Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study.

abstract：BACKGROUND:Previous studies have examined fine particulate matter (≤ 2.5 μm; PM2.5) and preterm birth, but there is a dearth of longitudinal studies on this topic and a paucity of studies that have investigated specific sources of this exposure. OBJECTIVES:Our aim was to assess whether anthropogenic sources are associ...

journal_title：Environmental health perspectives

authors： Pereira G,Bell ML,Lee HJ,Koutrakis P,Belanger K

更新日期：2014-10-01 00:00:00

abstract：:Occupational exposures to mineral particles cause pneumoconiosis and other diseases, including cancer. Recent studies have suggested that reactive oxygen species (ROS) may play a key role in the mechanisms of disease initiation and progression following exposure to these particles. ROS-induced primary stimuli result i...

journal_title：Environmental health perspectives

authors： Vallyathan V,Shi X,Castranova V

更新日期：1998-10-01 00:00:00

abstract：:Some have hypothesized that community water containing sodium silicofluoride and hydrofluosilicic acid may increase blood lead (PbB) concentrations in children by leaching of lead from water conduits and by increasing absorption of lead from water. Our analysis aimed to evaluate the relation between water fluoridation...

journal_title：Environmental health perspectives

authors： Macek MD,Matte TD,Sinks T,Malvitz DM

更新日期：2006-01-01 00:00:00

abstract：:Elemental boron was isolated in 1808. It typically occurs in nature as borates hydrated with varying amounts of water. Important compounds are boric acid and borax. Boron compounds are also used in the production of metals, enamels, and glasses. In trace amounts, boron is essential for the growth of many plants, and i...

journal_title：Environmental health perspectives

authors： Moseman RF

更新日期：1994-11-01 00:00:00

abstract：:We analyzed data from 798 lead workers to determine whether polymorphisms in the genes encoding delta-aminolevulinic acid dehydratase (ALAD), endothelial nitric oxide synthase (eNOS), and the vitamin D receptor (VDR) were associated with or modified relations of lead exposure and dose measures with renal outcomes. Lea...

journal_title：Environmental health perspectives

authors： Weaver VM,Schwartz BS,Ahn KD,Stewart WF,Kelsey KT,Todd AC,Wen J,Simon DJ,Lustberg ME,Parsons PJ,Silbergeld EK,Lee BK

更新日期：2003-10-01 00:00:00

abstract：:Differential CYP1A1 inducibility, reflecting variations in aromatic hydrocarbon receptor (AHR) affinity among inbred mouse strains, is an important determinant of environmental toxicity. We took advantage of the Ahr polymorphism in C57BL/6 and DBA/2 mice to develop an oligonucleotide-hybridization screening approach f...

journal_title：Environmental health perspectives

authors： Maier A,Micka J,Miller K,Denko T,Chang CY,Nebert DW,Alvaro Puga

更新日期：1998-07-01 00:00:00

abstract：:Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure to single chemicals, and there is little information available on how...

journal_title：Environmental health perspectives

authors： Carpenter DO,Arcaro KF,Bush B,Niemi WD,Pang S,Vakharia DD

更新日期：1998-12-01 00:00:00

abstract：:Preterm delivery can lead to serious infant health outcomes, including death and lifelong disability. Small increases in preterm delivery risk in relation to spatial gradients of air pollution have been reported, but previous studies may have controlled inadequately for individual factors. Using a time-series analysis...

journal_title：Environmental health perspectives

authors： Sagiv SK,Mendola P,Loomis D,Herring AH,Neas LM,Savitz DA,Poole C

更新日期：2005-05-01 00:00:00

abstract：:Uterine leiomyomas (fibroids, myomas) are the most common tumors occurring in the genital tract of women over 30 years of age. These benign uterine smooth-muscle tumors are estimated to be clinically significant in at least 25% of the American female population during their reproductive years. Furthermore, when thorou...

journal_title：Environmental health perspectives

authors： Newbold RR,DiAugustine RP,Risinger JI,Everitt JI,Walmer DK,Parrott EC,Dixon D

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Childhood lead exposure has been associated with growth delay. However, the association between blood lead levels (BLLs) and insulin-like growth factor 1 (IGF-1) has not been characterized in a large cohort with low-level lead exposure. METHODS:We recruited 394 boys 8-9 years of age from an industrial Russi...

