract：:In this paper, we report results of the second phase of a larger study designed to evaluate the effects on the immune system of living near a Superfund site containing organochlorine pesticides, volatile organic compounds, and metals. Phase II was conducted to determine whether living near the site, consisting of six ...

journal_title：Environmental health perspectives

authors： Vine MF,Stein L,Weigle K,Schroeder J,Degnan D,Tse CK,Hanchette C,Backer L

更新日期：2000-12-01 00:00:00

abstract：:Exposure to ultrafine particles (UFPs) from vehicle exhaust has been related to risk of cardiovascular and pulmonary disease and cancer, even though exposure assessment is difficult. We studied personal exposure in terms of number concentrations of UFPs in the breathing zone, using portable instruments in six 18-hr pe...

journal_title：Environmental health perspectives

authors： Vinzents PS,Møller P,Sørensen M,Knudsen LE,Hertel O,Jensen FP,Schibye B,Loft S

更新日期：2005-11-01 00:00:00

abstract：:Reaction of chromium(VI) with one equivalent of ascorbate was studied by electron paramagnetic resonance spectroscopy in the presence of 0.10 M 5,5-dimethyl-1-pyrroline-1-oxide (DMPO) at room temperature in 0.10 M (N-[2-hydroxyethyl]piperazine-N'-[2-ethanesulfonic acid]) (HEPES) and 0.05 M tris(hydroxymethyl)aminometh...

journal_title：Environmental health perspectives

authors： Stearns DM,Courtney KD,Giangrande PH,Phieffer LS,Wetterhahn KE

更新日期：1994-09-01 00:00:00

abstract：:Multiple chemical sensitivity (MCS) is a condition in which persons experience negative health effects in multiple organ systems from exposure to low levels of common chemicals. Although symptoms experienced from particular chemicals vary across persons, they are generally stable within persons. The sensitivities ofte...

journal_title：Environmental health perspectives

authors： Gibson PR,Elms AN,Ruding LA

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants, known human lung carcinogens, and potent mammary carcinogens in laboratory animals. However, the association between PAHs and breast cancer in women is unclear. Vehicular traffic is a major ambient source of PAH exposure. OBJEC...

journal_title：Environmental health perspectives

authors： Mordukhovich I,Beyea J,Herring AH,Hatch M,Stellman SD,Teitelbaum SL,Richardson DB,Millikan RC,Engel LS,Shantakumar S,Steck SE,Neugut AI,Rossner P Jr,Santella RM,Gammon MD

更新日期：2016-01-01 00:00:00

abstract：:The effects of chrysotile on DNA synthesis in the gastrointestinal tract of the rat were studied by measuring the uptake of tritium-labeled thymidine; whole stomach, small intestine, colon liver were removed, cleaned, and homogenized and the DNA was isolated and assayed for tritium label.A dose-response study indicate...

journal_title：Environmental health perspectives

authors： Amacher DE,Alarif A,Epstein SS

更新日期：1974-12-01 00:00:00

abstract：:Impairment of any of the major components of the immune system (T-cells, B-cells phagocytes, complement) may result in clinical immunodeficiency. Immune defects can arise from intrinsic or heritable defects of lymphoid elements, failure of normal cellular differentiation, viral infection or other acquired causes. Clin...

journal_title：Environmental health perspectives

authors： Heise ER

更新日期：1982-02-01 00:00:00

abstract：:Spontaneous fetal death has been observed among various mammalian species after exposure to polychlorinated biphenyls (PCBs). Our exposure-based cohort study assessed the relationship between consumption of PCB-contaminated Lake Ontario sport fish and spontaneous fetal death using 1820 multigravid fertile women from t...

journal_title：Environmental health perspectives

authors： Mendola P,Buck GM,Vena JE,Zielezny M,Sever LE

更新日期：1995-05-01 00:00:00

abstract：:On 15-16 September 1997, the U.S. Environmental Protection Agency sponsored the Conference on Preventable Causes of Cancer in Children. The conference was convened to examine rising trends in reported incidence of childhood cancer and the association of these trends with environmental exposures. This paper summarizes ...

journal_title：Environmental health perspectives

authors： Carroquino MJ,Galson SK,Licht J,Amler RW,Perera FP,Claxton LD,Landrigan PJ

更新日期：1998-06-01 00:00:00

abstract：:Present available information regarding ovarian tumors in hens is incomplete in most aspects, and this lack of knowledge hampers use of hens as models for study of ovarian cancer. A study of 466 hens ranging from 2 to 7 years of age and covering a period of more than 3 years has provided much needed information relati...

journal_title：Environmental health perspectives

authors： Fredrickson TN

更新日期：1987-08-01 00:00:00

abstract：:Direct studies of the function of a given cell type often require that the cell type be obtained in pure culture. A number of different specific metabolic activities have been attributed to pulmonary endothelial cells, yet with few exceptions the conclusions were based on indirect evidence. Thus, to improve our abilit...

journal_title：Environmental health perspectives

authors： Ryan US,Ryan JW

更新日期：1980-04-01 00:00:00

abstract：:To further the development and application of exposure markers in field investigations in reproductive epidemiology, we have synthesized recent examinations of the issues surrounding exposure measurements in reproductive epidemiology. The specific goals of this paper are to define exposure biomarkers and explore their...

journal_title：Environmental health perspectives

authors： Hogue CJ,Brewster MA

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent. OBJECTIVES:We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general popula...

journal_title：Environmental health perspectives

authors： Lassen TH,Frederiksen H,Jensen TK,Petersen JH,Joensen UN,Main KM,Skakkebaek NE,Juul A,Jørgensen N,Andersson AM

更新日期：2014-05-01 00:00:00

abstract：:Chronic exposure of rodents to high dose levels of drugs, food additives and environmental chemicals frequently results in liver enlargement. Several of these compounds have been found to enhance the incidence of liver tumors in animals briefly exposed previously to hepatocarcinogens. Accordingly, it has been advanced...

journal_title：Environmental health perspectives

authors： Kunz HW,Tennekes HA,Port RE,Schwartz M,Lorke D,Schaude G

更新日期：1983-04-01 00:00:00

abstract：:We found an epidemic of juvenile hypothyroidism among a population of self-defined "downwinders" living near the Hanford nuclear facility located in southeast Washington State. The episode followed massive releases of 131I. Self-reported data on 60 cases of juvenile hypothyroidism (<20 years of age) among a group of 8...

journal_title：Environmental health perspectives

authors： Goldsmith JR,Grossman CM,Morton WE,Nussbaum RH,Kordysh EA,Quastel MR,Sobel RB,Nussbaum FD

更新日期：1999-04-01 00:00:00

abstract：:Individual variability in human arsenic metabolism has been reported frequently in the literature. This variability could be an underlying determinant of individual susceptibility to arsenic-induced disease in humans. Recent analysis revealing familial aggregation of arsenic metabolic profiles suggests that genetic fa...

journal_title：Environmental health perspectives

authors： Yu L,Kalla K,Guthrie E,Vidrine A,Klimecki WT

更新日期：2003-08-01 00:00:00