Ozone and daily mortality in Shanghai, China.

Abstract:

BACKGROUND:Controversy remains regarding the relationship between ambient ozone and mortality worldwide. In mainland China, the largest developing country, there has been no prior study investigating the acute effect of O3 on death risk. Given the changes in types of air pollution from conventional coal combustion to the mixed coal combustion/motor vehicle emissions in China's large cities, it is worthwhile to investigate the acute effect of O3 on mortality outcomes in the country. OBJECTIVES:We conducted a time-series study to investigate the relation between O3 and daily mortality in Shanghai using 4 years of daily data (2001-2004). METHODS:We used the generalized additive model with penalized splines to analyze mortality, O3 pollution, and covariate data in warm and cold seasons. We considered daily counts of all-cause mortality and several cause-specific subcategories (respiratory and cardiovascular). We also examined these associations among several subpopulations based on age and sex. RESULTS:O3 was significantly associated with total and cardiovascular mortality in the cold season but not in the warm season. In the whole-year analysis, an increase of 10 microg/m3 of 2-day average (lag01) O3 corresponds to 0.45% [95% confidence interval (CI) , 0.16-0.73%], 0.53% (95% CI, 0.10-0.96%), and 0.35% (95% CI, -0.40 to 1.09%) increase of total nonaccidental, cardiovascular, and respiratory mortality, respectively. In the cold season, the estimates increased to 1.38% (95% CI, 0.68-2.07%), 1.53% (95% CI, 0.54-2.52%), and 0.95% (95% CI, -0.71 to 2.60%), respectively. In the warm season, we did not observe significant associations for both total and cause-specific mortality. The results were generally insensitive to model specifications such as lag structure of O3 concentrations and degree of freedom for time trend. Multipollutant models indicate that the effect of O3 was not confounded by particulate matter

authors

Zhang Y,Huang W,London SJ,Song G,Chen G,Jiang L,Zhao N,Chen B,Kan H

doi

10.1289/ehp.9014

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

1227-32

issue

8

eissn

0091-6765

issn

1552-9924

journal_volume

114

pub_type

杂志文章
  • Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.

    abstract::Chemoprotective phytochemicals exhibit multiple activities and interact with several cellular receptors, including the aryl hydrocarbon (Ah) receptor (AhR). In this study we investigated the AhR agonist/antagonist activities of the following flavonoids: chrysin, phloretin, kaempferol, galangin, naringenin, genistein, ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6322

    authors: Zhang S,Qin C,Safe SH

    更新日期:2003-12-01 00:00:00

  • Human cell exposure assays of Bacillus thuringiensis commercial insecticides: production of Bacillus cereus-like cytolytic effects from outgrowth of spores.

    abstract::Most contemporary bioinsecticides are derived from scaled-up cultures of Bacillus thuringiensis subspecies israelensis (Bti) and kurstaki (Btk), whose particulate fractions contain mostly B. thuringiensis spores (> 10(12)/L) and proteinaceous aggregates, including crystal-like parasporal inclusion bodies (PIB). Based ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108919

    authors: Tayabali AF,Seligy VL

    更新日期:2000-10-01 00:00:00

  • Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents.

    abstract::Of 240 pesticides screened for carcinogenicity by the U.S. Environmental Protection Agency Office of Pesticide Programs, at least 24 (10%) produce thyroid follicular cell tumors in rodents. Thirteen of the thyroid carcinogens also induce liver tumors, mainly in mice, and 9 chemicals produce tumors at other sites. Some...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.98106437

    authors: Hurley PM

    更新日期:1998-08-01 00:00:00

  • Hearing loss in workers exposed to toluene and noise.

    abstract::In this study we investigated the risk of hearing loss among workers exposed to both toluene and noise. We recruited 58 workers at an adhesive materials manufacturing plant who were exposured to both toluene and noise [78.6-87.1 A-weighted decibels; dB(A)], 58 workers exposed to noise only [83.5-90.1 dB(A)], and 58 ad...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8959

    authors: Chang SJ,Chen CJ,Lien CH,Sung FC

    更新日期:2006-08-01 00:00:00

  • Blood Cadmium Levels and Incident Cardiovascular Events during Follow-up in a Population-Based Cohort of Swedish Adults: The Malmö Diet and Cancer Study.

