Abstract:
:The possible risk for human health arising from consumption of lead-polluted shellfish was suggested by experiments on the bioavailability for mice of a "biologically detoxified" form of the metal. In this work, young mice were fed with a mixed diet including mussels collected in a Pb-polluted area. Metal concentrations in blood, kidney, liver, urine, and feces and the activity of erythrocytic delta-aminolevulinic acid dehydratase were determined after 1, 2, and 4 weeks. Comparisons were made with mice treated with balanced diet, mixed diet including control mussels, and drinking water with lead dissolved as acetate. In mice fed polluted mussels, lead concentrations increased in blood, kidney, and liver, whereas no significant accumulation was observed in urine. Different responses in mice treated with Pb(CH3COO)2 in drinking water are probably due to the diversity of lead chemical form in the two treatments. Our results demonstrate the bioavailability of biologically detoxified lead that can be transferred to a consumer with possible consequences also for human health.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Regoli F,Orlando Edoi
10.1289/ehp.94102s3335subject
Has Abstractpub_date
1994-09-01 00:00:00pages
335-8eissn
0091-6765issn
1552-9924journal_volume
102 Suppl 3pub_type
杂志文章abstract::Ambient monitoring of acid aerosols in four U.S. cities and in a rural region of southern Ontario clearly show distinct periods of strong acidity. Measurements made in Kingston, TN, and Steubenville, OH, resulted in 24-hr H+ ion concentrations exceeding 100 nmole/m3 more than 10 times during summer months. Periods of ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.897943
更新日期:1989-02-01 00:00:00
abstract::The effects of inhaled zinc oxide/hexachloroethane smoke (11,580 mg x min/m3) and intratracheally instilled zinc chloride (2.5 mg/kg body weight) have been studied in rat lung. The effects of subsequent treatment with 70% oxygen have been studied after both procedures. Both the inhalation of the smoke and instillation...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.85-1568343
更新日期:1990-04-01 00:00:00
abstract::Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7475
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Evidence indicates that air pollution contributes to cardiopulmonary mortality. There is ongoing debate regarding the size and shape of the pollution–mortality exposure–response relationship. There are also growing appeals for estimates of pollution–mortality relationships that use public data and are based ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP4438
更新日期:2019-07-01 00:00:00
abstract::In this study, we aimed to estimate the contribution of environmental pollutants to the incidence, prevalence, mortality, and costs of pediatric disease in American children. We examined four categories of illness: lead poisoning, asthma, cancer, and neurobehavioral disorders. To estimate the proportion of each attrib...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.02110721
更新日期:2002-07-01 00:00:00
abstract::Medically unexplained physical symptoms (MUPS) are persistent idiopathic symptoms that drive patients to seek medical care. MUPS syndromes include chronic fatigue syndrome, fibromyalgia syndrome, and multiple chemical sensitivities. When MUPS occur after an environmental exposure or injury, an adversarial social conte...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.02110s4641
更新日期:2002-08-01 00:00:00
abstract::With this research I tested the hypothesis that individual preferences for specific ecosystem components and restorative environments are significantly associated with quality of life (QOL). A total of 379 human subjects responded to a structured 18-item questionnaire on topophilia and to the 26-item World Health Orga...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7467
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:Cadmium (Cd) is a ubiquitous environmental toxicant that can accumulate in the placenta during pregnancy, where it may impair placental function and affect fetal development. OBJECTIVES:We aimed to investigate Cd-associated variations in placental DNA methylation (DNAM) and associations with gene expression...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP2192
更新日期:2018-01-22 00:00:00
abstract:BACKGROUND:Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited. OBJECTIVE:To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9662
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Research often suffers from overspecialization, a practice nurtured in academia and reinforced by funders. Indeed, investigators in household air pollution (HAP) and water, sanitation and hygiene (WaSH), working in poor parts of the world, rarely interact despite having similar training and using similar met...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP4752
更新日期:2019-02-01 00:00:00
abstract::Polybrominated biphenyls (PBBs) cause a mixed-type (phenobarbital- plus 3-methylcholanthrene-like) induction of liver microsomal drug metabolizing enzymes in rats. However, 2,2',4,4',5,5'-hexabromobiphenyl and 2,2',3,4,4',5,5'-heptabromobiphenyl, which together comprise less than 80% of PBBs (FireMaster), were shown t...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7823159
更新日期:1978-04-01 00:00:00
abstract::Mass poisonings, called yusho and yu-cheng, occurred in western Japan in 1968 and central Taiwan in 1979, respectively. These occurrences were separately caused by ingestion of rice oils contaminated with polychlorinated biphenyls (PCBs), polychlorinated dibenzofurans (PCDFs) and polychlorinated quaterphenyls. The tot...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8560321
更新日期:1985-05-01 00:00:00
abstract::Food allergy affects between 5% and 7.5% of children and between 1% and 2% of adults. The greater prevalence of food allergy in children reflects both the increased predisposition of children to develop food allergies and the development of immunologic tolerance to certain foods over time. Immunoglobulin (Ig) E-mediat...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.5702
更新日期:2003-02-01 00:00:00
abstract::Alzheimer's disease is a progressive degenerative brain disease of unknown etiology, characterized by the development of large numbers of neurofibrillary tangles and senile plaques in the brain. Aluminum salts may be used experimentally to produce lesions which are similar, but not identical, to the neurofibrillary ta...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8563149
