Abstract:
BACKGROUND:Hepatocellular carcinoma (HCC), or liver cancer, is the third leading cause of cancer deaths worldwide, with prevalence 16-32 times higher in developing countries than in developed countries. Aflatoxin, a contaminant produced by the fungi Aspergillus flavus and Aspergillus parasiticus in maize and nuts, is a known human liver carcinogen. OBJECTIVES:We sought to determine the global burden of HCC attributable to aflatoxin exposure. METHODS:We conducted a quantitative cancer risk assessment, for which we collected global data on food-borne aflatoxin levels, consumption of aflatoxin-contaminated foods, and hepatitis B virus (HBV) prevalence. We calculated the cancer potency of aflatoxin for HBV-postive and HBV-negative individuals, as well as the uncertainty in all variables, to estimate the global burden of aflatoxin-related HCC. RESULTS:Of the 550,000-600,000 new HCC cases worldwide each year, about 25,200-155,000 may be attributable to aflatoxin exposure. Most cases occur in sub-Saharan Africa, Southeast Asia, and China where populations suffer from both high HBV prevalence and largely uncontrolled aflatoxin exposure in food. CONCLUSIONS:Aflatoxin may play a causative role in 4.6-28.2% of all global HCC cases.
journal_name
Environ Health Perspectjournal_title
Environmental health perspectivesauthors
Liu Y,Wu Fdoi
10.1289/ehp.0901388subject
Has Abstractpub_date
2010-06-01 00:00:00pages
818-24issue
6eissn
0091-6765issn
1552-9924journal_volume
118pub_type
杂志文章abstract::The purpose of the investigation is to study whether an increased mortality from certain causes exists in an area around the Rönnskärsverken smelter works in northern Sweden. Founded in 1928, this metallurgical plant processing mainly nonferrous metals has since its initial operations been using ore with a high arseni...
journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7719133
更新日期:1977-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.7613127
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
doi:10.1289/ehp.90-1519487
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.908751
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更新日期:2014-06-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2014-02-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.9399129
更新日期:1993-03-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:1995-07-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2004-11-01 00:00:00
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更新日期:2001-03-01 00:00:00
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journal_title:Environmental health perspectives
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更新日期:2018-01-22 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1996-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1983-03-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章,评审
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更新日期:2001-03-01 00:00:00
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更新日期:2011-12-01 00:00:00
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journal_title:Environmental health perspectives
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.803589
更新日期:1980-04-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1988-06-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
doi:10.1289/ehp.99107633
更新日期:1999-08-01 00:00:00
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journal_title:Environmental health perspectives
pub_type: 杂志文章
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更新日期:1983-10-01 00:00:00
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journal_title:Environmental health perspectives
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