    abstract:BACKGROUND:Cadmium exposure may increase the risk of cardiovascular disease. The only published longitudinal study on cadmium and incident cardiovascular disease was performed in American Indians with relatively high cadmium exposure. OBJECTIVES:Our aim was to examine the association between blood cadmium at baseline ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1509735

    authors: Barregard L,Sallsten G,Fagerberg B,Borné Y,Persson M,Hedblad B,Engström G

    更新日期:2016-05-01 00:00:00

  • Health effects of metals: a role for evolution?

    abstract::Metals have been mined and used since ancient times. The industrial era has seen a sharp increase in both the amounts and variety of metals that find applications in industry. The inadvertent release of metals, such as from fossil fuel consumption, also adds to the global burden. A number of catastrophic outbreaks hav...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s19

    authors: Clarkson T

    更新日期:1995-02-01 00:00:00

  • Identification of environmental chemicals with estrogenic activity using a combination of in vitro assays.

    abstract::Environmental chemicals that function as estrogens have been suggested to be associated with an increase in disease and dysfunctions in animals and humans. To characterize chemicals that may act as estrogens in humans, we have compared three in vitro assays which measure aspects of human estrogen receptor (hER)-mediat...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.961041084

    authors: Klotz DM,Beckman BS,Hill SM,McLachlan JA,Walters MR,Arnold SF

    更新日期:1996-10-01 00:00:00

  • Residential Road Traffic Noise and High Depressive Symptoms after Five Years of Follow-up: Results from the Heinz Nixdorf Recall Study.

    abstract:BACKGROUND:Traffic noise affects a large number of people, particularly in urbanized areas. Noise causes stress and annoyance, but less is known about the relationship between noise and depression. OBJECTIVE:We investigated the association of residential road traffic noise with depressive symptoms using 5-year follow-...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409400

    authors: Orban E,McDonald K,Sutcliffe R,Hoffmann B,Fuks KB,Dragano N,Viehmann A,Erbel R,Jöckel KH,Pundt N,Moebus S

    更新日期:2016-05-01 00:00:00

  • Plasma microRNA expression and micronuclei frequency in workers exposed to polycyclic aromatic hydrocarbons.

    abstract:BACKGROUND:Ubiquitous polycyclic aromatic hydrocarbons (PAHs) have been shown to alter gene expression patterns and elevate micronuclei (MN) frequency, but the underlying mechanisms are largely unknown. MicroRNAs (miRNAs) are key gene regulators that may be influenced by PAH exposures and mediate their effects on MN fr...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307080

    authors: Deng Q,Huang S,Zhang X,Zhang W,Feng J,Wang T,Hu D,Guan L,Li J,Dai X,Deng H,Zhang X,Wu T

    更新日期:2014-07-01 00:00:00

  • The role of the Thomsen-Friedenreich antigen as a tumor-associated molecule.

    abstract::The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9088255

    authors: Dippold W,Steinborn A,Meyer zum Büschenfelde KH

    更新日期:1990-08-01 00:00:00

  • CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity.

    abstract:BACKGROUND:Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The prospect of EDCs causing adverse health effects in humans and wildlife has led to the development of scientific and regulatory approaches for evaluat...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP5580

    authors: Mansouri K,Kleinstreuer N,Abdelaziz AM,Alberga D,Alves VM,Andersson PL,Andrade CH,Bai F,Balabin I,Ballabio D,Benfenati E,Bhhatarai B,Boyer S,Chen J,Consonni V,Farag S,Fourches D,García-Sosa AT,Gramatica P,Grisoni F

    更新日期:2020-02-01 00:00:00

  • Plasma Concentrations of Per- and Polyfluoroalkyl Substances at Baseline and Associations with Glycemic Indicators and Diabetes Incidence among High-Risk Adults in the Diabetes Prevention Program Trial.

    abstract:BACKGROUND:Several per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutants almost universally detected in humans. Experimental evidence indicates that PFAS alter glucose metabolism and insulin secretion. However, epidemiological studies have yielded inconsistent results. OBJECTIVE:We sought ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,随机对照试验

    doi:10.1289/EHP1612

    authors: Cardenas A,Gold DR,Hauser R,Kleinman KP,Hivert MF,Calafat AM,Ye X,Webster TF,Horton ES,Oken E

    更新日期:2017-10-02 00:00:00

  • Maternal fish consumption, hair mercury, and infant cognition in a U.S. Cohort.