更新日期:1985-11-01 00:00:00
abstract::We conducted a study to examine seasonal changes in residential dust lead content and its relationship to blood lead in preschool children. We collected blood and dust samples (floors, windowsills, and carpets) to assess lead exposure. The geometric mean blood lead concentrations are 10.77 and 7.66 microg/dL for the d...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.00108177
更新日期:2000-02-01 00:00:00
abstract::Exposure to low levels of chemicals indoors is often to a mixture of volatile organic compounds (VOCs). It is of interest to determine if the symptomatic and sensory responses can be attributed to a single chemical or to a mixture of chemicals. To determine if sensory or symptomatic responses differ with exposure to s...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106739
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Perfluoroalkyl acids are persistent compounds used in various industrial -applications. Of these compounds, perfluorooctanoate (PFOA) is currently detected in humans worldwide. A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1104034
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Microcystin-producing Microcystis bloom is a severe water problem in the world. Some reports indicate that chronic exposure to microcystin may result in liver damage in adults, but information on effects in children is limited. OBJECTIVE:We investigated the relationship between microcystin exposure and live...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1002412
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:In the 1990s, the mercury-based preservative thimerosal was used in most pediatric vaccines. Although there are currently only two thimerosal-containing vaccines (TCVs) recommended for pediatric use, parental perceptions that vaccines pose safety concerns are affecting vaccination rates, particularly in ligh...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1408257
更新日期:2015-06-01 00:00:00
abstract::Biological markers of intermediate health outcomes sometimes provide a superior alternative to traditional measures of pollutant-related disease. Some opportunities and methodologic issues associated with using markers are discussed in the context of exposures to four complex mixtures: environmental tobacco smoke and ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.93101s4193
更新日期:1993-12-01 00:00:00
abstract::The nasal cavity is susceptible to chemically induced injury as a result of exposure to inhaled irritants. Some responses of the nasal mucosa to inhaled toxicants are species specific. These species-related differences in response may be due to variations in structural, physiologic, and biochemical factors, such as gr...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.85-1568334
更新日期:1990-04-01 00:00:00
abstract::Because of rampant concern that estrogenic chemicals in the environment may be adversely affecting the health of humans and wildlife, reliable methods for detecting and characterizing estrogenic chemicals are needed. It is important that general agreement be reached on which tests to use and that these tests then be a...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.961041296
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Polybrominated diphenyl ethers (PBDEs) are persistent chemicals that have been widely used as flame retardants in furniture, carpet padding, car seats, and other consumer products during the past three decades. OBJECTIVE:We examined whether in utero exposure to PBDEs is associated with child cognitive funct...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1307562
更新日期:2014-08-01 00:00:00
abstract::The pneumoconioses are associated with chronic inflammatory processes during which increased amounts of reactive oxygen species are formed in the lower respiratory tract. To characterize the effect(s) of these processes on the defense system against free radicals, we studied 91 individuals with long-term occupational ...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9084165
更新日期:1990-03-01 00:00:00
abstract::During a 2-year chronic inhalation study on methylene chloride (2000 or 0 ppm; 6 hr/day, 5 days/week), gas-uptake pharmacokinetic studies and tissue partition coefficient determinations were conducted on female B6C3F1, mice after 1 day, 1 month, 1 year, and 2 years of exposure. Using physiologically based pharmacokine...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.96104858
更新日期:1996-08-01 00:00:00
abstract::Human exposure to carcinogenic Cr(VI) compounds is found among workers in a large number of professional groups, and it can also occur through environmental pollution. A significant number of toxic waste sites contain Cr as a major contaminant. In this paper we summarize our efforts to apply measurements of DNA-protei...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.98106s4969
更新日期:1998-08-01 00:00:00
abstract::A comprehensive environmental fate and effects testing program, sponsored by the Chemical Manufacturers Association (CMA) Phthalate Esters Program Panel, has been completed. Based on the results, a preliminary safety assessment has shown that all of the 14 commercially important phthalates tested have sufficiently hig...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.8665337
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:In the United States, most of the treated sewage sludge (biosolids) is applied to farmland as a soil amendment. Critics suggest that rules regulating sewage sludge treatment and land application may be insufficient to protect public health and the environment. Neighbors of land application sites report illne...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.1205470
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES:We investigated the relation between urinary concentrations of GE metabolites i...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/EHP39
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Daily adult human exposure to bisphenol A (BPA) has been estimated at <1 µg/kg, with virtually complete first-pass conjugation in the liver in primates but not in mice. We measured unconjugated and conjugated BPA levels in serum from adult female rhesus monkeys and adult female mice after oral administration ...
journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.1002514
更新日期:2011-04-01 00:00:00