Personalized exposure assessment: promising approaches for human environmental health research.

abstract：BACKGROUND:Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulativ...

journal_title：Environmental health perspectives

authors： Zhang A,Park SK,Wright RO,Weisskopf MG,Mukherjee B,Nie H,Sparrow D,Hu H

更新日期：2010-09-01 00:00:00

abstract：:Ambient monitoring of acid aerosols in four U.S. cities and in a rural region of southern Ontario clearly show distinct periods of strong acidity. Measurements made in Kingston, TN, and Steubenville, OH, resulted in 24-hr H+ ion concentrations exceeding 100 nmole/m3 more than 10 times during summer months. Periods of ...

journal_title：Environmental health perspectives

authors： Spengler JD,Keeler GJ,Koutrakis P,Ryan PB,Raizenne M,Franklin CA

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Pterygium is a fibrovascular growth of the bulbar conjunctiva and underlying subconjunctival tissue that may cause blindness. The mechanism of pterygium formation is not yet fully understood, but pterygium has some tumorlike features. OBJECTIVES:The objective of this study was to evaluate the association be...

journal_title：Environmental health perspectives

authors： Lin W,Wang SL,Wu HJ,Chang KH,Yeh P,Chen CJ,Guo HR

更新日期：2008-07-01 00:00:00

abstract：:Cytotoxic chemicals have in common the ability to act specifically on cells in cycle. Bacteria are more sensitive in the exponential growth phase than when growing slowly in media. Similar observations have been made on a variety of systems ranging from bacteria, yeast, higher plants and invertebrates to vertebrates i...

journal_title：Environmental health perspectives

authors： Harbison RD

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:Environmental heat exposure is a public health concern. The impacts of environmental heat on mortality and morbidity at the population scale are well documented, but little is known about specific exposures that individuals experience. OBJECTIVES:The first objective of this work was to catalyze discussion o...

journal_title：Environmental health perspectives

authors： Kuras ER,Richardson MB,Calkins MM,Ebi KL,Hess JJ,Kintziger KW,Jagger MA,Middel A,Scott AA,Spector JT,Uejio CK,Vanos JK,Zaitchik BF,Gohlke JM,Hondula DM

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Decision analysis-a systematic approach to solving complex problems-offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and...

journal_title：Environmental health perspectives

authors： Malloy TF,Zaunbrecher VM,Batteate CM,Blake A,Carroll WF Jr,Corbett CJ,Hansen SF,Lempert RJ,Linkov I,McFadden R,Moran KD,Olivetti E,Ostrom NK,Romero M,Schoenung JM,Seager TP,Sinsheimer P,Thayer KA

更新日期：2017-06-13 00:00:00

abstract：:Differences in genetic susceptibility to hazardous chemicals affect individuals of both human and nonhuman populations. In both cases, differences in response to chemicals or general ill health result as a function of these differences in genetic susceptibility. However, ecological systems are a compilation of hundred...

journal_title：Environmental health perspectives

authors： Burger J

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent. OBJECTIVES:We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general popula...

journal_title：Environmental health perspectives

authors： Lassen TH,Frederiksen H,Jensen TK,Petersen JH,Joensen UN,Main KM,Skakkebaek NE,Juul A,Jørgensen N,Andersson AM

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:The World Health Organization is the agency responsible for reporting the Millennium Development Goal (MDG) indicator "percentage of population using solid fuels." In this article, we present the results of a comprehensive assessment of solid fuel use, conducted in 2005, and discuss the implications of our fi...

journal_title：Environmental health perspectives

authors： Rehfuess E,Mehta S,Prüss-Ustün A

更新日期：2006-03-01 00:00:00

abstract：:The destruction of the World Trade Center (WTC) on 11 September 2001 in New York City resulted in the massive release of pulverized dust and combustion products. The dust and smoke settled in the surrounding area, which encompassed a large residential community. We hypothesized that previously normal residents in the ...

journal_title：Environmental health perspectives

authors： Reibman J,Lin S,Hwang SA,Gulati M,Bowers JA,Rogers L,Berger KI,Hoerning A,Gomez M,Fitzgerald EF

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted loci of mouse blood cells. To date, no data has be...

