Abstract：
:The significance of the environment for health is increasingly being recognized. There is a need for systematic approaches to assessment of environmental factors most relevant to health, health outcomes most influenced by the environment, and the relationships between them, as well as for approaches to representing the results of such assessments in policy deliberations. As a step in the development of such methods, we used findings and data from the environmental protection and public health sectors to develop a set of measures representing topics relevant to children's environmental health. We used a definition of the environment that emphasized contaminants and a process that involved both analytic and deliberative elements. The steps in this process were to a) develop a conceptual framework to depict relationships between environment and health with relevant types of data and information, b) select topic areas of significance for children, c) identify best available data sources and devise measures, d) assess possible surrogate data sources and measures when needed, e) design and implement metrics for computation of measures using specified data elements, f) select graphical representations of measures, g) identify related measures, and h) identify data gaps. Representatives of policy and stakeholder audiences participated in this process. The measures are presented in three groups that reflect contaminants in the environment, contaminants in human tissues, and diseases and disorders. The measures present scientifically based representations of data understandable to stakeholders and policy makers that integrate key information from the health and environment sectors in a consistent format.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Kyle AD,Woodruff TJ,Axelrad DAdoi
10.1289/ehp.8321subject
Has Abstractpub_date
2006-03-01 00:00:00pages
447-52issue
3eissn
0091-6765issn
1552-9924journal_volume
114pub_type
杂志文章abstract：BACKGROUND:Trying to publish a paper in a top-rated peer-reviewed journal can be a difficult and frustrating experience for authors. It is important that authors understand the general review process before submitting manuscripts for publication. OBJECTIVES:Editors-in-chief and associate editors from top-tier journals...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1003280
更新日期：2011-07-01 00:00:00
abstract：:Fluorescence in situ hybridization with chromosome-specific composite DNA probes (chromosome painting) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed peop...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.96104s3489
更新日期：1996-05-01 00:00:00
abstract：:Epidemiological studies report a small but positive association between short-term increases in airborne particulate matter and small increases in morbidity and mortality from respiratory and cardiovascular disease in urban areas. However, the lack of a mechanistic explanation to link particle exposure and human healt...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.98106127
更新日期：1998-03-01 00:00:00
abstract：:The Centers for Disease Control and Prevention recommend that local public health agencies use local data to identify children at risk for lead exposure to ensure that they receive preventive services. The objective of this study was to demonstrate the usefulness of a geographic information system (GIS) in identifying...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.0110989
更新日期：2001-01-01 00:00:00
abstract：:We evaluated the effect of chronic exposure to dioxin and dioxin-like compounds on the pancreas in female Harlan Sprague-Dawley rats. This investigation represents part of an ongoing National Toxicology Program initiative to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated diox...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.6869
更新日期：2004-06-01 00:00:00
abstract：:The timing of some key embryological events is given for man, rat, chick, and certain other animals. Such times, however, are approximations, and variations occur among members of the same strain and even among members of the same litter. Some differences in developmental patterns are indicated. ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.761855
更新日期：1976-12-01 00:00:00
abstract：:This paper will briefly outline those elements which must be considered in assessing the effects of any given compound which might impinge on the actions of adrenocortical steroids. Considerations that ought to be taken into account include the following: the delivery to the affected cells of corticosteroids, the upta...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.813899
更新日期：1981-04-01 00:00:00
abstract：:We developed a sensitive and accurate analytical method for quantifying methyleugenol (ME) in human serum. Our method uses a simple solid-phase extraction followed by a highly specific analysis using isotope dilution gas chromatography-high resolution mass spectrometry. Our method is very accurate; its limit of detect...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.00108323
更新日期：2000-04-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8809
更新日期：2006-05-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.7720253
更新日期：1977-10-01 00:00:00
abstract：:The ability of a series of haloalkanes, haloethanols and haloacetaldehydes to induce mutations in Salmonella typhrimurium and preferentially to inhibit the growth of DNA polymerase-deficient E. coli (pol A(+)/pol A(-)) was investigated. For the haloalkanes investigated, the order of reactivities towards the E. coli po...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.772179
更新日期：1977-12-01 00:00:00
abstract：BACKGROUND:Widespread residential pesticide use throughout the United States has resulted in ubiquitous, low-level pesticide exposure. The mix of active pesticide ingredients is changing in response to 2000-2001 regulations restricting use of the organophosphorus insecticides chlorpyrifos and diazinon. OBJECTIVES:We a...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.11367
更新日期：2008-12-01 00:00:00
abstract：:In recent years, exposure of man to increasing amounts of metals has occurred rather generally from industrial contamination and variably from intake of dietary mineral supplements. Adverse effects of individual metals can be markedly altered by dietary levels of other essential and nonessential inorganic elements, es...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.7825137
