HFE H63D polymorphism as a modifier of the effect of cumulative lead exposure on pulse pressure: the Normative Aging Study.

abstract：:Embryonal carcinoma (EC) cells offer an interesting model system for evaluating differentiation because the cells are pluripotent, thus resembling germ cells and embryonic stem cells, and because a number of agents have been defined that are capable of promoting the differentiation of these cells. This chapter examine...

journal_title：Environmental health perspectives

authors： Astigiano S,Sherman MI,Abarzúa P

更新日期：1989-03-01 00:00:00

abstract：:Lead is a male reproductive toxicant. Data suggest that rats dosed with relatively high levels of lead acetate for short periods of time induced changes in the hypothalamic gonadotropin-releasing hormone (GnRH) at the molecular level, but these changes were attenuated with increased concentration of exposure. The curr...

journal_title：Environmental health perspectives

authors： Sokol RZ,Wang S,Wan YJ,Stanczyk FZ,Gentzschein E,Chapin RE

更新日期：2002-09-01 00:00:00

abstract：:We evaluated the effect of chronic exposure to dioxin and dioxin-like compounds on the pancreas in female Harlan Sprague-Dawley rats. This investigation represents part of an ongoing National Toxicology Program initiative to determine the relative potency of chronic toxicity and carcinogenicity of polychlorinated diox...

journal_title：Environmental health perspectives

authors： Nyska A,Jokinen MP,Brix AE,Sells DM,Wyde ME,Orzech D,Haseman JK,Flake G,Walker NJ

更新日期：2004-06-01 00:00:00

abstract：:Under a cooperative agreement between New York University and the Environmental Protection Agency, and in collaboration with the University of Sao Paulo (USP), a study is ongoing in Cubatao, Brazil, to try to establish exposure-response relationships on the impact of specific industrial effluents on respiratory functi...

journal_title：Environmental health perspectives

authors： Spektor DM,Hofmeister VA,Artaxo P,Brague JA,Echelar F,Nogueira DP,Hayes C,Thurston GD,Lippmann M

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Bacterial meningitis causes a high burden of disease in the African meningitis belt, with regular seasonal hyperendemicity and sporadic short, but intense, localized epidemics during the late dry season occurring at a small spatial scale [i.e., below the district level, in individual health centers (HCs)]. I...

journal_title：Environmental health perspectives

authors： Woringer M,Martiny N,Porgho S,Bicaba BW,Bar-Hen A,Mueller JE

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. OBJECTIVE:We evaluated the lifetime use of individual pesticides an...

journal_title：Environmental health perspectives

authors： Andreotti G,Beane Freeman LE,Shearer JJ,Lerro CC,Koutros S,Parks CG,Blair A,Lynch CF,Lubin JH,Sandler DP,Hofmann JN

更新日期：2020-06-01 00:00:00

abstract：:Previously, we found that exposure of neonatal rats to chlorpyrifos (CPF) produced brain cell damage and loss, with resultant abnormalities of synaptic development. We used the same biomarkers to examine prenatal CPF treatment so as to define the critical period of vulnerability. One group of pregnant rats received CP...

journal_title：Environmental health perspectives

authors： Qiao D,Seidler FJ,Padilla S,Slotkin TA

更新日期：2002-11-01 00:00:00

abstract：:Isoflavonoids and related compounds such as coumestrol have classically been categorized as phytoestrogens because these environmentally derived substances bind to the estrogen receptor (ER) and increase uterine wet weight in immature rats and mice. Assessment of the binding affinities of isoflavonoids for ER and subs...

journal_title：Environmental health perspectives

authors： Markaverich BM,Webb B,Densmore CL,Gregory RR

更新日期：1995-06-01 00:00:00

abstract：:Implementation of the Toxic Substances Control Act of 1977 creates the need to reliably establish testing priorities because laboratory resources are limited and the number of industrial chemicals requiring evaluation is overwhelming. The use of quantitative structure activity relationship (QSAR) models as rapid and p...

journal_title：Environmental health perspectives

authors： McKim JM,Bradbury SP,Niemi GJ

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health. OBJECTIVES:We studied the association of air pollution exposure during pregnancy and the first year of life with respiratory illnesses, ear infections, and eczema during the first 12-18 months of a...

journal_title：Environmental health perspectives

authors： Aguilera I,Pedersen M,Garcia-Esteban R,Ballester F,Basterrechea M,Esplugues A,Fernández-Somoano A,Lertxundi A,Tardón A,Sunyer J

更新日期：2013-03-01 00:00:00

abstract：:Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between carbaryl exposure and decreased semen quality. In the present study we explored whether environmental exposures to 1...