    abstract::Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether maternal fish consumption during pregnancy harms or benefits fetal brain development. We examined associations of maternal fish intake during pregnancy and maternal h...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8041

    authors: Oken E,Wright RO,Kleinman KP,Bellinger D,Amarasiriwardena CJ,Hu H,Rich-Edwards JW,Gillman MW

    更新日期:2005-10-01 00:00:00

  • Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

    abstract::Flavone and isoflavone phytoestrogens are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate. Aromatase is the enzyme that converts androgen to estrogen; therefore, these plant chemicals are thought to be capable of modifying the estrogen leve...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9810685

    authors: Kao YC,Zhou C,Sherman M,Laughton CA,Chen S

    更新日期:1998-02-01 00:00:00

  • Chronic air pollution exposure during pregnancy and maternal and fetal C-reactive protein levels: the Generation R Study.

    abstract:BACKGROUND:Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. OBJECTIVES:We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1104345

    authors: van den Hooven EH,de Kluizenaar Y,Pierik FH,Hofman A,van Ratingen SW,Zandveld PY,Lindemans J,Russcher H,Steegers EA,Miedema HM,Jaddoe VW

    更新日期:2012-05-01 00:00:00

  • Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Research Trends and Scientific Gaps.

    abstract:BACKGROUND:Millions of individuals worldwide, particularly those living in rural and developing areas, are exposed to harmful levels of inorganic arsenic (iAs) in their drinking water. Inorganic As exposure during key developmental periods is associated with a variety of adverse health effects, including those that are...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409360

    authors: Bailey KA,Smith AH,Tokar EJ,Graziano JH,Kim KW,Navasumrit P,Ruchirawat M,Thiantanawat A,Suk WA,Fry RC

    更新日期:2016-02-01 00:00:00

  • Considerations in assigning dose based on uncertainties from in vivo counting.

    abstract::Lung counting is highly geometry dependent, especially at low photon energies. Monte Carlo simulations have been used to determine the magnitude of the errors obtained if it is assumed that the deposition is homogeneous, when in fact it is not. Simulation for a germanium lung counting system consisting of four, 70 mm ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.97105s61393

    authors: Kramer GH

    更新日期:1997-12-01 00:00:00

  • Chelation of cadmium.

    abstract::The toxicity of cadmium is determined by chelation reactions: in vivo, Cd2+ exists exclusively in coordination complexes with biological ligands, or with administered chelating agents. The Cd2+ ion has some soft character, but it is not a typical soft ion. It has a high degree of polarizability, and its complexes with...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8454249

    authors: Andersen O

    更新日期:1984-03-01 00:00:00

  • Unfair trade: e-waste in Africa.

    abstract::Africa is quickly becoming a destination for information technology in the form of tons of used computers, fax machines, cell phones, and other electronics. Although many of these machines can be repaired and resold, up to 75% of the electronics shipped to Africa is junk. This equipment, when dumped, may leach lead, m...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.114-a232

    authors: Schmidt CW

    更新日期:2006-04-01 00:00:00

  • Copper-metallothioneins in the American lobster, Homarus americanus: potential role as Cu(I) donors to apohemocyanin.

    abstract::The physiological function of copper(I)-metallothionein is not well understood. The respiratory function of hemocyanin, a copper(I)-containing respiratory protein found in the hemolymph of many invertebrates, has been known a long time. However, the mechanism by which Cu(I) is inserted into the oxygen-binding site of ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.866593

    authors: Brouwer M,Whaling P,Engel DW

    更新日期:1986-03-01 00:00:00

  • Developmental neurotoxicity of chlorpyrifos: what is the vulnerable period?

    abstract::Previously, we found that exposure of neonatal rats to chlorpyrifos (CPF) produced brain cell damage and loss, with resultant abnormalities of synaptic development. We used the same biomarkers to examine prenatal CPF treatment so as to define the critical period of vulnerability. One group of pregnant rats received CP...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.021101097

    authors: Qiao D,Seidler FJ,Padilla S,Slotkin TA

    更新日期:2002-11-01 00:00:00

  • Human consumption of methyleugenol and its elimination from serum.

    abstract::Under a mandate from the U.S. Congress, the National Toxicology Program (NTP) of the U.S. Department of Health and Human Services conducts animal bioassays for carcinogenicity of potentially toxic chemicals to which the U.S. population might be exposed. Methyleugenol, a natural as well as synthesized substance, was no...

