Effects of heavy industrial pollution on respiratory function in the children of Cubatao, Brazil: a preliminary report.

Abstract:

:Under a cooperative agreement between New York University and the Environmental Protection Agency, and in collaboration with the University of Sao Paulo (USP), a study is ongoing in Cubatao, Brazil, to try to establish exposure-response relationships on the impact of specific industrial effluents on respiratory function in school-age children. Cubatao, located on the coast about 44 km from the city of Sao Paulo, is surrounded by U-shaped mountains (approximately 800 m) covered with subtropical forests. Its area is approximately 160 km2, and it has a population of approximately 90,000. The geography is such that it causes a consistent diurnal land-sea breeze pattern and the opposite during the night, with low dispersion of the air pollutants. In a small area (approximately 40 km2) against the mountains there is a concentration of over 20 large plants: oil refinery; iron and steel mill; fertilizer, cement, and gypsum production; coke kilns; and chemical, paint, and many other ancillary plants. During the 1988 school year, March through June, August through November, 600 six-year-old children, attending six different kindergarten schools, underwent monthly spirometry tests. Because the children live within a 500 m radius of their school, pollution monitors were located on each of the six schools. Particles were collected using dichotomous stacked filter units placed on 20 m towers to reduce the influence of dust from unpaved roads. The units use different pore size filters for coarse, 2 to 10 microns, and fine particles, (dp) less than 2 microns, and took separate samples for day and nighttime.(ABSTRACT TRUNCATED AT 250 WORDS)

authors

Spektor DM,Hofmeister VA,Artaxo P,Brague JA,Echelar F,Nogueira DP,Hayes C,Thurston GD,Lippmann M

doi

10.1289/ehp.94-1567962

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

51-4

eissn

0091-6765

issn

1552-9924

journal_volume

94

pub_type

杂志文章
  • Inhaled environmental/occupational irritants and allergens: mechanisms of cardiovascular and systemic responses. Introduction.

    abstract::The articles in this monograph focus on the mechanisms whereby ambient particulate matter (PM) and co-pollutants deposited in the respiratory tract cause cardiovascular and systemic effects, especially in persons with preexisting conditions such as allergic hyperresponsiveness and pulmonary, cardiac, and vascular dise...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.01109s4479

    authors: Yeates DB,Mauderly JL

    更新日期:2001-08-01 00:00:00

  • New tricks for an old assay.

    abstract::For decades, a number of guinea pig tests have been used to identify human contact allergens in workplace and consumer products, but these tests have limitations. In addition to using large numbers of test animals, they also provide only subjective measurements, because the allergic activity is measured by watching th...

    journal_title:Environmental health perspectives

    pub_type: 新闻

    doi:10.1289/ehp.98106a488

    authors: Clay R

    更新日期:1998-10-01 00:00:00

  • Epidemiologic studies of environmental agents and systemic autoimmune diseases.

    abstract::Systemic lupus erythematosus and systemic scleroderma are autoimmune diseases thought to have an exogenous trigger. This review summarizes relevant case-control and cohort studies that investigated exogenous sex hormones, silica, silicone, solvents, pesticides, mercuric chloride, and hair dyes as putative risk factors...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.99107s5743

    authors: Mayes MD

    更新日期:1999-10-01 00:00:00

  • Cord Blood Methylmercury and Fetal Growth Outcomes in Baltimore Newborns: Potential Confounding and Effect Modification by Omega-3 Fatty Acids, Selenium, and Sex.

    abstract:BACKGROUND:Methylmercury (MeHg) may affect fetal growth; however, prior research often lacked assessment of mercury speciation, confounders, and interactions. OBJECTIVE:Our objective was to assess the relationship between MeHg and fetal growth as well as the potential for confounding or interaction of this relationshi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1408596

    authors: Wells EM,Herbstman JB,Lin YH,Jarrett J,Verdon CP,Ward C,Caldwell KL,Hibbeln JR,Witter FR,Halden RU,Goldman LR

