Abstract:
BACKGROUND:Concern persists over endocrine-disrupting effects of persistent organic pollutants (POPs) on human growth and sexual maturation. Potential effects of toxicant exposures on testosterone levels during puberty are not well characterized. OBJECTIVES:In this study we evaluated the relationship between toxicants [polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (p,p´-DDE), hexachlorobenzene (HCB), and lead] and testosterone levels among 127 Akwesasne Mohawk males 10 to < 17 years of age with documented toxicant exposures. METHODS:Data were collected between February 1996 and January 2000. Fasting blood specimens were collected before breakfast by trained Akwesasne Mohawk staff. Multivariable regression models were used to estimates associations between toxicants and serum testosterone, adjusted for other toxicants, Tanner stage, and potential confounders. RESULTS:The sum of 16 PCB congeners (Σ16PCBs) that were detected in ≥ 50% of the population was significantly and negatively associated with serum testosterone levels, such that a 10% change in exposure was associated with a 5.6% decrease in testosterone (95% CI: -10.8, -0.5%). Of the 16 congeners, the more persistent ones (Σ8PerPCBs) were related to testosterone, whereas the less persistent ones, possibly reflecting more recent exposure, were not. When PCB congeners were subgrouped, the association was significant for the sum of eight more persistent PCBs (5.7% decrease; 95% CI: -11, -0.4%), and stronger than the sum of six less persistent congeners (3.1% decrease; 95% CI: -7.2, 0.9%). p,p´-DDE was positively but not significantly associated with serum testosterone (5.2% increase with a 10% increase in exposure; 95% CI: -0.5, 10.9%). Neither lead nor HCB was significantly associated with testosterone levels. CONCLUSIONS:Exposure to PCBs, particularly the more highly persistent congeners, may negatively influence testosterone levels among adolescent males. The positive relationship between p,p´-DDE and testosterone indicates that not all POPs act similarly. CITATION:Schell LM, Gallo MV, Deane GD, Nelder KR, DeCaprio AP, Jacobs A; Akwesasne Task Force on the Environment. 2014. Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene (p,p´-DDE) with testosterone levels in adolescent males. Environ Health Perspect 122:304-309; http://dx.doi.org/10.1289/ehp.1205984.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Schell LM,Gallo MV,Deane GD,Nelder KR,DeCaprio AP,Jacobs A,Akwesasne Task Force on the Environment.doi
10.1289/ehp.1205984subject
Has Abstractpub_date
2014-03-01 00:00:00pages
304-9issue
3eissn
0091-6765issn
1552-9924journal_volume
122pub_type
杂志文章abstract::The effects of inhaled zinc oxide/hexachloroethane smoke (11,580 mg x min/m3) and intratracheally instilled zinc chloride (2.5 mg/kg body weight) have been studied in rat lung. The effects of subsequent treatment with 70% oxygen have been studied after both procedures. Both the inhalation of the smoke and instillation...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.85-1568343
更新日期:1990-04-01 00:00:00
abstract::The phenomenon of fiber-induced cytotoxicity to P388D1 macrophagelike cells has been demonstrated to parallel (thus far without exception) the probability that the fiber will induce a pleural sarcoma (mesothelioma) in rats. This startling parallel in both cases seems to be essentially independent of the chemical natur...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.803491
更新日期:1980-02-01 00:00:00
abstract::Nationwide, 45 states issue health advisories for sport fish consumers. Chemical contaminants in some Great Lakes (GL) sport fish include compounds suspected of causing adverse reproductive and developmental effects. Although advisories to reduce consumption of contaminated fish, especially by women, have been issued ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.971051360
更新日期:1997-12-01 00:00:00
abstract::The consideration of ethical issues relating to pediatric environmental health is a recent phenomenon. Discussions of biomedical ethics, research on children, and environmental health research have a longer history. In the late 1990s, researchers at the Kennedy Krieger Institute in Baltimore, Maryland, undertook a stu...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9000
更新日期:2006-10-01 00:00:00
