Induction of drug metabolizing enzymes in polybrominated biphenyl-fed lactating rats and their pups.

abstract：BACKGROUND:Epidemiologic studies have demonstrated that occupational noise exposure is associated with hypertension, but the related mechanism in vascular structural changes is unclear. OBJECTIVE:This panel study aimed to investigate effects of occupational noise exposure on ambulatory vascular structural properties i...

journal_title：Environmental health perspectives

authors： Chang TY,Su TC,Lin SY,Jain RM,Chan CC

更新日期：2007-11-01 00:00:00

abstract：:Scientists at Pacific Northwest National Laboratory in Richland, Washington, have developed a unique imaging system capable of focusing on a single living cell within an organism. This new technology will be used in what the multidisciplinary team has termed a "cellular observatory" to study the effect of environmenta...

journal_title：Environmental health perspectives

authors： Medlin J

更新日期：1999-11-01 00:00:00

abstract：:Di(2-ethylhexyl) phthalate (DEHP) is used to make polyvinyl chloride (PVC) plastic tubing soft and flexible. Animal data show that adverse effects of DEHP exposure may include reduced fertility, reduced sperm production in males, and ovarian dysfunction in females. Known treatments that involve high DEHP exposures are...

journal_title：Environmental health perspectives

authors： Rais-Bahrami K,Nunez S,Revenis ME,Luban NL,Short BL

更新日期：2004-09-01 00:00:00

abstract：:A review of the experimental studies relating boron to biological effects on appendicular and axial bones in animal models suggests that numerous influences, known and unknown, affect the responsiveness of bone to dietary boron. Degrees of skeletal response to boron are modified by other nutritional variables that inc...

journal_title：Environmental health perspectives

authors： McCoy H,Kenney MA,Montgomery C,Irwin A,Williams L,Orrell R

更新日期：1994-11-01 00:00:00

abstract：:The destruction of the World Trade Center (WTC) on 11 September 2001 in New York City resulted in the massive release of pulverized dust and combustion products. The dust and smoke settled in the surrounding area, which encompassed a large residential community. We hypothesized that previously normal residents in the ...

journal_title：Environmental health perspectives

authors： Reibman J,Lin S,Hwang SA,Gulati M,Bowers JA,Rogers L,Berger KI,Hoerning A,Gomez M,Fitzgerald EF

更新日期：2005-04-01 00:00:00

abstract：:Heat is the primary weather-related cause of death in the United States. Increasing heat and humidity, at least partially related to anthropogenic climate change, suggest that a long-term increase in heat-related mortality could occur. We calculated the annual excess mortality on days when apparent temperatures--an in...

journal_title：Environmental health perspectives

authors： Davis RE,Knappenberger PC,Michaels PJ,Novicoff WM

更新日期：2003-11-01 00:00:00

abstract：:Lung counting is highly geometry dependent, especially at low photon energies. Monte Carlo simulations have been used to determine the magnitude of the errors obtained if it is assumed that the deposition is homogeneous, when in fact it is not. Simulation for a germanium lung counting system consisting of four, 70 mm ...

journal_title：Environmental health perspectives

authors： Kramer GH

更新日期：1997-12-01 00:00:00

abstract：:A microscopic, ultrastructural, and morphometric study was made of the gills of tench (Tinca tinca, L.) subjected to acute experimental lead nitrate poisoning. Twenty-one adult tench were subjected to poisoning and a further 22 were used as controls. Lesions were characterized by the appearance of edema and epithelial...

journal_title：Environmental health perspectives

authors： Roncero V,Vincente JA,Redondo E,Gãzquez A,Duran E

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES:We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. ME...

journal_title：Environmental health perspectives

authors： Villanueva CM,Gracia-Lavedan E,Bosetti C,Righi E,Molina AJ,Martín V,Boldo E,Aragonés N,Perez-Gomez B,Pollan M,Acebo IG,Altzibar JM,Zabala AJ,Ardanaz E,Peiró R,Tardón A,Chirlaque MD,Tavani A,Polesel J,Serraino D,Pi

更新日期：2017-01-01 00:00:00

abstract：:Although chemical exposure has been associated with reduced reproduction in certain North American fish, reptiles, and mammals, definitive cause-and-effect data are lacking in many instances. Because the increasing use and global transport of industrial chemicals pose significant risk to successful reproduction, metho...

