Inhaled environmental/occupational irritants and allergens: mechanisms of cardiovascular and systemic responses. Introduction.

abstract：:The risk assessment process is described with a focus on the hazard identification and dose-response components. Many of the scientific questions and uncertainties associated with these components are discussed, and the role for biomarkers and specimen banking in supporting these activities are assessed. Under hazard ...

journal_title：Environmental health perspectives

authors： Zenick H,Griffith J

更新日期：1995-04-01 00:00:00

abstract：:The ability of questionnaires to predict children's exposure to pesticides was examined as part of the Minnesota Children's Pesticide Exposure Study (MNCPES). The MNCPES focused on a probability sample of 102 children between the ages of 3 and 13 years living in either urban (Minneapolis and St. Paul, MN) or nonurban ...

journal_title：Environmental health perspectives

authors： Sexton K,Adgate JL,Eberly LE,Clayton CA,Whitmore RW,Pellizzari ED,Lioy PJ,Quackenboss JJ

更新日期：2003-01-01 00:00:00

abstract：:There is growing public pressure to minimize the use of vertebrates in ecotoxicity testing; therefore, effective alternatives to toxicity tests causing suffering are being sought. This report discusses alternatives and differs in some respects from the reports of the other three groups because the primary concern is w...

journal_title：Environmental health perspectives

authors： Walker C,Kaiser K,Klein W,Lagadic L,Peakall D,Sheffield S,Soldan T,Yasuno M

更新日期：1998-04-01 00:00:00

abstract：:Worldwide climate change and loss of biodiversity are issues of global scope and importance that have recently become subjects of considerable public concern. Unlike classical public health issues and many environmental issues, their perceived threat lies in their potential to disrupt ecological functioning and stabil...

journal_title：Environmental health perspectives

authors： Jutro PR

更新日期：1991-12-01 00:00:00

abstract：:Lipocortins are structurally related, glucocorticoid-inducible proteins that inhibit phospholipase A2 (PLA2), thereby reducing the liberation of arachidonic acid from phospholipids and so limiting the synthesis of eicosanoid inflammatory mediators. This study is the first demonstration of one lipocortin, lipocortin 1 ...

journal_title：Environmental health perspectives

authors： Smith SF,Tetley TD,Guz A,Flower RJ

更新日期：1990-04-01 00:00:00

abstract：:Environmental chemicals that function as estrogens have been suggested to be associated with an increase in disease and dysfunctions in animals and humans. To characterize chemicals that may act as estrogens in humans, we have compared three in vitro assays which measure aspects of human estrogen receptor (hER)-mediat...

journal_title：Environmental health perspectives

authors： Klotz DM,Beckman BS,Hill SM,McLachlan JA,Walters MR,Arnold SF

更新日期：1996-10-01 00:00:00

abstract：:Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such epidemiologic studies will most likely be prompted either by a known release of chemicals into the environment around the site, or by an unusual disease cluster in a population...

journal_title：Environmental health perspectives

authors： Buffler PA,Crane M,Key MM

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (AR...

journal_title：Environmental health perspectives

authors： Zhao R,Hou Y,Xue P,Woods CG,Fu J,Feng B,Guan D,Sun G,Chan JY,Waalkes MP,Andersen ME,Pi J

更新日期：2011-01-01 00:00:00

abstract：:A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning. Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls. Lesions were characterized by the appearance of edema and epithelial...

journal_title：Environmental health perspectives

authors： Roncero V,Vincente JA,Redondo E,Gãzquez A,Duran E

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Widespread residential pesticide use throughout the United States has resulted in ubiquitous, low-level pesticide exposure. The mix of active pesticide ingredients is changing in response to 2000-2001 regulations restricting use of the organophosphorus insecticides chlorpyrifos and diazinon. OBJECTIVES:We a...

journal_title：Environmental health perspectives

authors： Williams MK,Rundle A,Holmes D,Reyes M,Hoepner LA,Barr DB,Camann DE,Perera FP,Whyatt RM

