13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies for ecotoxicity.

abstract：BACKGROUND:Adverse cardiorespiratory health is associated with exposure to ambient particulate matter (PM). The highest PM concentrations in London occur in proximity to waste transfer stations (WTS), sites that experience high numbers of dust-laden, heavy-duty diesel vehicles transporting industrial and household wast...

journal_title：Environmental health perspectives

authors： Godri KJ,Duggan ST,Fuller GW,Baker T,Green D,Kelly FJ,Mudway IS

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The mortality impacts of hot and cold temperatures have been thoroughly documented, with most locations reporting a U-shaped relationship with a minimum mortality temperature (MMT) at which mortality is lowest. How MMT may have evolved over previous decades as the global mean surface temperature has increase...

journal_title：Environmental health perspectives

authors： Åström DO,Tornevi A,Ebi KL,Rocklöv J,Forsberg B

更新日期：2016-06-01 00:00:00

abstract：:Carbon tetrachloride produces liver cell injury in a variety of animal species. The first structurally recognizable changes occur in the endoplasmic reticulum, with alteration in ribosome-membrane interactions. Later there is an increase in intracellular fat, and the formation of tangled nets of the ergastoplasm. At n...

journal_title：Environmental health perspectives

authors： Smuckler EA

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) released the fourth edition of Guidelines for Drinking-Water Quality in July 2011. In this edition, the 400-µg/L drinking-water guideline for manganese (Mn) was discontinued with the assertion that because "this health-based value is well above concentrations of manganese ...

journal_title：Environmental health perspectives

authors： Frisbie SH,Mitchell EJ,Dustin H,Maynard DM,Sarkar B

更新日期：2012-06-01 00:00:00

abstract：:The purpose of the investigation is to study whether an increased mortality from certain causes exists in an area around the Rönnskärsverken smelter works in northern Sweden. Founded in 1928, this metallurgical plant processing mainly nonferrous metals has since its initial operations been using ore with a high arseni...

journal_title：Environmental health perspectives

authors： Pershagen G,Elinder CG,Bolander AM

更新日期：1977-08-01 00:00:00

abstract：:The Florence Statement on Triclosan and Triclocarban documents a consensus of more than 200 scientists and medical professionals on the hazards of and lack of demonstrated benefit from common uses of triclosan and triclocarban. These chemicals may be used in thousands of personal care and consumer products as well as ...

journal_title：Environmental health perspectives

authors： Halden RU,Lindeman AE,Aiello AE,Andrews D,Arnold WA,Fair P,Fuoco RE,Geer LA,Johnson PI,Lohmann R,McNeill K,Sacks VP,Schettler T,Weber R,Zoeller RT,Blum A

更新日期：2017-06-20 00:00:00

abstract：:To elucidate the effect of intake of mutagenic and/or carcinogenic pyrolysis products of proteins and amino acids on carcinogenesis in man, we have undertaken two epidemiologic cohort studies: one concerning the possible association of broiled fish consumption with cancer and the other concerning the cancer mortality ...

journal_title：Environmental health perspectives

authors： Kuratsune M,Ikeda M,Hayashi T

更新日期：1986-08-01 00:00:00

abstract：:There are a number of technical and statistical problems in monitoring the temporal and spatial variation of local area death rates in the United States for evidence of systematically elevated risks. An analytic strategy is proposed to reduce one of the major statistical concerns, i.e., that of identifying areas with ...

journal_title：Environmental health perspectives

authors： Manton KG,Stallard E,Creason JP,Riggan WB

更新日期：1985-05-01 00:00:00

abstract：:Chlorination has been the major strategy for disinfection of drinking water in the United States. Concern about the potential health effects of the reaction by-products of chlorine has prompted use of alternative strategies. One such method is chloramination, a treatment process that does not appear to have carcinogen...

journal_title：Environmental health perspectives

authors： Zierler S,Danley RA,Feingold L

更新日期：1986-11-01 00:00:00

abstract：INTRODUCTION:Ambient particulate pollution and traffic have been linked to myocardial infarction and cardiac death risk. Possible mechanisms include autonomic cardiac dysfunction. METHODS:In a repeated-measures study of 46 patients 43-75 years of age, we investigated associations of central-site ambient particulate po...