journal_title：Environmental health perspectives

authors： Fleisch AF,Burns JS,Williams PL,Lee MM,Sergeyev O,Korrick SA,Hauser R

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Prostaglandins (PGs) play key roles in development and maintenance of homeostasis of the adult body. Despite these important roles, it remains unclear whether the PG pathway is a target for endocrine disruption. However, several known endocrine-disrupting compounds (EDCs) share a high degree of structural si...

journal_title：Environmental health perspectives

authors： Kristensen DM,Skalkam ML,Audouze K,Lesné L,Desdoits-Lethimonier C,Frederiksen H,Brunak S,Skakkebæk NE,Jégou B,Hansen JB,Junker S,Leffers H

更新日期：2011-04-01 00:00:00

abstract：:Counties in the United States have been identified with chemical establishments whose primary manufacturing processes use vinyl chloride. Site-specific cancer mortality comparisons have revealed an excess of multiple myeloma in males associated with two of the manufacturing categories, synthetic rubber and synthetic f...

journal_title：Environmental health perspectives

authors： Mason TJ

更新日期：1975-06-01 00:00:00

abstract：:A brief history of the development of the field of aquatic toxicology is provided. In order to provide a perspective on the state-of-the-art in aquatic toxicology relative to classical toxicology, the two fields are compared from the standpoint of the type of scientist practicing each field, the respective objectives ...

journal_title：Environmental health perspectives

authors： Macek KJ

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:Exposure mixtures frequently occur in data across many domains, particularly in the fields of environmental and nutritional epidemiology. Various strategies have arisen to answer questions about exposure mixtures, including methods such as weighted quantile sum (WQS) regression that estimate a joint effect o...

journal_title：Environmental health perspectives

authors： Keil AP,Buckley JP,O'Brien KM,Ferguson KK,Zhao S,White AJ

更新日期：2020-04-01 00:00:00

abstract：:Biological monitoring of exposure to chemicals in the workplace is an important component of exposure assessment and prevention of adverse health effects. It should be employed in conjunction with ambient air monitoring to provide information on the absorbed dose of a chemical agent and the effect of all routes of exp...

journal_title：Environmental health perspectives

authors： Morgan MS

更新日期：1997-02-01 00:00:00

abstract：:Mammalian cells in culture have been used to study the genetic effects of physical and chemical agents. We have used Chinese hamster ovary (CHO) cells, clone K1-BH4, to quantify mutations at the X-linked, large (35 kb) hypoxanthine-guanine phosphoribosyltransferase (hprt) locus (the CHO/HPRT assay) induced by environm...

journal_title：Environmental health perspectives

authors： Hsie AW,Xu Z,Yu Y,An J,Meltz ML,Schwartz JL,Hrelia P

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:When conducting research with American Indian tribes, informed consent beyond conventional institutional review board (IRB) review is needed because of the potential for adverse consequences at a community or governmental level that are unrecognized by academic researchers. OBJECTIVES:In this article, we re...

journal_title：Environmental health perspectives

authors： Harding A,Harper B,Stone D,O'Neill C,Berger P,Harris S,Donatuto J

更新日期：2012-01-01 00:00:00

abstract：:Short-term increases in ambient air pollution have been associated with an increased incidence of acute cardiac events. We assessed the effect of inhalation exposure to concentrated ambient particles (CAPs) on myocardial ischemia in a canine model of coronary artery occlusion. Six mongrel dogs underwent thoracotomy fo...

journal_title：Environmental health perspectives

authors： Wellenius GA,Coull BA,Godleski JJ,Koutrakis P,Okabe K,Savage ST,Lawrence JE,Murthy GG,Verrier RL

更新日期：2003-04-01 00:00:00

abstract：:This study constitutes one part of a program for assessing the impact of coal-fired power plants on the surrounding communities. A questionnaire was mailed to a total of 12,000 subjects living in six areas with coal-fired plants and in matched reference areas. The participation rate was 77.3%. In one coal-fired plant/...

journal_title：Environmental health perspectives

authors： Pershagen G,Hammar N,Vartiainen E

更新日期：1986-12-01 00:00:00

abstract：:We have demonstrated that the pyrolysis products of amino acids and proteins in model systems are mutagenic. The mutagenic principles in the pyrolyzates of amino acids have been isolated and identified by Sugimura et al. We have isolated and identified amino-alpha-carbolines from pyrolyzed soybean globulin as mutagens...

