New Perspectives for Cancer Hazard Evaluation by the Report on Carcinogens: A Case Study Using Read-Across Methods in the Evaluation of Haloacetic Acids Found as Water Disinfection By-Products.

Abstract:

BACKGROUND:Due to the large number of chemicals not yet tested for carcinogenicity but to which people are exposed, the limited number of human and animal cancer studies conducted each year, and the frequent need for a timely response, mechanistic data are playing an increasingly important role in carcinogen hazard identification. OBJECTIVES:To provide a targeted approach to identify relevant mechanistic data in our cancer evaluation of haloacetic acids (HAAs), we used several approaches including systematic review, the 10 key characteristics of carcinogens (KCs), and read-across methods. Our objective in this commentary is to discuss the strengths, limitations, and challenges of these approaches in a cancer hazard assessment. METHODS:A cancer hazard assessment for 13 HAAs found as water disinfection by-products was conducted. Literature searches for mechanistic studies focused on the KCs and individual HAAs. Studies were screened for relevance and categorized by KCs and other relevant data, including chemical properties, toxicokinetics, and biological effects other than KCs. Mechanistic data were organized using the KCs, and strength of evidence was evaluated; this information informed potential modes of action (MOAs) and read-across-like approaches. Three read-across options were considered: evaluating HAAs as a class, as subclass(es), or as individual HAAs (analog approach). DISCUSSION:Because of data limitations and uncertainties, listing as a class or subclass(es) was ruled out, and an analog approach was used. Two brominated HAAs were identified as target (untested) chemicals based on their metabolism and similarity to source (tested) chemicals. In addition, four HAAs with animal cancer data had sufficient evidence for potential listing in the Report on Carcinogens (RoC). This is the first time that the KCs and other relevant data, in combination with read-across principles, were used to support a recommendation to list chemicals in the RoC that did not have animal cancer data. https://doi.org/10.1289/EHP5672.

authors

Atwood ST,Lunn RM,Garner SC,Jahnke GD

doi

10.1289/EHP5672

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

125003

issue

12

eissn

0091-6765

issn

1552-9924

journal_volume

127

pub_type

杂志文章
  • Hazardous solid waste from agriculture.

    abstract::Large quantities of food processing, crop, forestry, and animal solid wastes are generated in the United States each year. The major components of these wastes are biodegradable. However, they also contain components such as nitrogen, human and animal pathogens, medicinals, feed additives, salts, and certain metals, t...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.7827261

    authors: Loehr RC

    更新日期:1978-12-01 00:00:00

  • Assessment of Short- and Long-Term Mortality Displacement in Heat-Related Deaths in Brisbane, Australia, 1996-2004.

    abstract:BACKGROUND:Mortality displacement (or "harvesting") has been identified as a key issue in the assessment of the temperature-mortality relationship. However, only a few studies have addressed the "harvesting" issue and findings have not been consistent. OBJECTIVES:We examined the potential impact of both short- and lon...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1307606

    authors: Qiao Z,Guo Y,Yu W,Tong S

    更新日期:2015-08-01 00:00:00

  • Angiotensin-converting enzyme: II. Pulmonary endothelial cells in culture.

    abstract::Direct studies of the function of a given cell type often require that the cell type be obtained in pure culture. A number of different specific metabolic activities have been attributed to pulmonary endothelial cells, yet with few exceptions the conclusions were based on indirect evidence. Thus, to improve our abilit...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8035171

    authors: Ryan US,Ryan JW

    更新日期:1980-04-01 00:00:00

  • Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease.

    abstract:BACKGROUND:Air pollution exposure increases cardiovascular morbidity and mortality and is a major global public health concern. OBJECTIVES:We investigated the benefits of reducing personal exposure to urban air pollution in patients with coronary heart disease. METHODS:In an open randomized crossover trial, 98 patien...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,随机对照试验

    doi:10.1289/ehp.1103898

    authors: Langrish JP,Li X,Wang S,Lee MM,Barnes GD,Miller MR,Cassee FR,Boon NA,Donaldson K,Li J,Li L,Mills NL,Newby DE,Jiang L

    更新日期:2012-03-01 00:00:00

  • In vivo imaging of activated estrogen receptors in utero by estrogens and bisphenol A.