    更新日期:2016-03-01 00:00:00

  • Long-term Fine Particulate Matter Exposure and Nonaccidental and Cause-specific Mortality in a Large National Cohort of Chinese Men.

    abstract:BACKGROUND:Cohort studies in North America and western Europe have reported increased risk of mortality associated with long-term exposure to fine particles (PM2.5), but to date, no such studies have been reported in China, where higher levels of exposure are experienced. OBJECTIVES:We estimated the association betwee...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP1673

    authors: Yin P,Brauer M,Cohen A,Burnett RT,Liu J,Liu Y,Liang R,Wang W,Qi J,Wang L,Zhou M

    更新日期:2017-11-07 00:00:00

  • Prevalence and determinants of lead intoxication in Mexican children of low socioeconomic status.

    abstract::This paper reports on the prevalence of lead poisoning in children between 1 and 5 years of age living in a marginal area to the north of Mexico City and also includes an evaluation of sources of exposure to this metal in the same area. The results show that 67.5% of the children studied have blood lead (PbB) levels >...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.104-1469505

    authors: López-Carrillo L,Torres-Sánchez L,Garrido F,Papaqui-Hernández J,Palazuelos-Rendón E,López-Cervantes M

    更新日期:1996-11-01 00:00:00

  • Associations between organochlorine contaminant concentrations and clinical health parameters in loggerhead sea turtles from North Carolina, USA.

    abstract::Widespread and persistent organochlorine (OC) contaminants, such as polychlorinated biphenyls (PCBs) and pesticides, are known to have broad-ranging toxicities in wildlife. In this study we investigated, for the first time, their possible health effects on loggerhead sea turtles (Caretta caretta). Nonlethal fat biopsi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6923

    authors: Keller JM,Kucklick JR,Stamper MA,Harms CA,McClellan-Green PD

    更新日期:2004-07-01 00:00:00

  • Endocrine-disrupting chemicals and climate change: A worst-case combination for arctic marine mammals and seabirds?

    abstract::The effects of global change on biodiversity and ecosystem functioning encompass multiple complex dynamic processes. Climate change and exposure to endocrine-disrupting chemicals (EDCs) are currently regarded as two of the most serious anthropogenic threats to biodiversity and ecosystems. We should, therefore, be espe...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.8057

    authors: Jenssen BM

    更新日期:2006-04-01 00:00:00

  • Using metal-ligand binding characteristics to predict metal toxicity: quantitative ion character-activity relationships (QICARs).

    abstract::Ecological risk assessment can be enhanced with predictive models for metal toxicity. Modelings of published data were done under the simplifying assumption that intermetal trends in toxicity reflect relative metal-ligand complex stabilities. This idea has been invoked successfully since 1904 but has yet to be applied...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.98106s61419

    authors: Newman MC,McCloskey JT,Tatara CP

    更新日期:1998-12-01 00:00:00

  • Respiratory involvement and immune status in yusho patients.

    abstract::Clinical and experimental studies on respiratory involvement and alterations in immune status were carried out. Respiratory distress occurring in these patients has improved gradually for 14 years but still remains. Copious expectoration at an early stage of the disease may be related to the fact that a number of disc...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.59-1568074

    authors: Nakanishi Y,Shigematsu N,Kurita Y,Matsuba K,Kanegae H,Ishimaru S,Kawazoe Y

    更新日期:1985-02-01 00:00:00

  • Mutagenic and carcinogenic properties of polycyclic aromatic hydrocarbons.

    abstract::The rapid development of the chemical industry, combustion of fossil fuels, and smoking of tobacco have resulted in contact of the general population with benzo(a)pyrene and other carcinogenic aromatic hydrocarbons. Persons especially at risk occupationally are those engaged in thermal processing of oil shale, coal, a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7930185

    authors: Pashin YV,Bakhitova LM

    更新日期:1979-06-01 00:00:00

  • Workshop on perinatal exposure to dioxin-like compounds. V. Immunologic effects.

    abstract::The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compou...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.95103s2157

    authors: Birnbaum LS

    更新日期:1995-03-01 00:00:00

  • Age as a function in the development of sodium-related hypertension.

