In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice.

abstract：BACKGROUND:The mortality impacts of hot and cold temperatures have been thoroughly documented, with most locations reporting a U-shaped relationship with a minimum mortality temperature (MMT) at which mortality is lowest. How MMT may have evolved over previous decades as the global mean surface temperature has increase...

journal_title：Environmental health perspectives

authors： Åström DO,Tornevi A,Ebi KL,Rocklöv J,Forsberg B

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:We evaluated the association between drinking-water disinfection by-products and preterm births using improved exposure assessment and more appropriate analysis methods than used in prior studies. METHODS:During 1999-2001, vital record data were obtained for a large, racially diverse population residing in ...

journal_title：Environmental health perspectives

authors： Lewis C,Suffet IH,Hoggatt K,Ritz B

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Air pollution exposure increases cardiovascular morbidity and mortality and is a major global public health concern. OBJECTIVES:We investigated the benefits of reducing personal exposure to urban air pollution in patients with coronary heart disease. METHODS:In an open randomized crossover trial, 98 patien...

journal_title：Environmental health perspectives

authors： Langrish JP,Li X,Wang S,Lee MM,Barnes GD,Miller MR,Cassee FR,Boon NA,Donaldson K,Li J,Li L,Mills NL,Newby DE,Jiang L

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Animal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast cancer risk. OBJECTIVES:We examined the association between residential outdoor LAN ...

journal_title：Environmental health perspectives

authors： James P,Bertrand KA,Hart JE,Schernhammer ES,Tamimi RM,Laden F

更新日期：2017-08-17 00:00:00

abstract：:Techniques are available to minimize the concentration of asbestos fibers in drinking water. Filtration research conducted at locations on Lake Superior and in the Cascade Mountains in Washington has shown that amphibole and chrysotile fibers can be removed by granular media filtration. Removal percentages can exceed ...

journal_title：Environmental health perspectives

authors： Logsdon GS

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Millions of individuals worldwide, particularly those living in rural and developing areas, are exposed to harmful levels of inorganic arsenic (iAs) in their drinking water. Inorganic As exposure during key developmental periods is associated with a variety of adverse health effects, including those that are...

journal_title：Environmental health perspectives

authors： Bailey KA,Smith AH,Tokar EJ,Graziano JH,Kim KW,Navasumrit P,Ruchirawat M,Thiantanawat A,Suk WA,Fry RC

更新日期：2016-02-01 00:00:00

abstract：:Rats were instilled intrabronchially with 1 mg UICC amosite suspended in 0.2 mL of filtered saline; control animals received the saline instillation only. Five animals from each group were killed on various days after instillation, up to day 128/129. Total retrieved cell counts and differential cell analysis were perf...

journal_title：Environmental health perspectives

authors： Oberdoerster G,Ferin J,Marcello NL,Meinhold SH

更新日期：1983-09-01 00:00:00

abstract：:Cooking, heat processing, or pyrolysis of protein-rich foods induce the formation of a series of structurally related heterocyclic aromatic bases that have been found to be mutagens. The primary genetic assay utilized to detect and isolate these mutagens has been the his reversion assay in Salmonella typhimurium. The ...

journal_title：Environmental health perspectives

authors： Hatch FT

更新日期：1986-08-01 00:00:00

abstract：:The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in our laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of ma...

journal_title：Environmental health perspectives

authors： Sorenson WG,Gerberick GF,Lewis DM,Castranova V

更新日期：1986-04-01 00:00:00

abstract：:Microarrays provide an unprecedented opportunity for comprehensive concurrent analysis of thousands of genes. The global analysis of the response of genes to a toxic insult (toxicogenomics), as opposed to the historical method of examining a few select genes, provides a more complete picture of toxicologically signifi...

journal_title：Environmental health perspectives

authors： Newton RK,Aardema M,Aubrecht J

更新日期：2004-03-01 00:00:00

abstract：:Articles in the literature on alpha-1 antitrypsin (AAT) deficiency have been interpreted as indicating that AAT deficiency is a rare disease that affects mainly Caucasians (whites) from northern Europe. In a recent publication on the worldwide racial and ethnic distribution of AAT deficiency, new data were presented d...

