Role of alveolar macrophages in precipitation of mineral elements inhaled as soluble aerosols.

abstract：:Asbestos and other mineral fibers are carcinogenic to humans and animals but differ from many carcinogens in that they do not induce gene mutations. An understanding of these interesting human carcinogens, therefore, is an important problem in cancer research. Asbestos and other fibers induce predominantly two types o...

journal_title：Environmental health perspectives

authors： Barrett JC,Lamb PW,Wiseman RW

更新日期：1989-05-01 00:00:00

abstract：:There is accumulating evidence that the multistage carcinogenic process is associated with the progressive acquisition of mutations in cellular proto-oncogenes and in growth-suppressor genes. At the same time, several types of evidence indicate that nongenotoxic agents and epigenetic events also play an important role...

journal_title：Environmental health perspectives

authors： Weinstein IB

更新日期：1991-06-01 00:00:00

abstract：:This study investigated the association between biomarkers of fetal exposure to cigarette smoke at the end of pregnancy, cotinine in cord serum and in maternal and newborn urine samples, and quantitative measurement of smoking intake and exposure evaluated by maternal self-reported questionnaire. Study subjects were 4...

journal_title：Environmental health perspectives

authors： Pichini S,Basagaña XB,Pacifici R,Garcia O,Puig C,Vall O,Harris J,Zuccaro P,Segura J,Sunyer J

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Cirrhosis of the liver is thought to be a major cause of morbidity and mortality in sub-Saharan Africa, but few controlled studies on the etiology of cirrhosis have been conducted in this region. OBJECTIVES:We aimed to elucidate the association between environmental and infectious exposures and cirrhosis in...

journal_title：Environmental health perspectives

authors： Kuniholm MH,Lesi OA,Mendy M,Akano AO,Sam O,Hall AJ,Whittle H,Bah E,Goedert JJ,Hainaut P,Kirk GD

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Lead exposure is associated with elevated blood pressure during pregnancy; however, the magnitude of this relationship at low exposure levels is unclear. OBJECTIVES:Our goal was to determine the association between low-level lead exposure and blood pressure during late pregnancy. METHODS:We collected admis...

journal_title：Environmental health perspectives

authors： Wells EM,Navas-Acien A,Herbstman JB,Apelberg BJ,Silbergeld EK,Caldwell KL,Jones RL,Halden RU,Witter FR,Goldman LR

更新日期：2011-05-01 00:00:00

abstract：:To assess levels of chlorinated contaminants in breast milk, we measured organochlorine pesticides, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) in breast milk samples collected in 1994 according to the World Health Organization protocol from 92 donors...

journal_title：Environmental health perspectives

authors： Hooper K,Petreas MX,Chuvakova T,Kazbekova G,Druz N,Seminova G,Sharmanov T,Hayward D,She J,Visita P,Winkler J,McKinney M,Wade TJ,Grassman J,Stephens RD

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:The World Health Organization (WHO) released the fourth edition of Guidelines for Drinking-Water Quality in July 2011. In this edition, the 400-µg/L drinking-water guideline for manganese (Mn) was discontinued with the assertion that because "this health-based value is well above concentrations of manganese ...

journal_title：Environmental health perspectives

authors： Frisbie SH,Mitchell EJ,Dustin H,Maynard DM,Sarkar B

更新日期：2012-06-01 00:00:00

abstract：:Noise exposure causes changes at different levels in human organs, particularly the cardiovascular system, where it is responsible for increasing heart rate, peripheral vascular resistance, and blood pressure. In this study, we evaluated the effect of noise exposure on DNA integrity and ultrastructure of rat cardiomyo...

journal_title：Environmental health perspectives

authors： Lenzi P,Frenzilli G,Gesi M,Ferrucci M,Lazzeri G,Fornai F,Nigro M

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Exposure to arsenic via drinking water is a global environmental health problem. In utero exposure to arsenic via drinking water increases the risk of lower respiratory tract infections during infancy and mortality from bronchiectasis in early adulthood. OBJECTIVES:We aimed to investigate how arsenic exposu...

journal_title：Environmental health perspectives

authors： Ramsey KA,Bosco A,McKenna KL,Carter KW,Elliot JG,Berry LJ,Sly PD,Larcombe AN,Zosky GR

更新日期：2013-02-01 00:00:00

abstract：:We conducted a case-control study to determine the contribution of lead to blood from consumption of calcium supplements approximating the recommended daily intakes over a 6-month period. Subjects were males and females ages 21 to 47 years (geometric mean 32 years) with a geometric mean blood lead concentration of 2.5...

