Biochemical studies on the toxicity of slate mine dust.

abstract：:According to current data, the capacity to cause nonprogrammed or unscheduled cell proliferation in target tissues, a common characteristic of chemical carcinogens, may play a more important role in the development of tumors than does genotoxicity. This paper provides strong support for the validity of this conclusion...

journal_title：Environmental health perspectives

authors： Yoshikawa K

更新日期：1996-01-01 00:00:00

abstract：:Potential public health effects associated with exposure to metal emissions from hazardous waste incinerators through noninhalation pathways were evaluated. Instead of relying on modeling the movement of toxicants through various environmental media, an approach based on estimating changes from baseline levels of expo...

journal_title：Environmental health perspectives

authors： Sedman RM,Polisini JM,Esparza JR

更新日期：1994-06-01 00:00:00

abstract：:The potential impact of an agent altering male reproductive function is greater for humans than for animals. Consequently, it is essential that sensitive criteria be used to look for effects on a multiplicity of target sites when an agent is evaluated using an animal model. No animal model has reproductive characteris...

journal_title：Environmental health perspectives

authors： Amann RP

更新日期：1986-12-01 00:00:00

abstract：:Uterine leiomyomas (fibroids, myomas) are the most common tumors occurring in the genital tract of women over 30 years of age. These benign uterine smooth-muscle tumors are estimated to be clinically significant in at least 25% of the American female population during their reproductive years. Furthermore, when thorou...

journal_title：Environmental health perspectives

authors： Newbold RR,DiAugustine RP,Risinger JI,Everitt JI,Walmer DK,Parrott EC,Dixon D

更新日期：2000-10-01 00:00:00

abstract：:The immune system comprises a highly integrated network of multiple tissues and cell types with complicated interactions and effects. It is modulated by the endocrine and nervous systems and there is growing realization of its multifunctionality. The session focusing on immunologic effects of dioxin and related compou...

journal_title：Environmental health perspectives

authors： Birnbaum LS

更新日期：1995-03-01 00:00:00

abstract：:Scaling of the quantified dispositional parameters of xenobiotics from animals to man is of interest from the standpoint of toxicology (e.g., poisoning and risk assessment). Scaling is also important from the standpoint of therapeutics because it represents a strategy for predicting first-use-in-human doses in clinica...

journal_title：Environmental health perspectives

authors： Bachmann K,Pardoe D,White D

更新日期：1996-04-01 00:00:00

abstract：:There has been increased concern over health effects related to potential exposure of building occupants to bioaerosols. We report the case of a worker with a respiratory illness related to bioaerosol exposure in a water-damaged building with extensive fungal contamination. We performed environmental tests to evaluate...

journal_title：Environmental health perspectives

authors： Trout D,Bernstein J,Martinez K,Biagini R,Wallingford K

更新日期：2001-06-01 00:00:00

abstract：:Factors affecting the design of an epidemiologic study assessing possible health effects from chemical waste disposal sites are reviewed. Such epidemiologic studies will most likely be prompted either by a known release of chemicals into the environment around the site, or by an unusual disease cluster in a population...

journal_title：Environmental health perspectives

authors： Buffler PA,Crane M,Key MM

更新日期：1985-10-01 00:00:00

abstract：:Methylation is considered the detoxification pathway for inorganic arsenic (InAs), an established human carcinogen. Urinary speciation analysis is used to assess the distribution of metabolites [monomethylarsonate (MMA), dimethylarsinate (DMA), and unmethylated arsenic (InAs)], as indicators of methylation capacity. W...

journal_title：Environmental health perspectives

authors： Hopenhayn-Rich C,Biggs ML,Smith AH,Kalman DA,Moore LE

更新日期：1996-06-01 00:00:00

abstract：:Considerable attention has been given to the relationship between levels of fine particulate matter (particulate matter < or = 2.5 microm in aerodynamic diameter; PM(2.5) in the atmosphere and health effects in human populations. Since the U.S. Environmental Protection Agency began widespread monitoring of PM(2.5) lev...

journal_title：Environmental health perspectives

authors： Holloman CH,Bortnick SM,Morara M,Strauss WJ,Calder CA

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:The biological mechanisms involved in inflammatory response to air pollution are not clearly understood. OBJECTIVE:In this study we assessed the association of short-term air pollutant exposure with inflammatory markers and lung function. METHODS:We studied a cohort of 158 asthmatic and 50 nonasthmatic sch...