journal_title：Environmental health perspectives

authors： de Serres FJ

更新日期：2003-12-01 00:00:00

abstract：:In an earlier study we established that timely and adequate tissue repair response following the administration of a six-fold dose-range of thioacetamide (TA; 50, 150, and 300 mg/kg) prevented progression of injury and led to recovery and animal survival. Delayed and attenuated repair response after the 600 mg/kg TA d...

journal_title：Environmental health perspectives

authors： Mangipudy RS,Rao PS,Mehendale HM

更新日期：1996-07-01 00:00:00

abstract：:Historical aerial applications of the insecticide Matacil 1.8D provide an opportunity to look for potential effects of the endocrine disrupting compound 4-nonylphenol (4-NP) on Atlantic salmon (Salmo salar) populations. Matacil 1.8D contained the carbamate insecticide aminocarb, with 4-NP as primary solvent. Between 1...

journal_title：Environmental health perspectives

authors： Fairchild WL,Swansburg EO,Arsenault JT,Brown SB

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:We characterized an endocrine disruptor from ground corncob bedding material that interferes with male and female sexual behavior and ovarian cyclicity in rats and stimulates estrogen receptor (ER)-positive and ER-negative breast cancer cell proliferation. The agents were identified as an isomeric mixture of...

journal_title：Environmental health perspectives

authors： Markaverich BM,Crowley J,Rodriquez M,Shoulars K,Thompson T

更新日期：2007-12-01 00:00:00

abstract：:In different weather conditions, constituents and concentrations of pollutants, personal exposure, and biologic responses to air pollution may vary. In this study we assessed the effects of four air pollutants on mortality in both cool and warm seasons in Hong Kong, a subtropical city. Daily counts of mortality, due t...

journal_title：Environmental health perspectives

authors： Wong CM,Ma S,Hedley AJ,Lam TH

更新日期：2001-04-01 00:00:00

abstract：:To elucidate problems with microfungal infestation in indoor environments, a multidisciplinary collaborative pilot study, supported by a grant from the Danish Ministry of Housing and Urban Affairs, was performed on 72 mold-infected building materials from 23 buildings. Water leakage through roofs, rising damp, and def...

journal_title：Environmental health perspectives

authors： Gravesen S,Nielsen PA,Iversen R,Nielsen KF

更新日期：1999-06-01 00:00:00

abstract：:Biomarkers are desirable for quantitating human exposure to environmental tobacco smoke (ETS) and for predicting potential health risks for exposed individuals. A number of biomarkers of ETS have been proposed. At present cotinine, measured in blood, saliva, or urine, appears to be the most specific and the most sensi...

journal_title：Environmental health perspectives

authors： Benowitz NL

更新日期：1999-05-01 00:00:00

abstract：:Ecological risk assessment can be enhanced with predictive models for metal toxicity. Modelings of published data were done under the simplifying assumption that intermetal trends in toxicity reflect relative metal-ligand complex stabilities. This idea has been invoked successfully since 1904 but has yet to be applied...

journal_title：Environmental health perspectives

authors： Newman MC,McCloskey JT,Tatara CP

更新日期：1998-12-01 00:00:00

abstract：:Present available information regarding ovarian tumors in hens is incomplete in most aspects, and this lack of knowledge hampers use of hens as models for study of ovarian cancer. A study of 466 hens ranging from 2 to 7 years of age and covering a period of more than 3 years has provided much needed information relati...

journal_title：Environmental health perspectives

authors： Fredrickson TN

更新日期：1987-08-01 00:00:00

abstract：:In recent years there have been a significant number of publications on the benefits and challenges of community-based participatory research (CBPR). In this introduction we give an overview of three projects presented in this mini-monograph and highlight their commonalities and differences in developing community-uni...

journal_title：Environmental health perspectives

authors： Srinivasan S,Collman GW

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Concern persists over endocrine-disrupting effects of persistent organic pollutants (POPs) on human growth and sexual maturation. Potential effects of toxicant exposures on testosterone levels during puberty are not well characterized. OBJECTIVES:In this study we evaluated the relationship between toxicants...

journal_title：Environmental health perspectives

authors： Schell LM,Gallo MV,Deane GD,Nelder KR,DeCaprio AP,Jacobs A,Akwesasne Task Force on the Environment.

