The developing brain and the environment: an introduction.

Abstract:

:mental retardation: timing and thresholds; (italic)b(/italic)) endocrine dysfunction and developmental disabilities: dose and target implications; (italic)c(/italic)) attention-deficit disorder-ADHD and learning disabilities; and (italic)d(/italic)) new horizons: extending the boundaries. Support for the Rochester conference came from both public and private sources. The National Institute of Environmental Health Sciences (NIEHS), the National Institute of Child Health and Human Development, and the EPA represented the federal government. The conference also received grants from several foundations: the Jennifer Altman Foundation, the Heinz Family Foundation, the National Alliance for Autism Research, the Violence Research Foundation, the Wacker Foundation, and the Winslow Foundation. The second of these conferences helped launch a new Center for Children's Health and the Environment at the Mount Sinai School of Medicine. It was held in New York City on 24-25 May 1999, and was convened specifically to consider the intersection between neurodevelopmental impairment, environmental chemicals, and prevention. Over 300 health scientists, pediatricians, and public health professionals examined the growing body of evidence linking environmental toxins to neurobehavioral disorders. The conference title was Environmental Influences on Children: Brain, Development, and Behavior. The conference began by reviewing well-known examples of deleterious effects of environmental chemicals, including lead and PCBs, on children's brains. The conferees then considered the potential impact of environmental chemicals on neurological disorders with particular focus on ADHD, autism, and Parkinson's disease. The inclusion of Parkinson's disease was intended to signal the notion that exposures in early life may have an influence on the evolution of neurological disease in later life. Support for the Mount Sinai conference came from the Superfund Basic Research Program (NIEHS); The Pew Charitable Trusts; the Institute for Health and the Environment at the University of Albany School of Public Health; the Agency for Toxic Substances and Disease Research (ATSDR); the Ambulatory Pediatric Association; Myron A. Mehlman, PhD; the National Center for Environmental Assessment (EPA); the National Center for Environmental Health (CDC); the National Institute of Child Health and Human Development; the Office of Children's Health Protection (EPA); Physicians for Social Responsibility; The New York Academy of Medicine; The New York Community Trust; and the Wallace Genetic Foundation. The impact of environmental toxins on children's health has become a topic of major concern in the federal government. Eight new research centers in children's environmental health have been established in the past 2 years with joint funding from EPA and NIEHS. Clinical units that specialize in the treatment of children with environmentally induced illness have been developed across the nation with grant support from ATSDR. The American Academy of Pediatrics has just published its (italic)Handbook of Pediatric Environmental Health (/italic)((italic)17(/italic)), the "Green Book," which is available to pediatricians throughout the Americas. Children's environmental health has climbed to a critical position as we launch the new millennium. This monograph marks a significant milestone in the evolution of this emerging discipline.

authors

Weiss B,Landrigan PJ

doi

10.1289/ehp.00108s3373

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

373-4

eissn

0091-6765

issn

1552-9924

pii

sc271_5_1835

journal_volume

108 Suppl 3

pub_type

杂志文章
  • Environmental practices for biomedical research facilities.

    abstract::As a result of the Leadership Conference on Biomedical Research and the Environment, the Facilities Committee focused its work on the development of best environmental practices at biomedical research facilities at the university and independent research facility level as well as consideration of potential involvement...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108s6945

    authors: Medlin EL,Grupenhoff JT

    更新日期:2000-12-01 00:00:00

  • Biomarkers of environmental tobacco smoke exposure.

    abstract::Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals. A number of biomarkers of ETS have been proposed. At present cotinine, measured in blood, saliva, or urine, appears to be the most specific and the most sensi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.99107s2349

    authors: Benowitz NL

    更新日期:1999-05-01 00:00:00

  • Drinking Water Salinity and Maternal Health in Coastal Bangladesh: Implications of Climate Change.

    abstract::Background: Drinking water from natural sources in coastal Bangladesh has become contaminated by varying degrees of salinity due to saltwater intrusion from rising sea levels, cyclone and storm surges and upstream withdrawal of freshwater. Objective: Our objective was to estimate salt intake from drinking water source...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1002804

    authors: Khan AE,Ireson A,Kovats S,Mojumder SK,Khusru A,Rahman A,Vineis P

    更新日期:2011-04-12 00:00:00

  • Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins.

