Abstract:
:Antisera elicited in rabbits were used in radioimmunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) to determine femtomole quantities of deoxyguanosin-(8-yl)-acetylaminofluorene (dg-8-AAF) and deoxyguanosin-(8-yl)-aminofluorene (dg-8-AF). These adducts have been monitored in liver and kidney DNA of male Wistar-Furth rats fed 0.02% or 0.04% 2-acetylaminofluorene (2-AAF) either continuously or for a limited time followed by an interval on control diet. After 24 hr of 0.02% 2-AAF feeding, substantial levels of binding (80 fmole/mug DNA) were observed in liver DNA and increased with time, reaching a plateau of approximately 230 fmole/mug DNA at 30 days and thereafter. During the first week of continuous feeding about 80% of the total C-8 adducts in the liver DNA were deacetylated (dG-8-AF). By 25-60 days, dG-8-AF represented 97-100% of all C-8 adducts as measured by RIA and confirmed by HPLC. Values for C-8 adduct formation in kidney DNA were severalfold lower than in liver and dG-8-AF represented >90% of C-8 adducts at all times studied. In removal or repair experiments, rats were fed 2-AAF for 3, 7 or 28 days, the 2-AAF diet was discontinued and the liver adducts assayed after intervals on control diet. When dietary 2-AAF administration was for 3 or 7 days, removal of adducts was efficient and almost complete by 28 days on control diet, with preferential retention of dG-8-AF. However, when dietary 2-AAF administration was for 28 days, adduct levels were higher, the repair capacity was saturated and the removal of C-8 adducts was not complete after control diet for a 28-day interval. In a preliminary experiment when [(3)H]-2-AAF was fed for 3 days, after 25 days of 0.02% 2-AAF, the rates of newly formed adduct formation and removal were similar to those observed for the initial 3 days of 2-AAF feeding. These results demonstrate the predominance and persistence of dG-8-AF in liver and kidney DNA of 2-AAF-fed rats and suggest that the repair capacity of the whole rat liver was not diminished after 1 month of 2-AAF feeding.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Poirier MC,True B,Laishes BAdoi
10.1289/ehp.834993subject
Has Abstractpub_date
1983-03-01 00:00:00pages
93-9eissn
0091-6765issn
1552-9924journal_volume
49pub_type
杂志文章abstract::Benzene has been known to be a bone marrow poison for almost a century. However, it was not until the last decade that benzene's carcinogenic potential was demonstrated by epidemiologic studies. The proposed regulation by the Occupational Safety and Health Administration (OSHA) to lower exposure levels of benzene in t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.835275
更新日期:1983-10-01 00:00:00
abstract::The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency spon...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.96104s4715
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Animal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast cancer risk. OBJECTIVES:We examined the association between residential outdoor LAN ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP935
更新日期:2017-08-17 00:00:00
abstract:BACKGROUND:Bacterial meningitis causes a high burden of disease in the African meningitis belt, with regular seasonal hyperendemicity and sporadic short, but intense, localized epidemics during the late dry season occurring at a small spatial scale [i.e., below the district level, in individual health centers (HCs)]. I...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP2752
更新日期:2018-09-01 00:00:00
abstract::There is concern about the human health effects of inhalation of acid compounds found in urban air pollution. It was the purpose of this study to investigate three of these acid compounds, sulfur dioxide (SO2), sulfuric acid (H2SO4), and nitric acid (HNO3) in a group of allergic adolescent subjects. Subjects were expo...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8979173
更新日期:1989-02-01 00:00:00
abstract::Polycyclic aromatic hydrocarbons (PAHs) are toxic pollutants released by the World Trade Center (WTC) fires and various urban combustion sources. Benzo[a]pyrene (BaP) is a representative member of the class of PAHs. PAH-DNA adducts, or BaP-DNA adducts as their proxy, provide a measure of chemical-specific genetic dama...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7908
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:"Airwave" is the new communication system currently being rolled out across the United Kingdom for the police and emergency services, based on the Terrestrial Trunked Radio Telecommunications System (TETRA). Some police officers have complained about skin rashes, nausea, headaches, and depression as a conseq...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.0901416
更新日期:2010-06-01 00:00:00
abstract::During a 2-year chronic inhalation study on methylene chloride (2000 or 0 ppm; 6 hr/day, 5 days/week), gas-uptake pharmacokinetic studies and tissue partition coefficient determinations were conducted on female B6C3F1, mice after 1 day, 1 month, 1 year, and 2 years of exposure. Using physiologically based pharmacokine...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104858
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Industrial air pollution is a public health hazard. Previous evidence documented increased respiratory symptoms and hospitalizations in children who live near the factories in the largest chipboard manufacturing district in Italy (Viadana). OBJECTIVES:We evaluated the association of outdoor exposure to form...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307259
更新日期:2014-06-01 00:00:00
abstract::The effects of inhaled zinc oxide/hexachloroethane smoke (11,580 mg x min/m3) and intratracheally instilled zinc chloride (2.5 mg/kg body weight) have been studied in rat lung. The effects of subsequent treatment with 70% oxygen have been studied after both procedures. Both the inhalation of the smoke and instillation...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.85-1568343
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Pterygium is a fibrovascular growth of the bulbar conjunctiva and underlying subconjunctival tissue that may cause blindness. The mechanism of pterygium formation is not yet fully understood, but pterygium has some tumorlike features. OBJECTIVES:The objective of this study was to evaluate the association be...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.11111
更新日期:2008-07-01 00:00:00
abstract::Adults eating a Western diet digest and absorb ingested food containing approximately 100 g fat, 350 g carbohydrate, and 75 g protein daily. Normal fat absorption requires adequate gastric, pancreatic, liver-biliary, mucosal, and lymphatic function. Carbohydrate and protein absorption is much less dependent on liver-b...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7933101