journal_title：Environmental health perspectives

authors： Yoshida D,Matsumoto T,Okamoto H,Mizusaki S,Kushi A,Fukuhara Y

更新日期：1986-08-01 00:00:00

abstract：:Many mutagenic heterocyclic amines (HAs) have been isolated from cooked foods and pyrolysates of amino acids and proteins, and the carcinogenicity of 10 of these HAs in rodents and of 1 in monkeys has been reported. Quantification of these carcinogenic HAs in various kinds of cooked foods indicated that the level of 2...

journal_title：Environmental health perspectives

authors： Wakabayashi K,Ushiyama H,Takahashi M,Nukaya H,Kim SB,Hirose M,Ochiai M,Sugimura T,Nagao M

更新日期：1993-03-01 00:00:00

abstract：:Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An understanding of these interesting human carcinogens, therefore, is an important problem in cancer research. Asbestos and other fibers induce predominantly two types o...

journal_title：Environmental health perspectives

authors： Barrett JC,Lamb PW,Wiseman RW

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Traffic-related air pollution is emerging as a risk factor for Alzheimer's disease (AD) and impaired brain development. Individual differences in vulnerability to air pollution may involve the ε4 allele of Apolipoprotein E (APOE) gene, the primary genetic risk factor for AD. OBJECTIVE:We analyzed whether th...

journal_title：Environmental health perspectives

authors： Alemany S,Vilor-Tejedor N,García-Esteban R,Bustamante M,Dadvand P,Esnaola M,Mortamais M,Forns J,van Drooge BL,Álvarez-Pedrerol M,Grimalt JO,Rivas I,Querol X,Pujol J,Sunyer J

更新日期：2018-08-02 00:00:00

abstract：:Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...

journal_title：Environmental health perspectives

authors： Hood E,Tillett T,Phelps J

更新日期：2006-05-01 00:00:00

abstract：:The results of our previous and recent work on cadmium metabolism in relation to age and diet are presented. Experiments were performed on albino rats aged 1-26 weeks. In some experiments rats were given different foods (milk, meat, bread) instead of standard rat diet. Some animals received trisodium calcium salt of d...

journal_title：Environmental health perspectives

authors： Kostial K

更新日期：1984-03-01 00:00:00

abstract：:Beginning approximately 4 years after the Chernobyl nuclear accident a steady increase in the incidence of thyroid cancer was observed in children and adolescents of the Bryansk Oblast, which received the highest level of radionuclide contaminants in Russia. We examined the spatial relationship between the residence l...

journal_title：Environmental health perspectives

authors： Parshkov EM,Chebotareva IV,Sokolov VA,Dallas CE

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Microcystin-producing Microcystis bloom is a severe water problem in the world. Some reports indicate that chronic exposure to microcystin may result in liver damage in adults, but information on effects in children is limited. OBJECTIVE:We investigated the relationship between microcystin exposure and live...

journal_title：Environmental health perspectives

authors： Li Y,Chen JA,Zhao Q,Pu C,Qiu Z,Zhang R,Shu W

更新日期：2011-10-01 00:00:00

abstract：:The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to...

journal_title：Environmental health perspectives

authors： Schiffer B,Daxenberger A,Meyer K,Meyer HH

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:Cadmium (Cd) is a human toxicant and carcinogen. Genetic variation might affect long-term accumulation. Cd is absorbed via iron transporters. OBJECTIVES:We evaluated the impact of iron homeostasis genes [divalent metal transporter 1 (SLC11A2), transferrin (TF), transferrin receptors (TFR2 and TFRC), and fer...

journal_title：Environmental health perspectives

authors： Rentschler G,Kippler M,Axmon A,Raqib R,Ekström EC,Skerfving S,Vahter M,Broberg K

更新日期：2013-04-01 00:00:00

abstract：:This working paper summarizes the known ultrastructural and biochemical effects of lead, mercury, cadmium, and arsenic on subcellular organelle systems following in vivo administration. Documented metal-induced alterations in nuclear, mitochondrial, microsomal, and lysosomal functions are discussed in relation to thei...

journal_title：Environmental health perspectives

authors： Fowler BA

更新日期：1978-02-01 00:00:00