    abstract::The disruption of the reproductive system of male and female animals in the wild has been attributed to environmental chemicals (xenobiotics). The effects seen mirror alterations one might anticipate if the steroid hormone-dependent processes that regulate these systems were impaired. To determine whether xenobiotics ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.97105294

    authors: Danzo BJ

    更新日期:1997-03-01 00:00:00

  • Carcinogenicity of chlorinated methane and ethane compounds administered in drinking water to mice.

    abstract::The chlorinated hydrocarbons chloroform (CHCl3), 1,1-dichlorethane (1,1-DCE) and 1,2-dichloroethane (1,2-DCE) have been detected in finished drinking water. When administered to B6C3F1 mice by gavage in corn oil, these compounds have been shown to induce hepatic tumors. The present study examines the effect on liver t...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.866989

    authors: Klaunig JE,Ruch RJ,Pereira MA

    更新日期:1986-11-01 00:00:00

  • Real-time and integrated measurement of potential human exposure to particle-bound polycyclic aromatic hydrocarbons (PAHs) from aircraft exhaust.

    abstract::We used real-time monitors and low-volume air samplers to measure the potential human exposure to airborne polycyclic aromatic hydrocarbon (PAH) concentrations during various flight-related and ground-support activities of C-130H aircraft at an Air National Guard base. We used three types of photoelectric aerosol sens...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108853

    authors: Childers JW,Witherspoon CL,Smith LB,Pleil JD

    更新日期:2000-09-01 00:00:00

  • New Perspectives for Cancer Hazard Evaluation by the Report on Carcinogens: A Case Study Using Read-Across Methods in the Evaluation of Haloacetic Acids Found as Water Disinfection By-Products.

    abstract:BACKGROUND:Due to the large number of chemicals not yet tested for carcinogenicity but to which people are exposed, the limited number of human and animal cancer studies conducted each year, and the frequent need for a timely response, mechanistic data are playing an increasingly important role in carcinogen hazard ide...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP5672

    authors: Atwood ST,Lunn RM,Garner SC,Jahnke GD

    更新日期:2019-12-01 00:00:00

  • Integrating human health into environmental impact assessment: an unrealized opportunity for environmental health and justice.

    abstract:OBJECTIVES:The National Environmental Policy Act and related state laws require many public agencies to analyze and disclose potentially significant environmental effects of agency actions, including effects on human health. In this paper we review the purpose and procedures of environmental impact assessment (EIA), ex...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.11132

    authors: Bhatia R,Wernham A

    更新日期:2008-08-01 00:00:00

  • Association of Parkinson's Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case-Control Study in France.

    abstract:BACKGROUND:Pesticides have been associated with Parkinson's disease (PD), but there are few data on important exposure characteristics such as dose-effect relations. It is unknown whether associations depend on clinical PD subtypes. OBJECTIVES:We examined quantitative aspects of occupational pesticide exposure associa...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307970

    authors: Moisan F,Spinosi J,Delabre L,Gourlet V,Mazurie JL,Bénatru I,Goldberg M,Weisskopf MG,Imbernon E,Tzourio C,Elbaz A

    更新日期:2015-11-01 00:00:00

  • Roxarsone, inorganic arsenic, and other arsenic species in chicken: a U.S.-based market basket sample.

    abstract:BACKGROUND:Inorganic arsenic (iAs) causes cancer and possibly other adverse health outcomes. Arsenic-based drugs are permitted in poultry production; however, the contribution of chicken consumption to iAs intake is unknown. OBJECTIVES:We sought to characterize the arsenic species profile in chicken meat and estimate ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1206245

    authors: Nachman KE,Baron PA,Raber G,Francesconi KA,Navas-Acien A,Love DC

    更新日期:2013-07-01 00:00:00

  • Relative potency of xenobiotic estrogens in an acute in vivo mammalian assay.

    abstract::The in vivo effects of xenoestrogens are of interest in relation to their potential health risks and/or beneficial effects on humans and animals. However, the apparent in vivo potency of the examined response can be confounded by a short half-life, and the metabolism of estrogens is very dependent on the nature of con...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9810623

    authors: Milligan SR,Balasubramanian AV,Kalita JC

    更新日期:1998-01-01 00:00:00

  • Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus.

    abstract:BACKGROUND:Epidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear. OBJECTIVE:We developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters na...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1002258

    authors: Noah TL,Zhou H,Monaco J,Horvath K,Herbst M,Jaspers I

    更新日期:2011-01-01 00:00:00

  • Applications of physiologic pharmacokinetic modeling in carcinogenic risk assessment.