    abstract::The populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. Hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.792935

    authors: Tuthill RW,Calabrese EJ

    更新日期:1979-04-01 00:00:00

  • The molecular basis of chemical toxicity.

    abstract::Studies of structure-activity relationships and molecular mechanisms of action are fundamental to our understanding of the harmful effects of chemicals on the environment and their more direct effects on human health. It is important to identify factors that determine toxicological effects of foreign chemicals in biol...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.85615

    authors: McKinney JD

    更新日期:1985-09-01 00:00:00

  • Hemopoietic stem cells: stochastic differentiation and humoral control of proliferation.

    abstract::The central feature of hemopoiesis is life-long, stable cell renewal. This process is supported by hemopoietic stem cells which, in the steady state, appear to be dormant in cell cycling. The entry into cell cycle of the dormant stem cells may be promoted by such factors as interleukin-1, interleukin-6 (IL-6), and gra...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.8980199

    authors: Ogawa M

    更新日期:1989-03-01 00:00:00

  • Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study.

    abstract:BACKGROUND:The relationship of fine particulate matter < 2.5 microm in diameter (PM(2.5)) air pollution with mortality and cardiovascular disease is well established, with more recent long-term studies reporting larger effect sizes than earlier long-term studies. Some studies have suggested the coarse fraction, particl...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0900572

    authors: Puett RC,Hart JE,Yanosky JD,Paciorek C,Schwartz J,Suh H,Speizer FE,Laden F

    更新日期:2009-11-01 00:00:00

  • High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.

    abstract::Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breas...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.6220

    authors: Petreas M,She J,Brown FR,Winkler J,Windham G,Rogers E,Zhao G,Bhatia R,Charles MJ

    更新日期:2003-07-01 00:00:00

  • Comparative development of the nervous, respiratory, and cardiovascular systems.

    abstract::The timing of some key embryological events is given for man, rat, chick, and certain other animals. Such times, however, are approximations, and variations occur among members of the same strain and even among members of the same litter. Some differences in developmental patterns are indicated. ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.761855

    authors: Monie IW

    更新日期:1976-12-01 00:00:00

  • Weather variability, tides, and Barmah Forest virus disease in the Gladstone region, Australia.

    abstract::In this study we examined the impact of weather variability and tides on the transmission of Barmah Forest virus (BFV) disease and developed a weather-based forecasting model for BFV disease in the Gladstone region, Australia. We used seasonal autoregressive integrated moving-average (SARIMA) models to determine the c...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8568

    authors: Naish S,Hu W,Nicholls N,Mackenzie JS,McMichael AJ,Dale P,Tong S

    更新日期:2006-05-01 00:00:00

  • Changes in pest infestation levels, self-reported pesticide use, and permethrin exposure during pregnancy after the 2000-2001 U.S. Environmental Protection Agency restriction of organophosphates.

    abstract:BACKGROUND:Widespread residential pesticide use throughout the United States has resulted in ubiquitous, low-level pesticide exposure. The mix of active pesticide ingredients is changing in response to 2000-2001 regulations restricting use of the organophosphorus insecticides chlorpyrifos and diazinon. OBJECTIVES:We a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.11367

    authors: Williams MK,Rundle A,Holmes D,Reyes M,Hoepner LA,Barr DB,Camann DE,Perera FP,Whyatt RM

    更新日期:2008-12-01 00:00:00

  • Comparative mammalian metabolism of vinyl chloride and vinylidene chloride in relation to oncogenic potential.

    abstract::Elucidation of the role of vinyl chloride metabolites in the various reaction sequences which comprise the metabolic pathway, including the interaction of reactive metabolities with some purine and pyrimidine residues of target-organ DNA, provides some explanation for the (oncogenic) properties associated with the ori...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.772155

    authors: Hathway DE

    更新日期:1977-12-01 00:00:00

  • Soil contamination from PCB-containing buildings.

