Abstract：
:Millions of people worldwide are exposed to arsenic-contaminated drinking water, and ingestion of inorganic arsenic (InAs) has been associated with increased risks of cancer. The primary metabolic pathway of ingested InAs is methylation to monomethyl arsenic (MMA) and dimethyl arsenic (DMA). However, people vary greatly in the degree to which they methylate InAs, and recent evidence suggests that those who excrete high proportions of ingested arsenic as MMA are more susceptible than others to arsenic-caused cancer. To date, little is known about the factors that determine interindividual differences in arsenic methylation. In this study, we assessed the effect of diet on arsenic metabolism by measuring dietary intakes and urinary arsenic methylation patterns in 87 subjects from two arsenic-exposed regions in the western United States. Subjects in the lower quartile of protein intake excreted a higher proportion of ingested InAs as MMA (14.6 vs. 11.6%; p = 0.01) and a lower proportion as DMA (72.3 vs. 77.0%; p = 0.01) than did subjects in the upper quartile of protein intake. Subjects in the lower quartile of iron, zinc, and niacin intake also had higher urinary percent MMA and lower percent DMA levels than did subjects with higher intakes of these nutrients. These associations were also seen in multivariate regression analyses adjusted for age, sex, smoking, and total urinary arsenic. Given the previously reported links between high percent MMA and increased cancer risks, these findings are consistent with the theory that people with diets deficient in protein and other nutrients are more susceptible than others to arsenic-caused cancer.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Steinmaus C,Carrigan K,Kalman D,Atallah R,Yuan Y,Smith AHdoi
10.1289/ehp.7907subject
Has Abstractpub_date
2005-09-01 00:00:00pages
1153-9issue
9eissn
0091-6765issn
1552-9924journal_volume
113pub_type
杂志文章abstract：OBJECTIVE:We reviewed epidemiologic evidence related to occupational pesticide exposures and cancer incidence in the Agricultural Health Study (AHS) cohort. DATA SOURCES:Studies were identified from the AHS publication list available at http://aghealth.nci.nih.gov as well as through a Medline/PubMed database search in...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.0901731
更新日期：2010-08-01 00:00:00
abstract：:Untreated wastewater from the Mexico City basin has been used for decades to irrigate cropland in the Mezquital Valley, State of Hidalgo, Mexico. Excess irrigation water recharges the near-surface aquifer that is used as a domestic water supply source. We assessed the groundwater quality of three key groundwater sourc...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.99107553
更新日期：1999-07-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.97105s1105
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:Eliminating silicosis is a priority of the International Labour Organization and the World Health Organization. Prevalence is particularly high in developing countries. OBJECTIVES:We describe trends in silicosis among South African gold miners who had had an autopsy between 1975 and 2007 and quantify the co...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.0900918
更新日期：2010-03-01 00:00:00
abstract：:The 11 September 2001 terrorist attack on New York City's World Trade Center (WTC) caused an unprecedented environmental emergency. The collapse of the towers sent a tremendous cloud of crushed building materials and other pollutants into the air of lower Manhattan. In response to the calamity, federal, state, and cit...
journal_title：Environmental health perspectives
pub_type： 评论,杂志文章
doi：10.1289/ehp.111-1241533
更新日期：2003-06-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.011091303
更新日期：2001-12-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.845547
更新日期：1984-04-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.0901747
更新日期：2010-08-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,meta分析
doi：10.1289/ehp.99107s6841
更新日期：1999-12-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/EHP157
更新日期：2016-10-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.98106513
更新日期：1998-08-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.5702
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Exposure to perfluorooctane sulfonic acid (PFOS) or to perfluorooctanoic acid (PFOA) increases mouse and human peroxisome proliferator-activated receptor alpha (PPARα) subtype activity, which influences lipid metabolism. Because cholesterol is the substrate from which testosterone is synthesized, exposure to...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1408847
更新日期：2015-12-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8568
更新日期：2006-05-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1409191
更新日期：2016-03-01 00:00:00
abstract：:[This corrects the article DOI: https://doi.org/10.1289/EHP507.]. ...
journal_title：Environmental health perspectives
pub_type： 杂志文章,已发布勘误
doi：10.1289/EHP3422
更新日期：2018-02-20 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.97105s2521
更新日期：1997-03-01 00:00:00
abstract：:Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechan...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.887723
更新日期：1988-04-01 00:00:00
abstract：:There is widespread concern regarding the safety of silver-mercury amalgam dental restorations, yet little evidence to support their harm or safety. We examined whether mercury dental amalgams are adversely associated with cognitive functioning in a cross-sectional sample of healthy working adults. We studied 550 adul...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.5879
更新日期：2003-05-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8454111
更新日期：1984-03-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.97105s51235
更新日期：1997-09-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.929769
更新日期：1992-07-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.761617
更新日期：1976-08-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.96104s2173
更新日期：1996-04-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.9089137
更新日期：1990-11-01 00:00:00
abstract：BACKGROUND:Few human studies have examined bisphenol A (BPA) exposure in relation to semen quality and reproductive hormones in men, and results are divergent. OBJECTIVES:We examined associations between urinary BPA concentration and reproductive hormones, as well as semen quality, in young men from the general popula...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1307309
更新日期：2014-05-01 00:00:00
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journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.8454171
更新日期：1984-03-01 00:00:00
abstract：:Methyl eugenol is a naturally occurring material found in a variety of food sources, including spices, oils, and nutritionally important foods such as bananas and oranges. Given its natural occurrence, a broad cross-section of the population is likely exposed. The availability of biomonitoring and toxicology data offe...
journal_title：Environmental health perspectives
pub_type： 杂志文章,评审
doi：10.1289/ehp.9057
更新日期：2006-11-01 00:00:00
abstract：:It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. Therefore, we aimed to assess th...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.011091237
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:Lead exposure is associated with elevated blood pressure during pregnancy; however, the magnitude of this relationship at low exposure levels is unclear. OBJECTIVES:Our goal was to determine the association between low-level lead exposure and blood pressure during late pregnancy. METHODS:We collected admis...
journal_title：Environmental health perspectives
pub_type： 杂志文章
doi：10.1289/ehp.1002666
更新日期：2011-05-01 00:00:00
