Abstract:
:Neurobehavioral toxicology is now established as a core discipline of the environmental health sciences. Despite its recognized scientific prowess, stemming from its deep roots in psychology and neuroscience and its acknowledged successes, it faces additional demands and challenges. The latter, in fact, are a product of its achievements because success at one level leads to new and higher expectations. Now the discipline is counted upon to provide more definitive and extensive risk assessments than in the past. These new demands are the basis for the appraisals presented in the SGOMSEC 11 workshop. They extend beyond what would be offered in a primer of methodology. Instead, these appraisals are framed as issues into which what are usually construed as methodologies have been embedded.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Weiss B,Elsner Jdoi
10.1289/ehp.96104s2173subject
Has Abstractpub_date
1996-04-01 00:00:00pages
173-7eissn
0091-6765issn
1552-9924journal_volume
104 Suppl 2pub_type
杂志文章abstract:BACKGROUND:Cadmium exposure may increase the risk of cardiovascular disease. The only published longitudinal study on cadmium and incident cardiovascular disease was performed in American Indians with relatively high cadmium exposure. OBJECTIVES:Our aim was to examine the association between blood cadmium at baseline ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1509735
更新日期:2016-05-01 00:00:00
abstract::Flavone and isoflavone phytoestrogens are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate. Aromatase is the enzyme that converts androgen to estrogen; therefore, these plant chemicals are thought to be capable of modifying the estrogen leve...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9810685
更新日期:1998-02-01 00:00:00
abstract::The phenomenon of fiber-induced cytotoxicity to P388D1 macrophagelike cells has been demonstrated to parallel (thus far without exception) the probability that the fiber will induce a pleural sarcoma (mesothelioma) in rats. This startling parallel in both cases seems to be essentially independent of the chemical natur...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.803491
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:According to a wide variety of analyses and projections, the potential effects of global climate change on human health are large and diverse. The U.S. National Institutes of Health (NIH), through its basic, clinical, and population research portfolio of grants, has been increasing efforts to understand how ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1104518
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Methylmercury (MeHg) exposure has been linked to an increased risk of coronary heart disease (CHD). Paraoxonase 1 (PON1), an enzyme located in the high-density-lipoprotein (HDL) fraction of blood lipids, may protect against CHD by metabolizing toxic oxidized lipids associated with low-density liproprotein an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1003296
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Early-life exposure to lead is associated with deficits in neurodevelopment and with hematopoietic system toxicity. DNA methylation may be one of the underlying mechanisms for the adverse effects of prenatal lead on the offspring, but epigenome-wide methylation data for low levels of prenatal lead exposure a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1246
更新日期:2017-08-25 00:00:00
abstract::Differences in genetic susceptibility to hazardous chemicals affect individuals of both human and nonhuman populations. In both cases, differences in response to chemicals or general ill health result as a function of these differences in genetic susceptibility. However, ecological systems are a compilation of hundred...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s4843
更新日期:1997-06-01 00:00:00
abstract::A brief description of chromosome aberrations and sister chromatid exchange (SCE) as cytogenetic endpoints for evaluation of DNA damaging agents is presented. Problems associated with the use of cytogenetic assays as population monitors of radiation and chemical exposures are discussed. Adequate cell sample size requi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8142107
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:Policy decisions regarding climate change mitigation are increasingly incorporating the beneficial and adverse health impacts of greenhouse gas emission reduction strategies. Studies of such co-benefits and co-harms involve modeling approaches requiring a range of analytic decisions that affect the model out...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1306744
更新日期:2014-05-01 00:00:00
abstract::To analyze the implications for human health, the toxicologist requires four sets of data: the results of toxicity and other studies in animals; quantitative data on actual or potential human exposure; whatever information is available on effects of exposure in man; and the statistical extrapolations from the dose-res...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7932273
更新日期:1979-10-01 00:00:00
abstract::A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning. Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls. Lesions were characterized by the appearance of edema and epithelial...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9089137
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Epidemiologic studies have demonstrated that occupational noise exposure is associated with hypertension, but the related mechanism in vascular structural changes is unclear. OBJECTIVE:This panel study aimed to investigate effects of occupational noise exposure on ambulatory vascular structural properties i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10346
更新日期:2007-11-01 00:00:00
abstract::The neurochemical basis of memory has been approached experimentally in four different ways: the bioassay; the interventive approach; the interventive-correlative approach; and the correlative approach. These approaches are fundamentally similar to those used for the study of the chemistry of any behavior. Each of the...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.7826143
更新日期:1978-10-01 00:00:00
abstract:BACKGROUND:The mortality impacts of hot and cold temperatures have been thoroughly documented, with most locations reporting a U-shaped relationship with a minimum mortality temperature (MMT) at which mortality is lowest. How MMT may have evolved over previous decades as the global mean surface temperature has increase...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1509692