journal_title：Environmental health perspectives

authors： Gulson BL,Mizon KJ,Palmer JM,Korsch MJ,Taylor AJ

更新日期：2001-03-01 00:00:00

abstract：:Organophosphates in increasing amounts and wider varieties of molecular structure are being used to replace the organochlorine pesticides. It has been assumed that the organophosphates as a class would have a minimal chronic toxicity due to rapid hydrolysis and an unfavorable partitioning as regards to lipids. The phy...

journal_title：Environmental health perspectives

authors： Freed VH,Haque R,Schmedding D,Kohnert R

更新日期：1976-02-01 00:00:00

abstract：:The dissolution of mineral fibers has been studied in simulated physiological fluids using a dynamic testing procedure. Fibers of different chemical composition and obtained by different processes with a mean diameter of about 1 micron, have been characterized with respect to their solubility under various test condit...

journal_title：Environmental health perspectives

authors： Lehuédé P,de Meringo A

更新日期：1994-10-01 00:00:00

abstract：:The ability of questionnaires to predict children's exposure to pesticides was examined as part of the Minnesota Children's Pesticide Exposure Study (MNCPES). The MNCPES focused on a probability sample of 102 children between the ages of 3 and 13 years living in either urban (Minneapolis and St. Paul, MN) or nonurban ...

journal_title：Environmental health perspectives

authors： Sexton K,Adgate JL,Eberly LE,Clayton CA,Whitmore RW,Pellizzari ED,Lioy PJ,Quackenboss JJ

更新日期：2003-01-01 00:00:00

abstract：:A major goal of studying farmworkers is to better understand how their work environment, including exposure to pesticides, affects their health. Although a number of health conditions have been associated with pesticide exposure, clear linkages have yet to be made between exposure and health effects except in cases of...

journal_title：Environmental health perspectives

authors： McCauley LA,Anger WK,Keifer M,Langley R,Robson MG,Rohlman D

更新日期：2006-06-01 00:00:00

abstract：:The Environmental Public Health Tracking Network (EPHTN) proposes to link environmental hazards and exposures to health outcomes. Statistical methods used in case-control and cohort studies to link health outcomes to individual exposure estimates are well developed. However, reliable exposure estimates for many contam...

journal_title：Environmental health perspectives

authors： Mather FJ,White LE,Langlois EC,Shorter CF,Swalm CM,Shaffer JG,Hartley WR

更新日期：2004-10-01 00:00:00

abstract：:Chemoprotective phytochemicals exhibit multiple activities and interact with several cellular receptors, including the aryl hydrocarbon (Ah) receptor (AhR). In this study we investigated the AhR agonist/antagonist activities of the following flavonoids: chrysin, phloretin, kaempferol, galangin, naringenin, genistein, ...

journal_title：Environmental health perspectives

authors： Zhang S,Qin C,Safe SH

更新日期：2003-12-01 00:00:00

abstract：:This review presents a brief overview of the health effects and exposures of two criteria pollutants--ozone and particulate matter--and two toxic air pollutants--benzene and formaldehyde. These pollutants were selected from the six criteria pollutants and from the 189 toxic air pollutants on the basis of their prevale...

journal_title：Environmental health perspectives

authors： Suh HH,Bahadori T,Vallarino J,Spengler JD

更新日期：2000-08-01 00:00:00

abstract：:Human milk is a repository for certain classes of long-lived, fat-soluble environmental contaminant chemicals. Some members of this class, such as the chlorinated pesticides and the chlorinated biphenyls, can be expected to be present at chemical waste disposal sites. Analysis of samples of breast milk obtained from w...

journal_title：Environmental health perspectives

authors： Rogan W,Gladen B

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Diethylstilbestrol (DES) is a synthetic estrogen associated with adverse effects on reproductive organs. DES-induced toxicity of the mouse seminal vesicle (SV) is mediated by estrogen receptor α (ERα), which alters expression of seminal vesicle secretory protein IV (Svs4) and lactoferrin (Ltf) genes. OBJECT...

journal_title：Environmental health perspectives

authors： Li Y,Hamilton KJ,Lai AY,Burns KA,Li L,Wade PA,Korach KS

更新日期：2014-03-01 00:00:00

abstract：:The relationship between blood pressure and blood lead was examined in two population samples. One of these consisted of 1137 men aged 49 to 65 years, the other of 865 men and 856 women aged 18 to 64 years. Neither population had any known important exposure to lead, and the 95% ranges of blood lead levels were 6 to 2...

