Abstract:
:The Sertoli cell is the primary target for FSH action in the mammalian testis. These cells contain the majority of testicular plasma membrane receptors for this hormone. Receptor occupancy is directly correlated with a stimulation of adenylyl cyclase and a decrease in the activity of a cytoplasmic Ca++-sensitive cAMP phosphodiesterase. Regulation of these two enzymes allows increased intracellular accumulation of cAMP, activation of cAMP-dependent protein kinase and phosphorylation of a variety of protein substrates. All of these events occur within the first 30 min following exposure of isolated Sertoli cells to FSH. RNA and protein synthesis are also enhanced by FSH. Previous studies have suggested that this gonadotropin may augment the overall cellular synthesis of proteins. Our results reveal that protein kinase inhibitor (PKI) is selectively elevated by FSH both in vivo and in vitro. PKI thus becomes the initial intracellular protein whose synthesis is under FSH control. In addition to effects on protein synthesis, FSH also positively modulates the secretion of several specific proteins. One of the proteins in this latter category is androgen binding protein (ABP). Again, regulation can be observed both in vivo and in vitro. Elevated synthesis of PKI occurs prior to demonstrable secretion of ABP. Both of these events occur subsequent to the effects of FSH on cAMP metabolism. Indeed cAMP (or any of several nonhydrolyzable derivatives) can substitute for FSH in vitro. The temporal sequence of events subsequent to hormone binding and cAMP production are identical, but occur more rapidly. Together these data support the hypothesis that most of the biochemical steps leading to the synthesis and secretion of proteins by FSH are regulated by elevated levels of cAMP.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Tindall DJ,Tash JS,Means ARdoi
10.1289/ehp.81385subject
Has Abstractpub_date
1981-04-01 00:00:00pages
5-10eissn
0091-6765issn
1552-9924journal_volume
38pub_type
杂志文章abstract::A meeting on Marine Biomedical Research, sponsored by the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health and the Smithsonian Institution Museum of Natural History, was attended by approximately 125 scientists, directors and representatives from many of the country's marine b...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7613147
更新日期:1976-02-01 00:00:00
abstract::A combined cytogeneticurine metabolite analysis approach was used to assess potential interactive effects between Fenarimol (FN), a fungicide, and trichloroethylene (TRI), a halogenated solvent. FN was demonstrated to selectively induce P450-2B1 isoforms in different organs of treated mice. Since the rate of metabolis...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s931
更新日期:1994-11-01 00:00:00
abstract::The available data on the influence of selenium on the toxicity of methylmercury and of methylmercury on selenium as a nutrient and toxic agent are reviewed. Selenium as selenite has a relative protective effect on acute and subacute toxicity of methylmercury in the rat and the quail. The protective mechanism is far f...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.782557
更新日期:1978-08-01 00:00:00
abstract::Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7823227
更新日期:1978-04-01 00:00:00
abstract::Research conducted in recent years has increased public health concern about the toxicity of lead at low dose and has supported a reappraisal of the levels of lead exposure that may be safely tolerated in the workplace. In this article, which appears as part of a mini-monograph on adult lead exposure, we summarize a b...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9784
更新日期:2007-03-01 00:00:00
abstract::Between 1966 and 1986, the childhood leukemia rate in Woburn, Massachusetts, was 4-fold higher than the national average. A multidisciplinary research team from MIT, which is being supported by the NIEHS Superfund Basic Research Program, has explored the possible importance of a temporal correlation between the period...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103s693
更新日期:1995-09-01 00:00:00
abstract::Haloalkane toxicity originates from attack on biological targets by reactive intermediates derived from haloalkane metabolism by a hemoprotein, cytochrome P-450. Carbon-centered radicals and their peroxyl derivatives are most likely involved. The reactions of iron porphyrin--a model for cytochrome P-450--with various ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.856453
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:Ocean pollution affects marine organisms and ecosystems as well as humans. The International Oceanographic Commission recommends ocean health monitoring programs to investigate the presence of marine contaminants and the health of threatened species and the use of multiple and early-warning biomarker approac...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901809
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that have been widely used as flame retardants in furniture, carpet padding, car seats, and other consumer products during the past three decades. OBJECTIVE:We examined whether in utero exposure to PBDEs is associated with child cognitive funct...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307562
更新日期:2014-08-01 00:00:00
abstract::A series of experiments is described in which operant methodology is used to study the effects of drugs on "learning." Emphasis is placed on the technique of repeated acquisition as a behavioral baseline for studying this type of transition state. In this technique, each subject is required to learn a new discriminati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782677
更新日期:1978-10-01 00:00:00
abstract:BACKGROUND:Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. OBJECTIVE:Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age chil...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9961
更新日期:2007-09-01 00:00:00
abstract::The development of inhalation toxicology as a distinct discipline can be traced back well over one hundred years. The technology has advanced in terms of materials and designs used to construct inhalation chambers and the equipment used to generate controlled test atmospheres of a wide variety of gases, vapors, dusts,...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.85-1568347
