Inhalation of diesel engine exhaust affects spermatogenesis in growing male rats.

abstract：:Biological monitoring of exposure to chemicals in the workplace is an important component of exposure assessment and prevention of adverse health effects. It should be employed in conjunction with ambient air monitoring to provide information on the absorbed dose of a chemical agent and the effect of all routes of exp...

journal_title：Environmental health perspectives

authors： Morgan MS

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Prenatal and early-life periods may be critical windows for harmful effects of air pollution on infant health. OBJECTIVES:We studied the association of air pollution exposure during pregnancy and the first year of life with respiratory illnesses, ear infections, and eczema during the first 12-18 months of a...

journal_title：Environmental health perspectives

authors： Aguilera I,Pedersen M,Garcia-Esteban R,Ballester F,Basterrechea M,Esplugues A,Fernández-Somoano A,Lertxundi A,Tardón A,Sunyer J

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The National Institutes of Health's Environmental influences on Child Health Outcomes (ECHO) initiative aims to understand the impact of environmental factors on childhood disease. Over 40,000 chemicals are approved for commercial use. The challenge is to prioritize chemicals for biomonitoring that may prese...

journal_title：Environmental health perspectives

authors： Pellizzari ED,Woodruff TJ,Boyles RR,Kannan K,Beamer PI,Buckley JP,Wang A,Zhu Y,Bennett DH,(Environmental influences on Child Health Outcomes).

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Humans have been exposed to fine and ultrafine particles throughout their history. Since the Industrial Revolution, sources, doses, and types of nanoparticles have changed dramatically. In the last decade, the rapidly developing field of nanotechnology has led to an increase of engineered nanoparticles with ...

journal_title：Environmental health perspectives

authors： Wick P,Malek A,Manser P,Meili D,Maeder-Althaus X,Diener L,Diener PA,Zisch A,Krug HF,von Mandach U

更新日期：2010-03-01 00:00:00

abstract：:We examined 100 symptomatic Gulf War veterans (patients) and 100 controls for immunologic assays. The veterans and controls were compared for the percentage of T cells (CD3); B cells (CD19); helper:suppressor (CD4:CD8) ratio; natural killer (NK) cell activity; mitogenic response to phytohemagglutin (PHA) and pokeweed ...

journal_title：Environmental health perspectives

authors： Vojdani A,Thrasher JD

更新日期：2004-06-01 00:00:00

abstract：:The destruction of the World Trade Center (WTC) on 11 September 2001 in New York City resulted in the massive release of pulverized dust and combustion products. The dust and smoke settled in the surrounding area, which encompassed a large residential community. We hypothesized that previously normal residents in the ...

journal_title：Environmental health perspectives

authors： Reibman J,Lin S,Hwang SA,Gulati M,Bowers JA,Rogers L,Berger KI,Hoerning A,Gomez M,Fitzgerald EF

更新日期：2005-04-01 00:00:00

abstract：:Aluminum lactate [Al(lact)3] (hydrophilic, hydrolytically unstable) and aluminum acetylacetonate [Al(acae)3] (lipophilic, hydrolytically stable) were tested as potential toxicants to rabbits upon IV administration both as aqueous solutions and as liposome suspensions. Both chemicals behaved as cardiotoxic agents when ...

journal_title：Environmental health perspectives

authors： Bombi GG,Corain B,Favarato M,Giordano R,Nicolini M,Perazzolo M,Tapparo A,Zatta P

更新日期：1990-11-01 00:00:00

abstract：:Examining global effects of toxic metals on gene expression can be useful for elucidating patterns of biological response, discovering underlying mechanisms of toxicity, and identifying candidate metal-specific genetic markers of exposure and response. Using a 1,200 gene nylon array, we examined changes in gene expres...

journal_title：Environmental health perspectives

authors： Andrew AS,Warren AJ,Barchowsky A,Temple KA,Klei L,Soucy NV,O'Hara KA,Hamilton JW

更新日期：2003-05-01 00:00:00

abstract：:Cap43 is a protein whose RNA is induced under conditions of severe hypoxia or prolonged elevations of intracellular calcium. Additionally, Ni and Co also induce Cap43 because they produce a state of hypoxia in cells. Cap43 protein is expressed at low levels in normal tissues; however, in a variety of cancers, includin...

journal_title：Environmental health perspectives

authors： Cangul H,Salnikow K,Yee H,Zagzag D,Commes T,Costa M

更新日期：2002-10-01 00:00:00

abstract：:The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency spon...