journal_title：Environmental health perspectives

authors： Hose JE,Guillette LJ

更新日期：1995-05-01 00:00:00

abstract：:In recent years there has been an increasing focus in environmental risk assessment on children as a potentially susceptible population. There also has been growing recognition of the need for a systematic approach for organizing, evaluating, and incorporating the available data on children's susceptibilities in risk ...

journal_title：Environmental health perspectives

authors： Daston G,Faustman E,Ginsberg G,Fenner-Crisp P,Olin S,Sonawane B,Bruckner J,Breslin W,McLaughlin TJ

更新日期：2004-02-01 00:00:00

abstract：:Laboratory animal diets for studies to determine the endocrine-disrupting potential of chemicals are under scrutiny because they can affect both assay control values and assay sensitivity. Although phytoestrogen content is important, we have previously shown that a phytoestrogen-rich diet and a phytoestrogen-free diet...

journal_title：Environmental health perspectives

authors： Odum J,Tinwell H,Tobin G,Ashby J

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Evidence suggests that cardiovascular effects of air pollution are mediated by inflammation and that air pollution can induce genetic expression of the interleukin-6 gene (IL6). OBJECTIVES:We investigated whether IL6 and fibrinogen gene variants can affect plasma IL-6 responses to air pollution in patients ...

journal_title：Environmental health perspectives

authors： Ljungman P,Bellander T,Schneider A,Breitner S,Forastiere F,Hampel R,Illig T,Jacquemin B,Katsouyanni K,von Klot S,Koenig W,Lanki T,Nyberg F,Pekkanen J,Pistelli R,Pitsavos C,Rosenqvist M,Sunyer J,Peters A

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:There is ongoing discussion that inhaled nanoparticles (NPs, < 100 nm) may translocate from epithelial deposition sites of the lungs to systemic circulation. OBJECTIVES AND METHODS:We studied the disappearance of NPs from the epithelium by sequential lung retention and clearance and bronchoalveolar lavage (...

journal_title：Environmental health perspectives

authors： Semmler-Behnke M,Takenaka S,Fertsch S,Wenk A,Seitz J,Mayer P,Oberdörster G,Kreyling WG

更新日期：2007-05-01 00:00:00

abstract：:The decline of many amphibian species could be caused by their susceptibility to environmental pollutants that cause cellular stress and cell death. A variety of intracellular signal transduction pathways are activated by environmental stress factors, which result in cell death. Mitogen-activated protein kinases are i...

journal_title：Environmental health perspectives

authors： Carter LA,Tabor MB,Bonner JC,Bonner LA

更新日期：2002-07-01 00:00:00

abstract：:Mineral fibers and particulates represent one of the best documented, economically important, and ubiquitously occurring categories of human carcinogens. Yet, while a wealth of information exists concerning the mechanism of action of physical, chemical, and viral carcinogens, virtually nothing is known relative to the...

journal_title：Environmental health perspectives

authors： Hart RW,Daniel FB,Kindig OR,Beach CA,Joseph LB,Wells RC

更新日期：1980-02-01 00:00:00

abstract：:Ecological risk assessment can be enhanced with predictive models for metal toxicity. Modelings of published data were done under the simplifying assumption that intermetal trends in toxicity reflect relative metal-ligand complex stabilities. This idea has been invoked successfully since 1904 but has yet to be applied...

journal_title：Environmental health perspectives

authors： Newman MC,McCloskey JT,Tatara CP

更新日期：1998-12-01 00:00:00

abstract：:Millions of people worldwide are exposed to arsenic-contaminated drinking water, and ingestion of inorganic arsenic (InAs) has been associated with increased risks of cancer. The primary metabolic pathway of ingested InAs is methylation to monomethyl arsenic (MMA) and dimethyl arsenic (DMA). However, people vary great...

journal_title：Environmental health perspectives

authors： Steinmaus C,Carrigan K,Kalman D,Atallah R,Yuan Y,Smith AH

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Human epidemiological and animal studies suggest that developmental exposure to contaminants that activate the aryl hydrocarbon receptor (AHR) lead to suppression of immune system function throughout life. The persistence of immune deficiency throughout life suggests that the cellular target of AHR activatio...

journal_title：Environmental health perspectives

authors： Laiosa MD,Tate ER,Ahrenhoerster LS,Chen Y,Wang D

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:According to the 2007 National Research Council report Toxicology for the Twenty-First Century, modern methods (e.g., "omics," in vitro assays, high-throughput testing, computational methods) will lead to the emergence of a new approach to toxicology. The Salmonella mammalian microsome mutagenicity assay has...

