Blood lead levels and serum insulin-like growth factor 1 concentrations in peripubertal boys.

abstract：:N-Substituted aromatic compounds can be metabolized in most species to N-acetylated derivatives that are themselves subject to further enzymatic transformations, including hydrolysis and N,O-acyltransfer. These proceses can either potentiate or ameliorate the biological responses to these N-substituted derivatives. De...

journal_title：Environmental health perspectives

authors： King CM,Glowinski IB

更新日期：1983-03-01 00:00:00

abstract：:During the last three decades, the use of modern organic synthetic pesticides has increased about 40-fold. Total U.S. production, for domestic and expert use, in 1976 was about 1.4 million pounds. Crops receiving the most intensive application of various pesticides were cotton for insecticides, corn for herbicides, an...

journal_title：Environmental health perspectives

authors： Ridgway RL,Tinney JC,MacGregor JT,Starler NJ

更新日期：1978-12-01 00:00:00

abstract：:This study constitutes one part of a program for assessing the impact of coal-fired power plants on the surrounding communities. A questionnaire was mailed to a total of 12,000 subjects living in six areas with coal-fired plants and in matched reference areas. The participation rate was 77.3%. In one coal-fired plant/...

journal_title：Environmental health perspectives

authors： Pershagen G,Hammar N,Vartiainen E

更新日期：1986-12-01 00:00:00

abstract：:Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of various forms of cancer and of noncancerous diseases. Metabolic conversions of iAs that yield highly toxic and genotoxic methylarsonite (MAsIII) and dimethylarsinite (DMAsIII) may play a significant role in determining the extent an...

journal_title：Environmental health perspectives

authors： Valenzuela OL,Borja-Aburto VH,Garcia-Vargas GG,Cruz-Gonzalez MB,Garcia-Montalvo EA,Calderon-Aranda ES,Del Razo LM

更新日期：2005-03-01 00:00:00

abstract：:Possible effects of Chernobyl fallout on outcome of pregnancy in Finland were evaluated in a nationwide follow-up study. The outcomes were the rate of live births and stillbirths, pregnancy loss, and induced abortions by municipality. Exposure was assessed based on nationwide surveys of radiation dose rate from the Ch...

journal_title：Environmental health perspectives

authors： Auvinen A,Vahteristo M,Arvela H,Suomela M,Rahola T,Hakama M,Rytömaa T

更新日期：2001-02-01 00:00:00

abstract：:An association between human illness and exposure to Pfiesteria was first observed among laboratory personnel working with the microorganism. In 1997, in the setting of Pfiesteria activity on the Pocomoke River in Maryland, difficulties with learning and memory were epidemiologically associated with high-level exposur...

journal_title：Environmental health perspectives

authors： Morris JG Jr

更新日期：2001-10-01 00:00:00

abstract：:A wide variety of behavioral methods has been employed with animals to assess visual changes induced by drugs or toxicants. The methods range from simple to complex, from broad screening devices to narrowly focused techniques. Their relative advantages for the environmental toxicologist are discussed. Manipulation of ...

journal_title：Environmental health perspectives

authors： Evans HL

更新日期：1978-10-01 00:00:00

abstract：:This paper summarizes the clinical phenomenology of multiple chemical sensitivity (MCS), outlines the concepts and evidence for the olfactory-limbic, neural sensitization model for MCS, and discusses experimental design implications of the model for exposure-related research. Neural sensitization is the progressive am...

journal_title：Environmental health perspectives

authors： Bell IR,Schwartz GE,Baldwin CM,Hardin EE,Klimas NG,Kline JP,Patarca R,Song ZY

更新日期：1997-03-01 00:00:00

abstract：:There are a number of technical and statistical problems in monitoring the temporal and spatial variation of local area death rates in the United States for evidence of systematically elevated risks. An analytic strategy is proposed to reduce one of the major statistical concerns, i.e., that of identifying areas with ...

journal_title：Environmental health perspectives

authors： Manton KG,Stallard E,Creason JP,Riggan WB

更新日期：1985-05-01 00:00:00

abstract：:Elemental boron was isolated in 1808. It typically occurs in nature as borates hydrated with varying amounts of water. Important compounds are boric acid and borax. Boron compounds are also used in the production of metals, enamels, and glasses. In trace amounts, boron is essential for the growth of many plants, and i...