更新日期:1979-12-01 00:00:00
abstract::The many anatomical, physiological, and biochemical differences among various mammalian species make it difficult to extrapolate carcinogenic potency data from animals to humans. The process is further complicated by the multistep origin of most malignant tumors in animals and humans due to the interaction of target c...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.887773
更新日期:1988-04-01 00:00:00
abstract::Although most people are thought to receive their highest acute exposures to gasoline while refueling, relatively little is actually known about personal, nonoccupational exposures to gasoline during refueling activities. This study was designed to measure exposures associated with the use of an oxygenated fuel under ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.97105850
更新日期:1997-08-01 00:00:00
abstract::As a result of the Leadership Conference on Biomedical Research and the Environment, the Facilities Committee focused its work on the development of best environmental practices at biomedical research facilities at the university and independent research facility level as well as consideration of potential involvement...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108s6945
更新日期:2000-12-01 00:00:00
abstract::Environmental health is a subject that has only relatively recently become prominent in the social consciousness. Even as its significance becomes known, finding ways to integrate the subject into education for primary and secondary students is difficult because of federal testing requirements under the No Child Left ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.112-a814
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) has been consistently associated with preterm birth (PTB) to varying degrees, but roles of PM2.5 species have been less studied. OBJECTIVE:We estimated risk differences (RD) of PTB (reported per 106 pregnancies) associated with change in ambient co...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408953
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Toxicology studies have shown adverse effects of developmental exposure to industrial phenols. Evaluation in humans is challenged by potentially marked within-subject variability of phenol biomarkers in pregnant women, which is poorly characterized. OBJECTIVES:We aimed to characterize within-day, between-da...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP1994
更新日期:2018-03-16 00:00:00
abstract::Over 250 adults and children were exposed to chlordane when the wooden building surfaces and soil around an apartment complex were sprayed in 1987. Two hundred-sixteen adults had neurobehavioral functions measured and completed questionnaires for symptom frequency, mood status, confounding factors, and medical, rheuma...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.95103690
更新日期:1995-07-01 00:00:00
abstract:BACKGROUND:Epidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear. OBJECTIVE:We developed a model to examine influenza-induced innate immune responses in humans and test the hypothesis that exposure to cigarette smoke alters na...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002258
更新日期:2011-01-01 00:00:00
abstract::Surface IR (infrared) modes of crystalline and fumed (amorphous) silica particles, calcined at temperatures up to 1095 degrees C, have been studied by Fourier transform infrared spectroscopy. The ability of these same particles to lyse cells has been measured by a hemolysis protocol. The untreated crystalline and amor...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9086327
更新日期:1990-06-01 00:00:00
abstract::It has been estimated that 4 of 1,000 live births and 35% of spontaneous abortions are aneuploid and that an important proportion of embryo and newborn aneuploidy is of paternal origin. Exposure to organophosphorous pesticides (OP) has been associated with sperm hyperploidy/polyploidy. Therefore, we aimed to assess th...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.011091237
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVES:The National Environmental Policy Act and related state laws require many public agencies to analyze and disclose potentially significant environmental effects of agency actions, including effects on human health. In this paper we review the purpose and procedures of environmental impact assessment (EIA), ex...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.11132
更新日期:2008-08-01 00:00:00
abstract::Much public health research has been directed to studies of cancer risks due to chemical agents. Recently, increasing attention has been given to adverse reproductive outcomes as another, shorter-term biologic indicator of public health impact. Further, several low-level ubiquitous physical agents have been implicated...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.8981193
更新日期:1989-05-01 00:00:00
abstract::The combined effects of carbon monoxide and low temperature on daily variation in hospital admissions for congestive heart failure (CHF) were examined for a 4-year period in Chicago, Illinois. Medicare hospital admissions for CHF were analyzed as a function of the maximum hourly temperature, maximum hourly levels of c...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106649
更新日期:1998-10-01 00:00:00
abstract::Cytotoxic chemicals have in common the ability to act specifically on cells in cycle. Bacteria are more sensitive in the exponential growth phase than when growing slowly in media. Similar observations have been made on a variety of systems ranging from bacteria, yeast, higher plants and invertebrates to vertebrates i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.782487
更新日期:1978-06-01 00:00:00
abstract::Short articles on the following topics: *NIEHS Strategic Plan: New Frontiers in Environmental Sciences and Human Health; Beyond the Bench: Environmental Health Nursing: Putting Knowledge into Practice; Headliners: Inhibition of RLIP76 Causes Complete Regression of Melanoma in Mice. ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight. OBJECTIVES:We aimed to investigate the relationship between residential traffic and railway noise and a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1409052
更新日期:2016-03-01 00:00:00
abstract::The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentratio...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102s3335
更新日期:1994-09-01 00:00:00
abstract::We assessed the reproducibility of X-ray fluorescence-based lead measurements from multiple measurements made on a low-concentration plaster of paris phantom and in five subjects measured five times on two occasions. Over a 6-month period, 220 measurements of the same phantom were obtained and showed a standard deviat...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.94102690
更新日期:1994-08-01 00:00:00