abstract::The last decade has marked a radical change in the business of sustainability, say environmental activists and industrialists alike. On the wane are "greenwashing" campaigns in which corporations promote dubious environmental accomplishments to draw attention away from environmentally damaging practices. On the rise a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.110-a142
更新日期:2002-03-01 00:00:00
abstract::The combined effects of carbon monoxide and low temperature on daily variation in hospital admissions for congestive heart failure (CHF) were examined for a 4-year period in Chicago, Illinois. Medicare hospital admissions for CHF were analyzed as a function of the maximum hourly temperature, maximum hourly levels of c...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106649
更新日期:1998-10-01 00:00:00
abstract::The available data on the influence of selenium on the toxicity of methylmercury and of methylmercury on selenium as a nutrient and toxic agent are reviewed. Selenium as selenite has a relative protective effect on acute and subacute toxicity of methylmercury in the rat and the quail. The protective mechanism is far f...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.782557
更新日期:1978-08-01 00:00:00
abstract::Locating geographic hot spots of cancer may lead to new causal hypotheses and ultimately to new knowledge of cancer-causing factors. The Cape Cod region of Massachusetts has experienced elevated incidence of breast cancer compared with statewide averages. The origins of the excess remain largely unexplained, even afte...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110471
更新日期:2002-05-01 00:00:00
abstract::The heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was evaluated for carcinogenic effects in macaques, primarily cynomolgus monkeys. IQ was administered by gavage five times a week at doses of 10 or 20 mg/kg. IQ induced hepatocellular carcinoma in 55% of the animals at the low dose and in 95%...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102190
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. OBJECTIVE:We evaluated the lifetime use of individual pesticides an...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP6334
更新日期:2020-06-01 00:00:00
abstract::Basophilic hepatic foci, nodules, and trabecular hepatocellular carcinomas, collectively referred to as focal hepatic lesions, were induced by single injections of 5.0 micrograms of diethylnitrosamine (DEN) per gram body weight in 15-day-old C57BL/6J X C3HeB/FeJ F1 (B6C3 F1) mice. Groups of eight experimental and eigh...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8350149
更新日期:1983-04-01 00:00:00
abstract::Human health and aquatic animal health are organically related at three distinct interfaces. Aquatic animals serve as important contributors to the nutritional protein, lipid, and vitamin requirements of humans; as carriers and transmitters of many infectious and parasitic diseases to which humans are susceptible; and...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.9086245
更新日期:1990-06-01 00:00:00
abstract::With the "graying of America," the prevalence of neurodegenerative diseases such as Alzheimer disease (AD) and Parkinson disease (PD) will make increasingly greater demands on Medicare/Medicaid resources, which will greatly strain the national economy. It is imperative that prevention and intervention strategies for t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Although 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been associated with alterations in ovarian function and hormones in animals, it has not been studied in humans. On 10 July 1976, an explosion exposed residents of Seveso, Italy, to the highest levels of TCDD in a population. Twenty years later, we init...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9667
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Animal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast cancer risk. OBJECTIVES:We examined the association between residential outdoor LAN ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP935
更新日期:2017-08-17 00:00:00
abstract::On 15-16 September 1997, the U.S. Environmental Protection Agency sponsored the Conference on Preventable Causes of Cancer in Children. The conference was convened to examine rising trends in reported incidence of childhood cancer and the association of these trends with environmental exposures. This paper summarizes ...