    abstract::Environmental estrogens are of particular concern when exposure occurs during embryonic development. Although there are good models to study estrogenic activity of chemicals in adult animals, developmental exposure is much more difficult to test. The weak estrogenic activity of the environmental estrogen bisphenol A (...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7155

    authors: Lemmen JG,Arends RJ,van der Saag PT,van der Burg B

    更新日期:2004-11-01 00:00:00

  • Modification of the interleukin-6 response to air pollution by interleukin-6 and fibrinogen polymorphisms.

    abstract:BACKGROUND:Evidence suggests that cardiovascular effects of air pollution are mediated by inflammation and that air pollution can induce genetic expression of the interleukin-6 gene (IL6). OBJECTIVES:We investigated whether IL6 and fibrinogen gene variants can affect plasma IL-6 responses to air pollution in patients ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.0800370

    authors: Ljungman P,Bellander T,Schneider A,Breitner S,Forastiere F,Hampel R,Illig T,Jacquemin B,Katsouyanni K,von Klot S,Koenig W,Lanki T,Nyberg F,Pekkanen J,Pistelli R,Pitsavos C,Rosenqvist M,Sunyer J,Peters A

    更新日期:2009-09-01 00:00:00

  • Interaction of alkylmercuric compounds with sodium selenite. I. Metabolism of ethylmercuric chloride administered alone and in combination with sodium selenite in rats.

    abstract::The effect of sodium selenite administered intragastrically in repeated doses to rats receiving ethylmercuric chloride po in various repeated doses (0.25 or 2.5 mg Hg/kg) on the excretion, whole-body retention, and organ distribution of mercury was studied. Selenium was found to affect the distribution of ethylmercury...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.39-1568742

    authors: Brzeźnicka EA,Chmielnicka J

    更新日期:1981-06-01 00:00:00

  • Role of TET Dioxygenases and DNA Hydroxymethylation in Bisphenols-Stimulated Proliferation of Breast Cancer Cells.

    abstract:BACKGROUND:Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor targeting estrogen receptors (ERs), has been implicated in the promotion of breast cancer. Perinatal exposure of BPA could induce longitudinal alteration of DNA hydroxymethylation in imprinted loci of mouse blood cells. To date, no data has be...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP5862

    authors: Li Z,Lyu C,Ren Y,Wang H

    更新日期:2020-02-01 00:00:00

  • The fate of trenbolone acetate and melengestrol acetate after application as growth promoters in cattle: environmental studies.

    abstract::The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.011091145

    authors: Schiffer B,Daxenberger A,Meyer K,Meyer HH

    更新日期:2001-11-01 00:00:00

  • 13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies for ecotoxicity.

    abstract::There is growing public pressure to minimize the use of vertebrates in ecotoxicity testing; therefore, effective alternatives to toxicity tests causing suffering are being sought. This report discusses alternatives and differs in some respects from the reports of the other three groups because the primary concern is w...

    journal_title:Environmental health perspectives

    pub_type:

    doi:10.1289/ehp.98106441

    authors: Walker C,Kaiser K,Klein W,Lagadic L,Peakall D,Sheffield S,Soldan T,Yasuno M

    更新日期:1998-04-01 00:00:00

  • Individual differences in neural sensitization and the role of context in illness from low-level environmental chemical exposures.

    abstract::This paper summarizes the clinical phenomenology of multiple chemical sensitivity (MCS), outlines the concepts and evidence for the olfactory-limbic, neural sensitization model for MCS, and discusses experimental design implications of the model for exposure-related research. Neural sensitization is the progressive am...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.97105s2457

    authors: Bell IR,Schwartz GE,Baldwin CM,Hardin EE,Klimas NG,Kline JP,Patarca R,Song ZY

    更新日期:1997-03-01 00:00:00

  • Aflatoxin contamination of commercial maize products during an outbreak of acute aflatoxicosis in eastern and central Kenya.

    abstract::In April 2004, one of the largest aflatoxicosis outbreaks occurred in rural Kenya, resulting in 317 cases and 125 deaths. Aflatoxin-contaminated homegrown maize was the source of the outbreak, but the extent of regional contamination and status of maize in commercial markets (market maize) were unknown. We conducted a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7998

    authors: Lewis L,Onsongo M,Njapau H,Schurz-Rogers H,Luber G,Kieszak S,Nyamongo J,Backer L,Dahiye AM,Misore A,DeCock K,Rubin C,Kenya Aflatoxicosis Investigation Group.