journal_title：Environmental health perspectives

authors： Kavlock RJ,Daston GP,DeRosa C,Fenner-Crisp P,Gray LE,Kaattari S,Lucier G,Luster M,Mac MJ,Maczka C,Miller R,Moore J,Rolland R,Scott G,Sheehan DM,Sinks T,Tilson HA

更新日期：1996-08-01 00:00:00

abstract：:Along the Texas-Mexico border, the prevalence of neural tube defects (NTDs) among Mexican-American women doubled during 1990-1991. The human outbreak began during the same crop year as epizootics attributed to exposure to fumonisin, a mycotoxin that often contaminates corn. Because Mexican Americans in Texas consume l...

journal_title：Environmental health perspectives

authors： Missmer SA,Suarez L,Felkner M,Wang E,Merrill AH Jr,Rothman KJ,Hendricks KA

更新日期：2006-02-01 00:00:00

abstract：:The general methods used to complete measurements of human exposures are identified and illustrations are provided for the cases of indirect and direct methods used for exposure analysis. The application of the techniques for external measurements of exposure, microenvironmental and personal monitors, are placed in th...

journal_title：Environmental health perspectives

authors： Lioy PJ

更新日期：1995-04-01 00:00:00

abstract：:Risk assessment is a process often divided into the following steps: a) hazard identification, b) dose-response assessment, c) exposure assessment, and d) risk characterization. Regulatory toxicity studies usually are aimed at providing data for the first two steps. Human case reports, environmental research, and in v...

journal_title：Environmental health perspectives

authors： Harry GJ,Billingsley M,Bruinink A,Campbell IL,Classen W,Dorman DC,Galli C,Ray D,Smith RA,Tilson HA

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. OBJECTIVE:We examined 42 Faroese whaling men (30-70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whal...

journal_title：Environmental health perspectives

authors： Choi AL,Weihe P,Budtz-Jørgensen E,Jørgensen PJ,Salonen JT,Tuomainen TP,Murata K,Nielsen HP,Petersen MS,Askham J,Grandjean P

更新日期：2009-03-01 00:00:00

abstract：:Numerous publications and reports have expressed health and safety concerns about the production and use of nanoparticles, especially in areas of exposure monitoring, personal use, and environmental fate and transport. We suggest that stable isotopic tracers, which have been used widely in the earth sciences and in me...

journal_title：Environmental health perspectives

authors： Gulson B,Wong H

更新日期：2006-10-01 00:00:00

abstract：:Asbestos and silica are well-known fibrogenic dusts. However, there is no comprehensive understanding of the molecular and cellular events that lead to fibrosis as a consequence of asbestos or silica inhalation. Previous studies have shown that asbestos stimulates superoxide anion production in alveolar macrophages th...

journal_title：Environmental health perspectives

authors： Holian A,Kelley K,Hamilton RF Jr

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Cadmium exposure may increase the risk of cardiovascular disease. The only published longitudinal study on cadmium and incident cardiovascular disease was performed in American Indians with relatively high cadmium exposure. OBJECTIVES:Our aim was to examine the association between blood cadmium at baseline ...

journal_title：Environmental health perspectives

authors： Barregard L,Sallsten G,Fagerberg B,Borné Y,Persson M,Hedblad B,Engström G

更新日期：2016-05-01 00:00:00

abstract：:There is accumulating evidence that the multistage carcinogenic process is associated with the progressive acquisition of mutations in cellular proto-oncogenes and in growth-suppressor genes. At the same time, several types of evidence indicate that nongenotoxic agents and epigenetic events also play an important role...

journal_title：Environmental health perspectives

authors： Weinstein IB

更新日期：1991-06-01 00:00:00

abstract：:Hamsters were exposed to an aerosol of fused aluminosilicate particles (FAP) labeled with 57Co. Three groups of animals were given bronchopulmonary lavage, beginning at either 1 week, 1 month, or 6 months after exposure. Each treated group was lavaged eight times over a period of 25 days. Each lavage involved 10 salin...

journal_title：Environmental health perspectives

authors： Ellender M,Hodgson A,Wood KL,Moody JC

更新日期：1992-07-01 00:00:00

abstract：:Often a compound's biological activity is determined by complex relationships between its structural components. Such a relationship often can only be adequately described and exploited by multivariate structure-activity relationship (SAR) studies that can deal with many variables simultaneously. Pattern recognition (...