journal_title：Environmental health perspectives

authors： Claxton LD,Umbuzeiro Gde A,DeMarini DM

更新日期：2010-11-01 00:00:00

abstract：:We used real-time monitors and low-volume air samplers to measure the potential human exposure to airborne polycyclic aromatic hydrocarbon (PAH) concentrations during various flight-related and ground-support activities of C-130H aircraft at an Air National Guard base. We used three types of photoelectric aerosol sens...

journal_title：Environmental health perspectives

authors： Childers JW,Witherspoon CL,Smith LB,Pleil JD

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC), or liver cancer, is the third leading cause of cancer deaths worldwide, with prevalence 16-32 times higher in developing countries than in developed countries. Aflatoxin, a contaminant produced by the fungi Aspergillus flavus and Aspergillus parasiticus in maize and nuts, is a...

journal_title：Environmental health perspectives

authors： Liu Y,Wu F

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Extreme heat events (EHEs) are increasing in frequency in large U.S. cities and are responsible for a greater annual number of climate-related fatalities, on average, than any other form of extreme weather. In addition, low-density, sprawling patterns of urban development have been associated with enhanced s...

journal_title：Environmental health perspectives

authors： Stone B,Hess JJ,Frumkin H

更新日期：2010-10-01 00:00:00

abstract：:In an attempt to elucidate the relationship between DNA adduct formation and tumorigenesis, DNA adducts were measured in the livers and bladders of mice during chronic exposure to several different doses of 2-acetylaminofluorene (2-AAF) and 4-aminobiphenyl (4-ABP). Continuous oral administration of these compounds for...

journal_title：Environmental health perspectives

authors： Poirier MC,Beland FA

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Reported associations between gestational tobacco exposure and autism spectrum disorders (ASDs) have been inconsistent. OBJECTIVE:We estimated the association between maternal smoking during pregnancy and ASDs among children 8 years of age. METHODS:This population-based case-cohort study included 633,989 c...

journal_title：Environmental health perspectives

authors： Kalkbrenner AE,Braun JM,Durkin MS,Maenner MJ,Cunniff C,Lee LC,Pettygrove S,Nicholas JS,Daniels JL

更新日期：2012-07-01 00:00:00

abstract：:Exposure to ultrafine particles (UFPs) from vehicle exhaust has been related to risk of cardiovascular and pulmonary disease and cancer, even though exposure assessment is difficult. We studied personal exposure in terms of number concentrations of UFPs in the breathing zone, using portable instruments in six 18-hr pe...

journal_title：Environmental health perspectives

authors： Vinzents PS,Møller P,Sørensen M,Knudsen LE,Hertel O,Jensen FP,Schibye B,Loft S

更新日期：2005-11-01 00:00:00

abstract：:1,3-Butadiene is a major monomer in the rubber and plastics industry and is one of the highest-production industrial chemicals in the United States. Although not highly acutely toxic to rodents, inhalation of concentrations as low as 6.25 ppm causes tumors in mice. Butadiene is oncogenic in rats, but much higher expos...

journal_title：Environmental health perspectives

authors： Birnbaum LS

更新日期：1993-12-01 00:00:00

abstract：:Environmental health and environmental quality issues along the U.S.-Mexico border have been of concern for several years. The enactment of the North American Free Trade Agreement and the presence of the maquiladoras (foreign-owned industries using imported raw materials) have intensified those concerns recently. Effo...

journal_title：Environmental health perspectives

authors： Carter DE,Peña C,Varady R,Suk WA

更新日期：1996-06-01 00:00:00

abstract：:Acute exposures to isobutane, propane, F-12, and F-11 in concentrations of 250, 500, or 1000 ppm for periods of 1 min to 8 hr did not produce any untoward physiological effects as determined by the methods employed which included serial EKG's and continuous monitoring of modified V5 by telemetry during exposure. Repet...

journal_title：Environmental health perspectives

authors： Stewart RD,Newton PE,Baretta ED,Herrmann AA,Forster HV,Soto RJ

更新日期：1978-10-01 00:00:00

abstract：:We examined the estrogenicity of binary mixtures of the hydroxylated polychlorinated biphenyls (OHPCBs) 2,4,6-trichloro-4'-biphenylol (2,4,6-TCB-4'-OH) and 2,3,4,5-tetrachloro-4'-biphenylol and the pesticides endosulfan and dieldrin. The OHPCBs and pesticides were tested in both the MCF-7 focus assay and a competitive...

journal_title：Environmental health perspectives

authors： Arcaro KF,Vakharia DD,Yang Y,Gierthy JF

更新日期：1998-08-01 00:00:00