更新日期:1990-04-01 00:00:00
abstract::We extended our previous analyses of term low birth weight (LBW) and preterm birth to 1994-2000, a period of declining air pollution levels in the South Coast Air Basin. We speculated that the effects we observed previously for carbon monoxide, particulate matter < 10 microm in aerodynamic diameter (PM10), and traffic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7751
更新日期:2005-09-01 00:00:00
abstract::The role of the knowledge of high risk groups in the standard-setting process is examined. The overall conclusion is that many potential high risk segments of the population have not been studied adequately and that this deficiency in our knowledge markedly reduces the ability of decision makers to derive appropriate ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8352257
更新日期:1983-10-01 00:00:00
abstract::Dose influences mechanism; and over a wide range of doses, one can envision that mechanism will change with changing dose. This basic concept in toxicology is juxtaposed with the biologic importance of maintaining normal DNA methylation status to provide the focus of this paper. The idea that altered DNA methylation p...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.98106s1285
更新日期:1998-02-01 00:00:00
abstract::Neonatal treatment of female mice with diethystilbestrol (DES) is known to induce ovary-independent persistent proliferation and cornification of vaginal epithelium. This irreversibly changed vaginal epithelium persistently expressed higher levels of c-jun and c-fos mRNAs, which was not altered by postpubertal estroge...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s779
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:Exposure to metals has been implicated in the pathogenesis of Parkinson disease (PD). OBJECTIVES:We sought to examine in a large prospective study of female nurses whether exposure to airborne metals was associated with risk of PD. METHODS:We linked the U.S. Environmental Protection Agency (EPA)'s Air Toxi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307218
更新日期:2014-09-01 00:00:00
abstract::Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract::Exposure to aflatoxin B1 (AFB1), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the intraindividual variability in AFB1-albumin adducts, the most reliable long-term biomarker of AFB1 exposure, and whether the baseline ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.01109833
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:Methylmercury (MeHg) may affect fetal growth; however, prior research often lacked assessment of mercury speciation, confounders, and interactions. OBJECTIVE:Our objective was to assess the relationship between MeHg and fetal growth as well as the potential for confounding or interaction of this relationshi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408596
更新日期:2016-03-01 00:00:00
abstract::Okadaic acid, dinophysistoxin-1 (35-methylokadaic acid), and calyculin A are the okadaic acid class of non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters, which do not bind to the phorbol ester receptors in cell membranes or activate protein kinase C in vitro. They have potent tumor-promoting activiti...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9193211
更新日期:1991-06-01 00:00:00
abstract::In rats, a single administration of acrylonitrile (vinyl cyanide) produces a rapidly occurring bilateral adrenal apoplexy. Structure-activity studies have shown that a close derivative, propionitrile (ethyl cyanide), causes duodenal ulcer without markedly affecting the adrenal glands. Prolonging the two-carbon chain o...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7511135
更新日期:1975-06-01 00:00:00
abstract::Neurobehavioral toxicology is now established as a core discipline of the environmental health sciences. Despite its recognized scientific prowess, stemming from its deep roots in psychology and neuroscience and its acknowledged successes, it faces additional demands and challenges. The latter, in fact, are a product ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104s2173
更新日期:1996-04-01 00:00:00
abstract::To assess levels of chlorinated contaminants in breast milk, we measured organochlorine pesticides, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) in breast milk samples collected in 1994 according to the World Health Organization protocol from 92 donors...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106797
更新日期:1998-12-01 00:00:00
abstract::Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9089217
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVE:Daily adult human exposure to bisphenol A (BPA) has been estimated at <1 µg/kg, with virtually complete first-pass conjugation in the liver in primates but not in mice. We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1002514
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Cancer may be a stem cell (SC)-based disease involving formation of cancer SCs (CSCs) potentially arising from transformation of normal SCs. Cadmium has been linked to human pancreatic cancer. OBJECTIVE:We studied cadmium exposure of human pancreatic ductal epithelial (HPDE) cells and whether SCs may be tar...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205082
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Exposure to transportation noise is widespread and has been associated with obesity in some studies. However, the evidence from longitudinal studies is limited and little is known about effects of combined exposure to different noise sources. OBJECTIVES:The aim of this longitudinal study was to estimate the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1910
更新日期:2017-11-20 00:00:00
abstract::Systemic lupus erythematosus and systemic scleroderma are autoimmune diseases thought to have an exogenous trigger. This review summarizes relevant case-control and cohort studies that investigated exogenous sex hormones, silica, silicone, solvents, pesticides, mercuric chloride, and hair dyes as putative risk factors...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.99107s5743
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organoch...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10486
更新日期:2007-12-01 00:00:00