journal_title：Environmental health perspectives

authors： Elwood PC,Davey-Smith G,Oldham PD,Toothill C

更新日期：1988-06-01 00:00:00

abstract：:The Clean Air Act requires that sensitive subgroups of exposed populations be protected from adverse health effects of air pollution exposure. Hence, data suggesting the existence of sensitive subgroups can have an important impact on regulatory decisions. Some investigators have interpreted differences among individu...

journal_title：Environmental health perspectives

authors： Brunekreef B,Kinney PL,Ware JH,Dockery D,Speizer FE,Spengler JD,Ferris BG Jr

更新日期：1991-01-01 00:00:00

abstract：:A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant articles were retrieved from preliminary computer database searches by using various key word descriptors and extensive cross-referencing. A priori evaluation criteria were established including...

journal_title：Environmental health perspectives

authors： Calabrese EJ,Baldwin LA

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Arsenic is metabolized through a series of oxidative methylation reactions by arsenic (3) methyltransferase (As3MT) to yield methylated intermediates. Although arsenic exposure is known to increase the risk of atherosclerosis, the contribution of arsenic methylation and As3MT remains undefined. OBJECTIVES:O...

journal_title：Environmental health perspectives

authors： Negro Silva LF,Lemaire M,Lemarié CA,Plourde D,Bolt AM,Chiavatti C,Bohle DS,Slavkovich V,Graziano JH,Lehoux S,Mann KK

更新日期：2017-07-05 00:00:00

abstract：:Elemental boron was isolated in 1808. It typically occurs in nature as borates hydrated with varying amounts of water. Important compounds are boric acid and borax. Boron compounds are also used in the production of metals, enamels, and glasses. In trace amounts, boron is essential for the growth of many plants, and i...

journal_title：Environmental health perspectives

authors： Moseman RF

更新日期：1994-11-01 00:00:00

abstract：:Data from experiments on the induction of specific-locus mutations in model systems are used in genetic risk assessment to estimate potential adverse effects in the human population. In such assessments with radiation or chemical mutagens, the following information is required: a) spontaneous and induced forward-mutat...

journal_title：Environmental health perspectives

authors： de Serres FJ

更新日期：1994-01-01 00:00:00

abstract：:The Thomsen-Friedenreich antigen (Gal-GalNAc) represents a tumor-associated molecule, which is assumed to be one of the few chemically well-defined antigens with a proven association with malignancy. In order to analyze the role of the carbohydrate structure Gal-GalNAc for gastrointestinal tumors, we immunized Balb/c ...

journal_title：Environmental health perspectives

authors： Dippold W,Steinborn A,Meyer zum Büschenfelde KH

更新日期：1990-08-01 00:00:00

abstract：:Previous studies in our laboratory demonstrated that high-performance liquid chromatography (HPLC) analysis of ground corncob bedding extracts characterized two components (peak I and peak II) that disrupted endocrine function in male and female rats and stimulated breast and prostate cancer cell proliferation in vitr...

journal_title：Environmental health perspectives

authors： Markaverich BM,Crowley JR,Alejandro MA,Shoulars K,Casajuna N,Mani S,Reyna A,Sharp J

更新日期：2005-12-01 00:00:00

abstract：:Millions of people worldwide are exposed to arsenic-contaminated drinking water, and ingestion of inorganic arsenic (InAs) has been associated with increased risks of cancer. The primary metabolic pathway of ingested InAs is methylation to monomethyl arsenic (MMA) and dimethyl arsenic (DMA). However, people vary great...

journal_title：Environmental health perspectives

authors： Steinmaus C,Carrigan K,Kalman D,Atallah R,Yuan Y,Smith AH

更新日期：2005-09-01 00:00:00

abstract：:Embryonal carcinoma (EC) cells offer an interesting model system for evaluating differentiation because the cells are pluripotent, thus resembling germ cells and embryonic stem cells, and because a number of agents have been defined that are capable of promoting the differentiation of these cells. This chapter examine...

journal_title：Environmental health perspectives

authors： Astigiano S,Sherman MI,Abarzúa P

更新日期：1989-03-01 00:00:00

abstract：:We report on findings from a 2-year follow-up study of immigrants originating from exposed areas around the site of the 1986 Chernobyl accident matched with comparison subjects emigrating from other republics in the Confederation of Independent States. In the initial study of 708 immigrants, the samples were matched b...

journal_title：Environmental health perspectives

authors： Cwikel J,Abdelgani A,Goldsmith JR,Quastel M,Yevelson II

更新日期：1997-12-01 00:00:00