journal_title：Environmental health perspectives

authors： Moseman RF

更新日期：1994-11-01 00:00:00

abstract：:Implications of the multistage theory of carcinogenesis for evaluating the effect of exposure to carcinogens in the workplace are described. This theory predicts different patterns of excess risk related to duration of exposure, age at initial exposure, and follow-up time since exposure stopped, depending upon which s...

journal_title：Environmental health perspectives

authors： Brown CC,Chu KC

更新日期：1983-04-01 00:00:00

abstract：:The available data on the influence of selenium on the toxicity of methylmercury and of methylmercury on selenium as a nutrient and toxic agent are reviewed. Selenium as selenite has a relative protective effect on acute and subacute toxicity of methylmercury in the rat and the quail. The protective mechanism is far f...

journal_title：Environmental health perspectives

authors： Skerfving S

更新日期：1978-08-01 00:00:00

abstract：:Neonatal treatment of female mice with diethystilbestrol (DES) is known to induce ovary-independent persistent proliferation and cornification of vaginal epithelium. This irreversibly changed vaginal epithelium persistently expressed higher levels of c-jun and c-fos mRNAs, which was not altered by postpubertal estroge...

journal_title：Environmental health perspectives

authors： Iguchi T,Fukazawa Y,Bern HA

更新日期：1995-10-01 00:00:00

abstract：:Rats continuously exposed to NO2 at 0.04, 0.4, and 4.0 ppm for as long as 27 months were submitted to morphological observation and electronmicroscopic morphometry of the lung. At 4 ppm exposure for 9 months, bronchial epithelium showed typical proliferation, which progressed further at 18 months. At this stage, proli...

journal_title：Environmental health perspectives

authors： Kubota K,Murakami M,Takenaka S,Kawai K,Kyono H

更新日期：1987-08-01 00:00:00

abstract：:Lipocortins are structurally related, glucocorticoid-inducible proteins that inhibit phospholipase A2 (PLA2), thereby reducing the liberation of arachidonic acid from phospholipids and so limiting the synthesis of eicosanoid inflammatory mediators. This study is the first demonstration of one lipocortin, lipocortin 1 ...

journal_title：Environmental health perspectives

authors： Smith SF,Tetley TD,Guz A,Flower RJ

更新日期：1990-04-01 00:00:00

abstract：:The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compou...

journal_title：Environmental health perspectives

authors： Birnbaum LS

更新日期：1995-03-01 00:00:00

abstract：:The physiological function of copper(I)-metallothionein is not well understood. The respiratory function of hemocyanin, a copper(I)-containing respiratory protein found in the hemolymph of many invertebrates, has been known a long time. However, the mechanism by which Cu(I) is inserted into the oxygen-binding site of ...

journal_title：Environmental health perspectives

authors： Brouwer M,Whaling P,Engel DW

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Urbanization has been correlated with hypertension (HTN) in developing countries undergoing rapid economic and environmental transitions. OBJECTIVES:We examined the relationships among living environment (urban, suburban, and rural), day/night land surface temperatures (LST), and blood pressure in selected ...

journal_title：Environmental health perspectives

authors： Estes MG Jr,Al-Hamdan MZ,Crosson W,Estes SM,Quattrochi D,Kent S,McClure LA

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Arsenicals (roxarsone and nitarsone) used in poultry production likely increase inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and roxarsone or nitarsone concentrations in poultry meat. However, the association between poultry intake and exposure to these arsenic species, ...

journal_title：Environmental health perspectives

authors： Nigra AE,Nachman KE,Love DC,Grau-Perez M,Navas-Acien A

更新日期：2017-03-01 00:00:00

abstract：:Between 1966 and 1986, the childhood leukemia rate in Woburn, Massachusetts, was 4-fold higher than the national average. A multidisciplinary research team from MIT, which is being supported by the NIEHS Superfund Basic Research Program, has explored the possible importance of a temporal correlation between the period...