journal_title:Environmental health perspectives
pub_type:
doi:10.1289/ehp.98106867
更新日期:1998-06-01 00:00:00
abstract::The lungs may be exposed to potentially toxic metabolites that are either formed in situ or which are present in the circulation. Therefore, pulmonary injury may be a prominent effect of certain classes of chemicals that undergo bioactivation in the body. The specific types of lung cells damaged may depend upon factor...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.845547
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Thyroid hormones are important regulators of brain development. During critical periods of development, even transient disorders in thyroid hormone availability may lead to profound neurologic impairment. Animal experiments have shown that certain environmental pollutants, including heavy metals and organoch...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.10486
更新日期:2007-12-01 00:00:00
abstract::The purpose of the investigation is to study whether an increased mortality from certain causes exists in an area around the Rönnskärsverken smelter works in northern Sweden. Founded in 1928, this metallurgical plant processing mainly nonferrous metals has since its initial operations been using ore with a high arseni...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7719133
更新日期:1977-08-01 00:00:00
abstract::This paper will briefly outline those elements which must be considered in assessing the effects of any given compound which might impinge on the actions of adrenocortical steroids. Considerations that ought to be taken into account include the following: the delivery to the affected cells of corticosteroids, the upta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.813899
更新日期:1981-04-01 00:00:00
abstract::Biological markers of intermediate health outcomes sometimes provide a superior alternative to traditional measures of pollutant-related disease. Some opportunities and methodologic issues associated with using markers are discussed in the context of exposures to four complex mixtures: environmental tobacco smoke and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s4193
更新日期:1993-12-01 00:00:00
abstract::Under a mandate from the U.S. Congress, the National Toxicology Program (NTP) of the U.S. Department of Health and Human Services conducts animal bioassays for carcinogenicity of potentially toxic chemicals to which the U.S. population might be exposed. Methyleugenol, a natural as well as synthesized substance, was no...
journal_title:Environmental health perspectives
pub_type: 临床试验,杂志文章
doi:10.1289/ehp.6766
更新日期:2004-05-01 00:00:00
abstract::Individual variability in human arsenic metabolism has been reported frequently in the literature. This variability could be an underlying determinant of individual susceptibility to arsenic-induced disease in humans. Recent analysis revealing familial aggregation of arsenic metabolic profiles suggests that genetic fa...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.6420
更新日期:2003-08-01 00:00:00
abstract::We conducted a study on building-related respiratory disease and associated social impact in an office building with water incursions in the northeastern United States. An initial questionnaire had 67% participation (888/1,327). Compared with the U.S. adult population, prevalence ratios were 2.2-2.5 for wheezing, life...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7559
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Millions of individuals worldwide, particularly those living in rural and developing areas, are exposed to harmful levels of inorganic arsenic (iAs) in their drinking water. Inorganic As exposure during key developmental periods is associated with a variety of adverse health effects, including those that are...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409360
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:Lead exposure is associated with elevated blood pressure during pregnancy; however, the magnitude of this relationship at low exposure levels is unclear. OBJECTIVES:Our goal was to determine the association between low-level lead exposure and blood pressure during late pregnancy. METHODS:We collected admis...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002666
更新日期:2011-05-01 00:00:00
abstract::We assessed chlorinated hydrocarbon contamination of mink and river otters on the Columbia and Fraser River systems of northwestern North America, in relation to morphological measures of condition. We obtained carcasses of mink and river otters from commercial trappers during the winters 1994-1995 and 1995-1996. Necr...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107141
更新日期:1999-02-01 00:00:00
abstract::This paper concerns the testing for Hardy-Weinberg equilibrium and the estimation of gene frequency in the human leukocyte antigens (HLA) system. An extensive simulation study for both testing and estimation is given for investigating the performance of the projection method by Eguchi and Matsuura, which has a closed ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9087149
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:Cumulative lead exposure is associated with a widened pulse pressure (PP; the -difference between systolic and diastolic blood pressure), a marker of arterial stiffness and a predictor of cardiovascular disease. Polymorphisms in the hemochromatosis gene (HFE) have been shown to modify the impact of cumulativ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002251
更新日期:2010-09-01 00:00:00
abstract::Soil ingestion estimates play an important role in risk assessment of contaminated sites, and estimates of soil ingestion in children are of special interest. Current estimates of soil ingestion are trace-element specific and vary widely among elements. Although expressed as daily estimates, the actual estimates have ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103276
更新日期:1995-03-01 00:00:00