journal_title：Environmental health perspectives

authors： Meeker JD,Ryan L,Barr DB,Herrick RF,Bennett DH,Bravo R,Hauser R

更新日期：2004-12-01 00:00:00

abstract：:We present a model of the distribution of noise annoyance with the mean varying as a function of the noise exposure. Day-night level (DNL) and day-evening-night level (DENL) were used as noise descriptors. Because the entire annoyance distribution has been modeled, any annoyance measure that summarizes this distributi...

journal_title：Environmental health perspectives

authors： Miedema HM,Oudshoorn CG

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Evidence suggests that cardiovascular effects of air pollution are mediated by inflammation and that air pollution can induce genetic expression of the interleukin-6 gene (IL6). OBJECTIVES:We investigated whether IL6 and fibrinogen gene variants can affect plasma IL-6 responses to air pollution in patients ...

journal_title：Environmental health perspectives

authors： Ljungman P,Bellander T,Schneider A,Breitner S,Forastiere F,Hampel R,Illig T,Jacquemin B,Katsouyanni K,von Klot S,Koenig W,Lanki T,Nyberg F,Pekkanen J,Pistelli R,Pitsavos C,Rosenqvist M,Sunyer J,Peters A

更新日期：2009-09-01 00:00:00

abstract：:Male reproduction has been given little attention in science and in medical practice. However, a recent metaanalysis on semen quality, which clearly pointed to a decrease over the past 50 years, has been repeatedly quoted. Three recent reports have found that semen quality has declined among candidate semen donors dur...

journal_title：Environmental health perspectives

authors： Carlsen E,Giwercman A,Keiding N,Skakkebaek NE

更新日期：1995-10-01 00:00:00

abstract：:The type II cell plays an important role in the response of the alveolar epithelium after lung injury through its synthesis and secretion of pulmonary surfactant, and by acting as the stem cell for the replacement of damaged type I epithelial cells. The nonciliated bronchiolar epithelial (Clara) cell is thought to pla...

journal_title：Environmental health perspectives

authors： Finkelstein JN,Johnston C,Barrett T,Oberdörster G

更新日期：1997-09-01 00:00:00

abstract：:Previous occupational cohort studies of benzene-exposed workers have for the most part used only death certificates to validate diagnoses of workers developing leukemia and other hematopoietic and lymphoproliferative malignancies and related disorders (HLD). In a follow-up study of 74,828 benzene-exposed workers and a...

journal_title：Environmental health perspectives

authors： Linet MS,Yin SN,Travis LB,Li CY,Zhang ZN,Li DG,Rothman N,Li GL,Chow WH,Donaldson J,Dosemeci M,Wacholder S,Blot WJ,Hayes RB

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Prostaglandins (PGs) play key roles in development and maintenance of homeostasis of the adult body. Despite these important roles, it remains unclear whether the PG pathway is a target for endocrine disruption. However, several known endocrine-disrupting compounds (EDCs) share a high degree of structural si...

journal_title：Environmental health perspectives

authors： Kristensen DM,Skalkam ML,Audouze K,Lesné L,Desdoits-Lethimonier C,Frederiksen H,Brunak S,Skakkebæk NE,Jégou B,Hansen JB,Junker S,Leffers H

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Perfluoroalkyl acids are persistent compounds used in various industrial -applications. Of these compounds, perfluorooctanoate (PFOA) is currently detected in humans worldwide. A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in ...

journal_title：Environmental health perspectives

authors： Halldorsson TI,Rytter D,Haug LS,Bech BH,Danielsen I,Becher G,Henriksen TB,Olsen SF

更新日期：2012-05-01 00:00:00

abstract：:We previously reported that cell cultures of human proximal tubule (HPT) cells respond to ionic cadmium in a manner consistent with well-defined Cd(2+)-elicited responses reported for in vivo systems. However, one unique finding was that the transepithelial electrical resistance and tight junction sealing strands were...

journal_title：Environmental health perspectives

authors： Hazen-Martin DJ,Todd JH,Sens MA,Khan W,Bylander JE,Smyth BJ,Sens DA

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Endocrine disrupting chemicals (EDCs) are xenobiotics that mimic the interaction of natural hormones and alter synthesis, transport, or metabolic pathways. The prospect of EDCs causing adverse health effects in humans and wildlife has led to the development of scientific and regulatory approaches for evaluat...

journal_title：Environmental health perspectives

authors： Mansouri K,Kleinstreuer N,Abdelaziz AM,Alberga D,Alves VM,Andersson PL,Andrade CH,Bai F,Balabin I,Ballabio D,Benfenati E,Bhhatarai B,Boyer S,Chen J,Consonni V,Farag S,Fourches D,García-Sosa AT,Gramatica P,Grisoni F

