Abstract:
BACKGROUND:Environmental exposures to phthalates, particularly high-molecular-weight (HMW) phthalates, are suspected to contribute to allergy. OBJECTIVE:We assessed whether phthalate metabolites are associated with allergic symptoms and sensitization in a large nationally representative sample. METHODS:We used data on urinary phthalate metabolites and allergic symptoms (hay fever, rhinitis, allergy, wheeze, asthma) and sensitization from participants ≥ 6 years of age in the National Health and Nutrition Examination Survey (NHANES) 2005-2006. Allergen sensitization was defined as a positive response to at least one of 19 specific IgE antigens (≥ 0.35 kU/L). Odds ratios (ORs) per one log10 unit change in phthalate concentration were estimated using logistic regression adjusting for age, race, body mass index, gender, creatinine, and cotinine. Separate analyses were conducted for children (6-17 years of age) and adults. RESULTS:The HMW phthalate metabolite monobenzyl phthalate (MBzP) was the only metabolite positively associated with current allergic symptoms in adults (wheeze, asthma, hay fever, and rhinitis). Mono-(3-carboxypropyl) phthalate and the sum of diethylhexyl phthalate metabolites (both representing HMW phthalate exposures) were positively associated with allergic sensitization in adults. Conversely, in children, HMW phthalate metabolites were inversely associated with asthma and hay fever. Of the low-molecular-weight phthalate metabolites, monoethyl phthalate was inversely associated with allergic sensitization in adults (OR = 0.79; 95% CI: 0.70, 0.90). CONCLUSION:In this cross-sectional analysis of a nationally representative sample, HMW phthalate metabolites, particularly MBzP, were positively associated with allergic symptoms and sensitization in adults, but there was no strong evidence for associations between phthalates and allergy in children 6-17 years of age.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Hoppin JA,Jaramillo R,London SJ,Bertelsen RJ,Salo PM,Sandler DP,Zeldin DCdoi
10.1289/ehp.1206211subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1129-34issue
10eissn
0091-6765issn
1552-9924journal_volume
121pub_type
杂志文章abstract:BACKGROUND:Endocrine-disrupting chemicals have been shown to have broad effects on development, but their mutagenic actions that can lead to cancer have been less clearly demonstrated. Physiological levels of estrogen have been shown to stimulate DNA damage in breast epithelial cells through mechanisms mediated by estr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP5221
更新日期:2020-01-01 00:00:00
abstract::We estimated the disease burden from water, sanitation, and hygiene at the global level taking into account various disease outcomes, principally diarrheal diseases. The disability-adjusted life year (DALY) combines the burden from death and disability in a single index and permits the comparison of the burden from wa...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.110-1240845
更新日期:2002-05-01 00:00:00
abstract::The Centers for Disease Control and Prevention recommend that local public health agencies use local data to identify children at risk for lead exposure to ensure that they receive preventive services. The objective of this study was to demonstrate the usefulness of a geographic information system (GIS) in identifying...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0110989
更新日期:2001-01-01 00:00:00
abstract::Many naturally occurring and man-made chemicals present in the environment possess estrogenic activity. Examples include plant and fungal products, pesticides, plasticizers, and other agricultural and industrial chemicals. These environmental estrogens as well as endogenous ovarian estrogens are thought to initiate th...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s729
更新日期:1995-10-01 00:00:00
abstract::Perinatal exposure to carcinogens may contribute to the determination of susceptibility to cancer in two situations: a) exposure in utero of embryonal or fetal somatic cells to carcinogens, and b) prezygotic exposure of the germ cells of one or both parents to carcinogens. Epidemiological as well as experimental studi...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.929839
更新日期:1992-11-01 00:00:00
abstract::The cytotoxic action of a series of mineral dusts has been studied using Chinese hamster V79-4 cells obtained from three separate laboratories in the UK. The dusts which have been studied include samples of asbestos from the Union Internationale Contre le Cancer reference series and an internationally available sample...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8351189
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:The mechanisms governing the correlation between exposure to ultrafine particles and the increased incidence of cardiovascular disease remain unknown. Ultrafine particles appear to cross the pulmonary epithelial barrier into the bloodstream, raising the possibility of direct contact with the vascular endothe...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8497
更新日期:2007-03-01 00:00:00
abstract::Cytochrome P450 (CYP) enzymes catalyze the generation of reactive species capable of binding with cellular macromolecules, leading to acute and delayed toxicity. Since individual CYP forms differ markedly in their substrate preferences and regulation, the expression profiles of CYP in various cell types are important ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.97105s4767
更新日期:1997-06-01 00:00:00
abstract::This study constitutes one part of a program for assessing the impact of coal-fired power plants on the surrounding communities. A questionnaire was mailed to a total of 12,000 subjects living in six areas with coal-fired plants and in matched reference areas. The participation rate was 77.3%. In one coal-fired plant/...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8670239
更新日期:1986-12-01 00:00:00
abstract::This study investigated the association between biomarkers of fetal exposure to cigarette smoke at the end of pregnancy, cotinine in cord serum and in maternal and newborn urine samples, and quantitative measurement of smoking intake and exposure evaluated by maternal self-reported questionnaire. Study subjects were 4...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.001081079
更新日期:2000-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.95103s427
更新日期:1995-05-01 00:00:00
abstract::The available data on binary interactions are yet to be considered within the context of mixture risk assessment because of our inability to predict the effect of a third or a fourth chemical in the mixture on the interacting binary pairs. Physiologically based pharmacokinetic (PBPK) models represent a potentially use...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110s6989
更新日期:2002-12-01 00:00:00
abstract::The Tradescantia genetic system developed by the late Dr. Arnold H. Sparrow for the study of effects of ionizing radiation is applicable to chemical mutagen detection. Early radiobiological data demonstrated that the stamen hairs were sensitive to as little as 0.25 rad of x-rays and that the number of cells showing a ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782751
更新日期:1978-12-01 00:00:00
abstract::The types of biological response to an environmental agent can depend on dose, thus in this case a family of widely different dose-response relationships would be expected. For those situations where the magnitude of the effect may be determined on probabilistic grounds as a function of dose ("stochastic" model), no p...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.814245
更新日期:1981-12-01 00:00:00
abstract::Participants at the Napa Conference on Genetic and Molecular Ecotoxicology assessed the status of this field in light of heightened concerns about the genetic effects of exposure to hazardous substances and recent advancements in our capabilities to measure those effects. We present here a synthesis of the ideas discu...