更新日期：1978-08-01 00:00:00
abstract：:The role of lime in the formation of reactive oxygen species (ROS), i.e., O2-., H2O2, and OH., from betel-quid components (extracts of areca nut and catechu) was investigated in vitro using a chemiluminescence technique and an assay for oxidative DNA damage involving analysis of 8-hydroxy-2'-deoxyguanosine. Of the var...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.9298203
更新日期：1992-11-01 00:00:00
abstract：:Biological monitoring of exposure to chemicals in the workplace is an important component of exposure assessment and prevention of adverse health effects. It should be employed in conjunction with ambient air monitoring to provide information on the absorbed dose of a chemical agent and the effect of all routes of exp...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.97105s1105
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight. OBJECTIVES:We aimed to investigate the relationship between residential traffic and railway noise and a...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1409052
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVE:The World Health Organization is the agency responsible for reporting the Millennium Development Goal (MDG) indicator "percentage of population using solid fuels." In this article, we present the results of a comprehensive assessment of solid fuel use, conducted in 2005, and discuss the implications of our fi...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8603
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer is controversial, but animal studies directly linking DDT to risk are lacking. Concerns with DDT reside in its environmental persistence, bioaccumulation in breast adipose tissue, and endocrine-disrupting actions. Whereas most attent...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1104327
更新日期：2012-08-01 00:00:00
abstract：:We have previously reported that rats are resilient to the hepatotoxic and lethal combination of chlordecone (CD) and carbon tetrachloride (CCl4) during early postnatal development. The overall findings pointed to stimulated cell division and tissue repair mechanisms as the underlying cause of resistance. The objectiv...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.98106597
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND:Although public concern has focused on the environmental impact of the Deepwater Horizon oil spill, the public health impact on a broad range of coastal communities is minimally known. OBJECTIVE:We sought to determine the acute level of distress (depression, anxiety), mechanisms of adjustment (coping, resil...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1002915
更新日期：2011-06-01 00:00:00
abstract：:Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.106-1533118
更新日期：1998-07-01 00:00:00
abstract：:The 11 September 2001 terrorist attack on New York City's World Trade Center (WTC) caused an unprecedented environmental emergency. The collapse of the towers sent a tremendous cloud of crushed building materials and other pollutants into the air of lower Manhattan. In response to the calamity, federal, state, and cit...
journal_title：Environmental health perspectives
pub_type： 评论,杂志文章
doi：10.1289/ehp.111-1241533
更新日期：2003-06-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP2663
更新日期：2018-06-27 00:00:00
abstract：:Human milk is a repository for certain classes of long-lived, fat-soluble environmental contaminant chemicals. Some members of this class, such as the chlorinated pesticides and the chlorinated biphenyls, can be expected to be present at chemical waste disposal sites. Analysis of samples of breast milk obtained from w...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.834887
更新日期：1983-02-01 00:00:00
abstract：:The main source of cadmium in the diet is cereal or meat, especially in liver and kidney. Since the cadmium in both liver and kidney is bound to metallothionein, a heat-stable protein, the gastrointestinal absorption and metabolism of cadmium metallothionein (CdMt) was studied in detail. The selective renal cadmium de...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.7928127
更新日期：1979-02-01 00:00:00
abstract：:Epidemiologic studies demonstrate that infection, specifically pneumonia, contributes substantially to the increased morbidity and mortality among elderly individuals following exposure to ambient particulate matter (PM). This laboratory has previously demonstrated that a single inhalation exposure of Streptococcus pn...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.02110s5871
更新日期：2002-10-01 00:00:00
abstract：:mental retardation: timing and thresholds; (italic)b(/italic)) endocrine dysfunction and developmental disabilities: dose and target implications; (italic)c(/italic)) attention-deficit disorder-ADHD and learning disabilities; and (italic)d(/italic)) new horizons: extending the boundaries. Support for the Rochester con...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.00108s3373
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:Perchlorate, thiocyanate, and nitrate are sodium/iodide symporter (NIS) inhibitors that block iodide uptake into the thyroid, thus affecting thyroid function. Thyroid dysfunction can adversely affect somatic growth and development in children. To our knowledge, no studies have examined effects of NIS inhibit...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1409309
更新日期：2016-04-01 00:00:00
abstract：:Whole blood oxygen equilibrium curves (O2 ECs), blood buffer lines, and several hematologic properties were determined for adult guinea pigs exposed to 700 ppm methyl isocyanate (MIC) for 15 min. MIC inhalation effected a significant reduction of blood O2 affinity; the half-saturation pressure (P50) at 38 degrees C in...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.877235
更新日期：1987-06-01 00:00:00
abstract：:Children and their parents in residences are often protected by insecticides from nuisance and disease-bearing mosquitoes. The annual worldwide consumption of the four major types of residential insecticide products--aerosols, mosquito coils, liquid vaporizers, and vaporizing mats--is in the billions of units. Mosquit...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.6177
更新日期：2003-09-01 00:00:00