    更新日期:2005-12-01 00:00:00

  • Accelerated mammary tumor onset in a HER2/Neu mouse model exposed to DDT metabolites locally delivered to the mammary gland.

    abstract:BACKGROUND:The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer is controversial, but animal studies directly linking DDT to risk are lacking. Concerns with DDT reside in its environmental persistence, bioaccumulation in breast adipose tissue, and endocrine-disrupting actions. Whereas most attent...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1104327

    authors: Johnson NA,Ho A,Cline JM,Hughes CL,Foster WG,Davis VL

    更新日期:2012-08-01 00:00:00

  • Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: nongenotoxic carcinogens and genotoxic noncarcinogens.

    abstract::According to current data, the capacity to cause nonprogrammed or unscheduled cell proliferation in target tissues, a common characteristic of chemical carcinogens, may play a more important role in the development of tumors than does genotoxicity. This paper provides strong support for the validity of this conclusion...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.9610440

    authors: Yoshikawa K

    更新日期:1996-01-01 00:00:00

  • Benchmark calculations for perchlorate from three human cohorts.

    abstract::The presence of low concentrations of perchlorate in some drinking water sources has led to concern regarding potential effects on the thyroid. In a recently published report, the National Academy of Sciences indicated that the perchlorate dose required to cause hypothyroidism in adults would probably be > 0.40 mg/kg-...

    journal_title:Environmental health perspectives

    pub_type: 临床试验,杂志文章

    doi:10.1289/ehp.7814

    authors: Crump KS,Gibbs JP

    更新日期:2005-08-01 00:00:00

  • Acrolein depletes the neuropeptides CGRP and substance P in sensory nerves in rat respiratory tract.

    abstract::The mammalian respiratory tract is densely innervated by autonomic and sensory nerves around airways and blood vessels. Subsets of these nerves contain a number of putative neurotransmitter peptides, such as substance P and calcitonin gene-related peptide (CGRP) in sensory nerves and vasoactive intestinal polypeptide ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.85-1568331

    authors: Springall DR,Edginton JA,Price PN,Swanston DW,Noel C,Bloom SR,Polak JM

    更新日期:1990-04-01 00:00:00

  • Chemical characterization and bioactivity of polycyclic aromatic hydrocarbons from non-oxidative thermal treatment of pyrene-contaminated soil at 250-1,000 degrees C.

    abstract::In this paper we report yields, identities, and mutagenicities of products from heating a polycyclic aromatic hydrocarbon (PAH)-contaminated, Superfund-related synthetic soil matrix without exogenous oxygen. We heated batch samples of soil pretreated with 5.08 wt% (by weight) pyrene in a tubular furnace under a consta...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.00108709

    authors: Richter H,Risoul V,Lafleur AL,Plummer EF,Howard JB,Peters WA

    更新日期:2000-08-01 00:00:00

  • Nutritional needs in environmental intoxication: vitamin E and air pollution, an example.

    abstract::Dietary vitamin E affects the susceptibility of mice and rats to ozone and nitrogen dioxide, suggesting a free radical mechanism of toxicity. Conventional peroxidation does not completely explain the effects of alterations of lung fatty acid composition on both nitrogen dioxide and ozone toxicity. A new scheme is prop...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.7929105

    authors: Menzel DB

    更新日期:1979-04-01 00:00:00

  • Long-Term Exposure to Transportation Noise in Relation to Development of Obesity—a Cohort Study.

    abstract:BACKGROUND:Exposure to transportation noise is widespread and has been associated with obesity in some studies. However, the evidence from longitudinal studies is limited and little is known about effects of combined exposure to different noise sources. OBJECTIVES:The aim of this longitudinal study was to estimate the...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP1910

    authors: Pyko A,Eriksson C,Lind T,Mitkovskaya N,Wallas A,Ögren M,Östenson CG,Pershagen G

    更新日期:2017-11-20 00:00:00

  • Relationships between DNA adduct formation and carcinogenesis.

    abstract::An impressive array of evidence has been obtained during the past decade establishing correlations between specific DNA adducts and carcinogenesis. Many of the studies utilized organ specific differences in carcinogenesis to establish the correlations. More recently, we have investigated similar relationships between ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.8562177

    authors: Swenberg JA,Richardson FC,Boucheron JA,Dyroff MC

    更新日期:1985-10-01 00:00:00

  • Road Traffic and Railway Noise Exposures and Adiposity in Adults: A Cross-Sectional Analysis of the Danish Diet, Cancer, and Health Cohort.

    abstract:BACKGROUND:Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight. OBJECTIVES:We aimed to investigate the relationship between residential traffic and railway noise and a...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409052

    authors: Christensen JS,Raaschou-Nielsen O,Tjønneland A,Overvad K,Nordsborg RB,Ketzel M,Sørensen TIa,Sørensen M