更新日期：2008-12-01 00:00:00

abstract：:Pyrethroids are important insecticides used in agriculture, forestry, horticulture, and in the home. In humans, they are rapidly metabolized and renally eliminated. In numerous studies, pyrethroid metabolites have been detected in urine after occupational exposure to insecticides. In this study, we used a new, reliabl...

journal_title：Environmental health perspectives

authors： Heudorf U,Angerer J

更新日期：2001-03-01 00:00:00

abstract：:Concern about apparent increases in the prevalence of hypospadias--a congenital male reproductive-tract abnormality--in the 1960s to 1980s and the possible connection to increasing exposures to endocrine-disrupting chemicals have underlined the importance of effective surveillance of hypospadias prevalence in the popu...

journal_title：Environmental health perspectives

authors： Dolk H,Vrijheid M,Scott JE,Addor MC,Botting B,de Vigan C,de Walle H,Garne E,Loane M,Pierini A,Garcia-Minaur S,Physick N,Tenconi R,Wiesel A,Calzolari E,Stone D

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Particulate matter (PM) air pollution has been associated with cardiovascular morbidity and mortality, and elevated blood pressure (BP) is a known risk factor for cardiovascular disease. A small number of studies have investigated the relationship between PM and BP and found mixed results. Evidence suggests ...

journal_title：Environmental health perspectives

authors： Mordukhovich I,Wilker E,Suh H,Wright R,Sparrow D,Vokonas PS,Schwartz J

更新日期：2009-11-01 00:00:00

abstract：:Acute exposures to isobutane, propane, F-12, and F-11 in concentrations of 250, 500, or 1000 ppm for periods of 1 min to 8 hr did not produce any untoward physiological effects as determined by the methods employed which included serial EKG's and continuous monitoring of modified V5 by telemetry during exposure. Repet...

journal_title：Environmental health perspectives

authors： Stewart RD,Newton PE,Baretta ED,Herrmann AA,Forster HV,Soto RJ

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Although numerous epidemiologic studies now use models of intraurban exposure, there has been little systematic evaluation of the performance of different models. OBJECTIVES:In this present article we proposed a modeling framework for assessing exposure model performance and the role of spatial autocorrelat...

journal_title：Environmental health perspectives

authors： Molitor J,Jerrett M,Chang CC,Molitor NT,Gauderman J,Berhane K,McConnell R,Lurmann F,Wu J,Winer A,Thomas D

更新日期：2007-08-01 00:00:00

abstract：:This paper summarizes two roundtable discussions held at the conclusion of the International Conference on Biopersistence of Respirable Synthetic Fibres and Minerals. The first round table addressed the role of biopersistence in the pathogenicity of fiber-induced disease. The panel included T. W. Hesterberg (Chairman)...

journal_title：Environmental health perspectives

authors： McClellan RO,Hesterberg TW

更新日期：1994-10-01 00:00:00

abstract：:The hexavalent oxidation state of chromium [Cr(VI)] is a well-established human carcinogen, although the mechanism of cancer induction is currently unknown. Intracellular reduction of Cr(VI) forms Cr(V), which is thought to play a fundamental role in the mechanism of DNA damage by this carcinogen. Two separate pathway...

journal_title：Environmental health perspectives

authors： Sugden KD,Martin BD

更新日期：2002-10-01 00:00:00

abstract：:Whole blood oxygen equilibrium curves (O2 ECs), blood buffer lines, and several hematologic properties were determined for adult guinea pigs exposed to 700 ppm methyl isocyanate (MIC) for 15 min. MIC inhalation effected a significant reduction of blood O2 affinity; the half-saturation pressure (P50) at 38 degrees C in...

journal_title：Environmental health perspectives

authors： Maginniss LA,Szewczak JM,Troup CM

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:The 1974 Safe Drinking Water Act (SDWA) regulates >170,000 public water systems to protect health, but not >13 million private wells. State and local government requirements for private well water testing are rare and inconsistent; the responsibility to ensure water safety remains with individual households....

journal_title：Environmental health perspectives

authors： Zheng Y,Flanagan SV

更新日期：2017-08-03 00:00:00

abstract：:Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1...

