Abstract：
INTRODUCTION:Ambient particulate pollution and traffic have been linked to myocardial infarction and cardiac death risk. Possible mechanisms include autonomic cardiac dysfunction. METHODS:In a repeated-measures study of 46 patients 43-75 years of age, we investigated associations of central-site ambient particulate pollution, including black carbon (BC) (a marker for regional and local traffic), and report of traffic exposure with changes in half-hourly averaged heart rate variability (HRV), a marker of autonomic function measured by 24-hr Holter electrocardiogram monitoring. Each patient was observed up to four times within 1 year after a percutaneous intervention for myocardial infarction, acute coronary syndrome without infarction, or stable coronary artery disease (4,955 half-hour observations). For each half-hour period, diary data defined whether the patient was home or not home, or in traffic. RESULTS:A decrease in high frequency (HF; an HRV marker of vagal tone) of 16.4% [95% confidence interval (CI), 20.7 to 11.8%] was associated with an interquartile range of 0.3-microg/m3 increase in prior 5-day averaged ambient BC. Decreases in HF were independently associated both with the previous 2-hr averaged BC (10.4%; 95% CI, 15.4 to 5.2%) and with being in traffic in the previous 2 hr (38.5%; 95% CI, 57.4 to 11.1%). We also observed independent responses for particulate air matter with aerodynamic diameter < or = 2.5 microm and for gases (ozone or nitrogen dioxide). CONCLUSION:After hospitalization for coronary artery disease, both particulate pollution and being in traffic, a marker of stress and pollution, were associated with decreased HRV.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Zanobetti A,Gold DR,Stone PH,Suh HH,Schwartz J,Coull BA,Speizer FEdoi
10.1289/ehp.0901003subject
Has Abstractpub_date
2010-03-01 00:00:00pages
324-30issue
3eissn
0091-6765issn
1552-9924journal_volume
118pub_type
杂志文章abstract：:The X-ray crystallographic structural determinations of synthetic estrogens and antiestrogens provide reliable information on the global minimum energy conformation of these molecules or a local minimum energy conformation that is within 1 or 2 kcal/mole of the global minimum. In favorable cases, state-of-the-art mole...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.8561111
更新日期：1985-09-01 00:00:00
abstract：:The association between ambient air pollution and adverse health effects, such as emergency room visits, hospitalizations, and mortality from respiratory and cardiovascular diseases, has been studied extensively in many countries, including Canada. Recently, studies conducted in China, the Czech Republic, and the Unit...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.6251
更新日期：2003-11-01 00:00:00
abstract：BACKGROUND:Although adverse effects of high temperature on mortality have been studied extensively in urban areas, little is known of the heat-mortality associations outside of cities. OBJECTIVE:We investigated whether heat-mortality associations differed between urban and nonurban areas and how urbanicity affected th...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP204
更新日期：2016-12-01 00:00:00
abstract：:New technologies and methods for assessing human exposure to chemicals, dietary and lifestyle factors, infectious agents, and other stressors provide an opportunity to extend the range of human health investigations and advance our understanding of the relationship between environmental exposure and disease. An ad hoc...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.7651
更新日期：2005-07-01 00:00:00
abstract：:In recent years there have been a significant number of publications on the benefits and challenges of community-based participatory research (CBPR). In this introduction we give an overview of three projects presented in this mini-monograph and highlight their commonalities and differences in developing community-uni...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.7911
更新日期：2005-12-01 00:00:00
abstract：:Neurobehavioral toxicology is now established as a core discipline of the environmental health sciences. Despite its recognized scientific prowess, stemming from its deep roots in psychology and neuroscience and its acknowledged successes, it faces additional demands and challenges. The latter, in fact, are a product ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.96104s2173
更新日期：1996-04-01 00:00:00
abstract：:Because of its unique geology, Minnesota can be divided into four agricultural regions: south-central region one (corn, soybeans); west-central region two (wheat, corn, soybeans); northwest region three (wheat, sugar beets, potatoes); and northeast region four (forested and urban in character). Cancer mortality (1980-...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.99107205
更新日期：1999-03-01 00:00:00
abstract：:The clinical use of polymeric materials in the body to repair and restore damaged or diseased tissues and organs is substantially increasing on an annual basis. Concomitant with this use is an increase in materials related research on medically used polymers. Information on the historical and current clinical use of p...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.751171
更新日期：1975-06-01 00:00:00
abstract：BACKGROUND:Biomass smoke is an important source of particulate matter (PM), and much remains to be discovered with respect to the human health effects associated with this specific PM source. Exposure to biomass smoke can occur in one of two main categories: short-term exposures consist of periodic, seasonal exposures ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.11378
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Benzene is a common industrial chemical known to induce leukemia and other blood disorders, as well as aneuploidy, in both human blood cells and sperm at exposures > 10 ppm. Recent reports have identified health effects at exposure levels < 1 ppm, the permissible exposure limit (PEL; 8 hr) set by the U.S. Oc...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.0901531
更新日期：2010-06-01 00:00:00
abstract：:Enhanced transport of trace metal in porous media can occur in the presence of a ligand or "carrier" that has a high affinity for binding the pollutant, is dispersed and mobile in the soil environment, is recalcitrant with respect to microbial degradation, and is acceptable to the public. These aspects of the facilita...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.95103s153
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND:Exposure to transportation noise is widespread and has been associated with obesity in some studies. However, the evidence from longitudinal studies is limited and little is known about effects of combined exposure to different noise sources. OBJECTIVES:The aim of this longitudinal study was to estimate the...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP1910
更新日期：2017-11-20 00:00:00
abstract：BACKGROUND:Because of complex interactions of climate variables at the levels of the pathogen, vector, and host, the potential influence of climate change on vector-borne and zoonotic diseases (VBZDs) is poorly understood and difficult to predict. Climate effects on the nonvector-borne zoonotic diseases are especially ...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.0901389