journal_title：Environmental health perspectives

authors： Zanobetti A,Gold DR,Stone PH,Suh HH,Schwartz J,Coull BA,Speizer FE

更新日期：2010-03-01 00:00:00

abstract：:Predictions of carcinogenic activity are made for 30 chemicals currently being assessed for rodent carcinogenicity by the U.S. National Toxicology Program. The predictions are based upon the chemical structure, the anticipated or reported mutagenicity, and the reported sub-chronic toxicity of each chemical. It is pred...

journal_title：Environmental health perspectives

authors： Ashby J

更新日期：1996-10-01 00:00:00

abstract：:The relationship between blood pressure and blood lead was examined in two population samples. One of these consisted of 1137 men aged 49 to 65 years, the other of 865 men and 856 women aged 18 to 64 years. Neither population had any known important exposure to lead, and the 95% ranges of blood lead levels were 6 to 2...

journal_title：Environmental health perspectives

authors： Elwood PC,Davey-Smith G,Oldham PD,Toothill C

更新日期：1988-06-01 00:00:00

abstract：:The findings of studies investigating whether exposures to ionizing radiation before birth, either pre- or post-conception, increase the risk of childhood cancer have provoked much scientific controversy. An epidemiological association between the abdominal exposure of pregnant women to diagnostic X-rays and childhood...

journal_title：Environmental health perspectives

authors： Wakeford R

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:We previously demonstrated that among 54 infants in neonatal intensive care units, exposure to polyvinyl chloride plastic medical devices containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) is associated with urinary concentrations of mono(2-ethylhexyl) phthalate (MEHP) , a DEHP metabolite. In this f...

journal_title：Environmental health perspectives

authors： Weuve J,Sánchez BN,Calafat AM,Schettler T,Green RA,Hu H,Hauser R

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals. OBJECTIVES:We used handwipes to estimate exposure to PBDEs in house dust among toddlers and examined sex, age, breast-feeding, race, and parents' education as predictors of serum PBDEs. METHODS:Eight...

journal_title：Environmental health perspectives

authors： Stapleton HM,Eagle S,Sjödin A,Webster TF

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg) may affect fetal growth; however, prior research often lacked assessment of mercury speciation, confounders, and interactions. OBJECTIVE:Our objective was to assess the relationship between MeHg and fetal growth as well as the potential for confounding or interaction of this relationshi...

journal_title：Environmental health perspectives

authors： Wells EM,Herbstman JB,Lin YH,Jarrett J,Verdon CP,Ward C,Caldwell KL,Hibbeln JR,Witter FR,Halden RU,Goldman LR

更新日期：2016-03-01 00:00:00

abstract：:During 1992 and 1993 the Wisconsin Division of Health investigated five cases in which copper-contaminated drinking water was suspected of causing gastrointestinal upsets. Each of these case studies was conducted after our office was notified of high copper levels in drinking water or notified of unexplained illnesses...

journal_title：Environmental health perspectives

authors： Knobeloch L,Ziarnik M,Howard J,Theis B,Farmer D,Anderson H,Proctor M

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Exposure to arsenic via drinking water is a global environmental health problem. In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in early adulthood. OBJECTIVES:We aimed to investigate how arsenic exposu...

journal_title：Environmental health perspectives

authors： Ramsey KA,Bosco A,McKenna KL,Carter KW,Elliot JG,Berry LJ,Sly PD,Larcombe AN,Zosky GR

更新日期：2013-02-01 00:00:00

abstract：:Okadaic acid, dinophysistoxin-1 (35-methylokadaic acid), and calyculin A are the okadaic acid class of non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters, which do not bind to the phorbol ester receptors in cell membranes or activate protein kinase C in vitro. They have potent tumor-promoting activiti...

journal_title：Environmental health perspectives

authors： Fujiki H,Suganuma M,Yoshizawa S,Nishiwaki S,Winyar B,Sugimura T

更新日期：1991-06-01 00:00:00

abstract：:Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to ris...

journal_title：Environmental health perspectives

authors： Thomas RS,Rank DR,Penn SG,Zastrow GM,Hayes KR,Hu T,Pande K,Lewis M,Jovanovich SB,Bradfield CA