    更新日期:2016-03-01 00:00:00

  • Survey of county-level heat preparedness and response to the 2011 summer heat in 30 U.S. States.

    abstract:BACKGROUND:Adapting to extreme heat is becoming more critical as our climate changes. Previous research reveals that very few communities in the United States have programs to sufficiently prevent health problems during hot weather. OBJECTIVE:Our goal was to examine county-level local heat preparedness and response in...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1306693

    authors: White-Newsome JL,Ekwurzel B,Baer-Schultz M,Ebi KL,O'Neill MS,Anderson GB

    更新日期:2014-06-01 00:00:00

  • Prenatal Exposure to PM2.5 and Cardiac Vagal Tone during Infancy: Findings from a Multiethnic Birth Cohort.

    abstract:BACKGROUND:The autonomic nervous system plays a key role in maintaining homeostasis and responding to external stimuli. In adults, exposure to fine particulate matter ( PM ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP4434

    authors: Cowell WJ,Brunst KJ,Malin AJ,Coull BA,Gennings C,Kloog I,Lipton L,Wright RO,Enlow MB,Wright RJ

    更新日期:2019-10-01 00:00:00

  • Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits.

    abstract:BACKGROUND:Modern toxicology is shifting from an observational to a mechanistic science. As part of this shift, high-throughput toxicity assays are being developed using alternative, nonmammalian species to prioritize chemicals and develop prediction models of human toxicity. METHODS:The nematode Caenorhabditis elegan...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.1409645

    authors: Boyd WA,Smith MV,Co CA,Pirone JR,Rice JR,Shockley KR,Freedman JH

    更新日期:2016-05-01 00:00:00

  • Different slopes for different folks: socioeconomic and racial/ethnic disparities in asthma and hay fever among 173,859 U.S. men and women.

    abstract::Although allergic diseases such as asthma and hay fever are a major cause of morbidity in industrialized countries, most studies have focused on patterns of prevalence among children and adolescents, with relatively few studies on variations in prevalence by race/ethnicity and socioeconomic position among adults. Our ...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.02110s2211

    authors: Chen JT,Krieger N,Van Den Eeden SK,Quesenberry CP

    更新日期:2002-04-01 00:00:00

  • Genetic predispositions and childhood cancer.

    abstract::This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章,评审

    doi:10.1289/ehp.98106801

    authors: Shannon K

    更新日期:1998-06-01 00:00:00

  • Discriminating different classes of toxicants by transcript profiling.

    abstract::Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing. The aim of the present study was to determine if biological samples from rats treated with various compounds can be classi...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/txg.7036

    authors: Steiner G,Suter L,Boess F,Gasser R,de Vera MC,Albertini S,Ruepp S

    更新日期:2004-08-01 00:00:00

  • Concerning the need for more sophisticated animal models in sensory behavioral toxicology.

    abstract::It is necessary but not sufficient to develop laboratory animal models in sensory behavioral toxicology for screening toxic substances and for the analysis of sensory impairment at threshold levels of stimulation. It is important to develop more thorough and quantitative tests of impairment which in their greater comp...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.824477

    authors: Stebbins WC

    更新日期:1982-04-01 00:00:00

  • The role of plants and plant/microbial systems in the reduction of exposure.

    abstract::The activities of plants and plant/microbial associations may offer a viable means of accomplishing the in situ remediation of contaminated soils. Two uses of plants for phytoremediation are reported here. In one set of studies, the ability of plants to foster degradative microorganisms was investigated. Results indic...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/ehp.95103s413

    authors: Shann JR

    更新日期:1995-06-01 00:00:00

  • Long-term Fine Particulate Matter Exposure and Nonaccidental and Cause-specific Mortality in a Large National Cohort of Chinese Men.

    abstract:BACKGROUND:Cohort studies in North America and western Europe have reported increased risk of mortality associated with long-term exposure to fine particles (PM2.5), but to date, no such studies have been reported in China, where higher levels of exposure are experienced. OBJECTIVES:We estimated the association betwee...

    journal_title:Environmental health perspectives

    pub_type: 杂志文章

    doi:10.1289/EHP1673

    authors: Yin P,Brauer M,Cohen A,Burnett RT,Liu J,Liu Y,Liang R,Wang W,Qi J,Wang L,Zhou M

    更新日期:2017-11-07 00:00:00