journal_title：Environmental health perspectives

authors： Meeker JD,Ryan L,Barr DB,Herrick RF,Bennett DH,Bravo R,Hauser R

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:In the United States, most of the treated sewage sludge (biosolids) is applied to farmland as a soil amendment. Critics suggest that rules regulating sewage sludge treatment and land application may be insufficient to protect public health and the environment. Neighbors of land application sites report illne...

journal_title：Environmental health perspectives

authors： Lowman A,McDonald MA,Wing S,Muhammad N

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is thought to be a major cause of morbidity and mortality in sub-Saharan Africa, but few controlled studies on the etiology of cirrhosis have been conducted in this region. OBJECTIVES:We aimed to elucidate the association between environmental and infectious exposures and cirrhosis in...

journal_title：Environmental health perspectives

authors： Kuniholm MH,Lesi OA,Mendy M,Akano AO,Sam O,Hall AJ,Whittle H,Bah E,Goedert JJ,Hainaut P,Kirk GD

更新日期：2008-11-01 00:00:00

abstract：:Calcium has been implicated as a regulatory factor in many physiological and pathophysiological processes in the renal cell. Under physiological conditions, the cytosolic free calcium concentration is maintained at approximately 100 nM. Most of the releasable cell Ca2+ resides in the nonmitochondrial compartments. In ...

journal_title：Environmental health perspectives

authors： Bonventre JV

更新日期：1990-03-01 00:00:00

abstract：:Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...

journal_title：Environmental health perspectives

authors： Maier A,Micka J,Miller K,Denko T,Chang CY,Nebert DW,Alvaro Puga

更新日期：1998-07-01 00:00:00

abstract：:The timing of some key embryological events is given for man, rat, chick, and certain other animals. Such times, however, are approximations, and variations occur among members of the same strain and even among members of the same litter. Some differences in developmental patterns are indicated. ...

journal_title：Environmental health perspectives

authors： Monie IW

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:Psychological sequelae are among the most pronounced effects in populations following exposure to oil spills. Women in particular represent a vulnerable yet influential population but have remained relatively understudied with respect to the Deepwater Horizon oil spill (DHOS). OBJECTIVE:To describe the rela...

journal_title：Environmental health perspectives

authors： Rung AL,Gaston S,Oral E,Robinson WT,Fontham E,Harrington DJ,Trapido E,Peters ES

更新日期：2016-09-01 00:00:00

abstract：:Effects of respirable aerosols of sulfuric acid, ammonium sulfate, sodium sulfite, and ammonium persulfate on lungs of rats are reviewed. The literature regarding interactions between ozone or nitrogen dioxide and acidic aerosols (ammonium sulfate, sulfuric acid) is discussed. An unexpected interaction between nitroge...

journal_title：Environmental health perspectives

authors： Last JA

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Cadmium is a commonly occurring toxic food contaminant, but health consequences of early-life exposure are poorly understood. OBJECTIVES:We evaluated the associations between cadmium exposure and neurobehavioral development in preschool children. METHODS:In our population-based mother-child cohort study in...

journal_title：Environmental health perspectives

authors： Kippler M,Tofail F,Hamadani JD,Gardner RM,Grantham-McGregor SM,Bottai M,Vahter M

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Microcystin-LR, a cyclic heptapeptide, possesses the ability to inhibit the serine/threonine protein phosphatases PP1 and PP2A and, consequently, exhibits acute hepatocytotoxicity. Moreover, microcystin-LR induces cellular proliferation, resulting in tumor-promoting activity in hepatocytes. However, mechanis...

journal_title：Environmental health perspectives

authors： Takumi S,Komatsu M,Furukawa T,Ikeda R,Sumizawa T,Akenaga H,Maeda Y,Aoyama K,Arizono K,Ando S,Takeuchi T

更新日期：2010-09-01 00:00:00

abstract：:The significance of the environment for health is increasingly being recognized. There is a need for systematic approaches to assessment of environmental factors most relevant to health, health outcomes most influenced by the environment, and the relationships between them, as well as for approaches to representing th...

journal_title：Environmental health perspectives

authors： Kyle AD,Woodruff TJ,Axelrad DA

更新日期：2006-03-01 00:00:00