journal_title：Environmental health perspectives

authors： Barraza-Villarreal A,Sunyer J,Hernandez-Cadena L,Escamilla-Nuñez MC,Sienra-Monge JJ,Ramírez-Aguilar M,Cortez-Lugo M,Holguin F,Diaz-Sánchez D,Olin AC,Romieu I

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Although indoor residual spraying (IRS) with dichlorodiphenyltrichloroethane (DDT) and pyrethroids effectively controls malaria, it potentially increases human exposure to these insecticides. Previous studies suggest that prenatal exposure to these insecticides may impact human neurodevelopment. OBJECTIVES:...

journal_title：Environmental health perspectives

authors： Eskenazi B,An S,Rauch SA,Coker ES,Maphula A,Obida M,Crause M,Kogut KR,Bornman R,Chevrier J

更新日期：2018-04-06 00:00:00

abstract：:A set of 53 individuals from a population highly exposed to airborne hexachlorobenzene (HCB) were selected to study the elimination kinetics of this chemical in humans. The volunteers provided blood, 24-hr urine, and feces samples for analysis of HCB and metabolites. The serum HCB concentrations ranged from 2.4 to 1,4...

journal_title：Environmental health perspectives

authors： To-Figueras J,Barrot C,Sala M,Otero R,Silva M,Ozalla MD,Herrero C,Corbella J,Grimalt J,Sunyer J

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Thallium (Tl) is a highly toxic heavy metal widely present in the environment. Case reports have suggested that maternal exposure to high levels of Tl during pregnancy is associated with low birth weight (LBW), but epidemiological data are limited. OBJECTIVES:This study was designed to evaluate whether pren...

journal_title：Environmental health perspectives

authors： Xia W,Du X,Zheng T,Zhang B,Li Y,Bassig BA,Zhou A,Wang Y,Xiong C,Li Z,Yao Y,Hu J,Zhou Y,Liu J,Xue W,Ma Y,Pan X,Peng Y,Xu S

更新日期：2016-01-01 00:00:00

abstract：:Of 240 pesticides screened for carcinogenicity by the U.S. Environmental Protection Agency Office of Pesticide Programs, at least 24 (10%) produce thyroid follicular cell tumors in rodents. Thirteen of the thyroid carcinogens also induce liver tumors, mainly in mice, and 9 chemicals produce tumors at other sites. Some...

journal_title：Environmental health perspectives

authors： Hurley PM

更新日期：1998-08-01 00:00:00

abstract：:The destruction of the World Trade Center (WTC) on 11 September 2001 in New York City resulted in the massive release of pulverized dust and combustion products. The dust and smoke settled in the surrounding area, which encompassed a large residential community. We hypothesized that previously normal residents in the ...

journal_title：Environmental health perspectives

authors： Reibman J,Lin S,Hwang SA,Gulati M,Bowers JA,Rogers L,Berger KI,Hoerning A,Gomez M,Fitzgerald EF

更新日期：2005-04-01 00:00:00

abstract：:Polybrominated biphenyls (PBBs) cause a mixed-type (phenobarbital- plus 3-methylcholanthrene-like) induction of liver microsomal drug metabolizing enzymes in rats. However, 2,2',4,4',5,5'-hexabromobiphenyl and 2,2',3,4,4',5,5'-heptabromobiphenyl, which together comprise less than 80% of PBBs (FireMaster), were shown t...

journal_title：Environmental health perspectives

authors： Moore RW,Dannan GA,Aust SD

更新日期：1978-04-01 00:00:00

abstract：:This paper reports the results of a comprehensive survey of the effects of the accidental release of radiation caused by the accident at the Chernobyl nuclear power station in April 1986. The accident and the resulting release of radiation and radioactive products into the atmosphere produced the most serious environm...

journal_title：Environmental health perspectives

authors： Kulakov VI,Sokur TN,Volobuev AI,Tzibulskaya IS,Malisheva VA,Zikin BI,Ezova LC,Belyaeva LA,Bonartzev PD,Speranskaya NV

更新日期：1993-07-01 00:00:00

abstract：:In the aquatic environment, diet is an important route of exposure for the common contaminant and procarcinogen benzo(a)pyrene (BaP). Dietary organisms vary in their BaP content and in contaminated areas often contain other xenobiotics including cytochrome P4501A inducers. This study examined the effect of dose and pr...

journal_title：Environmental health perspectives

authors： Kleinow KM,James MO,Tong Z,Venugopalan CS

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Recent findings suggest that maternal smoking during pregnancy may play a role in the development of metabolic alterations in offspring during childhood. However, whether such exposure increases the risk of developing similar metabolic alterations during adulthood is uncertain. OBJECTIVE:We evaluated the as...