    abstract::The use of physiologically based pharmacokinetic (PBPK) models has been proposed as a means of estimating the dose of the reactive metabolites of carcinogenic xenobiotics reaching target tissues, thereby affording an opportunity to base estimates of potential cancer risk on tissue dose rather than external levels of e...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.94102s1137

    authors: Krewski D,Withey JR,Ku LF,Andersen ME

    更新日期:1994-12-01 00:00:00

  • Formation of mutagens by heating foods and model systems.

    abstract::We have demonstrated that the pyrolysis products of amino acids and proteins in model systems are mutagenic. The mutagenic principles in the pyrolyzates of amino acids have been isolated and identified by Sugimura et al. We have isolated and identified amino-alpha-carbolines from pyrolyzed soybean globulin as mutagens...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.866755

    authors: Yoshida D,Matsumoto T,Okamoto H,Mizusaki S,Kushi A,Fukuhara Y

    更新日期:1986-08-01 00:00:00

  • Individual differences in neural sensitization and the role of context in illness from low-level environmental chemical exposures.

    abstract::This paper summarizes the clinical phenomenology of multiple chemical sensitivity (MCS), outlines the concepts and evidence for the olfactory-limbic, neural sensitization model for MCS, and discusses experimental design implications of the model for exposure-related research. Neural sensitization is the progressive am...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.97105s2457

    authors: Bell IR,Schwartz GE,Baldwin CM,Hardin EE,Klimas NG,Kline JP,Patarca R,Song ZY

    更新日期:1997-03-01 00:00:00

  • Traffic-Related Air Pollution, APOEε4 Status, and Neurodevelopmental Outcomes among School Children Enrolled in the BREATHE Project (Catalonia, Spain).

    abstract:BACKGROUND:Traffic-related air pollution is emerging as a risk factor for Alzheimer's disease (AD) and impaired brain development. Individual differences in vulnerability to air pollution may involve the ε4 allele of Apolipoprotein E (APOE) gene, the primary genetic risk factor for AD. OBJECTIVE:We analyzed whether th...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP2246

    authors: Alemany S,Vilor-Tejedor N,García-Esteban R,Bustamante M,Dadvand P,Esnaola M,Mortamais M,Forns J,van Drooge BL,Álvarez-Pedrerol M,Grimalt JO,Rivas I,Querol X,Pujol J,Sunyer J

    更新日期:2018-08-02 00:00:00

  • Effects of sex hormones on oncogene expression in the vagina and on development of sexual dimorphism of the pelvis and anococcygeus muscle in the mouse.

    abstract::Neonatal treatment of female mice with diethystilbestrol (DES) is known to induce ovary-independent persistent proliferation and cornification of vaginal epithelium. This irreversibly changed vaginal epithelium persistently expressed higher levels of c-jun and c-fos mRNAs, which was not altered by postpubertal estroge...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s779

    authors: Iguchi T,Fukazawa Y,Bern HA

    更新日期:1995-10-01 00:00:00

  • Poultry Consumption and Arsenic Exposure in the U.S. Population.

    abstract:BACKGROUND:Arsenicals (roxarsone and nitarsone) used in poultry production likely increase inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and roxarsone or nitarsone concentrations in poultry meat. However, the association between poultry intake and exposure to these arsenic species, ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP351

    authors: Nigra AE,Nachman KE,Love DC,Grau-Perez M,Navas-Acien A

    更新日期:2017-03-01 00:00:00

  • Chemical agents and the immune response.

    abstract::Our desire to understand the potential adverse human health effects of environmental chemical exposure has coincided with an increased understanding of the immune system and an appreciation of its complex regulatory network. This has spawned a broad interest in the area of immunotoxicology within the scientific commun...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.93100219

    authors: Luster MI,Rosenthal GJ

    更新日期:1993-04-01 00:00:00

  • Long-term, low-dose lead exposure alters the gonadotropin-releasing hormone system in the male rat.

    abstract::Lead is a male reproductive toxicant. Data suggest that rats dosed with relatively high levels of lead acetate for short periods of time induced changes in the hypothalamic gonadotropin-releasing hormone (GnRH) at the molecular level, but these changes were attenuated with increased concentration of exposure. The curr...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.02110871

    authors: Sokol RZ,Wang S,Wan YJ,Stanczyk FZ,Gentzschein E,Chapin RE

    更新日期:2002-09-01 00:00:00

  • Unventilated indoor coal-fired stoves in Guizhou province, China: reduction of arsenic exposure through behavior changes resulting from mitigation and health education in populations with arsenicosis.