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Tens of millions of Americans suffer from a range of adverse health outcomes due to noise exposure, including heart disease and hearing loss. Reducing environmental noise pollution is achievable and consistent with national prevention goals, yet there is no national plan to reduce environmental noise polluti...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307272
更新日期:2014-02-01 00:00:00
abstract::The cytotoxic action of a series of mineral dusts has been studied using Chinese hamster V79-4 cells obtained from three separate laboratories in the UK. The dusts which have been studied include samples of asbestos from the Union Internationale Contre le Cancer reference series and an internationally available sample...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8351189
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:In an effort to decrease the rates of smoking conventional tobacco cigarettes, electronic cigarettes (e-cigarettes) have been proposed as an effective smoking cessation tool. However, little is known about their toxicological impacts. This is concerning given that e-cigarette use is perceived as less harmful...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6067
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Epidemiologic and experimental studies have reported a variety of health effects in response to ozone (O3) exposure, and some have indicated that certain populations may be at increased or decreased risk of O3-related health effects. OBJECTIVES:We sought to identify potential response-modifying factors to d...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1307541
更新日期:2014-11-01 00:00:00
abstract::Environmental pollution with the nephrotoxic metal cadmium is considered a potential health risk for the general population. In 1976 it was reported that the cadmium concentration in human kidney cortex in Sweden had increased in parallel with increasing levels in soil and grain during the twentieth century. Since the...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106175
更新日期:1998-04-01 00:00:00
abstract::Alveolar macrophages were treated with carbon blacks and adsorbates in order to evaluate the biologic effect of adsorbate, adsorbent and adsorbate-adsorbent complexes. Their capacity to phagocytize a subsequent challenge via the Fc-membrane receptor was quantified. Phagocytosis was suppressed in a dose-related manner ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9086337
更新日期:1990-06-01 00:00:00
abstract::During the last three decades, the impact of chemical pollution has focused almost exclusively on the conventional "priority" pollutants, especially those acutely toxic/carcinogenic pesticides and industrial intermediates displaying persistence in the environment. This spectrum of chemicals, however, is only one piece...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.99107s6907
更新日期:1999-12-01 00:00:00
abstract::Health is defined as homeostasis of the cellular ecology, and a state where there has not been an inordinate loss, reversible or irreversible, of the structural and/or functional reserves of the body. An adverse health effect is defined as the causation, promotion, facilitation and/or exacerbation of a structural and/...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8352177
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:Environmental exposures to phthalates, particularly high-molecular-weight (HMW) phthalates, are suspected to contribute to allergy. OBJECTIVE:We assessed whether phthalate metabolites are associated with allergic symptoms and sensitization in a large nationally representative sample. METHODS:We used data o...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1206211
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:One of the most widely used classes of insecticides is the synthetic pyrethroids. Although pyrethroids are less acutely toxic to humans than to insects, in vitro studies have suggested that pyrethroids may be estrogenic. OBJECTIVES:We assessed pubertal effects by orally administering 0.5, 1.0, and 5.0 mg/kg...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11119
更新日期:2008-09-01 00:00:00
abstract::Effects of respirable aerosols of sulfuric acid, ammonium sulfate, sodium sulfite, and ammonium persulfate on lungs of rats are reviewed. The literature regarding interactions between ozone or nitrogen dioxide and acidic aerosols (ammonium sulfate, sulfuric acid) is discussed. An unexpected interaction between nitroge...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8979115
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:"Airwave" is the new communication system currently being rolled out across the United Kingdom for the police and emergency services, based on the Terrestrial Trunked Radio Telecommunications System (TETRA). Some police officers have complained about skin rashes, nausea, headaches, and depression as a conseq...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901416
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Epidemiologic studies of postnatal PCB exposure and behavior have not reported consistent evidence of adverse associations, possibly because of challenges in exposure estimation. We previously developed a pharmacokinetic model to improve estimation of children's PCB exposure. OBJECTIVES:We aimed to assess w...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408084
更新日期:2015-09-01 00:00:00
abstract::We measured tumor-associated proteins (TAPs) and pollutants in blood, serum, and urine of 200 nonsmoking women 50-65 years of age, residing in the rural municipality of Peer or in Hoboken or Wilrijk, industrial suburbs of Antwerp, Belgium. Persons with occupational exposures or commuting to other towns were excluded. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8811
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (AR...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002304
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The World Health Organization is the agency responsible for reporting the Millennium Development Goal (MDG) indicator "percentage of population using solid fuels." In this article, we present the results of a comprehensive assessment of solid fuel use, conducted in 2005, and discuss the implications of our fi...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8603
更新日期:2006-03-01 00:00:00