journal_title：Environmental health perspectives

authors： Durant JL,Chen J,Hemond HF,Thilly WG

更新日期：1995-09-01 00:00:00

abstract：:Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we measured PAH-DNA adducts by enzyme-linked immunosorbent assay in WBCs obtained from 47 California wildland (forest) fire...

journal_title：Environmental health perspectives

authors： Rothman N,Poirier MC,Haas RA,Correa-Villasenor A,Ford P,Hansen JA,O'Toole T,Strickland PT

更新日期：1993-03-01 00:00:00

abstract：:For decades, a number of guinea pig tests have been used to identify human contact allergens in workplace and consumer products, but these tests have limitations. In addition to using large numbers of test animals, they also provide only subjective measurements, because the allergic activity is measured by watching th...

journal_title：Environmental health perspectives

authors： Clay R

更新日期：1998-10-01 00:00:00

abstract：:A brief history of the development of the field of aquatic toxicology is provided. In order to provide a perspective on the state-of-the-art in aquatic toxicology relative to classical toxicology, the two fields are compared from the standpoint of the type of scientist practicing each field, the respective objectives ...

journal_title：Environmental health perspectives

authors： Macek KJ

更新日期：1980-02-01 00:00:00

abstract：BACKGROUND:The presence of pharmaceuticals in aquatic environments and in drinking water has prompted significant public interest regarding potential adverse ecological effects and risks to human health. OBJECTIVES:The Environmental Health Summit held in North Carolina, 10-11 November 2008, explored the issues associa...

journal_title：Environmental health perspectives

authors： Rodriguez-Mozaz S,Weinberg HS

更新日期：2010-07-01 00:00:00

abstract：:Epidemiologic studies report associations between particulate air pollution and cardiopulmonary morbidity and mortality. Although the underlying pathophysiologic mechanisms remain unclear, it has been hypothesized that altered autonomic function and pulmonary/systemic inflammation may play a role. In this study we exp...

journal_title：Environmental health perspectives

authors： Pope CA 3rd,Hansen ML,Long RW,Nielsen KR,Eatough NL,Wilson WE,Eatough DJ

更新日期：2004-03-01 00:00:00

abstract：:Metals continually rank at the top of the U.S. Environmental Protection Agency's annual list of agents that pose the greatest hazard to the people of the United States. Metals aren't going away, either. They do not biodegrade, and they often concentrate in human and animal cells and tissue. Many metals are known human...

journal_title：Environmental health perspectives

authors： Fisher BE

更新日期：1999-05-01 00:00:00

abstract：:We conducted experiments to determine whether diesel engine exhaust affects reproductive endocrine function in growing rats. The rats were assigned to three groups: a group exposed to total diesel engine exhaust containing 5.63 mg/m3 particulate matter, 4.10 ppm nitrogen dioxide, and 8.10 ppm nitrogen oxide; a group e...

journal_title：Environmental health perspectives

authors： Watanabe N,Oonuki Y

更新日期：1999-07-01 00:00:00

abstract：:Whole blood oxygen equilibrium curves (O2 ECs), blood buffer lines, and several hematologic properties were determined for adult guinea pigs exposed to 700 ppm methyl isocyanate (MIC) for 15 min. MIC inhalation effected a significant reduction of blood O2 affinity; the half-saturation pressure (P50) at 38 degrees C in...

journal_title：Environmental health perspectives

authors： Maginniss LA,Szewczak JM,Troup CM

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:There is a need to identify and evaluate an effective mitigation program for arsenic exposure from drinking water in Bangladesh. OBJECTIVE:We evaluated the effectiveness of a multifaceted mitigation program to reduce As exposure among 11,746 individuals in a prospective cohort study initiated in 2000 in Ara...

journal_title：Environmental health perspectives

authors： Chen Y,van Geen A,Graziano JH,Pfaff A,Madajewicz M,Parvez F,Hussain AZ,Slavkovich V,Islam T,Ahsan H

更新日期：2007-06-01 00:00:00

abstract：:Many populations of amphibians are declining on all six continents on which they occur. Some causes of amphibian declines, such as habitat destruction, direct application of xenobiotics, and introduction of predators or competitors, are clearly attributable to human activities. Infectious disease appears to be the dir...

journal_title：Environmental health perspectives

authors： Carey C

更新日期：2000-03-01 00:00:00