journal_title：Environmental health perspectives

authors： Li Z,Lyu C,Ren Y,Wang H

更新日期：2020-02-01 00:00:00

abstract：:For workers in the nuclear industry, the primary route for the entry of radioactive materials into the body is by inhalation, and the rate of clearance of particles from the pulmonary region of the lung is an important factor in determining radiation dose. It is the function of alveolar macrophages (AM) to maintain th...

journal_title：Environmental health perspectives

authors： Kellington JP,Gibson K,Buckle TM,Talbot RJ,Hornby SB

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Green spaces have been associated with both health benefits and risks in children; however, available evidence simultaneously investigating these conflicting influences, especially in association with different types of greenness, is scarce. OBJECTIVES:We aimed to simultaneously evaluate health benefits and...

journal_title：Environmental health perspectives

authors： Dadvand P,Villanueva CM,Font-Ribera L,Martinez D,Basagaña X,Belmonte J,Vrijheid M,Gražulevičienė R,Kogevinas M,Nieuwenhuijsen MJ

更新日期：2014-12-01 00:00:00

abstract：:Male reproduction has been given little attention in science and in medical practice. However, a recent metaanalysis on semen quality, which clearly pointed to a decrease over the past 50 years, has been repeatedly quoted. Three recent reports have found that semen quality has declined among candidate semen donors dur...

journal_title：Environmental health perspectives

authors： Carlsen E,Giwercman A,Keiding N,Skakkebaek NE

更新日期：1995-10-01 00:00:00

abstract：:The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) has highly pleiotropic effects on cells in culture and on tissues in vivo, including effects on protein kinase C (PKC) activation and gene expression. In order to determine the mechanism of activation of gene transcription by TPA, DNA sequences whose transc...

journal_title：Environmental health perspectives

authors： Johnson MD,Housey GM,O'Brian CA,Kirschmeier PT,Weinstein IB

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Few studies have been conducted to identify risk factors for balance and vestibular dysfunction in general populations, but previous studies have reported evidence of adverse effects of lead and cadmium on balance control in high-risk groups. OBJECTIVE:We evaluated the relationship between blood lead and ca...

journal_title：Environmental health perspectives

authors： Min KB,Lee KJ,Park JB,Min JY

更新日期：2012-03-01 00:00:00

abstract：:The assessment of mixture effects of estrogenic agents is regarded as an issue of high priority by many governmental agencies and expert decision-making bodies all over the world. However, the few mixture studies published so far have suffered from conceptual and experimental problems and are considered to be inconclu...

journal_title：Environmental health perspectives

authors： Payne J,Rajapakse N,Wilkins M,Kortenkamp A

更新日期：2000-10-01 00:00:00

abstract：:Basophilic hepatic foci, nodules, and trabecular hepatocellular carcinomas, collectively referred to as focal hepatic lesions, were induced by single injections of 5.0 micrograms of diethylnitrosamine (DEN) per gram body weight in 15-day-old C57BL/6J X C3HeB/FeJ F1 (B6C3 F1) mice. Groups of eight experimental and eigh...

journal_title：Environmental health perspectives

authors： Goldfarb S,Pugh TD,Koen H,He YZ

更新日期：1983-04-01 00:00:00

abstract：:A brief description of chromosome aberrations and sister chromatid exchange (SCE) as cytogenetic endpoints for evaluation of DNA damaging agents is presented. Problems associated with the use of cytogenetic assays as population monitors of radiation and chemical exposures are discussed. Adequate cell sample size requi...

journal_title：Environmental health perspectives

authors： Conner MK,Wald N

更新日期：1981-12-01 00:00:00

abstract：:In an earlier study we established that timely and adequate tissue repair response following the administration of a six-fold dose-range of thioacetamide (TA; 50, 150, and 300 mg/kg) prevented progression of injury and led to recovery and animal survival. Delayed and attenuated repair response after the 600 mg/kg TA d...

journal_title：Environmental health perspectives

authors： Mangipudy RS,Rao PS,Mehendale HM

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. OBJECTIVE:We evaluated the lifetime use of individual pesticides an...

journal_title：Environmental health perspectives

authors： Andreotti G,Beane Freeman LE,Shearer JJ,Lerro CC,Koutros S,Parks CG,Blair A,Lynch CF,Lubin JH,Sandler DP,Hofmann JN