更新日期：2002-12-01 00:00:00

abstract：:The susceptibility to arsenic-induced diseases differs greatly between individuals, possibly due to interindividual variations in As metabolism that affect retention and distribution of toxic metabolites. To elucidate the role of genetic factors in As metabolism, we studied how polymorphisms in six genes affected the ...

journal_title：Environmental health perspectives

authors： Schläwicke Engström K,Broberg K,Concha G,Nermell B,Warholm M,Vahter M

更新日期：2007-04-01 00:00:00

abstract：:Background: Drinking water from natural sources in coastal Bangladesh has become contaminated by varying degrees of salinity due to saltwater intrusion from rising sea levels, cyclone and storm surges and upstream withdrawal of freshwater. Objective: Our objective was to estimate salt intake from drinking water source...

journal_title：Environmental health perspectives

authors： Khan AE,Ireson A,Kovats S,Mojumder SK,Khusru A,Rahman A,Vineis P

更新日期：2011-04-12 00:00:00

abstract：:Recent increases have been reported in industrial countries for several sites of cancer. The causes of these increases remain unknown. Efforts should proceed to identify those occupational groups with increases in the same sites, as these may indicate relevant exposures. Two analyses were undertaken: trends in cancer ...

journal_title：Environmental health perspectives

authors： Davis DL,Blair A,Hoel DG

更新日期：1993-04-01 00:00:00

abstract：:In 1976, near Seveso, Italy, an industrial accident caused the release of large quantities of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) into the atmosphere, resulting in the highest levels of the toxicant ever recorded in humans. The contaminated area was divided into three zones (A, B, R) corresponding to decreasing...

journal_title：Environmental health perspectives

authors： Landi MT,Consonni D,Patterson DG Jr,Needham LL,Lucier G,Brambilla P,Cazzaniga MA,Mocarelli P,Pesatori AC,Bertazzi PA,Caporaso NE

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Developmental exposure to polychlorinated biphenyls (PCBs) or methylmercury (MeHg) can result in a variety of neurotoxic effects, including long-term auditory deficits. However, little is known about the effects of combined exposure to PCBs and MeHg on auditory function. OBJECTIVE:We developmentally exposed...

journal_title：Environmental health perspectives

authors： Powers BE,Poon E,Sable HJ,Schantz SL

更新日期：2009-07-01 00:00:00

abstract：:The accumulation of genetic damage in the forms of activated proto-oncogenes and inactivated tumor-suppressor genes is the driving force in the evolution of a normal cell to a malignant cell. For example, both the activation of ras oncogenes and the inactivation of several suppressor genes, including p53, have been ob...

journal_title：Environmental health perspectives

authors： Anderson MW,Reynolds SH,You M,Maronpot RM

更新日期：1992-11-01 00:00:00

abstract：:Whole blood oxygen equilibrium curves (O2 ECs), blood buffer lines, and several hematologic properties were determined for adult guinea pigs exposed to 700 ppm methyl isocyanate (MIC) for 15 min. MIC inhalation effected a significant reduction of blood O2 affinity; the half-saturation pressure (P50) at 38 degrees C in...

journal_title：Environmental health perspectives

authors： Maginniss LA,Szewczak JM,Troup CM

更新日期：1987-06-01 00:00:00

abstract：:Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...

journal_title：Environmental health perspectives

authors： Maier A,Micka J,Miller K,Denko T,Chang CY,Nebert DW,Alvaro Puga

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Industrial air pollution is a public health hazard. Previous evidence documented increased respiratory symptoms and hospitalizations in children who live near the factories in the largest chipboard manufacturing district in Italy (Viadana). OBJECTIVES:We evaluated the association of outdoor exposure to form...

journal_title：Environmental health perspectives

authors： Marcon A,Fracasso ME,Marchetti P,Doria D,Girardi P,Guarda L,Pesce G,Pironi V,Ricci P,de Marco R

更新日期：2014-06-01 00:00:00

abstract：:The timing of some key embryological events is given for man, rat, chick, and certain other animals. Such times, however, are approximations, and variations occur among members of the same strain and even among members of the same litter. Some differences in developmental patterns are indicated. ...

journal_title：Environmental health perspectives

authors： Monie IW

更新日期：1976-12-01 00:00:00