    journal_title:Environmental health perspectives

    pub_type: 临床试验,杂志文章

    doi:10.1289/ehp.6766

    authors: Schecter A,Lucier GW,Cunningham ML,Abdo KM,Blumenthal G,Silver AG,Melnick R,Portier C,Barr DB,Barr JR,Stanfill SB,Patterson DG Jr,Needham LL,Stopford W,Masten S,Mignogna J,Tung KC

    更新日期:2004-05-01 00:00:00

  • Reaction products of aquatic humic substances with chlorine.

    abstract::A major concern of the chlorination of aquatic humic materials is the ubiquitous production of trihalomethanes. A large number of other chlorinated organic compounds, however, have been shown to be formed by chlorine's reaction with humic substances. In this study, humic material was concentrated from a coastal North ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.824663

    authors: Johnson JD,Christman RF,Norwood DL,Millington DS

    更新日期:1982-12-01 00:00:00

  • Implications of aquatic animal health for human health.

    abstract::Human health and aquatic animal health are organically related at three distinct interfaces. Aquatic animals serve as important contributors to the nutritional protein, lipid, and vitamin requirements of humans; as carriers and transmitters of many infectious and parasitic diseases to which humans are susceptible; and...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.9086245

    authors: Dawe CJ

    更新日期:1990-06-01 00:00:00

  • Protracted neurotoxicity from chlordane sprayed to kill termites.

    abstract::Over 250 adults and children were exposed to chlordane when the wooden building surfaces and soil around an apartment complex were sprayed in 1987. Two hundred-sixteen adults had neurobehavioral functions measured and completed questionnaires for symptom frequency, mood status, confounding factors, and medical, rheuma...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.95103690

    authors: Kilburn KH,Thornton JC

    更新日期:1995-07-01 00:00:00

  • Respiratory symptoms and annoyance in the vicinity of coal-fired plants.

    abstract::This study constitutes one part of a program for assessing the impact of coal-fired power plants on the surrounding communities. A questionnaire was mailed to a total of 12,000 subjects living in six areas with coal-fired plants and in matched reference areas. The participation rate was 77.3%. In one coal-fired plant/...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8670239

    authors: Pershagen G,Hammar N,Vartiainen E

    更新日期:1986-12-01 00:00:00

  • Developmental toxicity of ethylene glycol monopropyl ether acetate (EGPEA) in the rat.

    abstract::Pregnant rats were exposed by inhalation to vapor concentrations of 100, 200, 400 or 800 ppm of ethylene glycol monopropyl ether acetate on days 6 through 15 of gestation. Concentrations of 400 and 800 ppm reduced the feed intake, mean body weight and red blood cell counts. Mean corpuscular volume and mean corpuscular...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.845725

    authors: Krasavage WJ,Katz GV

    更新日期:1984-08-01 00:00:00

  • Tetrahydrofurandiol stimulation of phospholipase A2, lipoxygenase, and cyclooxygenase gene expression and MCF-7 human breast cancer cell proliferation.

    abstract:BACKGROUND:We characterized an endocrine disruptor from ground corncob bedding material that interferes with male and female sexual behavior and ovarian cyclicity in rats and stimulates estrogen receptor (ER)-positive and ER-negative breast cancer cell proliferation. The agents were identified as an isomeric mixture of...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.10659

    authors: Markaverich BM,Crowley J,Rodriquez M,Shoulars K,Thompson T

    更新日期:2007-12-01 00:00:00

  • Use of biomonitoring data to evaluate methyl eugenol exposure.

    abstract::Methyl eugenol is a naturally occurring material found in a variety of food sources, including spices, oils, and nutritionally important foods such as bananas and oranges. Given its natural occurrence, a broad cross-section of the population is likely exposed. The availability of biomonitoring and toxicology data offe...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.9057

    authors: Robison SH,Barr DB

    更新日期:2006-11-01 00:00:00

  • Exposure to Elemental Carbon, Organic Carbon, Nitrate, and Sulfate Fractions of Fine Particulate Matter and Risk of Preterm Birth in New Jersey, Ohio, and Pennsylvania (2000-2005).

    abstract:BACKGROUND:Particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) has been consistently associated with preterm birth (PTB) to varying degrees, but roles of PM2.5 species have been less studied. OBJECTIVE:We estimated risk differences (RD) of PTB (reported per 106 pregnancies) associated with change in ambient co...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1408953

    authors: Rappazzo KM,Daniels JL,Messer LC,Poole C,Lobdell DT

    更新日期:2015-10-01 00:00:00