journal_title：Environmental health perspectives

authors： Stouch TR,Jurs PC

更新日期：1985-09-01 00:00:00

abstract：:The current Good Manufacturing Practice (cGMP) and effluent emission (use and disposal) regulations of the U.S. Food and Drug Administration (FDA) and manufacturing effluent discharge and emission regulations of the U.S. Environmental Protection Agency (U.S. EPA) require contained manufacture, use, and disposal of pha...

journal_title：Environmental health perspectives

authors： Velagaleti R,Burns PK,Gill M,Prothro J

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:We have previously shown that adult male mice exposure to low doses of an ubiquitous endocrine disruptor, di(2-ethylhexyl) phthalate (DEHP), alters courtship behavior. OBJECTIVE:The effects of adult exposure to low doses of DEHP alone or in an environmental phthalate mixture on estrous cyclicity, reproducti...

journal_title：Environmental health perspectives

authors： Adam N,Brusamonti L,Mhaouty-Kodja S

更新日期：2021-01-01 00:00:00

abstract：:We report the results of a coordinated mitigation effort aimed at reducing arsenic (As) exposure in three counties of Guizhou province, China. Mitigation occurred in 2005 and encompassed 21 villages with 47,000 inhabitants, who were exposed to high levels of As in their diet through consumption of As-contaminated chil...

journal_title：Environmental health perspectives

authors： An D,Li D,Liang Y,Jing Z

更新日期：2007-04-01 00:00:00

abstract：:Many assays for oncogenic transformation have been developed ranging from those in established rodent cell lines where morphological alteration is scored, to those in human cells growing in nude mice where tumor invasiveness is scored. In general, systems that are most quantitative are also the least relevant in terms...

journal_title：Environmental health perspectives

authors： Hall EJ,Hei TK

更新日期：1990-08-01 00:00:00

abstract：:A brief review of the literature indicates that nutritional deficiencies have been shown to increase the absorption and toxicity of orally ingested lead and cadmium. Results from recent studies indicates that low level oral ingestion of cadmium and lead perturbs the metabolism of zinc, copper, and iron and that these ...

journal_title：Environmental health perspectives

authors： Petering HG

更新日期：1978-08-01 00:00:00

abstract：:Metallothioneins (MTs) are encoded by a multigene family in man. We have isolated those genes and analyzed the structure of some of them. The MT-II variant is encoded by a single functional gene: MT-IIA. The MT-IIB gene is a processed pseudogene derived from a reverse transcript of MT-II mRNA. On the other hand, the M...

journal_title：Environmental health perspectives

authors： Karin M,Richards RI

更新日期：1984-03-01 00:00:00

abstract：:Pregnant Sprague Dawley rats were given 0, 0.25, 0.5, 1, 5, and 10 mg of a commercial polybrominated biphenyl, FireMaster BP-6 (PBB), in olive oil by gavage each day from days 7 through 15 of pregnancy. Laboratory chow and water were given ad libitum. Treatment with PBB had no significant effect on body weight gain, f...

journal_title：Environmental health perspectives

authors： Harris SJ,Cecil HC,Bitman J

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:Methylmercury (MeHg) exposure assessments among average fish consumers in the United States may underestimate exposures among U.S. subpopulations with high intakes of regionally specific fish. OBJECTIVES:We examined relationships among fish consumption, estimated mercury (Hg) intake, and measured Hg exposur...

journal_title：Environmental health perspectives

authors： Lincoln RA,Shine JP,Chesney EJ,Vorhees DJ,Grandjean P,Senn DB

更新日期：2011-02-01 00:00:00

abstract：:The biopersistence of fibers and minerals in the respiratory tract is an important parameter in the toxicity of those materials. The biopersistence of respirable synthetic fibers and minerals in man can be most closely evaluated in an animal model. While acellular and in vitro systems are important for initial evaluat...

journal_title：Environmental health perspectives

authors： Bernstein DM,Mast R,Anderson R,Hesterberg TW,Musselman R,Kamstrup O,Hadley J

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Drinking water in multiple water districts in the Mid-Ohio Valley has been contaminated with perfluorooctanoic acid (PFOA), which was released by a nearby DuPont chemical plant. Two highly contaminated water districts began granular activated carbon filtration in 2007. OBJECTIVES:To determine the rate of de...

journal_title：Environmental health perspectives

authors： Bartell SM,Calafat AM,Lyu C,Kato K,Ryan PB,Steenland K

更新日期：2010-02-01 00:00:00