Abstract:
:Cap43 is a protein whose RNA is induced under conditions of severe hypoxia or prolonged elevations of intracellular calcium. Additionally, Ni and Co also induce Cap43 because they produce a state of hypoxia in cells. Cap43 protein is expressed at low levels in normal tissues; however, in a variety of cancers, including lung, brain, melanoma, liver, prostate, breast, and renal cancers, Cap43 protein is overexpressed in cancer cells. The low level of expression of Cap43 in some normal tissues compared with their cancerous counterparts, combined with the high stability of Cap43 protein and mRNA, makes the Cap43 gene a new, important cancer marker. We hypothesize that the mechanism of Cap43 overexpression in cancer cells involves a state of hypoxia characteristic of cancer cells where the Cap43 protein becomes a signature for this hypoxic state.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Cangul H,Salnikow K,Yee H,Zagzag D,Commes T,Costa Mdoi
10.1289/ehp.02110s5783subject
Has Abstractpub_date
2002-10-01 00:00:00pages
783-8eissn
0091-6765issn
1552-9924pii
sc271_5_1835journal_volume
110 Suppl 5pub_type
杂志文章abstract::The activities of plants and plant/microbial associations may offer a viable means of accomplishing the in situ remediation of contaminated soils. Two uses of plants for phytoremediation are reported here. In one set of studies, the ability of plants to foster degradative microorganisms was investigated. Results indic...
journal_title:Environmental health perspectives
pub_type: 杂志文章
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journal_title:Environmental health perspectives
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更新日期:2020-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s847
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107633
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journal_title:Environmental health perspectives
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更新日期:1983-04-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2010-09-01 00:00:00
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1990-04-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.98106155
更新日期:1998-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107205
更新日期:1999-03-01 00:00:00
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更新日期:2014-10-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.939957
更新日期:1993-03-01 00:00:00
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journal_title:Environmental health perspectives
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doi:10.1289/ehp.8456213
更新日期:1984-06-01 00:00:00
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更新日期:2011-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102958
更新日期:1994-11-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8762
更新日期:2006-09-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108323
更新日期:2000-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:1998-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2004-03-01 00:00:00
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
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更新日期:2010-10-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1992-07-01 00:00:00
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更新日期:2003-04-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2002-11-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1986-04-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2011-02-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1979-10-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2016-05-01 00:00:00