    abstract:BACKGROUND:Polychlorinated biphenyls (PCBs) in construction materials, such as caulking used around windows and expansion joints, may constitute a source of PCB contamination in the building interiors and in surrounding soil. Several studies of soil contamination have been conducted around buildings where the caulking ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9646

    authors: Herrick RF,Lefkowitz DJ,Weymouth GA

    更新日期:2007-02-01 00:00:00

  • Evidence on the human health effects of low-level methylmercury exposure.

    abstract:BACKGROUND:Methylmercury (MeHg) is a known neuro-toxicant. Emerging evidence indicates it may have adverse effects on the neuro-logic and other body systems at common low levels of exposure. Impacts of MeHg exposure could vary by individual susceptibility or be confounded by beneficial nutrients in fish containing MeHg...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.1104494

    authors: Karagas MR,Choi AL,Oken E,Horvat M,Schoeny R,Kamai E,Cowell W,Grandjean P,Korrick S

    更新日期:2012-06-01 00:00:00

  • Immune cell functions in industrial workers after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: dissociation of antigen-specific T-cell responses in cultures of diluted whole blood and of isolated peripheral blood mononuclear cells.

    abstract::A comparative analysis was performed of the phenotype and function of peripheral blood leukocytes of two age-matched cohorts of industrial workers in chemical plants, one of which was exposed occupationally to high concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Median actual TCDD burdens were 116 ng/kg ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.98106701

    authors: Ernst M,Flesch-Janys D,Morgenstern I,Manz A

    更新日期:1998-04-01 00:00:00

  • Database development in toxicogenomics: issues and efforts.

    abstract::The marriage of toxicology and genomics has created not only opportunities but also novel informatics challenges. As with the larger field of gene expression analysis, toxicogenomics faces the problems of probe annotation and data comparison across different array platforms. Toxicogenomics studies are generally built ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.6697

    authors: Mattes WB,Pettit SD,Sansone SA,Bushel PR,Waters MD

    更新日期:2004-03-01 00:00:00

  • Needs for public health intervention and needs for new research on vinyl halides and their polymers: a public policy perspective.

    abstract::Consideration of needs for public health interventions and new research requires comparative assessments of the health benefits that are likely to result from alternative uses of limited regulatory and technical resources. This paper briefly examines regulatory and research priorities in the light of recent informatio...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8141227

    authors: Hattis D

    更新日期:1981-10-01 00:00:00

  • Effects of noise and electromagnetic fields on reproductive outcomes.

    abstract::Much public health research has been directed to studies of cancer risks due to chemical agents. Recently, increasing attention has been given to adverse reproductive outcomes as another, shorter-term biologic indicator of public health impact. Further, several low-level ubiquitous physical agents have been implicated...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.8981193

    authors: Meyer RE,Aldrich TE,Easterly CE

    更新日期:1989-05-01 00:00:00

  • Effects of the workplace on fertility and related reproductive outcomes.

    abstract::This report reviews the recent literature on the adverse effects of occupational factors on fertility and related reproductive outcomes. Few studies fulfill the criteria of good study design because of small sample size, insensitive measures of effect, selection, recall, and observation bias, weak if any control of co...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.93101s281

    authors: Baranski B

    更新日期:1993-07-01 00:00:00

  • Experimental lead nitrate poisoning: microscopic and ultrastructural study of the gills of tench (Tinca tinca, L.).

    abstract::A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning. Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls. Lesions were characterized by the appearance of edema and epithelial...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.9089137

    authors: Roncero V,Vincente JA,Redondo E,Gãzquez A,Duran E

    更新日期:1990-11-01 00:00:00

  • Infectious disease and worldwide declines of amphibian populations, with comments on emerging diseases in coral reef organisms and in humans.

    abstract::Many populations of amphibians are declining on all six continents on which they occur. Some causes of amphibian declines, such as habitat destruction, direct application of xenobiotics, and introduction of predators or competitors, are clearly attributable to human activities. Infectious disease appears to be the dir...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.00108s1143

    authors: Carey C

    更新日期:2000-03-01 00:00:00