更新日期：2020-02-01 00:00:00

abstract：:This study assessed whether exposure of male rats to two estrogenic, environmental chemicals, 4-octylphenol (OP) and butyl benzyl phthalate (BBP) during gestation or during the first 21 days of postnatal life, affected testicular size or spermatogenesis in adulthood (90-95 days of age). Chemicals were administered via...

journal_title：Environmental health perspectives

authors： Sharpe RM,Fisher JS,Millar MM,Jobling S,Sumpter JP

更新日期：1995-12-01 00:00:00

abstract：:This paper will briefly outline those elements which must be considered in assessing the effects of any given compound which might impinge on the actions of adrenocortical steroids. Considerations that ought to be taken into account include the following: the delivery to the affected cells of corticosteroids, the upta...

journal_title：Environmental health perspectives

authors： Thompson EB

更新日期：1981-04-01 00:00:00

abstract：:A brief history of the development of the field of aquatic toxicology is provided. In order to provide a perspective on the state-of-the-art in aquatic toxicology relative to classical toxicology, the two fields are compared from the standpoint of the type of scientist practicing each field, the respective objectives ...

journal_title：Environmental health perspectives

authors： Macek KJ

更新日期：1980-02-01 00:00:00

abstract：:The carcinogenic activities of sodium chlorite in B6C3F1 mice were examined. Sodium chlorite was given at concentrations of 0 (control), 0.025% (low dose), or 0.05% (high dose) in the drinking water of 150 female and 150 male mice for 80 weeks, after which time the animals were returned to distilled water without sodi...

journal_title：Environmental health perspectives

authors： Yokose Y,Uchida K,Nakae D,Shiraiwa K,Yamamoto K,Konishi Y

更新日期：1987-12-01 00:00:00

abstract：:The subchronic inhalation toxicology of ethylene glycol monoethyl ether (EGEE) was evaluated in rats and rabbits using a 13-week exposure regimen. Groups of 20 rabbits (10 M, 10 F) and 30 rats (15 M, 15 F) were exposed to a vapor of 25 ppm, 100 ppm, or 400 ppm, 6 hr/day, 5 days/week. The control groups received air on...

journal_title：Environmental health perspectives

authors： Barbee SJ,Terrill JB,DeSousa DJ,Conaway CC

更新日期：1984-08-01 00:00:00

abstract：:The U.S. Environmental Protection Agency is under a congressional mandate to revise its current standard for arsenic in drinking water. We present a risk assessment for cancers of the bladder, liver, and lung from exposure to arsenic in water, based on data from 42 villages in an arseniasis-endemic region of Taiwan. W...

journal_title：Environmental health perspectives

authors： Morales KH,Ryan L,Kuo TL,Wu MM,Chen CJ

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Endocrine-disrupting chemicals have been shown to have broad effects on development, but their mutagenic actions that can lead to cancer have been less clearly demonstrated. Physiological levels of estrogen have been shown to stimulate DNA damage in breast epithelial cells through mechanisms mediated by estr...

journal_title：Environmental health perspectives

authors： Majhi PD,Sharma A,Roberts AL,Daniele E,Majewski AR,Chuong LM,Black AL,Vandenberg LN,Schneider SS,Dunphy KA,Jerry DJ

更新日期：2020-01-01 00:00:00

abstract：:An increased gastrointestinal cancer risk is associated with occupational exposure to asbestos fiber. Examination of tissues obtained from extrapulmonary organs of exposed workmen demonstrates the presence of asbestos fibers and bodies. The amount of fiber present in these tissues is many magnitudes less than encounte...

journal_title：Environmental health perspectives

authors： Langer AM

更新日期：1974-12-01 00:00:00

abstract：BACKGROUND:Human exposure to inorganic arsenic (iAs), a potent oxidative stressor, causes various dermal disorders, including hyperkeratosis and skin cancer. Nuclear factor-erythroid 2-related factor 1 (NRF1, also called NFE2L1) plays a critical role in regulating the expression of many antioxidant response element (AR...

journal_title：Environmental health perspectives

authors： Zhao R,Hou Y,Xue P,Woods CG,Fu J,Feng B,Guan D,Sun G,Chan JY,Waalkes MP,Andersen ME,Pi J

更新日期：2011-01-01 00:00:00

abstract：:Studies of structure-activity relationships and molecular mechanisms of action are fundamental to our understanding of the harmful effects of chemicals on the environment and their more direct effects on human health. It is important to identify factors that determine toxicological effects of foreign chemicals in biol...

journal_title：Environmental health perspectives

authors： McKinney JD

更新日期：1985-09-01 00:00:00