    abstract::We report the results of a coordinated mitigation effort aimed at reducing arsenic (As) exposure in three counties of Guizhou province, China. Mitigation occurred in 2005 and encompassed 21 villages with 47,000 inhabitants, who were exposed to high levels of As in their diet through consumption of As-contaminated chil...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9273

    authors: An D,Li D,Liang Y,Jing Z

    更新日期:2007-04-01 00:00:00

  • Maternal Plasma Perfluoroalkyl Substances and Miscarriage: A Nested Case-Control Study in the Danish National Birth Cohort.

    abstract:BACKGROUND:Per- and polyfluoroalkyl substances (PFAS) are widespread persistent organic pollutants and endocrine disruptors. High doses of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) exposure can cause pregnancy loss and infant deaths in animals, but the associations between PFAS exposures and...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP6202

    authors: Liew Z,Luo J,Nohr EA,Bech BH,Bossi R,Arah OA,Olsen J

    更新日期:2020-04-01 00:00:00

  • The effect of heat waves on mental health in a temperate Australian city.

    abstract:OBJECTIVE:The goal of this study was to identify mental, behavioral, and cognitive disorders that may be triggered or exacerbated during heat waves, predisposing individuals to heat-related morbidity and mortality. DESIGN:Using health outcome data from Adelaide, South Australia, for 1993-2006, we estimated the effect ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.11339

    authors: Hansen A,Bi P,Nitschke M,Ryan P,Pisaniello D,Tucker G

    更新日期:2008-10-01 00:00:00

  • High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.

    abstract::Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breas...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6220

    authors: Petreas M,She J,Brown FR,Winkler J,Windham G,Rogers E,Zhao G,Bhatia R,Charles MJ

    更新日期:2003-07-01 00:00:00

  • Urinary trivalent methylated arsenic species in a population chronically exposed to inorganic arsenic.

    abstract::Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of various forms of cancer and of noncancerous diseases. Metabolic conversions of iAs that yield highly toxic and genotoxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII) may play a significant role in determining the extent an...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7519

    authors: Valenzuela OL,Borja-Aburto VH,Garcia-Vargas GG,Cruz-Gonzalez MB,Garcia-Montalvo EA,Calderon-Aranda ES,Del Razo LM

    更新日期:2005-03-01 00:00:00

  • Missing from the table: role of the environmental public health community in governmental advisory commissions related to Marcellus Shale drilling.

    abstract:BACKGROUND:The Marcellus Shale is a vast natural gas field underlying parts of Pennsylvania, New York, West Virginia, Virginia, and Maryland. Rapid development of this field has been enabled by advances in hydrofracking techniques that include injection of chemical and physical agents deep underground. Response to publ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1104594

    authors: Goldstein BD,Kriesky J,Pavliakova B

    更新日期:2012-04-01 00:00:00

  • Does an association between pesticide use and subsequent declines in catch of Atlantic salmon (Salmo salar) represent a case of endocrine disruption?

    abstract::Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.99107349

    authors: Fairchild WL,Swansburg EO,Arsenault JT,Brown SB

    更新日期:1999-05-01 00:00:00

  • Environmental determinants of infectious disease: a framework for tracking causal links and guiding public health research.

    abstract:BACKGROUND:Discoveries that emerging and re-emerging pathogens have their origin in environmental change has created an urgent need to understand how these environmental changes impact disease burden. In this article we present a framework that provides a context from which to examine the relationship between environme...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9806

    authors: Eisenberg JN,Desai MA,Levy K,Bates SJ,Liang S,Naumoff K,Scott JC

    更新日期:2007-08-01 00:00:00

  • A Quantile-Based g-Computation Approach to Addressing the Effects of Exposure Mixtures.

    abstract:BACKGROUND:Exposure mixtures frequently occur in data across many domains, particularly in the fields of environmental and nutritional epidemiology. Various strategies have arisen to answer questions about exposure mixtures, including methods such as weighted quantile sum (WQS) regression that estimate a joint effect o...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP5838

    authors: Keil AP,Buckley JP,O'Brien KM,Ferguson KK,Zhao S,White AJ

    更新日期:2020-04-01 00:00:00

  • Factors affecting Sertoli cell function in the testis.

    abstract::The Sertoli cell is the primary target for FSH action in the mammalian testis. These cells contain the majority of testicular plasma membrane receptors for this hormone. Receptor occupancy is directly correlated with a stimulation of adenylyl cyclase and a decrease in the activity of a cytoplasmic Ca++-sensitive cAMP ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.81385

    authors: Tindall DJ,Tash JS,Means AR

    更新日期:1981-04-01 00:00:00