更新日期：2010-11-01 00:00:00
abstract：:The National Center for Health Statistics (NCHS) conducts a variety of surveys designed to provide cross-sectional estimates of the prevalence of various factors measuring the health of Americans. When these cross-sectional estimates are put together and plotted over time, they provide a picture of the trends in the h...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8562267
更新日期：1985-10-01 00:00:00
abstract：:We used real-time monitors and low-volume air samplers to measure the potential human exposure to airborne polycyclic aromatic hydrocarbon (PAH) concentrations during various flight-related and ground-support activities of C-130H aircraft at an Air National Guard base. We used three types of photoelectric aerosol sens...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.00108853
更新日期：2000-09-01 00:00:00
abstract：:The problem of byssinosis has plagued cotton textile mills for hundreds of years, and it is still a problem today. With the regulations on airborne raw cotton dust set by OSHA and the ACGIH, research regarding the measurement of cotton dust in lint fiber is a necessity. A procedure known as the mass concentration part...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8666167
更新日期：1986-04-01 00:00:00
abstract：:Uterine leiomyomas (fibroids, myomas) are the most common tumors occurring in the genital tract of women over 30 years of age. These benign uterine smooth-muscle tumors are estimated to be clinically significant in at least 25% of the American female population during their reproductive years. Furthermore, when thorou...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.00108s5769
更新日期：2000-10-01 00:00:00
abstract：:The hexavalent oxidation state of chromium [Cr(VI)] is a well-established human carcinogen, although the mechanism of cancer induction is currently unknown. Intracellular reduction of Cr(VI) forms Cr(V), which is thought to play a fundamental role in the mechanism of DNA damage by this carcinogen. Two separate pathway...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.02110s5725
更新日期：2002-10-01 00:00:00
abstract：:U.S. chemical plants currently have potentially catastrophic vulnerabilities as terrorist targets. The possible consequences of these vulnerabilities echo from the tragedies of the Bhopal incident in 1984 to the terrorist attacks on 11 September 2001 and, most recently, Hurricanes Katrina and Rita. Findings from a 200...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8762
更新日期：2006-09-01 00:00:00
abstract：OBJECTIVES:We evaluated the association between drinking-water disinfection by-products and preterm births using improved exposure assessment and more appropriate analysis methods than used in prior studies. METHODS:During 1999-2001, vital record data were obtained for a large, racially diverse population residing in ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.9394
更新日期：2007-02-01 00:00:00
abstract：:Bisphenol A (BPA) is the monomer used to manufacture polycarbonate plastic, the resin lining of cans, and other products, with global capacity in excess of 6.4 billion lb/year. Because the ester bonds in these BPA-based polymers are subject to hydrolysis, leaching of BPA has led to widespread human exposure. A recent ...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.7713
更新日期：2005-08-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess whether the joint effects of three androgen receptor antagonists (vinclozolin, flutamide, procymidone) on male sexual differentiation after in utero and postnatal exposures can be predicted based on dose-response data of the individual chemicals. METHODS:Test chemicals and...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.9360
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Exposures to high-dose ionizing radiation and high-dose rate ionizing radiation are established risk factors for childhood acute leukemia (AL). The risk of AL following exposure to lower doses due to natural background radiation (NBR) has yet to be conclusively determined. METHODS:AL cases diagnosed over 19...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP296
更新日期：2017-04-01 00:00:00
abstract：:In this paper we report yields, identities, and mutagenicities of products from heating a polycyclic aromatic hydrocarbon (PAH)-contaminated, Superfund-related synthetic soil matrix without exogenous oxygen. We heated batch samples of soil pretreated with 5.08 wt% (by weight) pyrene in a tubular furnace under a consta...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.00108709
更新日期：2000-08-01 00:00:00
abstract：:Fish and shellfish caught in polluted waters contain potentially dangerous amounts of toxic and carcinogenic chemicals. Public concern was heightened when a large percentage of winter flounder taken from Boston Harbor was found to have visible cancer of the liver; winter flounder outside the estuary area had no liver ...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.90-1519487
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Environmental heat exposure is a public health concern. The impacts of environmental heat on mortality and morbidity at the population scale are well documented, but little is known about specific exposures that individuals experience. OBJECTIVES:The first objective of this work was to catalyze discussion o...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP556
更新日期：2017-08-01 00:00:00
abstract：:The susceptibility to arsenic-induced diseases differs greatly between individuals, possibly due to interindividual variations in As metabolism that affect retention and distribution of toxic metabolites. To elucidate the role of genetic factors in As metabolism, we studied how polymorphisms in six genes affected the ...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.9734
更新日期：2007-04-01 00:00:00
abstract：:This working paper summarizes the known ultrastructural and biochemical effects of lead, mercury, cadmium, and arsenic on subcellular organelle systems following in vivo administration. Documented metal-induced alterations in nuclear, mitochondrial, microsomal, and lysosomal functions are discussed in relation to thei...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.782237
更新日期：1978-02-01 00:00:00
abstract：BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent, bioaccumulative, and endocrine-disrupting chemicals. OBJECTIVES:We used handwipes to estimate exposure to PBDEs in house dust among toddlers and examined sex, age, breast-feeding, race, and parents' education as predictors of serum PBDEs. METHODS:Eight...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1104802
更新日期：2012-07-01 00:00:00
abstract：:A wide range of chemicals with diverse structures derived from plant and environmental origins are reported to have hormonal activity. The potential for appreciable exposure of humans to such substances prompts the need to develop sensitive screening methods to quantitate and evaluate the risk to the public. Yeast cel...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.97105734
更新日期：1997-07-01 00:00:00