journal_title：Environmental health perspectives

authors： Cupul-Uicab LA,Skjaerven R,Haug K,Travlos GS,Wilson RE,Eggesbø M,Hoppin JA,Whitworth KW,Longnecker MP

更新日期：2012-11-01 00:00:00

abstract：:Chlorination has been the major strategy for disinfection of drinking water in the United States. Concern about the potential health effects of the reaction by-products of chlorine has prompted use of alternative strategies. One such method is chloramination, a treatment process that does not appear to have carcinogen...

journal_title：Environmental health perspectives

authors： Zierler S,Danley RA,Feingold L

更新日期：1986-11-01 00:00:00

abstract：:The physiological function of copper(I)-metallothionein is not well understood. The respiratory function of hemocyanin, a copper(I)-containing respiratory protein found in the hemolymph of many invertebrates, has been known a long time. However, the mechanism by which Cu(I) is inserted into the oxygen-binding site of ...

journal_title：Environmental health perspectives

authors： Brouwer M,Whaling P,Engel DW

更新日期：1986-03-01 00:00:00

abstract：:We have previously reported that rats are resilient to the hepatotoxic and lethal combination of chlordecone (CD) and carbon tetrachloride (CCl4) during early postnatal development. The overall findings pointed to stimulated cell division and tissue repair mechanisms as the underlying cause of resistance. The objectiv...

journal_title：Environmental health perspectives

authors： Dalu A,Rao PS,Mehendale HM

更新日期：1998-09-01 00:00:00

abstract：:[This corrects the article DOI: https://doi.org/10.1289/EHP507.]. ...

journal_title：Environmental health perspectives

authors： Fann N,Kim SY,Olives C,Sheppard L

更新日期：2018-02-20 00:00:00

abstract：:It has been hypothesized that environmental exposure to synthetic estrogenic chemicals and related endocrine-active compounds may be responsible for a global decrease in sperm counts, decreased male reproductive capacity, and breast cancer in women. Results of recent studies show that there are large demographic varia...

journal_title：Environmental health perspectives

authors： Safe SH

更新日期：2000-06-01 00:00:00

abstract：:Epidemiologic studies long have played a role in the understanding of the effects of the general environment and various occupational exposures on the occurrence of acute and chronic diseases of the lung. This article is an overview of epidemiologic study designs that have particular relevance to studies of environmen...

journal_title：Environmental health perspectives

authors： Tager IB

更新日期：2000-08-01 00:00:00

abstract：:In this article we report a simple and efficient method for detecting nonsteroidal estrogens in a biologic sample. This method uses polyclonal antibodies to estradiol (E2) to immunoprecipitate these major biologically active steroidal estrogens, leaving behind the nonsteroidal estrogens, which are then detected in a c...

journal_title：Environmental health perspectives

authors： Natarajan K,Overstreet JW,Rogers JM,Denison MS,Chen J,Lohstroh PN,McConnell DS,Lasley BL

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Psychological sequelae are among the most pronounced effects in populations following exposure to oil spills. Women in particular represent a vulnerable yet influential population but have remained relatively understudied with respect to the Deepwater Horizon oil spill (DHOS). OBJECTIVE:To describe the rela...

journal_title：Environmental health perspectives

authors： Rung AL,Gaston S,Oral E,Robinson WT,Fontham E,Harrington DJ,Trapido E,Peters ES

更新日期：2016-09-01 00:00:00

abstract：:This paper summarizes the clinical phenomenology of multiple chemical sensitivity (MCS), outlines the concepts and evidence for the olfactory-limbic, neural sensitization model for MCS, and discusses experimental design implications of the model for exposure-related research. Neural sensitization is the progressive am...

journal_title：Environmental health perspectives

authors： Bell IR,Schwartz GE,Baldwin CM,Hardin EE,Klimas NG,Kline JP,Patarca R,Song ZY

更新日期：1997-03-01 00:00:00

abstract：:Principles and practices of pediatric neurotoxicology are reviewed here with the purpose of guiding the design and execution of the planned National Children's Study. The developing human central nervous system is the target organ most vulnerable to environmental chemicals. An investigation of the effects of environme...

journal_title：Environmental health perspectives

authors： Dietrich KN,Eskenazi B,Schantz S,Yolton K,Rauh VA,Johnson CB,Alkon A,Canfield RL,Pessah IN,Berman RF

更新日期：2005-10-01 00:00:00