journal_title:Environmental health perspectives
pub_type: 共识发展会议,杂志文章,评审
doi:10.1289/ehp.94102s123
更新日期:1994-12-01 00:00:00
abstract::The historical exposures to aromatic amines of various occupational groups are briefly reviewed. Modern studies indicate that other occupational groups might have risks worth investigating; these include machinists and workers in the chemical industry. Details of a recent investigation into the exposure of dye workers...
journal_title:Environmental health perspectives
pub_type: 历史文章,杂志文章
doi:10.1289/ehp.834913
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited. OBJECTIVE:To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9662
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Although a long latency period of toxicity after exposure to methylmercury (MeHg) is known to exist in humans, few animal studies have addressed this issue. Substantiation of delayed MeHg toxicity in animals would affect the risk evaluation of MeHg. OBJECTIVES:Our goal in this study was to demonstrate the e...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10906
更新日期:2008-06-01 00:00:00
abstract::[This corrects the article DOI: https://doi.org/10.1289/EHP507.]. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,已发布勘误
doi:10.1289/EHP3422
更新日期:2018-02-20 00:00:00
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journal_title:Environmental health perspectives
pub_type:
doi:10.1289/ehp.98106441
更新日期:1998-04-01 00:00:00
abstract::We extended our previous analyses of term low birth weight (LBW) and preterm birth to 1994-2000, a period of declining air pollution levels in the South Coast Air Basin. We speculated that the effects we observed previously for carbon monoxide, particulate matter < 10 microm in aerodynamic diameter (PM10), and traffic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7751
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Organophosphate developmental neurotoxicity involves multiple mechanisms converging on neural cell replication and differentiation. OBJECTIVES:We evaluated mechanisms contributing to the adverse effects of chlorpyrifos (CPF) on DNA synthesis, cell number and size, and cell signaling mediated by adenylyl cyc...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10194
更新日期:2007-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.761775
更新日期:1976-10-01 00:00:00
abstract::The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentratio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s3335
更新日期:1994-09-01 00:00:00
abstract::A series of experiments is described in which operant methodology is used to study the effects of drugs on "learning." Emphasis is placed on the technique of repeated acquisition as a behavioral baseline for studying this type of transition state. In this technique, each subject is required to learn a new discriminati...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782677
更新日期:1978-10-01 00:00:00
abstract::This article reviews the epidemiologic studies of the association of ischemic heart disease risk and environmental tobacco smoke (ETS) exposure from a spouse who smokes. Seventeen studies (nine cohort, eight case-control) comprising more than 485,000 lifelong nonsmokers and 7,345 coronary heart disease (CHD) events we...
journal_title:Environmental health perspectives
pub_type: 杂志文章,meta分析
doi:10.1289/ehp.99107s6841
更新日期:1999-12-01 00:00:00
abstract::[This corrects the article DOI: 10.1289/EHP2580.]. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,已发布勘误
doi:10.1289/EHP4002
更新日期:2018-07-05 00:00:00
abstract::Impairment of any of the major components of the immune system (T-cells, B-cells phagocytes, complement) may result in clinical immunodeficiency. Immune defects can arise from intrinsic or heritable defects of lymphoid elements, failure of normal cellular differentiation, viral infection or other acquired causes. Clin...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.82439
更新日期:1982-02-01 00:00:00
abstract::Cooking, heat processing, or pyrolysis of protein-rich foods induce the formation of a series of structurally related heterocyclic aromatic bases that have been found to be mutagens. The primary genetic assay utilized to detect and isolate these mutagens has been the his reversion assay in Salmonella typhimurium. The ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.866793
更新日期:1986-08-01 00:00:00
abstract::Implications of the multistage theory of carcinogenesis for evaluating the effect of exposure to carcinogens in the workplace are described. This theory predicts different patterns of excess risk related to duration of exposure, age at initial exposure, and follow-up time since exposure stopped, depending upon which s...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350293
更新日期:1983-04-01 00:00:00