更新日期：2020-06-01 00:00:00

abstract：:Metallothionein from livers of mice was isolated by gel chromatography and isoelectric focusing. One of two forms thus obtained contained 32 percent cysteine. This form, labeled in vitro with 109Cd, was injected intravenously in mice, and the distribution of 109Cd was studied. Animals killed after 4 hrs had over 80 pe...

journal_title：Environmental health perspectives

authors： Nordberg M,Nordberg GF

更新日期：1975-12-01 00:00:00

abstract：:In this study, we aimed to estimate the contribution of environmental pollutants to the incidence, prevalence, mortality, and costs of pediatric disease in American children. We examined four categories of illness: lead poisoning, asthma, cancer, and neurobehavioral disorders. To estimate the proportion of each attrib...

journal_title：Environmental health perspectives

authors： Landrigan PJ,Schechter CB,Lipton JM,Fahs MC,Schwartz J

更新日期：2002-07-01 00:00:00

abstract：:Toxicity testing in AS52 cells (24-hr exposures) gave LC50 values of 2 to 130 micrograms Ni/ml for particulate nickel compounds and 45 to 60 micrograms Ni/ml for water-soluble salts (NiCl2, NiSO4, Ni(CH3COO)2). The Ni(OH)2, NiCO3, and sulfides (Ni3S2, Ni7S6, "amorphous NiS") exhibited similar toxicities (LC50's of 2 t...

journal_title：Environmental health perspectives

authors： Fletcher GG,Rossetto FE,Turnbull JD,Nieboer E

更新日期：1994-09-01 00:00:00

abstract：:In this study we investigated the potential impact of climate change in Portugal on heat-related mortality, air pollution-related health effects, and selected vectorborne diseases. The assessment used climate scenarios from two regional climate models for a range of future time periods. The annual heat-related death r...

journal_title：Environmental health perspectives

authors： Casimiro E,Calheiros J,Santos FD,Kovats S

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. OBJECTIVE:We examined 42 Faroese whaling men (30-70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whal...

journal_title：Environmental health perspectives

authors： Choi AL,Weihe P,Budtz-Jørgensen E,Jørgensen PJ,Salonen JT,Tuomainen TP,Murata K,Nielsen HP,Petersen MS,Askham J,Grandjean P

更新日期：2009-03-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH-DNA adducts, or BaP-DNA adducts as their proxy, provide a measure of chemical-specific genetic dama...

journal_title：Environmental health perspectives

authors： Perera FP,Tang D,Rauh V,Lester K,Tsai WY,Tu YH,Weiss L,Hoepner L,King J,Del Priore G,Lederman SA

更新日期：2005-08-01 00:00:00

abstract：:Exposure to aflatoxin B1 (AFB1), an important cofactor in the etiology of hepatocellular carcinoma in Taiwan, is influenced by dietary and other factors. The present study examined the intraindividual variability in AFB1-albumin adducts, the most reliable long-term biomarker of AFB1 exposure, and whether the baseline ...

journal_title：Environmental health perspectives

authors： Ahsan H,Wang LY,Chen CJ,Tsai WY,Santella RM

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:The etiologies of the male urogenital anomalies hypospadias and cryptorchidism remain unclear. It has been suggested that maternal diet and environmental contaminants may affect the risk of these anomalies via placental or hormonal disturbances. OBJECTIVES:We examined associations between organic food consu...

journal_title：Environmental health perspectives

authors： Brantsæter AL,Torjusen H,Meltzer HM,Papadopoulou E,Hoppin JA,Alexander J,Lieblein G,Roos G,Holten JM,Swartz J,Haugen M

更新日期：2016-03-01 00:00:00

abstract：:Alveolar macrophages were treated with carbon blacks and adsorbates in order to evaluate the biologic effect of adsorbate, adsorbent and adsorbate-adsorbent complexes. Their capacity to phagocytize a subsequent challenge via the Fc-membrane receptor was quantified. Phagocytosis was suppressed in a dose-related manner ...

journal_title：Environmental health perspectives

authors： Jakab GJ,Risby TH,Sehnert SS,Hmieleski RR,Farrington JE

更新日期：1990-06-01 00:00:00