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) affects 71 million American adults and remains the leading cause of death in the United States and Europe. Despite studies that suggest that the development of CVD may be linked to intrauterine growth or early events in childhood, little direct experimental evidence supports the ...

journal_title：Environmental health perspectives

authors： Ng SP,Conklin DJ,Bhatnagar A,Bolanowski DD,Lyon J,Zelikoff JT

更新日期：2009-07-01 00:00:00

abstract：:The occurrence of high cadmium levels in the digestive gland (hepatopancreas) of the crab Cancer pagurus is reviewed and its possible significance to human health is discussed. Previous attempts to isolate this cadmium in its native form are briefly reviewed and the present method used in this laboratory to isolate cr...

journal_title：Environmental health perspectives

authors： Overnell J

更新日期：1986-03-01 00:00:00

abstract：:Predictions of carcinogenic activity are made for 30 chemicals currently being assessed for rodent carcinogenicity by the U.S. National Toxicology Program. The predictions are based upon the chemical structure, the anticipated or reported mutagenicity, and the reported sub-chronic toxicity of each chemical. It is pred...

journal_title：Environmental health perspectives

authors： Ashby J

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Mortality displacement (or "harvesting") has been identified as a key issue in the assessment of the temperature-mortality relationship. However, only a few studies have addressed the "harvesting" issue and findings have not been consistent. OBJECTIVES:We examined the potential impact of both short- and lon...

journal_title：Environmental health perspectives

authors： Qiao Z,Guo Y,Yu W,Tong S

更新日期：2015-08-01 00:00:00

abstract：:Antisera elicited in rabbits were used in radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) to determine femtomole quantities of deoxyguanosin-(8-yl)-acetylaminofluorene (dg-8-AAF) and deoxyguanosin-(8-yl)-aminofluorene (dg-8-AF). These adducts have been monitored in liver and kidney DNA of male Wis...

journal_title：Environmental health perspectives

authors： Poirier MC,True B,Laishes BA

更新日期：1983-03-01 00:00:00

abstract：:Some of the statistical properties of a simple two-stage model of carcinogenesis are explored. The implications of additive treatment effects versus independent treatment effects on the shape of the dose-response curve are considered. Response that is low-dose linear results in the cases where the mutation rates are a...

journal_title：Environmental health perspectives

authors： Portier CJ

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Due to the large number of chemicals not yet tested for carcinogenicity but to which people are exposed, the limited number of human and animal cancer studies conducted each year, and the frequent need for a timely response, mechanistic data are playing an increasingly important role in carcinogen hazard ide...

journal_title：Environmental health perspectives

authors： Atwood ST,Lunn RM,Garner SC,Jahnke GD

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Controversy remains regarding the relationship between ambient ozone and mortality worldwide. In mainland China, the largest developing country, there has been no prior study investigating the acute effect of O3 on death risk. Given the changes in types of air pollution from conventional coal combustion to t...

journal_title：Environmental health perspectives

authors： Zhang Y,Huang W,London SJ,Song G,Chen G,Jiang L,Zhao N,Chen B,Kan H

更新日期：2006-08-01 00:00:00

abstract：:High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA) ] with no known historical cadmium contamination, we investiga...

journal_title：Environmental health perspectives

authors： Akesson A,Bjellerup P,Lundh T,Lidfeldt J,Nerbrand C,Samsioe G,Skerfving S,Vahter M

更新日期：2006-06-01 00:00:00